2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-106924
    DF-1111301 127842-07-3 98%
    DF 1111301 is a new antiallergic compound endowed of antihistamine-H1 and anti-PAF activities.
    DF-1111301
  • HY-106957
    Efletirizine 150756-35-7 98%
    Efletirizine (EFZ) is an orally active antihistamine with high selectivity and affinity to the H1-receptor. Efletirizine can be used for allergic disease research.
    Efletirizine
  • HY-106983
    GR 250495X 192057-17-3 98%
    GR 250495X is an inhaled glucocorticoid receptor agonist. GR 250495X is designed as a antedrug, which takes effect locally in the lungs but is rapidly metabolized and inactivated in the bloodstream after entering the systemic circulation, thereby minimizing systemic side effects. GR 250495X can be used in asthma research.
    GR 250495X
  • HY-106987
    SP/W 5186 139146-65-9 98%
    SP/W-5186 is a nitric oxide (NO) donor agent containing a cysteine structure. SP/W-5186 can improve cardiac function, reduce myocardial damage, protect vascular endothelial function and inhibit inflammation and oxidative stress. SP/W-5186 has the ability to inhibit oxidative damage induced by peroxynitrite (ONOO⁻). SP/W-5186 can be used in the research of myocardial ischemia-reperfusion injury.
    SP/W 5186
  • HY-107013
    CP-544439 230954-09-3 98%
    CP-544439 is a potent and orally active matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 0.75 nM.
    CP-544439
  • HY-107043
    7β-Hydroxy-epi-androsterone 25848-69-5 98%
    7β-Hydroxy-epi-androsterone (7β-Hydroxy-EpiA) can bind to ERβ and has anti-inflammatory and neuroprotective properties. 7β-Hydroxy-epi-androsterone is an endogenous androgenic derivative of dehydroepiandrosterone.
    7β-Hydroxy-epi-androsterone
  • HY-107085
    Talmetacin 67489-39-8 98%
    Talmetacin exhibits anti-inflammatory and analgesic efficacy.
    Talmetacin
  • HY-107122
    MK-5932 1021539-02-5 98%
    MK-5932 is an orally active, selective, dissociated partial glucocorticoid receptor agonist. MK-5932 inhibits IL-6. MK-5932 induces lymphopenia. MK-5932 restores glucose levels to normal. MK-5932 shows anti-inflammatory effects.
    MK-5932
  • HY-107203
    Propentofylline 55242-55-2 99.88%
    Propentofylline is a xanthine-derivative that inhibits adenosine uptake and blocks phosphodiesterase activity. Propentofylline has neuroprotective, antiproliferative, and anti-inflammatory effects that improve cognition and dementia severity in patients with Alzheimer's disease or vascular dementia.
    Propentofylline
  • HY-107247
    Escin IIb 158800-83-0 98%
    Escin IIb, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIb showed potent protective effects against ethanol-induced gastric mucosal lesions.
    Escin IIb
  • HY-107248
    Escin IIa 158732-55-9 98%
    Escin IIa, isolated from horse chestnut, the seeds of Aesculus hippocastanum L., has positive effects on acute inflammation in animals. Escin IIa has gastroprotections on ethanol-induced gastric mucosal lesions in rats.
    Escin IIa
  • HY-107273
    Delavinone 96997-98-7 98%
    Delavinone (Sinpeinine A) is an alkaloid. Delavinone is suitable for electrospray ionization (ESI) positive electrode detection.
    Delavinone
  • HY-107320
    Amtolmetin guacil 87344-06-7 99.93%
    Amtolmetin guacil is an effective nonsteroidal anti-Inflammatory agent with pain-relieving effects. Amtolmetin guacil inhibits prostaglandin synthesis and cyclooxygenase (COX). Amtolmetin guacil can stimulate capsaicin receptors present on the gastrointestinal wall and also releases gastroprotective nitric oxide (NO). Amtolmetin guacil can be used to research knee osteoarthritis.
    Amtolmetin guacil
  • HY-107340
    Diftalone 21626-89-1 98%
    Diftalone (Aladione) is an anti-inflammatory agent. Diftalone can be used for research of inflammatory disease, such as rheumatoid arthritis.
    Diftalone
  • HY-107360
    Lobenzarit disodium 64808-48-6 99.94%
    Lobenzarit disodium (CCA) is an anti-arthritic and anti-oxidative agent.
    Lobenzarit disodium
  • HY-107470
    Antitumor agent-21 1256037-58-7 98%
    Antitumor agent-21 is an aryl-quinolin derivative, with potential anticancer, anti-inflammatory, anti-proliferative, anti-hormonal effects and inhibition of vasculogenic mimicry .
    Antitumor agent-21
  • HY-107495
    Betahistine EP Impurity C 5452-87-9 98.38%
    Betahistine EP Impurity C (NSC19005) is an impurity of Betahistine. Betahistine is a potent, orally active and well-tolerated histamine H1 receptor agonist and H3 receptor antagonist used for the study of rheumatoid arthritis (RA).
    Betahistine EP Impurity C
  • HY-107561
    A-943931 hydrochloride 1227675-50-4 98%
    A-943931 (Compound 10) is a histamine H4 receptor antagonists. A-943931 has improved pharmacotropic and in vivo efficacy in models of pain and inflammation. A-943931 can be used in vivo anti-inflammatory and anti-nociception research .
    A-943931 hydrochloride
  • HY-107563
    ROS 234 184576-87-2 98%
    ROS 234 is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access.
    ROS 234
  • HY-107564
    Impentamine dihydrobromide 149629-70-9 98%
    Impentamine dihydrobromide (VUF 4702 dihydrobromide) is a histamine H3 receptor antagonist with potential antihistamine activity. Impentamine dihydrobromide shows the strongest selective H3 antagonism among a series of 4(5)-(ω-aminoalkyl)-1H-imidazole compounds. The pA2 value of impentamine dihydrobromide is 8.4, showing its high efficacy in guinea pig jejunum. Impentamine dihydrobromide has a specific antagonistic binding site with the H3 receptor.
    Impentamine dihydrobromide
Cat. No. Product Name / Synonyms Application Reactivity