L-Ascorbic acid sodium salt (Synonyms: Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt)

Name: L-Ascorbic acid sodium salt
Brand: MedChemExpress
SKU: HY-B0166A
Rating: 5.0 (63 reviews)

Cat. No.: HY-B0166A Purity: 99.01%: Data Sheet
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L-Ascorbic acid sodium salt (Sodium ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid sodium salt selectively inhibits Ca_v3.2 channels with an IC₅₀ of 6.5 μM. L-Ascorbic acid sodium salt is also a collagen deposition enhancer and an elastogenesis inhibitor.

For research use only. We do not sell to patients.

L-Ascorbic acid sodium salt Chemical Structure

CAS No. : 134-03-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

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Based on 63 publication(s) in Google Scholar

Other Forms of L-Ascorbic acid sodium salt:

L-Ascorbic acid In-stock
L-Ascorbic acid (GMP Like) In-stock
L-Ascorbic acid (sodium salt) (Standard) Get quote

57 Publications Citing Use of MCE L-Ascorbic acid sodium salt

Cell Viability Assay

IHC

: L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Antioxidants (Basel). 2024 May 27.; L-Ascorbic acid (Vitamin C) (50-500 μM; 6 h) significantly increases the viability of heat-stressed gastric cancer cells at concentrations of 200 μM and 300 μM.

: L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2024 May 31;24(1):192. [Abstract]; L-Ascorbic acid (AA) (150 μL of 1.5 M; i.p.; every two days) enhances the expression of GPX4 and SLC7A11 proteins in mouse liver.

: L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2024 May 31;24(1):192. [Abstract]; L-Ascorbic acid (AA) (150ul of 1.5 M; i.p.; every two days) significantly decreases the expression of Ki67 in C57BL/6 mice.

: L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Food Funct. 2022 May 10;13(9):5089-5101. [Abstract]; L-Ascorbic acid (Vitamin C) (100 μM; 10 min–4 h) upregulates the protein expression levels of IGF-1, p-IGF-1R, and SVCT2 in a time-dependent manner.

: L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Cell Biol Toxicol. 2021 Jul 20. [Abstract]; L-Ascorbic acid (300 μM, 10 μL intrathecal injection) reduces the levels of CaV3.2, p-CaMKII, and Cx43 in mice.

: L-Ascorbic acid sodium salt purchased from MedChemExpress. Usage Cited in: Antioxid Redox Signal. 2020 Dec 10;33(17):1191-1208. [Abstract]; L-Ascorbic acid (Vitamin C) (250 μM, 1 h) significantly alleviates the growth suppression induced by combined SAS and PAG treatment only in OVISE cells, but shows no effect in KOC-7C cells.

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

T-type calcium channel

Microbial Metabolite

In Vitro

The conditioned?medium?for?B16F10?cells significantly inhibits?cell?apoptosis?induced by?L-Ascorbic acid sodium salt (Sodium?L-ascorbate) (10 mM), and the effective ingredients in the?medium?show a relative molecular mass below 5,000^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tg rats treated with L-Ascorbic acid sodium salt (Sodium?L-ascorbate) show a higher incidence of carcinoma (29.6%), compared to those without L-Ascorbic acid sodium salt (15.4%). Independent of the L-Ascorbic acid sodium salt treatment, transgenic rats exhibit various kinds of malignant tumors in various organs^[5].
After 12 weeks of PEITC-treatment, both simple hyperplasia and papillary or nodular (PN) hyperplasia have developed in all animals, but the majority of these lesions have disappeared at week 48, irrespective of the L-Ascorbic acid sodium salt-treatment. The same lesions after 24 weeks of PEITC-treatment have progressed to dysplasia and carcinoma, in a small number of cases by week 48, but enhancement by the L-Ascorbic acid sodium salt-treatment is evident only with simple hyperplasias and PN hyperplasias in rats^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

Molecular Weight

198.11

Formula

C₆H₇NaO₆

CAS No.

134-03-2

Appearance

Solid

Color

White to light yellow

SMILES

O[C@@H](CO)[C@]1([H])C(O[Na])=C(O)C(O1)=O

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (504.77 mM; Need ultrasonic)

DMSO : 1 mg/mL (5.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.0477 mL	25.2385 mL	50.4770 mL
5 mM	1.0095 mL	5.0477 mL	10.0954 mL
10 mM	0.5048 mL	2.5239 mL	5.0477 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (252.39 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (281 KB) SDS (393 KB)

COA (254 KB) HNMR (115 KB) RP-HPLC (338 KB)

Handling Instructions (2659 KB)

References

[1]. Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [Content Brief]

[2]. Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [Content Brief]

[3]. Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83. [Content Brief]

[4]. Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50. [Content Brief]

[5]. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7. [Content Brief]

[6]. Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53. [Content Brief]

Animal Administration
^[3]

A total of 40 7-week-old male Tg rats are divided into 2 groups. Twenty-seven (group 1) and 13 (group 2) rats are given a powdered MF diet with or without 5% sodium L-ascorbate, respectively. Similarly, a total of 42 7-week-old male Non-tg rats are divided into 2 groups, and 30 (group 3) and 12 (group 4) animals are given a diet with or without 5% sodium L-ascorbate, respectively.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Hinek A, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [Content Brief]

[2]. Aleksander Hinek, et al. Sodium L-ascorbate enhances elastic fibers deposition by fibroblasts from normal and pathologic human skin. J Dermatol Sci. 2014 Sep;75(3):173-82. [Content Brief]

[3]. Michael T Nelson, et al. Molecular mechanisms of subtype-specific inhibition of neuronal T-type calcium channels by ascorbate. J Neurosci. 2007 Nov 14;27(46):12577-83. [Content Brief]

[4]. Yang X, et al. Mouse melanoma cell line B16F10-derived conditioned medium inhibits sodium L-ascorbate-induced B16F10 cell apoptosis. Nan Fang Yi Ke Da Xue Xue Bao. 2012 Feb;32(2):146-50. [Content Brief]

[5]. Morimura K, et al. Lack of urinary bladder carcinogenicity of sodium L-ascorbate in human c-Ha-ras proto-oncogene transgenic rats. Toxicol Pathol. 2005;33(7):764-7. [Content Brief]

[6]. Takagi H, et al. Limited tumor-initiating activity of phenylethyl isothiocyanate by promotion with sodium L-ascorbate in a rat two-stage urinary bladder carcinogenesis model. Cancer Lett. 2005 Mar 10;219(2):147-53. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	5.0477 mL	25.2385 mL	50.4770 mL	126.1925 mL
DMSO / H₂O	5 mM	1.0095 mL	5.0477 mL	10.0954 mL	25.2385 mL
H₂O	10 mM	0.5048 mL	2.5239 mL	5.0477 mL	12.6193 mL
	15 mM	0.3365 mL	1.6826 mL	3.3651 mL	8.4128 mL
	20 mM	0.2524 mL	1.2619 mL	2.5239 mL	6.3096 mL
	25 mM	0.2019 mL	1.0095 mL	2.0191 mL	5.0477 mL
	30 mM	0.1683 mL	0.8413 mL	1.6826 mL	4.2064 mL
	40 mM	0.1262 mL	0.6310 mL	1.2619 mL	3.1548 mL
	50 mM	0.1010 mL	0.5048 mL	1.0095 mL	2.5239 mL
	60 mM	0.0841 mL	0.4206 mL	0.8413 mL	2.1032 mL
	80 mM	0.0631 mL	0.3155 mL	0.6310 mL	1.5774 mL
	100 mM	0.0505 mL	0.2524 mL	0.5048 mL	1.2619 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

L-Ascorbic acid sodium salt Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Ascorbic acid134-03-2Sodium ascorbate Sodium L-ascorbateVitamin CReactive Oxygen SpeciesCalcium ChannelApoptosisEndogenous MetaboliteCa2+ channelsCa channelsInhibitorinhibitorinhibit

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L-Ascorbic acid sodium salt (Synonyms: Sodium ascorbate; Sodium L-ascorbate; Vitamin C sodium salt)

Customer Review

Other Forms of L-Ascorbic acid sodium salt:

L-Ascorbic acid sodium salt Related Antibodies

57 Publications Citing Use of MCE L-Ascorbic acid sodium salt

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

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View All Calcium Channel Isoform Specific Products:

Biological Activity

Protocol

Purity & Documentation

References

Customer Review

L-Ascorbic acid sodium salt Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

L-Ascorbic acid sodium salt Related Classifications

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