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taxol

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (3) Akt (1) Apoptosis (8) Autophagy (1) CDK (1) Cytochrome P450 (3) Drug Derivative (1) Drug Metabolite (1) Endogenous Metabolite (1) Fluorescent Dye (2) HIF/HIF Prolyl-Hydroxylase (1) HIV (1) Isotope-Labeled Compounds (1) Microtubule/Tubulin (8) Mitochondrial Metabolism (1) MMP (1) mTOR (1) P-glycoprotein (3) p38 MAPK (1) Paraptosis (1) Phosphodiesterase (PDE) (1) PI3K (1) Potassium Channel (1) PROTACs (2) Reference Standards (4) VEGFR (1)
By Research Areas:	Cancer (21) Cardiovascular Disease (2) Infection (1)

By Targets:

ADC Payload (3)

Akt (1)

Apoptosis (8)

Autophagy (1)

CDK (1)

Cytochrome P450 (3)

Drug Derivative (1)

Drug Metabolite (1)

Endogenous Metabolite (1)

Fluorescent Dye (2)

HIF/HIF Prolyl-Hydroxylase (1)

HIV (1)

Isotope-Labeled Compounds (1)

Microtubule/Tubulin (8)

Mitochondrial Metabolism (1)

MMP (1)

mTOR (1)

P-glycoprotein (3)

p38 MAPK (1)

Paraptosis (1)

Phosphodiesterase (PDE) (1)

PI3K (1)

Potassium Channel (1)

PROTACs (2)

Reference Standards (4)

VEGFR (1)

By Research Areas:

Cancer (21)

Cardiovascular Disease (2)

Infection (1)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0227

7-epi-Taxol 3 Publications Verification 7-epi-Paclitaxel	Microtubule/Tubulin	Cancer
7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-N2380

N-Benzoyl-(2R,3S)-3-phenylisoserine	Others	Cancer
N-Benzoyl-(2R,3S)-3-phenylisoserine is a Taxol C-13 Side Chain and crucial for the strong antitumor activity of Taxol .

HY-B0015

Paclitaxel Maximum Cited Publications 307 Publications Verification	Microtubule/Tubulin ADC Payload Apoptosis Autophagy	Cardiovascular Disease Cancer
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-77574

7-xylosyltaxol 7-Xylosylpaclitaxel; taxol-7-xyloside	Microtubule/Tubulin	Cancer
7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.

HY-D2341

6FC-GABA-Taxol	Fluorescent Dye	Cancer
6FC-GABA-Taxol is a fluorescent probe with cell permeability, which is formed by connecting 6FC to the anticancer drug Taxol (HY-B0015) via γ-aminobutyric acid (GABA). 6FC-GABA-Taxol can bind to microtubules in living cells and image them through confocal microscopy. Additionally, 6FC-GABA-Taxol enables the quantification of microtubule binding using flow cytometry without the addition of efflux inhibitors .

HY-N0227R

*7-epi-Taxol* (Standard)** 7-epi-Paclitaxel (Standard)	Reference Standards Microtubule/Tubulin	Cancer
7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-D1386

*JF526-Taxol* TFA**	Fluorescent Dye	Others
JF526-Taxol (TFA) is a versatile scaffold for fluorogenic probes including ligands for self-labeling tags, stains for endogenous structures, and spontaneously blinking labels for super-resolution immunofluorescence .

HY-158429

PROTAC CYP1B1 degrader-2	PROTACs Cytochrome P450	Cancer
PROTAC CYP1B1 degrader-2 (compound PV2) is a von Hippel-Landau (VHL) E3 ligase-based CYP1B1 degrader with the DC₅₀ of 1.0 nM at 24 h in A549/Taxol cells. PROTAC CYP1B1 degrader-2 inhibits growth, migration, and invasion of A549/Taxol cell(Sturcture Note:(Blue: VHL ligand (HY-112078), Black: linker (HY-W007700), Pink: CYP1B1 ligand (HY-159006) .

HY-135746R

OR-1896 (Standard)	Reference Standards Potassium Channel Phosphodiesterase (PDE) Drug Metabolite Apoptosis	Cardiovascular Disease
7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-162098

PROTAC tubulin-Degrader-1	PROTACs Microtubule/Tubulin Apoptosis	Cancer
PROTAC tubulin-Degrader-1 is a α/β/β3-tubulin PROTAC degrader. PROTAC tubulin-Degrader-1 exhibits potent anti-proliferative activity against multiple human tumor cell lines. PROTAC tubulin-Degrader-1 induces G2/M phase arrest and apoptosis and inhibits colony formation in A549 and A549/Taxol cells. PROTAC tubulin-Degrader-1demonstrates potent anti-tumor efficacy in A549 and A549/Taxol (Taxol-resistant) xenograft model. PROTAC tubulin-Degrader-1 can be used for the study of non-small cell lung cancer (NSCLC). (Pink: Tubulin ligand (HY-N2146), Blue: CRBN Ligand (HY-10984), Black: Linker (HY-N6056)) .

HY-N15573

7-epi-10-Deacetylcephalomannine	Drug Derivative	Others
7-epi-10-Deacetylcephalomannine is a taxol-related compound found in the needles of Taxus sumatrana .

HY-77572

7-Epi 10-desacetyl paclitaxel 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel	ADC Payload	Cancer
7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC₅₀ of 85 μM .

HY-N7289

Taxuspine B	Others	Cancer
Taxuspine B is a natural product, that can be isolated from Japanese yew Taxus. Taxuspine B exhibits appreciable taxol-like activity to reduce CaCl₂-induced depolymerixation of microtubules among the taxoids .

HY-175206

P-gp-IN-30	P-glycoprotein	Cancer
P-gp-IN-30 (Compound 13) is a P-glycoprotein (P-gp) inhibitor by targeting YB-1. P-gp-IN-30 significantly enhances sensitivity to Paclitaxel by reducing total YB-1 and nucleus YB-1 protein expression, inhibiting the expression and function of downstream P-gp, further suppressing the efflux rate of Paclitaxel. P-gp-IN-30 potently inhibits tumor growth in A549/Taxol xenografts mice model with combination of Paclitaxel (HY-B0015). P-gp-IN-30 can be used for non-small cell lung cancer (NSCLC) research .

HY-168008

P-gp inhibitor 25	P-glycoprotein	Cancer
P-gp inhibitor 25 (compound 16c) is a P-gp inhibitor. P-gp inhibitor 25 can enhance the oral absorption of paclitaxel (HY-B0015). P-gp inhibitor 25 can be used in anti-cancer research .

HY-W009245

Bz-RS-iSer(3-Ph)-OMe	HIV	Infection Cancer
Bz-RS-iSer(3-Ph)-OMe (compound 2), a Taxol derivative, inhibits HSV replication cycle at low cytotoxicity, blocks mitotic divisions of Vero cells, influences M-MSV induced tumor size and affects immune response by inhibiting PHA-induced T lymphocyte proliferation .

HY-118143

AG-1801	Endogenous Metabolite	Others
AG-1801, a nitrobenzopyridine derivative, is a tyrosine phosphorylation inhibitor. AG-1801 can induce the disintegration of the microtubule network in living cells, and does not inhibit microtubule polymerization in vitro. AG-1801 can be used for the study of microtubule-related signaling pathways .

HY-159006

CYP1B1 ligand 3	Cytochrome P450	Cancer
CYP1B1 ligand 3 (Compound A1) is a selective inhibitor for cytochrome P450 enzyme CYP1B1 with an IC₅₀ of 11.9 nM. CYP1B1 ligand 3 can be utilized for the synthesis of PROTAC CYP1B1 degrader-2 (HY-158429) .

HY-77572R

7-Epi 10-desacetyl paclitaxel (Standard) 7-epi-10-deacetyltaxol (Standard); 10-Deacetyl-7-epipaclitaxel (Standard)	ADC Payload Reference Standards	Cancer
7-Epi 10-desacetyl paclitaxel (Standard) is the analytical standard of 7-Epi 10-desacetyl paclitaxel. This product is intended for research and analytical applications. 7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM .

HY-B0011A

Docetaxel Trihydrate 130+ Cited Publications RP-56976 Trihydrate	Microtubule/Tubulin Apoptosis	Cancer
Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule depolymerization with an IC₅₀ value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of bcl-2 and bcl-xL gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .

HY-B0011AS

Docetaxel-d5 trihydrate RP-56976-d₅ trihydrate	Isotope-Labeled Compounds Microtubule/Tubulin Apoptosis	Cancer
Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC₅₀ value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .

HY-B0011AR

Docetaxel Trihydrate (Standard) RP-56976 Trihydrate (Standard)	Reference Standards Microtubule/Tubulin Apoptosis	Cancer
Docetaxel (Trihydrate) (Standard) is the analytical standard of Docetaxel (Trihydrate). This product is intended for research and analytical applications. Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC₅₀ value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .

HY-130133

DHW-221	PI3K mTOR Akt Apoptosis Paraptosis p38 MAPK Mitochondrial Metabolism P-glycoprotein CDK MMP HIF/HIF Prolyl-Hydroxylase VEGFR	Cancer
DHW-221 is a potent orally active dual PI3K/mTOR inhibitor, exhibiting low nanomolar potency against all four Class I PI3K isoforms and mTOR (PI3Kα, IC₅₀ = 0.50 nM; PI3Kβ, IC₅₀ = 1.9 nM; PI3Kγ, IC₅₀ = 1.8 nM; PI3Kδ, IC₅₀ = 0.74 nM; mTOR, IC₅₀ = 3.9 nM). DHW-221 exerts antitumor effects by blocking the PI3K/Akt/mTOR pathway and inducing mitochondrial apoptosis and paraptosis (via Endoplasmic Reticulum (ER) stress and MAPK signaling) and arrests cell cycle, thereby inhibiting cell migration, invasion and angiogenesis. DHW-221 inhibits tumor growth in both the A549/Taxol (HY-B0015) and the HCC827 xenograft mouse models. DHW-221 can be used for non-small cell lung cancer (NSCLC), colon and breast cancer research ^[1][2][3].

HY-118487A

OB-24 free base	Others	Cancer
OB-24 free base is a compound that potently and selectively inhibits heme oxygenase 1 (HO-1) and has the potential to inhibit advanced prostate cancer. OB-24 significantly reduces protein carbonylation and the formation of reactive oxygen species by selectively inhibiting HO-1 activity in prostate cancer cells. OB-24 significantly inhibited cell proliferation in vitro and inhibited tumor growth and lymph node and lung metastasis in vivo. OB-24 exhibits powerful synergy when used in combination with Taxol .

HY-175836

CYP1B1-IN-12	Cytochrome P450 Apoptosis	Cancer
CYP1B1-IN-12 is a selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC₅₀ of 6.05 nM. CYP1B1-IN-12 demonstrates remarkable selectivity, exceeding 1600-fold and 16,000-fold over CYP1A1 and CYP1A2, respectively. CYP1B1-IN-12 can enhance Paclitaxel (HY-B0015)-mediated apoptosis and restore Paclitaxel sensitivity in A549/Taxol-resistant cells. CYP1B1-IN-12 can inhibit the epithelial-mesenchymal transition process and reduce cells migration and invasion. CYP1B1-IN-12 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC) .

Cat. No.	Product Name	Type

HY-D2341

6FC-GABA-Taxol	Fluorescent Dyes/Probes
6FC-GABA-Taxol is a fluorescent probe with cell permeability, which is formed by connecting 6FC to the anticancer drug Taxol (HY-B0015) via γ-aminobutyric acid (GABA). 6FC-GABA-Taxol can bind to microtubules in living cells and image them through confocal microscopy. Additionally, 6FC-GABA-Taxol enables the quantification of microtubule binding using flow cytometry without the addition of efflux inhibitors .

6FC-GABA-Taxol

Fluorescent Dyes/Probes

6FC-GABA-Taxol is a fluorescent probe with cell permeability, which is formed by connecting 6FC to the anticancer drug Taxol (HY-B0015) via γ-aminobutyric acid (GABA). 6FC-GABA-Taxol can bind to microtubules in living cells and image them through confocal microscopy. Additionally, 6FC-GABA-Taxol enables the quantification of microtubule binding using flow cytometry without the addition of efflux inhibitors .

HY-D1386

*JF526-Taxol* TFA**	Fluorescent Dyes/Probes
JF526-Taxol (TFA) is a versatile scaffold for fluorogenic probes including ligands for self-labeling tags, stains for endogenous structures, and spontaneously blinking labels for super-resolution immunofluorescence .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0227

7-epi-Taxol 3 Publications Verification 7-epi-Paclitaxel	Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Microtubule/Tubulin
7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-N2380

N-Benzoyl-(2R,3S)-3-phenylisoserine	Alkaloids Classification of Application Fields Other Alkaloids Taxaceae Source classification Plants Disease Research Fields Taxus wallichiana Zucc. Cancer	Others
N-Benzoyl-(2R,3S)-3-phenylisoserine is a Taxol C-13 Side Chain and crucial for the strong antitumor activity of Taxol .

HY-B0015

Paclitaxel 305+ Cited Publications	Structural Classification Classification of Application Fields Terpenoids Taxaceae Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	Microtubule/Tubulin ADC Payload Apoptosis Autophagy
Paclitaxel is a naturally occurring antineoplastic agent and stabilizes tubulin polymerization. Paclitaxel can cause both mitotic arrest and apoptotic cell death. Paclitaxel also induces autophagy .

HY-77572

7-Epi 10-desacetyl paclitaxel 7-epi-10-deacetyltaxol; 10-Deacetyl-7-epipaclitaxel	Microorganisms Classification of Application Fields Terpenoids Taxaceae Source classification Diterpenoids Plants Disease Research Fields Taxus chinensis (Pilger) Rehd. Cancer	ADC Payload
7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC₅₀ of 85 μM .

HY-77574

7-xylosyltaxol 7-Xylosylpaclitaxel; taxol-7-xyloside	Classification of Application Fields Terpenoids Source classification Taxaceae Diterpenoids Plants Disease Research Fields Cancer Taxus chinensis (Pilger) Rehd.	Microtubule/Tubulin
7-xylosyltaxol(Taxol-7-xyloside) is a taxol (Paclitaxel) derivative; Paclitaxel binds to tubulin and inhibits the disassembly of microtubules.

HY-N0227R

*7-epi-Taxol* (Standard)** 7-epi-Paclitaxel (Standard)	Terpenoids Taxaceae Source classification Diterpenoids Plants Taxus chinensis (Pilger) Rehd.	Reference Standards Microtubule/Tubulin
7-epi-Taxol (Standard) is the analytical standard of 7-epi-Taxol. This product is intended for research and analytical applications. 7-epi-Taxol is an active metabolite of taxol, with activity comparable to that of taxol against cell replication, promoting microtubule bundle formation and against microtubule depolymerization.

HY-N15573

7-epi-10-Deacetylcephalomannine	Natural Products Taxaceae Source classification Taxus sumatrana (Miq.) de Laub. Plants	Drug Derivative
7-epi-10-Deacetylcephalomannine is a taxol-related compound found in the needles of Taxus sumatrana .

HY-N7289

Taxuspine B	Taxus cuspidata Siebold & Zucc. Ketones, Aldehydes, Acids Source classification Taxaceae Plants	Others
Taxuspine B is a natural product, that can be isolated from Japanese yew Taxus. Taxuspine B exhibits appreciable taxol-like activity to reduce CaCl₂-induced depolymerixation of microtubules among the taxoids .

HY-77572R

7-Epi 10-desacetyl paclitaxel (Standard) 7-epi-10-deacetyltaxol (Standard); 10-Deacetyl-7-epipaclitaxel (Standard)	Microorganisms Terpenoids Taxaceae Source classification Diterpenoids Plants Taxus chinensis (Pilger) Rehd.	ADC Payload Reference Standards
7-Epi 10-desacetyl paclitaxel (Standard) is the analytical standard of 7-Epi 10-desacetyl paclitaxel. This product is intended for research and analytical applications. 7-Epi 10-desacetyl paclitaxel (7-epi-10-deacetyltaxol), a taxol derivative, exhibits cytotoxicity against HeLa cells with an IC50 of 85 μM .

Cat. No.	Product Name	Chemical Structure

HY-B0011AS

Docetaxel-d5 trihydrate
Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC₅₀ value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC₅₀ value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .

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