2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Stem Cell/Wnt MAPK/ERK Pathway PI3K/Akt/mTOR
  3. HSP ERK CDK Akt
  4. SST0116CL1 free base

SST0116CL1 free base is a HSP90 inhibitor (IC50: 0.21 μM). SST0116CL1 free base binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 free base induces degradation of Her2 in BT-474 cell (IC50: 0.2 μM). SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base can be used for the study of leukemia, gastric and ovarian carcinoma.

For research use only. We do not sell to patients.

SST0116CL1 free base

SST0116CL1 free base Chemical Structure

CAS No. : 1202920-93-1

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SST0116CL1 free base Related Antibodies

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Description

SST0116CL1 free base is a HSP90 inhibitor (IC50: 0.21 μM). SST0116CL1 free base binds to the ATP binding pocket of Hsp90, and interferes with Hsp90 chaperone function thus resulting in client protein (EGFR, CDK4 and AKT) degradation. SST0116CL1 free base induces degradation of Her2 in BT-474 cell (IC50: 0.2 μM). SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base has antiproliferative activity and inhibits tumor growth. SST0116CL1 free base can be used for the study of leukemia, gastric and ovarian carcinoma[1].

IC50 & Target[1]

HSP90

 

In Vitro

SST0116CL1 has antiproliferative activity on different tumor cell lines, with IC50s of 0.81 μM (A431), 0.11 μM (NCI-H460), 0.81 μM (A2780), 0.40 μM (MV4;11), 0.23 μM (GTL-16), 0.62 μM (BT474), 0.34 μM (HT-1080)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SST0116CL1 free base Related Antibodies
Molecular Weight

446.50

Formula

C22H30N4O6
CAS No.
SMILES

O=C(NCC)C1=NOC(C2=CC(C(C)C)=C(O)C=C2O)=C1NC(CCN3CCOCC3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SST0116CL1 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SST0116CL11202920-93-1HSPERKCDKAktHeat shock proteinsExtracellular signal regulated kinasesCyclin dependent kinasePKBProtein kinase BInhibitorinhibitorinhibit

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