2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B2064
    Carboxin
    		Inhibitor 99.82%
    Carboxin (Carboxine) is a systemic agricultural fungicide and seed protectant.
    Carboxin
  • HY-N0849
    Dictamine
    		Inhibitor 99.60%
    Dictamnine (Dictamine) exhibits cytotoxicity to human cervical and colon cancer cells and also has antibacterial and antifungal activities.
    Dictamine
  • HY-B0453
    Econazole nitrate
    		Inhibitor ≥98.0%
    Econazole nitrate is an imidazole class antifungal medication. Econazole nitrate also has antibacterial activity.
    Econazole nitrate
  • HY-N0216S
    Benzoic acid-d5
    		Inhibitor 99.16%
    Benzoic acid-d5 is a deuterium substitute for Benzoic acid. Benzoic acid is an aromatic alcohol that occurs naturally in many plants and is a common additive in food, beverages, cosmetics and other products. Benzoic acid can act as a preservative by inhibiting bacteria and fungi.
    Benzoic acid-d<sub>5</sub>
  • HY-B0301
    Bifonazole
    		Inhibitor 99.95%
    Bifonazole (Bay H-4502) is an imidazole antifungal agent.
    Bifonazole
  • HY-Y0319G
    Magnesium acetate tetrahydrate
    		Inhibitor 99.47%
    Magnesium acetate tetrahydrate is a carboxylic acid and short-chain fatty acid (SCFAs). Magnesium acetate tetrahydrate activates AMPK, increases ROS, cleaved caspase 9, PPARα, downregulates SREBP-1c, ChREBP expression. Magnesium acetate tetrahydrate exhibits antifungal activity against Saccharomyces cerevisiae W303-1A. Magnesium acetate tetrahydrate regulates energy metabolism. Magnesium acetate tetrahydrate has anticancer activity against gastric cancer. Magnesium acetate tetrahydrate induces writhing reaction and ulcerative colitis. Magnesium acetate tetrahydrate can be used in the researches for gastric cancer, ulcerative colitis, hepatic steatosis, and pain.
    Magnesium acetate tetrahydrate
  • HY-B0963
    Cloxiquine
    		Inhibitor 99.94%
    Cloxiquine (5-Chloro-8-quinolinol) is an antibacterial, antifungal and antiamoebic agent. Cloxiquine can be used for the research of tuberculosis and dermatoses. Cloxiquine suppresses the growth and metastasis of melanoma cells through activation of PPARγ.
    Cloxiquine
  • HY-B1729
    Phenoxyethanol
    		Inhibitor 99.49%
    Phenoxyethanol has a broad spectrum of antimicrobial agent. Phenoxyethanol is an uncouple agent in oxidative phosphorylation from respiration and competitively inhibits malate dehydrogenase. Phenoxyethanol is used as a preservative in cosmetic, vaccine, and textile, et al.
    Phenoxyethanol
  • HY-B2033
    Pyrimethanil
    		Inhibitor 99.85%
    Pyrimethanil is an anilinopyrimidine and broad-spectrum contact fungicide for the control of Botrytis spp. on a wide variety of crops. Pyrimethanil inhibits the biosynthesis of methionine and other amino acids in Botrytis cinerea. Pyrimethanil can be used for the research of fungal diseases prevention on fruit, vegetable and ornamental plants with mold infection.
    Pyrimethanil
  • HY-N1944
    Nerolidol
    		Inhibitor ≥98.0%
    Nerolidol has multiple natural membrane activities, possesses anti-cancer, anti-inflammatory, antibacterial and anti-insect activity. Nerolidol Suppresses parasitic activity, suppresses bloodsucking diseases, bloodworm diseases, and other diseases. Nerolidol can protect the cells from lipid and protein properties, damage to DNA, and protect the cells from damage.
    Nerolidol
  • HY-N7151
    Aurachin D
    		Inhibitor 99.62%
    Aurachin D is an antibiotic. Aurachin D inhibits Gram-positive bacteria and a few funguses. Aurachin D blocks NADH oxidation in beef heart submitochondrial particles.
    Aurachin D
  • HY-W021040
    Fludioxonil
    		Inhibitor 99.94%
    Fludioxonil (CGA-173506) is a phenylpyrrole-type fungicide with oral activity that can inhibit the growth of S. sclerotiorum. Fludioxonil promotes tumor growth and metastasis, and induces cardiac toxicity. Fludioxonil causes cytoskeletal disruption, DNA damage, and apoptosis in mouse glioma cells.
    Fludioxonil
  • HY-12638
    Dichlorophen
    		Inhibitor 98.55%
    Dichlorophen (DDM) is an anticestodal agent. Dichlorophen is an antimicrobial agent shown to exert activity against cestodes, protozoa, fungi, and bacteria.
    Dichlorophen
  • HY-B1790
    Terconazole
    		Inhibitor 99.93%
    Terconazole is a broad-spectrum antifungal medication for the treatment of vaginal yeast infection.
    Terconazole
  • HY-N1434
    Methyl p-coumarate
    		Inhibitor 99.80%
    Methyl p-coumarate (Methyl 4-hydroxycinnamate), an orally active esterified derivative of p-Coumaric acid (pCA), can be isolated from the flower of Trixis michuacana var longifolia. Methyl p-coumarate could inhibit the melanin formation in B16 mouse melanoma cells. Methyl p-coumarate also has strong in vitro inhibitory effect on A. alternata and other pathogens.
    Methyl p-coumarate
  • HY-76200S
    Voriconazole-d3
    		Inhibitor 99.56%
    Voriconazole-d3 is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes.
    Voriconazole-d<sub>3</sub>
  • HY-N2071
    Cedrol
    		Inhibitor 99.76%
    Cedrol is a potent competitive inhibitor of cytochrome P-450(CYP) enzyme. Cedrol plays an anticancer role by inducing cell cycle arrest and Caspase-dependent apoptosis. Cedrol acts as a neutrophil agonist that can desensitize cells to subsequent stimulation of N-formyl peptides. Cedrol prevents neuropathic pain caused by chronic contractile injury by inhibiting oxidative stress and inflammation. In addition, Cedrol has antibacterial, hair loss prevention and anti-anxiety properties.
    Cedrol
  • HY-121721
    Inz-5
    		Inhibitor 98.82%
    Inz-5 is a fungal-selective mitochondrial cytochrome bc1 inhibitor. Inz-5 impairs fungal virulence and prevents the evolution of agent resistance.
    Inz-5
  • HY-106681
    Lagosin
    		Inhibitor
    Lagosin (Fungichromin) is a polyene macrolide antibiotic. Lagosin has demonstrated broad-spectrum antifungal activity and is impervious to agent resistance.
    Lagosin
  • HY-B0850
    Difenoconazole
    		Inhibitor 99.93%
    Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth.
    Difenoconazole
Cat. No. Product Name / Synonyms Application Reactivity