2. Signaling Pathways
  3. GPCR/G Protein
    Immunology/Inflammation
  4. CCR

CCR

CC chemokine receptor

CCR

Related Products

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CCR (Chemokine receptors) are cytokine receptors found on the surface of certain cells that interact with a type of cytokine called achemokine. There have been 19 distinct chemokine receptors described in mammals. Each has a 7-transmembrane (7TM) structure and couples to G-protein for signal transduction within a cell, making them members of a large protein family of G protein-coupled receptors. Following interaction with their specific chemokine ligands, chemokine receptors trigger a flux in intracellular calcium (Ca2+) ions (calcium signaling). This causes cell responses, including the onset of a process known as chemotaxis that traffics the cell to a desired location within the organism. Chemokine receptors are divided into different families, CXC chemokine receptors, CC chemokine receptors, CX3C chemokine receptors and XC chemokine receptors that correspond to the 4 distinct subfamilies of chemokines they bind. Specific chemokine receptors provide the portals for HIV to get into cells, and others contribute to inflammatory diseases and cancer.

CCR Isoform Specific Products:

CCR Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-RS02166
    CCR7 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR7 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR7 Human Pre-designed siRNA Set A
  • HY-RS02155
    Ccr3 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ccr3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr3 Mouse Pre-designed siRNA Set A
  • HY-176799
    LMD-584
    		Agonist
    LMD-584 is an agonist of CCR8. LMD-584 is also an analog of LMD-009 (HY-121885).
    LMD-584
  • HY-P991653
    HGS004
    		Inhibitor
    HGS004 is a humanized IgG4 monoclonal antibody inhibitor targeting CCR5. HGS004 has potent antivival activity against a diverse panel of CCR5-tropic HIV-1 and durg (such as Maraviroc (HY-13004))-resistant strains. HGS004 can be used for HIV-1 infections research.
    HGS004
  • HY-RS02158
    Ccr4 Mouse Pre-designed siRNA Set A
    		Inhibitor

    Ccr4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ccr4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ccr4 Mouse Pre-designed siRNA Set A
  • HY-162512
    CB-0821
    		Inhibitor
    CB-0821 is a high affinity CCR5 inhibitor with a Ki of 0.04 nM. CB-0821 binds efficiently to the hydrophobic pocket of the CCR5 protein, to inhibit the interactions between viral protein and CCR5, thereby inhibiting viral entry. CB-0821 has the potential for anti-HIV research.
    CB-0821
  • HY-P991520
    LM-108
    		Inhibitor
    LM-108 is an anti-CCR8 monoclonal antibody. LM-108 selectively depletes tumor-infiltrating targeting tumor-infiltrating regulatory T cells (Tregs). LM-108 can be used for the study of gastric cancer.
    LM-108
  • HY-RS02163
    CCR6 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR6 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR6 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR6 Human Pre-designed siRNA Set A
  • HY-13004S
    Maraviroc-d6
    		Antagonist
    Maraviroc-d6 (UK-427857-d6) is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV.
    Maraviroc-d<sub>6</sub>
  • HY-P990923
    Lanerkitug
    HY-P990923 is an CCR8-targeting IgG1λ2 type human antibody, the recommed isotype control is Human IgG1 lambda2, Isotype Control (HY-P990096).
    Lanerkitug
  • HY-P991718
    Tagmokitug
    		Inhibitor
    Tagmokitug is a humanized IgG1κ monoclonal antibody inhibitor targeting CCR8. Tagmokitug has antitumor activity. Tagmokitug can be used for tumor immunotherapy research, such as breast, colon and lung cancer.
    Tagmokitug
  • HY-N11723
    Catenarin
    		Inhibitor
    Catenarin, an anthraquinone compound, inhibits CCR5- and CXCR4-mediated chemotaxis. Catenarin reduces the phosphorylation of mitogen-activated protein kinases (p38 and JNK) and their upstream kinases (MKK6 and MKK7), and calcium mobilization. Catenarin shows anti-inflammatory effect and suppresses leukocyte migration in the diabetes. Catenarin exhibits significant inhibitory effects against Gram-positive bacteria. Catenarin prevents type 1 diabetes (T1D) in nonobese diabetic mice[1][2].
    Catenarin
  • HY-P990653
    R707
    		Inhibitor
    R707 is a human antibody expressed in CHO cells that targets CCR7/CD197. R707 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.36 kDa. The isotype control for R707 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    R707
  • HY-103360A
    cis-J-113863
    		Antagonist
    cis-J-113863 is a competitive chemokine receptor 1 (CCR1) antagonist, with IC50 values of 0.9 and 5.8 nM for human and mouse CCR1 receptors, respectively.
    cis-J-113863
  • HY-124668A
    CCR1 antagonist 13
    		Antagonist
    CCR1 antagonist 13 is a selective CCR1 small molecule antagonist.
    CCR1 antagonist 13
  • HY-P991540
    AT008
    AT008 is an anti-GPCR monoclonal antibody that blocks the binding of chemokine ligands to its cell surface receptor CCR4. AT008 can be studied in research for certain haematological and solid cancers.
    AT008
  • HY-162505
    SQA1
    		Antagonist
    SQA1, a squaramide (SQA) derivative, is a CCR6 antagonist with a Kd of 250 nM. SQA1 is also a CXCR2 inhibitor. The intracellular pocket occupied by SQA1 overlaps with the G protein binding site and stabilizes the closed conformation of the intracellular pocket.
    SQA1
  • HY-RS02172
    CCR9 Human Pre-designed siRNA Set A
    		Inhibitor

    CCR9 Human Pre-designed siRNA Set A contains three designed siRNAs for CCR9 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    CCR9 Human Pre-designed siRNA Set A
  • HY-123902
    Ophiobolin C
    		Inhibitor
    Ophiobolin C inhibits CCR5 binding to the envelop protein gp120 and CD4, which is responsible for mediating the entry of HIV-1 into cells. Ophiobolin C is also cytotoxic to chronic lymphocytic leukemia cells.
    Ophiobolin C
  • HY-15724R
    Vercirnon (Standard)
    		Antagonist
    Vercirnon (Standard) is the analytical standard of Vercirnon. This product is intended for research and analytical applications. Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 μM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively.
    Vercirnon (Standard)
Cat. No. Product Name / Synonyms Species Source
Cat. No. Product Name / Synonyms Application Reactivity
CCR Isoform Comparison

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