Verbascose 

Verbascose, an alacto-oligosac-charides (GOS), has potent immunostimulatory activity. Verbascose acts as a potential natural immunomodulatory agent^[1].

Verbascose (25, 50, 100, 200, 400 μg/mL; 12, 24, 36, 48 hours) significantly increases the viability of RAW264.7 cells^[1].
Verbascose has notable activity of promoting peritoneal macrophages to devour neutral red in a dose-dependent manner and exhibits its maximum activity of cell phagocytosis at a concentration of 200 μg/mL^[1].
Verbascose induces significant increases of NO production. Verbascose can enhance the ability of devouring neutral red of peritoneal macrophages and promote the release of nitric oxide and immune reactive molecules such as interleukin (IL)-6, IL-1β, interferon (IFN)-α, and IFN-γ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Verbascose (30, 90, 120 mg/kg/day; sc; for 8 days) at a medium dose of 90 mg/kg body weight can significantly increase the index of spleen, activity of lysozyme in spleen and serum, hemolysin level in serum, and swelling rate of earlap in the delayed type of hypersensitivity (DTH) of immunosuppressed female Kunming mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

828.72

C₃₀H₅₂O₂₆

546-62-3

Solid

White to off-white

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• [1]. Zhuqing Dai, et al. Immunomodulatory activity in vitro and in vivo of verbascose from mung beans (Phaseolus aureus). J Agric Food Chem. 2014 Nov 5;62(44):10727-35.  [Content Brief]