2. Signaling Pathways
  3. GPCR/G Protein
    Immunology/Inflammation
  4. CCR

CCR

CC chemokine receptor

CCR

Related Products

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CCR (Chemokine receptors) are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called achemokine. There have been 19 distinct chemokine receptors described in mammals. Each has a 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. Specific chemokine receptors provide the portals for HIV to get into cells, and others contribute to inflammatory diseases and cancer.

CCR Isoform Specific Products:

CCR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P991541
    HGS101
    		Ligand
    HGS101 is a fully human CCR5 monoclonal antibody with high affinity to CCR5. HGS101 binds to the 2nd extracellular loop (ECL-2) and acts as a signal antagonist. HGS101 restores Maraviroc (HY-13004) inhibition of Maraviroc-resistant HIV-1 infection of PBMCs. HGS101 shows anti-HIV activity by inhibiting CCR5 signaling in simian immunodeficiency virus-uninfected RMs models.
    HGS101
  • HY-B0155B
    Vicriviroc malate
    		Antagonist
    Vicriviroc (SCH 417690) malate is an orally active CCR5 antagonist with the IC50 of 10 nM, and also inhibts MIP-1α and intracellular calcium release induced by the ligand RANTES (10 nM) with the IC50 values of 0.91 nM and 16 nM,,respectively. Vicriviroc malate can inhibits human immunodeficiency virus type 1 (HIV-1) infection, and can also used for study of cancer.
    Vicriviroc malate
  • HY-176255
    TBK1 degrader-4
    		Inhibitor
    TBK1 degrader-4 (Compound 30) is a molecular glue degrader targeting TBK1. TBK1 degrader-4 effectively inhibits cyst growth, alleviates inflammation, and reduces the levels of pro-inflammatory factors such as Ccl2, IFNβ, and IL-6. TBK1 degrader-4 is promising for research of autosomal dominant polycystic kidney disease (ADPKD).
    TBK1 degrader-4
  • HY-RS02147
    CCR1 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR1 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR1 Human Pre-designed siRNA Set A
  • HY-RS02151
    CCR2 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR2 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR2 Human Pre-designed siRNA Set A
  • HY-103406
    PNU-177864
    		Inhibitor
    PNU-177864 is a potent, selective, orally active dopamine D3 receptor antagonist. PNU-177864 induces phospholipid metabolism in vivo and has anti-schizophrenia activity.
    PNU-177864
  • HY-171683
    Anti-CCL2 (Carlumab)-VcMMAE
    		Antagonist
    Anti-CCL2 (Carlumab)-VcMMAE is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated with valine-citrulline (vc) and the tubulin inhibitor MMAE (HY-15162). The ADC toxic molecule and linker part are McMMAE (HY-15575). Anti-CCL2 (Carlumab)-VcMMAE induces apoptosis and can be used in cancer research.
    Anti-CCL2 (Carlumab)-VcMMAE
  • HY-148232
    BAY-3153
    		Antagonist
    BAY-3153, a chemical probe, is a selective CCR1 (C-C motif chemokine receptor 1) antagonist (human IC50=3 nM; rat IC50=11 nM; mice IC50=81 nM).
    BAY-3153
  • HY-153669
    SB-649701
    		Antagonist
    SB-649701 is a potent human CCR8 antagonist, with a pIC50 of 7.7. AZ084 can be used for the research of asthma.
    SB-649701
  • HY-171680
    Anti-CCL2 (Carlumab)-SMCC-DM1
    		Antagonist
    Anti-CCL2 (Carlumab)-SMCC-DM1 is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated to the linker SMCC (HY-42360) and the cytotoxic microtubule inhibitor DM1 (HY-19792). The ADC toxic molecule and linker part are SMCC-DM1 (HY-101070). Anti-CCL2 (Carlumab)-SMCC-DM1 can be used in the research of cancer, especially prostate cancer.
    Anti-CCL2 (Carlumab)-SMCC-DM1
  • HY-172161
    CCR6 antagonist 2
    		Antagonist
    CCR6 antagonist 2 (Compound 20c) is the antagonist for CCR6 with a Ki of 1.1 nM. CCR6 antagonist 2 inhibits CCL20-induced calcium ion influx (IC50 = 4.9 nM), inhibits the chemotactic migration of CCR6+ T cells (IC50 = 190 nM).
    CCR6 antagonist 2
  • HY-152131
    CCR5 antagonist 2
    		Antagonist
    CCR5 antagonist 2 (Compound 25) is a CCR5 antagonist with an IC50 of 8.34 nM. CCR5 antagonist 2 shows broad-spectrum anti-HIV-1 activities.
    CCR5 antagonist 2
  • HY-174139
    CMKLR1 antagonist 2
    		Antagonist
    CMKLR1 antagonist 2 (compound 16) is a full and competitive chemerin/chemokine-like receptor 1 (CMKLR1) antagonist with an IC50 of 37 μM. CMKLR1 antagonist 2 can be used for study of inflammation.
    CMKLR1 antagonist 2
  • HY-108432
    BMS-741672
    		Antagonist
    BMS-741672 is a selective and orally active CCR2 antagonist with an IC50 of 1.1 nM. BMS-741672 shows >700-fold selective for CCR2 than CCR5.
    BMS-741672
  • HY-RS02169
    CCR8 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR8 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR8 Human Pre-designed siRNA Set A
  • HY-173516
    CCR5-IN-1
    		Inhibitor
    CCR5-IN-1 (compound 3ad) is a selective allosteric CCR5 inhibitor with an IC50 of 1.09 μM. CCR5-IN-1 can be used in the study of cardiovascular, central nervous system, immune system, and infectious diseases.
    CCR5-IN-1
  • HY-171681
    Anti-CCL2 (Carlumab)-SPDB-DM4
    		Antagonist
    Anti-CCL2 (Carlumab)-SPDB-DM4 is an antibody-drug conjugate (ADC) consisting of the humanized anti-CCL2 (chemokine ligand 2) antibody Carlumab (HY-P99188) conjugated with the linker SPDB (HY-12448) and the tubulin inhibitor DM4 (HY-12454). The ADC toxic molecule and linker part are sulfo-SPDB-DM4 (HY-101141). Anti-CCL2 (Carlumab)-SPDB-DM4 can be used in cancer research.
    Anti-CCL2 (Carlumab)-SPDB-DM4
  • HY-100261
    CCR5 antagonist 1
    		Antagonist
    CCR5 antagonist 1 is a CCR5 antagonist which can inhibit HIV replication extracted from WO 2004054974 A2.
    CCR5 antagonist 1
  • HY-163761
    LT166
    LT166 is a fluorescent ligand for CC chemokine receptor 1 (CCR1) with a KD of 1.90 μM.
    LT166
  • HY-P991135
    Enzelkitug
    		Inhibitor
    Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the human C-C motif chemokine receptor 8 (CCR8). Enzelkitug is promising for research of various solid tumors and hematological malignancies.
    Enzelkitug
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
CCR Isoform Comparison

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