2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel Apoptosis
  3. Orexin Receptor (OX Receptor) Calcium Channel Caspase Apoptosis
  4. Almorexant (Standard)

Almorexant (Standard) is the analytical standard of Almorexant. This product is intended for research and analytical applications. Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis .

For research use only. We do not sell to patients.

Almorexant (Standard) Chemical Structure

Almorexant (Standard) Chemical Structure

CAS No. : 871224-64-5

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Description
Molecular Weight

512.56

Formula

C29H31F3N2O3
CAS No.
SMILES

CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Almorexant (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Almorexant (Standard)871224-64-5Orexin Receptor (OX Receptor)Calcium ChannelCaspaseApoptosisHypocretin ReceptorHCRT ReceptorCa2+ channelsCa channelsAsPC-1 cellsHPAF-II cellsPancreatic ductal adenocarcinomaPDACGPCRapoptosispancreatic cancernarcolepsyorexinhypocretinCataplexyInhibitorinhibitorinhibit

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