2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-155700
    SDH-IN-6
    		Inhibitor
    SDH-IN-6 (compound 6i) is a potent succinate dehydrogenase (SDH) inhibitor. SDH-IN-6 has antifungal activity against Valsa mali with an EC50 value of 1.77 mg/L.
    SDH-IN-6
  • HY-156252
    Antifungal agent 75
    		Inhibitor
    Antifungal agent 75 (compound 6r) is a potent antifungal agent against Candida albicans. Antifungal agent 75 significantly inhibits the formation of C. albicans biofilm, increases the permeability of the cell membrane, reduces the ergosterol level of the cell membrane, damages the membrane structure, and destroys the integrity of the cell structure to exert excellent antifungal activity.
    Antifungal agent 75
  • HY-149653
    SDH-IN-10
    		Inhibitor
    SDH-IN-10 is a potent succinate dehydrogenase inhibitor (SDHI) with antifungal effects.
    SDH-IN-10
  • HY-125666
    Agistatin B
    Agistatin B, isolated from fungus, is a mycotoxin. Agistatin B inhibits cholesterol synthesis.
    Agistatin B
  • HY-N10293
    Monaschromone
    		Inhibitor
    Monaschromone, a polyketide metabolite, significantly inhibits the growth of B. cinerea, A. solani, M. oryzae, and G. saubinettii, with the MIC values ranging from 6.25 to 12.5 μM.
    Monaschromone
  • HY-129208
    Viridicatumtoxin
    		Inhibitor
    Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD50 of 122.4 mg/kg in rats.
    Viridicatumtoxin
  • HY-N3353
    Luteone
    		Inhibitor 98.65%
    Luteone is a natural isoflavone, with antioxidant, antibacterial and antifung activities.
    Luteone
  • HY-146427
    Antifungal agent 29
    		Inhibitor
    Antifungal agent 29 (compound 9d) is a potent, selective and non-toxic antifungal agent. Antifungal agent 29 shows antifungal activity towards Cryptococcus neoformans (MIC ≤ 0.23 μM).
    Antifungal agent 29
  • HY-145348
    MK-5204
    		Inhibitor
    MK-5204 is an orally active β-1,3-glucan synthesis inhibitor.
    MK-5204
  • HY-122785
    Fusapyrone
    		Inhibitor
    Fusapyrone is a broad-spectrum antifungal metabolite first isolated from Fusarium species. It has been investigated for use in the control of postharvest crop diseases such as inhibiting the growth of ochratoxin-producing strains of Aspergillus section Nigri in wine grapes.
    Fusapyrone
  • HY-139905
    Antifungal agent 19
    		Inhibitor
    Antifungal agent 19 shows the potent antifungal activity (EC50 = 0.72 μM).
    Antifungal agent 19
  • HY-N10958
    Wikstrol A
    		Inhibitor
    Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC50 value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC50 value of 67.8 µM.
    Wikstrol A
  • HY-163284
    SDH-IN-12
    SDH-IN-12 (compound 9b) is a succinate dehydrogenase inhibitor, which exhibits activity against S. sclerotiorum and C. arachidicola, with EC50s of 0.97 and 2.07 μM, respectively. SDH-IN-12 reveals no significant herbicidal activity against monocotyledonous and dicotyledonous plants.
    SDH-IN-12
  • HY-123230S1
    Trifloxystrobin-d3
    Trifloxystrobin-d3 is the deuterium labeled Trifloxystrobin (HY-123230). Trifloxystrobin (CGA 279202) is a type of fungicide. Trifloxystrobin has toxicity, antiparasitic activity and induce apoptosis, oxidative stress and DNA damage. Trifloxystrobin can be used for the reaesrch of fungal diseases.
    Trifloxystrobin-d<sub>3</sub>
  • HY-W774918R
    Oxaziclomefone (Standard)
    Oxaziclomefone (Standard) is the analytical standard of Oxaziclomefone. This product is intended for research and analytical applications. Oxaziclomefone is a broad-spectrum pesticide with fungal activity. Oxaziclomefone effectively controls a variety of crop diseases and has significant effects against plant pathogenic fungi. Oxaziclomefone is widely used in agriculture to protect crops from diseases and improve crop yield and quality.
    Oxaziclomefone (Standard)
  • HY-149821
    Antifungal agent 50
    		Inhibitor
    Antifungal agent 50 is an antifungal agent, displaying MICs <0.063-1 μg/mL.
    Antifungal agent 50
  • HY-N10288
    Eucalyptacid A
    		Inhibitor
    Eucalyptacid A, an antifungal metabolite, exhibits antifungal activities against Alternaria solani, with MIC values from 6.25 to 50 μM.
    Eucalyptacid A
  • HY-P2450
    Leucinostatin A
    		Inhibitor
    Leucinostatin A (Antibiotic P168) is a nonapeptide exerting a remarkable activity especially against Candida albicans and Cryptococcus neoformans. Leucinostatin A is a hydrophobic nonapeptide antibiotic. Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells. Antiprotozoal activies.
    Leucinostatin A
  • HY-P5564
    BTL peptide
    		Inhibitor
    BTL peptide is an antifungal peptide. BTL peptide is active against B. maydis, A. brassicae, A. niger and C. personata.
    BTL peptide
  • HY-133651
    2,2-Dibromopropanoic acid
    		Inhibitor
    2,2-Dibromopropanoic acid is a dibromo product based on propionic acid. Propionic acid is a short chain fatty acid and acts as chemical intermediate. Propionic acid is also a mold inhibitor and widely used in food preservative.
    2,2-Dibromopropanoic acid
Cat. No. Product Name / Synonyms Application Reactivity