2. Immunology/Inflammation GPCR/G Protein Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. PGE synthase Prostaglandin Receptor β-catenin STAT c-Myc
  4. SZ0232

SZ0232 is a microsomal prostaglandin E synthase-2 (mPGES-2) inhibitor. SZ0232 inhibits the activity of mPGES-2, downregulates the PGE2-EP4 signal, and thereby blocks the β-catenin/STAT3/c-Myc proliferation pathway. SZ0232 inhibits the abnormal proliferation of cyst epithelial cells and significantly inhibits cyst growth in both in vitro and in vivo models. SZ0232 can be used for the study of autosomal dominant polycystic kidney disease (ADPKD).

For research use only. We do not sell to patients.

SZ0232

SZ0232 Chemical Structure

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Description

SZ0232 is a microsomal prostaglandin E synthase-2 (mPGES-2) inhibitor. SZ0232 inhibits the activity of mPGES-2, downregulates the PGE2-EP4 signal, and thereby blocks the β-catenin/STAT3/c-Myc proliferation pathway. SZ0232 inhibits the abnormal proliferation of cyst epithelial cells and significantly inhibits cyst growth in both in vitro and in vivo models. SZ0232 can be used for the study of autosomal dominant polycystic kidney disease (ADPKD)[1].

IC50 & Target[1]

EP4

 

STAT3

 

Molecular Weight

520.56

Formula

C22H28N6O7S
SMILES

O=S(NC(C=C1OCCNC(N)=O)=CC=C1OCCNC(N)=O)(C2=CC=C(C=C2)N3CCCC3=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SZ0232 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SZ0232SZ 0232SZ-0232PGE synthaseProstaglandin Receptorβ-cateninSTATc-MycProstaglandin E synthaseBeta cateninMycADPKDmPGES-2PGE2proliferationβ-catenin/STAT3Inhibitorinhibitorinhibit

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