2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel
  5. Calcium Channel Isoform

Calcium Channel

 

Calcium Channel Related Products (804):

Cat. No. Product Name Effect Purity
  • HY-B0419R
    Manidipine (Standard)
    		Inhibitor
    Manidipine (Standard) is the analytical standard of Manidipine. This product is intended for research and analytical applications. Manidipine is an orally active calcium channel antagonist. Manidipine regulates the expression of cytokines (IL-1β, IL-6). Manidipine has a hypotensive effect. Manidipine can be used in the study of cardiovascular diseases (such as hypertension, myocardial ischemia-reperfusion injury, ventricular hypertrophy), kidney diseases (such as glomerular diseases), and epilepsy.
  • HY-118136
    CGP 28392
    		Activator
    CGP 28392 is an activator for calcium channel, and reactivates the oxygen evolution in calcium-deficient photosystem II (PS II) particles.
  • HY-108981
    CERM11956
    		Inhibitor
    CERM11956 is a potent anti-ischaemic agent. CERM11956 is a derivative of bepridil(HY-16952).
  • HY-17403R
    Manidipine dihydrochloride (Standard)
    		Inhibitor
    Manidipine (dihydrochloride) (Standard) is the analytical standard of Manidipine (dihydrochloride). This product is intended for research and analytical applications. Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection.
  • HY-14744D
    Levamlodipine besylate Hemipentahydrate
    		Inhibitor
    Levamlodipine besylate hemipentahydrate is the besylate hemipentahydrate salt form of Levamlodipine (HY-14744). Levamlodipine besylate hemipentahydrate is an orally active calcium channel blocker with antioxidant and vasodilatory properties. Levamlodipine besylate hemipentahydrate can reduce serum malondialdehyde (MDA) levels, increase superoxide dismutase (SOD) activity, and improve oxidative stress. Levamlodipine besylate hemipentahydrate can be used for research on vascular dementia, hypertension, and cerebrovascular diseases.
  • HY-B0612C
    (R)-Lercanidipine
    		Inhibitor
    (R)-Lercanidipine is the R-enantiomer of Lercanidipine. (R)-lercanidipine is a calcium channel blocker.
  • HY-17404S1
    Cilnidipine-d4
    		Inhibitor
    Cilnidipine-d4 (FRC-8653-d4) is deuterium labeled Cilnidipine. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel. Antihypertensive effects.
  • HY-10805R
    Almorexant (Standard)
    		Inhibitor
    Almorexant (Standard) is the analytical standard of Almorexant. This product is intended for research and analytical applications. Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis .
  • HY-W794363
    D-myo-Inositol-1,4,5,6-tetraphosphate sodium
    D-myo-Inositol-1,4,5,6-tetraphosphate sodium is one of several different inositol oligophosphate isomers implicated in signal transduction.
  • HY-A0016R
    Dronedarone (Standard)
    		Inhibitor
    Dronedarone (Standard) is the analytical standard of Dronedarone. This product is intended for research and analytical applications. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4.
  • HY-123468A
    HA-1004 di(hydrochloride)
    		Inhibitor
    HA-1004 dihydrochloride is a selective inhibitor of PKA, which can inhibit lipolysis and induce vascular relaxation. HA-1004 dihydrochloride is also a dual inhibitor of cyclic GMP-dependent protein kinase and cyclic AMP-dependent protein, and is involved in smooth muscle, second messenger, cyclic AMP and cyclic GMP regulation mechanisms. HA-1004 dihydrochloride is an antagonist for calcium, that can be used as a vasodilator to inhibit the contraction of rabbit aortic strips, or to antagonize ERK and tyrosine hydroxylase (TH) phosphorylation in morphine abstinence rat models.
  • HY-A0057AR
    Gabapentin hydrochloride (Standard)
    		Inhibitor
    Gabapentin (hydrochloride) (Standard) is the analytical standard of Gabapentin (hydrochloride). This product is intended for research and analytical applications. Gabapentin hydrochloride is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin hydrochloride inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin hydrochloride is a GABA analog that can be used to relieve neuropathic pain.
  • HY-124229
    PD 122860
    		Inhibitor
    PD 122860 is a calcium channel blocker. PD 122860 also can stimulate sodium channel. PD 122860 can be used for the research of cardiovascular and cerebrovascular diseases.
  • HY-N1072R
    Wilforgine (Standard)
    Wilforgine (Standard) is the analytical standard of Wilforgine. This product is intended for research and analytical applications. Wilforgine is a bioactive sesquiterpene alkaloid in Tripterygium wilfordii Hook. F. Wilforgine can induce microstructural and ultrastructural changes in the muscles of Mythimna separata larvae, and the sites of action are proposed to be calcium receptors or channels in the muscular system.
  • HY-17007S2
    Saquinavir-13C6
    Saquinavir-13C6 (Ro 31-8959-13C6) is 13C labeled Saquinavir (HY-17007). Saquinavir (Ro 31-8959) is an orally active HIV protease inhibitor that can be used in the research of AIDS. Saquinavir also has anti-inflammatory activity and can induce apoptosis of human red blood cells.
  • HY-N2522R
    Carboxyatractyloside dipotassium (Standard)
    Carboxyatractyloside (dipotassium) (Standard) is the analytical standard of Carboxyatractyloside dipotassium (HY-N2522). This product is intended for research and analytical applications. Carboxyatractyloside dipotassium is a diterpenoid. Carboxyatractyloside dipotassium can be isolated from plants of the genus Xanthium. Carboxyatractyloside dipotassium is an ADP/ATP carrier inhibitor, inhibiting mitochondrial ADP/ATP transport. Carboxyatractyloside dipotassium promotes ROS production, induces Ca2+ release, and leads to mitochondrial dysfunction. Carboxyatractyloside dipotassium induces lethargy, weakness, and epileptic seizures in rats.
  • HY-12515R
    Nicardipine (Standard)
    		Inhibitor
    Nicardipine (Standard) is the analytical standard of Nicardipine. This product is intended for research and analytical applications. Nicardipine (YC-93 free base) is a calcium channel blocker with an IC50 of 1 μM for blocking cardiac calcium channels. Nicardipine acts as an agent for chronic stable angina and for controlling blood pressure.
  • HY-N7503R
    Psoralenoside (Standard)
    		Inhibitor
    Psoralenoside is a benzofuran glycoside from Psoralea corylifolia. Psoralenoside exhibits high binding affinities against histaminergic H1, calmodulin, and voltage-gated L-type calcium channels (E-value≥-6.5 Kcal/mol). Psoralenoside shows estrogen-like activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity.
  • HY-B0632R
    Diltiazem (Standard)
    		Inhibitor
    Diltiazem (Standard) is the analytical standard of Diltiazem. This product is intended for research and analytical applications. Diltiazem is an orally active L-type Ca2+ channel blocker. Diltiazem shows antihypertensive and antiarrhythmic effects. Diltiazem can be used for the research of cardiac arrhythmia, hypertension, and angina pectoris.
  • HY-17402R
    Nisoldipine (Standard)
    		Inhibitor
    Nisoldipine (Standard) is the analytical standard of Nisoldipine. This product is intended for research and analytical applications. Nisoldipine (BAY-k 5552; Sular) is a highly efficient and specific L-type Cav1.2 channel blocker with an IC50 of 10 nM.