2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Lipoxygenase

Lipoxygenase

LOX

Lipoxygenase

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Lipoxygenases (LOXs) are a family of enzymes that are responsible for the metabolism of arachidonic and docosahexaenoic acid and for the formation of several eicosanoids and docosanoids, including leukotrienes, lipoxins and neuroprotectins. Depending on cells' redox state and other milieu conditions, these enzymes are engaged in oxidative stress and cell death mechanisms or in cell protection. Lipoxygenases are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention.

Lipoxygenases are classified on the basis of site of arachidonate oxygenation into 5-, 8-, 9-, 11-, 12- and 15-LOX. The prominent animal LOXs are 5-LOX, 8-LOX, 12-LOX and 15-LOX, while the plant LOXs are mostly 5-LOX and 15-LOX. Among these, 5-LOX is the most predominant isoform associated with the formation of 5-hydroperoxyeicosatetraenoic acid (5-HpETE) and other bioactive lipid mediators.

Lipoxygenase Isoform Specific Products:

Lipoxygenase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-113691
    (E)-L-652343
    (E)-L-652343 is a compound with potent cyclooxygenase and 5-lipoxygenase inhibitory activity. (E)-L-652343 can effectively inhibit the synthesis of products of these two pathways in vivo. (E)-L-652343 showed high sensitivity and specificity in the detection of geometric isomers in canine and human plasma. (E)-L-652343 showed selective metabolism in vivo, and the elimination rate of the E isomer was faster than that of the Z isomer.
    (E)-L-652343
  • HY-110399R
    Cirsiliol (Standard)
    		Inhibitor
    Cirsiliol (Standard) is the analytical standard of Cirsiliol. This product is intended for research and analytical applications. Cirsiliol is a potent and selective 5-lipoxygenase inhibitor and a competitive low affinity benzodiazepine receptor ligand.
    Cirsiliol (Standard)
  • HY-B1452R
    Licofelone (Standard)
    		Inhibitor
    Licofelone (Standard) is the analytical standard of Licofelone. This product is intended for research and analytical applications. Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM, respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis, and decreases the production of proinflammatory leukotrienes and prostaglandins.
    Licofelone (Standard)
  • HY-106897
    BF389
    		Inhibitor
    BF389 (Biofor 389) is an orally active anti-inflammatory and analesis agent. BF389 is also an inhibitor of cyclooxygenase and 5-lipoxygenase, with IC50s of 4 and 8 ug/mL for COX-1 and COX-2 respectively. BF389 can be used for arthritis research.
    BF389
  • HY-118848
    A63162
    		Inhibitor
    A63162 is a specific 5-lipoxygenase (5-LOX) inhibitor. A63162 inhibits mitogen (PHA)-induced horse mononuclear cell (BMC) proliferation and inhibits Calcimycin (HY-N6687)-induced leukotriene LTB4 synthesis at the same concentration. A63162 can be used in the study of chronic obstructive pulmonary disease, arthritis and inflammatory bowel disease.
    A63162
  • HY-117853S
    Atreleuton-d4
    		Inhibitor
    Atreleuton-d4 (ABT-761-d4; VIA-2291-d4) is deuterium-labeled Atreleuton (HY-117853).
    Atreleuton-d<sub>4</sub>
  • HY-N2056R
    11-Keto-beta-boswellic acid (Standard)
    		Inhibitor
    11-Keto-beta-boswellic acid (Standard) is the analytical standard of 11-?Keto-?beta-?boswellic acid. This product is intended for research and analytical applications. 11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.
    11-Keto-beta-boswellic acid (Standard)
  • HY-161907
    h15-LOX-2 inhibitor 2
    		Inhibitor
    h15-LOX-2 inhibitor 2 (Compound 10) is an inhibitor of h15-LOX, with IC50 and Ki values of 26.9 μM and 16.4 μM, respectively.
    h15-LOX-2 inhibitor 2
  • HY-N0493R
    Pectolinarigenin (Standard)
    		Inhibitor
    Pectolinarigenin (Standard) is the analytical standard of Pectolinarigenin. This product is intended for research and analytical applications. Pectolinarigenin is a dual inhibitor of COX-2/5-LOX. Anti-inflammatory activity. Pectolinarigenin has potent inhibitory activities on melanogenesis.
    Pectolinarigenin (Standard)
  • HY-19023
    L-651896
    		Inhibitor
    L-651896 is a compound with anti-inflammatory and antiproliferative activities that inhibits 5-lipoxygenase and cyclooxygenase, thereby reducing the production of leukotrienes and prostaglandins. L-651896 can be used in the study of skin diseases and other inflammatory diseases.
    L-651896
  • HY-123391
    PD 127443
    		Inhibitor
    PD 127443 is an inhibitor of 5-lipoxygenase and cyclooxygenase. PD 127443 has anti-inflammatory activity.
    PD 127443
  • HY-N3073
    Picralinal
    		Inhibitor
    Picralinal (Picraline, 16-de(acetoxymethyl)-16-formyl-) is a Triterpenoids product that can be isolated from the whole plants of Scilla scilloides..
    Picralinal
  • HY-169138
    ZD 2138
    		Inhibitor
    ZD 2138 is an inhibitor of 5-lipoxygenase. ZD-2138 can alleviate bronchoconstriction induced by aspirin (HY-14654) and can be used in asthma research.
    ZD 2138
  • HY-109500R
    Masoprocol (Standard)
    		Inhibitor
    Masoprocol (Standard) is the analytical standard of Masoprocol. This product is intended for research and analytical applications. Masoprocol (meso-Nordihydroguaiaretic acid) is a potent and orally active lipoxygenase inhibitor. Masoprocol shows antihyperglycemic activity. Masoprocol decreases the glucose concentration and hepatic triglyceride in vivo. Masoprocol has the potential for the research of type II diabetes.
    Masoprocol (Standard)
  • HY-12886R
    Docebenone (Standard)
    		Inhibitor
    Docebenone (Standard) is the analytical standard of Docebenone. This product is intended for research and analytical applications. Docebenone (AA 861) is a potent, selective and orally active 5-LO (5-lipoxygenase) inhibitor.
    Docebenone (Standard)
  • HY-U00438
    LP117
    		Inhibitor
    LP117 is a novel and potent inhibitor of 5-Lipoxygenase (5-LO) product synthesis with an IC50 of 1.1 μM.
    LP117
  • HY-120721
    Lagunamycin
    		Inhibitor
    Lagunamycin is a 5-lipoxygenase inhibitor isolated from the culture medium of Streptomyces sp. AA0310. Lagunamycin has a significant inhibitory activity against rat 5-lipoxygenase with an IC50 value of 6.08 μM. Lagunamycin can effectively inhibit 5-lipoxygenase without causing lipid peroxidation, indicating that it has an effective inhibitory effect without causing side effects.
    Lagunamycin
  • HY-117784
    BI-L-357
    		Inhibitor
    BI-L-357 is a succinate derived from BI-L-226 that acts as a precursor, enhances oral bioavailability and inhibits 5-lipoxygenase-mediated leukotriene production.
    BI-L-357
  • HY-113807
    ZLJ-6
    		Inhibitor
    ZLJ-6 is a dual COX and 5-LOX inhibitor with oral activity. The IC50 values for COX-1, COX-2 and 5-LOX were 0.73, 0.31 and 0.99 μM, respectively. ZLJ-6 has anti-inflammatory and analgesic activity.
    ZLJ-6
  • HY-19212
    S-2474
    		Inhibitor
    S-2474 is an inhibitor of COX-2 and 5-lipoxygenase (5-LO), with IC50s of 11 nM and 27 μM for COX-2 and COX-1 in human intact cells, and used as a nonsteroidal anti-inflammatory agent.
    S-2474
Cat. No. Product Name / Synonyms Application Reactivity
Lipoxygenase Isoform Comparison

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