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tissue-plasminogen activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Annexin A (2) Apoptosis (3) Biochemical Assay Reagents (3) Factor Xa (1) Isotope-Labeled Compounds (1) MMP (3) Progesterone Receptor (1) Reference Standards (1) Ser/Thr Protease (3) Thrombin (3)
By Research Areas:	Cancer (2) Cardiovascular Disease (10) Endocrinology (1) Neurological Disease (3)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Tissue Factor Pathway Inhibitor (TFPI) PAI-1 MALT1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108845

Tenecteplase TNK-tPA	Ser/Thr Protease	Cardiovascular Disease
Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke .

HY-137837

D-Ile-Pro-Arg p-nitroanilide dihydrochloride 1 Publications Verification	Biochemical Assay Reagents	Others
D-Ile-Pro-Arg p-nitroanilide dihydrochloride is a chromogenic peptide substrate of tissue plasminogen activator (tPA) .

HY-B0099

Edaravone Maximum Cited Publications 34 Publications Verification MCI-186	MMP Apoptosis	Neurological Disease
Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

HY-B0099R

Edaravone (Standard) MCI-186 (Standard)	Reference Standards MMP Apoptosis	Neurological Disease
Edaravone (Standard) is the analytical standard of Edaravone. This product is intended for research and analytical applications. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

HY-B0099S

Edaravone-d5 MCI-186-d₅	Isotope-Labeled Compounds MMP Apoptosis	Neurological Disease
Edaravone-d₅ is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator .

HY-106404

RPR 130737	Factor Xa	Cardiovascular Disease
RPR 130737 is a selective, potent and competitive inhibitor for factor Xa with a K_i of 2.4 nM. RPR 130737 shows selectivity of more than 1000-fold over thrombin, activated protein C, plasmin, tissue-plasminogen activator and trypsin. RPR 130737 can prolong plasma activated partial thromboplastin time and prothrombin time. RPR 130737 shows no effect on platelet aggregation. RPR 130737 can be used for the research of cardiovascular disease, such as thrombosis .

HY-P5981

Chromozym t-PA	Biochemical Assay Reagents	Others
Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration

HY-P2821B

Murine Plasminogen	Biochemical Assay Reagents	Cardiovascular Disease
Murine Plasminogen is purified from freshly collected murine plasma and is an inactive precursor of the protease plasmin. It is activated to the serine protease plasmin by urokinase, streptokinase, or tissue plasminogen activator.

HY-120491

L 722151	Thrombin	Cardiovascular Disease
L 722151 is a competitive inhibitor for factor XIIIa with K_i of 49 µM. L 722151 accelerates tissue plasminogen activator-catalyzed clot dissolution, and exhibits antithrombotic efficacy .

HY-P10005

D-Val-Gly-Arg-pNA	Ser/Thr Protease	Cardiovascular Disease
D-Val-Gly-Arg-pNA is a chromogenic substrate of TPA (tissue plasminogen activator). D-Val-Gly-Arg-pNA can be used to detect the amidolytic activity of TPA I and TPA II .

HY-P2333

LCKLSL 5+ Cited Publications	Annexin A	Cardiovascular Disease
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the *binding of tissue plasminogen* activator (tPA) to AnxA2**. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-P2333A

LCKLSL hydrochloride 5+ Cited Publications	Annexin A	Cardiovascular Disease
LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the *binding of tissue plasminogen* activator (tPA) to AnxA2**. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-B0111

Drospirenone Dihydrospirorenone	Progesterone Receptor Androgen Receptor	Endocrinology Cancer
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. .

HY-108865

Alteplase Actilyse; Activase	Ser/Thr Protease	Cardiovascular Disease Cancer
Alteplase (Actilyse; Activase), a tissue plasminogen activator prepared by recombination, is a thrombolytic agent that play important roles in acute ischemic stroke, pulmonary embolism, acute myocardial infarction, and occluded catheters . The product size below only indicate the effective content of Alteplase. The ratio of Alteplase effective content : total content = 1:46-1:50. The actual ratio depends on the batch.)

HY-100897A

Sulodexide solution	Thrombin	Cardiovascular Disease
Sulodexide solution is a mixture of glycosaminoglycans that can be administered by injection. It is composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease.

HY-100897

Sulodexide	Thrombin	Cardiovascular Disease
Sulodexide is a mixture of glycosaminoglycans available in soft capsule form for oral administration. It is composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease . Sulodexide is a glycosaminoglycan mixture available in soft gelatin capsule form for oral administration.

Cat. No.	Product Name	Target	Research Area

HY-P2333

LCKLSL 5+ Cited Publications	Annexin A	Cardiovascular Disease
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the *binding of tissue plasminogen* activator (tPA) to AnxA2**. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-P2333A

LCKLSL hydrochloride 5+ Cited Publications	Annexin A	Cardiovascular Disease
LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the *binding of tissue plasminogen* activator (tPA) to AnxA2**. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-P5981

Chromozym t-PA	Biochemical Assay Reagents	Others
Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration

HY-P10005

D-Val-Gly-Arg-pNA	Ser/Thr Protease	Cardiovascular Disease
D-Val-Gly-Arg-pNA is a chromogenic substrate of TPA (tissue plasminogen activator). D-Val-Gly-Arg-pNA can be used to detect the amidolytic activity of TPA I and TPA II .

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	HEK293 (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71051

	T-PA Protein, Human (HEK293, His) 4 Publications Verification T-PA; TPA; t-plasminogen activator; tissue plasminogen activator;	Human	HEK293
	T-PA is a key proteolytic enzyme that coordinates the conversion of the abundant but inactive zymogen plasminogen to its active form plasmin via hydrolysis of a single Arg-Val bond. This enzymatic conversion helps regulate plasmin-mediated proteolysis, a key process in tissue remodeling, degradation, and various pathophysiological events. T-PA Protein, Human (HEK293, His) is the recombinant human-derived T-PA protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73451

	T-PA Protein, Human (HEK293) T-PA; TPA; t-plasminogen activator; tissue plasminogen activator	Human	HEK293
	The T-PA protein encoded by this gene is a secreted serine protease that converts plasminogen into plasmin, a key enzyme involved in tissue remodeling and cell migration. The proteolytic process produces heavy and light chains, forming heterodimeric enzymes. T-PA Protein, Human (HEK293) is the recombinant human-derived T-PA protein, expressed by HEK293 , with tag free.

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Edaravone-d5
Edaravone-d₅ is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator .

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83461

	Tissue Type Plasminogen Activator Antibody (YA3206) TPA; T-PA; TPA1; PLAT; tissue plasminogen activator	WB, IHC-P	Human, Mouse, Rat
	Tissue Type Plasminogen Activator Antibody (YA3206) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tissue Type Plasminogen Activator.

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