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Results for "

tauopathies

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

1

Peptides

1

Inhibitory Antibodies

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-144681
    Ceperognastat

    LY3372689

    		 OGA Tau Protein Neurological Disease
    Ceperognastat (LY3372689) is an orally active O-GlcNAcase (OGA) enzyme inhibitor. Ceperognastat can be used for tauopathies research, including Alzheimer’s disease .
    Ceperognastat
  • HY-154987
    MARK4 inhibitor 3

    		MARK Cancer
    MAPK4 inhibitor 3 (compound 23b) is an inhibitor of MAPK4 with an IC50 value of 1.01 μM. MAPK4 inhibitor 3 inhibits cancer cells growth. MAPK4 inhibitor 3 can be used for research on cancer and tauopathies .
    MARK4 inhibitor 3
  • HY-161307
    T-518

    		HDAC Microtubule/Tubulin Neurological Disease
    T-518 is an orally active, BBB-penetrant and potent DFMO-based HDAC6 inhibitor with high selectivity (IC50 = 36 nM). T-518 improves axonal transport. T-518 ameliorates object recognition deficit. T-518 can be studied in research for Alzheimer’s disease and tauopathy .
    T-518
  • HY-134968
    TTBK1-IN-1
    1 Publications Verification

    		 Tau Protein Neurological Disease
    TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor with an IC50 of 2.7 nM. TTBK1-IN-1 can be used for the research of alzheimer’s disease and related tauopathies . TTBK1-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    TTBK1-IN-1
  • HY-156586
    Egalognastat

    ASN90

    		 OGA Tau Protein Neurological Disease
    Egalognastat (ASN90) is a selective, brain-penetrant and orally active O-GlcNAcase (OGA) enzyme inhibitor with an IC50 value of 10.2 nM. Egalognastat increases O-GlcNAcylation of intracellular proteins like tau and α-synuclein, preventing their aggregation and toxicity. Egalognastat does not inhibit hexosaminidase (Hex). Egalognastat can be used for the research of neurodegenerative diseases, such as tauopathies and α-synucleinopathies (e.g., Alzheimer’s disease and Parkinson’s disease) .
    Egalognastat
  • HY-134968A
    (R)-TTBK1-IN-1

    		Tau Protein Neurological Disease
    (R)-TTBK1-IN-1 is a potent, selective and brain-penetrant tau tubulin kinase 1 (TTBK1) inhibitor. (R)-TTBK1-IN-1 is an enantiomer of TTBK1-IN-1 (HY-134968). (R)-TTBK1-IN-1 can be used in the research of alzheimer’s disease and related tauopathies . (R)-TTBK1-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    (R)-TTBK1-IN-1
  • HY-D0961
    Gallocyanine chloride

    		Fluorescent Dye Wnt β-catenin Neurological Disease Inflammation/Immunology Cancer
    Gallocyanine chloride is a synthetic blue dyestuff that can be used as a potential agent for the research of Alzheimer's disease and related neurodegenerative tauopathies. Gallocyanine chloride inhibits DKK1/LRP6 interaction (IC50=6.38 μM), activates Wnt signaling pathway, and causes β-catenin accumulation. Gallocyanine chloride exhibits anti-metastasis, anti-inflammatory and anti-fibrosis activities. Gallocyanine chloride can be used as a fluorescent probe for detection of superoxide anion radicals .
    Gallocyanine chloride
  • HY-116279
    JG-48

    		HSP Neurological Disease
    JG-48 is a Hsp70 inhibitor that can reduce tau levels in models of tauopathy .
    JG-48
  • HY-147321
    3'-DMTr-dG(iBu)

    		Tau Protein HBV Infection Neurological Disease
    3'-DMTr-dG(iBu) is a nucleoside for the synthesis of nucleic acid, such as antiviral agents used in the research of viral infection (HBV, HDV), and oligonucleotides against Alzheimer’s disease and other tauopathies .
    3'-DMTr-dG(iBu)
  • HY-120744
    LDN-193665

    		Tau Protein Others
    LDN-193665 is a Tau kinase inhibitor with tauopathy-modifying activity. LDN-193665 inhibits Tau phosphorylation, improves tauopathy in animal models, reduces Sarkosyl-insoluble Tau, and restores memory. It may be necessary to simultaneously target multiple kinases to effectively inhibit tauopathies.
    LDN-193665
  • HY-148112
    Casein kinase 1δ-IN-1

    		Casein Kinase Neurological Disease
    Casein kinase 1δ-IN-1 is an inhibitor of casein kinase 1δ (CK1δ). Casein kinase 1δ-IN-1 can be used for the research of neurodegenerative diseases such as tauopathies .
    Casein kinase 1δ-IN-1
  • HY-P10861
    RI-AG03

    		Tau Protein Neurological Disease
    RI-AG03 is an orally active and a BBB-penetrable Tau aggregation peptide inhibitor. RI-AG03 inhibits Tau aggregation and improves associated neurodegeneration and behavioral phenotypes in both in vivo and in vitro models. RI-AG03 can be used in the study of tauopathies such as Alzheimer's disease .
    RI-AG03
  • HY-P99163
    Tilavonemab

    ABBV-8E12; C2N-8E12

    		 Tau Protein Neurological Disease
    Tilavonemab (ABBV-8E12) is a humanized anti-tau monoclonal antibody that binds to amino acids 25-30 near the N-terminus of the tau protein. Tilavonemab can block the ability of human and mouse neurons to uptake tau aggregates. Tilavonemab can be used for research on Alzheimer’s disease and other tauopathies .
    Tilavonemab
  • HY-151335
    KU-177

    		HSP Cancer
    KU-177 is a potent inhibitor of Hsp90 ATPase homologue 1 (Aha1), ablates Aha1-driven enhancement of Hsp90-dependent tau aggregation. KU-177 also disrupts Aha1/Hsp90 interactions (IC50=4.08 μM) without inhibition of Hsp90’s ATPase activity. KU-177 can be used for tauopathies research .
    KU-177
  • HY-B0478
    Trazodone hydrochloride
    3 Publications Verification

    AF-1161

    		 5-HT Receptor Neurological Disease
    Trazodone hydrochloride (AF-1161) is a serotonin receptor antagonist and reuptake inhibitor with anti-neuroinflammatory effects. Trazodone hydrochloride can be used for research in major depressive disorder and also holds potential for studies related to sleep disorders .
    Trazodone hydrochloride
  • HY-137557
    Florzolotau

    APN1607; PM-PBB3

    		 Biochemical Assay Reagents Neurological Disease
    Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used to detect Alzheimer's disease (AD) and other tau proteinopathies. Its binding sites are located in the β-helix of the paired helical filaments (PHFs) and straight filaments (SFs) of the tau protein, as well as in the C-shaped cavity of the SFs. In addition, APN-1607 can bind to the intraneuronal inclusions in Alzheimer's disease (AD), primary age-related tauopathy (PART), and posterior cortical atrophy (PCA). Florzolotau is expected to be used in PET imaging research of neurological diseases, especially tau proteinopathies .
    Florzolotau
  • HY-134850
    QC-01–175

    		PROTACs Tau Protein Neurological Disease
    QC-01-175 is a heterobifunctional molecule, which degrades aberrant tau. QC-01-175 reduces the levels of A152T and P301L mutant tau protein and protects neurons from tau-mediated toxicity and improve cell survival (Pink: ligand for target protein Aberrant tau ligand 1 (HY-W453397); Black: linker NH2-PEG3 (HY-W007545); Blue: ligand for E3 ligase Pomalidomide (HY-10984)) .
    QC-01–175

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