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By Targets:	Adrenergic Receptor (2) Androgen Receptor (1) Biochemical Assay Reagents (1) C-type Lectin-like Receptors (CTLRs) (3) Dopamine Receptor (2) Endogenous Metabolite (5) FGFR (1) Integrin (1) Isotope-Labeled Compounds (1) mAChR (1) MHC (1) NF-κB (2) PARP (1) PROTACs (1) TNF Receptor (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (6) Endocrinology (3) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (4)
Oligonucleotides:	Antisense Oligonucleotides (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113405

21-Deoxycortisol	Endogenous Metabolite	Endocrinology
21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-W159303

7-Hydroxy-2,2-dimethyl-4-chromanone	C-type Lectin-like Receptors (CTLRs)	Others
7-Hydroxy-2,2-dimethyl-4-chromanone (compound 41) is an inhibitor of *DC-SIGN* (Dendritic Cell-Specific Intercellular Adhesion Molecule 3 grabbing non-integrin), with an IC₅₀ of 4.66 mM . DC-SIGN is the C-type lectin receptor presenting on the surface of both macrophages and dendritic cells .

HY-113405S1

21-Deoxycortisol-d8	Isotope-Labeled Compounds Endogenous Metabolite	Endocrinology
21-Deoxycortisol-d₈ is the deuterium labeled 21-Deoxycortisol. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-P990398

*Anti-DC-SIGN/CD209 Antibody*	Integrin	Inflammation/Immunology
Anti-DC-SIGN/CD209 Antibody is a CHO-expressed humanized antibody that targets *DC-SIGN/CD209. Anti-DC-SIGN/CD209 Antibody is composed of huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-DC-SIGN*/CD209 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-113405R

21-Deoxycortisol (Standard)	Endogenous Metabolite	Endocrinology
21-Deoxycortisol (Standard) is the analytical standard of 21-Deoxycortisol. This product is intended for research and analytical applications. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-B1219

Pentolinium tartrate	Others	Neurological Disease
Pentolinium tartrate is a ganglionic blocking agent. Pentolinium tartrate lowers blood pressure and permits regression of the signs and symptoms associated with severe hypertension .

HY-153489A

ISIS 329993 sodium ISIS-CRPRx sodium	C-type Lectin-like Receptors (CTLRs)	Cardiovascular Disease
ISIS 329993 sodium is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx sodium has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis

HY-153489

ISIS 329993 ISIS-CRPRx	C-type Lectin-like Receptors (CTLRs)	Cardiovascular Disease
ISIS 329993 (ISIS-CRPRx) is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis

HY-150177

Mannose 6 phosphate	Endogenous Metabolite	Metabolic Disease
Mannose 6 phosphate is a source of energy for cellular metabolism through their involvement in glycolysis. Mannose 6 phosphate can protect proteins in the dermis scaffold against oxidation and degradation. Mannose 6 phosphate can reverse the visible signs of aging .

HY-B0389S19

D-Glucose-13C,d Glucose-¹³C,d; D-(+)-Glucose-¹³C,d; Dextrose-¹³C,d	Endogenous Metabolite	Metabolic Disease Cancer
D-Glucose- ¹³C,d is the deuterium and ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sign

HY-N0471B

L-Hyoscyamine hydrobromide Hyoscyamine hydrobromide	mAChR	Neurological Disease
L-Hyoscyamine (Hyoscyamine) hydrobromide is an anticholinergic agent that may potentially affect breastfeeding and milk production. L-Hyoscyamine hydrobromide is not likely to interfere with breastfeeding when used in single doses. L-Hyoscyamine hydrobromide should be monitored for signs of decreased lactation during long-term use.

HY-D0348

Celliton Fast Blue Green B Disperse Blue 7; 1,4-DiOH-5,8-bis(2-OHethyl)aminoanthraquinone	Biochemical Assay Reagents	Others
Celliton Fast Blue Green B (Disperse Blue 7), a blue-green dye used in textiles. The aqueous extract of Celliton Fast Blue Green B causes no signs of skin irritation and sensitization in laboratory animals. Celliton Fast Blue Green B colored textiles with no irritation in human .

HY-106973A

Nolomirole hydrochloride CHF 1035	Dopamine Receptor Adrenergic Receptor	Cardiovascular Disease
Nolomirole (CHF 1035) hydrochloride is an orally active and selective DA2 dopaminergic receptor/α2-adrenoceptor agonist. Nolomirole attenuates the heart failure signs in the Monocrotaline (HY-N0750)-induced congestive heart failure model. Nolomirole increases cardiac output .

HY-106973

Nolomirole CHF 1035 free base	Dopamine Receptor Adrenergic Receptor	Cardiovascular Disease
Nolomirole (CHF 1035) is an orally active and selective DA2 dopaminergic receptor/α2-adrenoceptor agonist. Nolomirole attenuates the heart failure signs in the Monocrotaline (HY-N0750)-induced congestive heart failure model. Nolomirole increases cardiac output .

HY-132292

ARD-2128	PROTACs Androgen Receptor	Cancer
ARD-2128 is a highly potent, orally bioavailable PROTAC androgen receptor (AR) degrader. ARD-2128 effectively reduces AR protein, suppresses AR-regulated genes in tumor tissues, and inhibits growth of tumor without signs of toxicity. ARD-2128 has the potential for the research of the prostate cancer .

HY-P991400

GSK1995057	TNF Receptor	Inflammation/Immunology
GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 attenuates pulmonary neutrophilia, inflammatory cytokine release and signs of endothelial injury in bronchoalveolar lavage and serum samples. GSK1995057 can be used in Acute lung injury and Adult respiratory distress syndrome research. Recommended isotype control: dAb (VHH-His) .

HY-107818

4-Hydroxychalcone	NF-κB	Cardiovascular Disease Inflammation/Immunology
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity . 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice .

HY-107818R

4-Hydroxychalcone (Standard)	NF-κB	Cardiovascular Disease Inflammation/Immunology
4-Hydroxychalcone (Standard) is the analytical standard of 4-Hydroxychalcone. This product is intended for research and analytical applications. 4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity . 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice .

HY-P2459

MOG (35-55), human	MHC	Neurological Disease
MOG (35-55), human is a component of CNS myelin. MOG (35-55), human is different from mMOG (35-55) by a proline for serine substitution at position 42. MOG (35-55), human is also immunogenic via bind to H-2b class II MHC and recognized by T cells, but not encephalitogenic, and is only partially cross-reactive with mMOG35–55. MOG (35-55), human induces minimal clinical signs of EAE relative to the rodent peptide .

HY-15048

GPI 15427	PARP	Inflammation/Immunology
GPI 15427 is a potent inhibitor of the enzyme poly (ADP-ribose) polymerase-1 (PARP-1), which plays a harmful role during inflammation. In a rat model of gut injury and inflammation, including splanchnic artery occlusion (SAO) shock and dinitrobenzene sulfonic acid (DNBS)-induced colitis, GPI 15427 demonstrated strong anti-inflammatory effects. It reduced inflammatory cell infiltration, histological injury, and delayed clinical signs of inflammation. GPI 15427 also diminished the accumulation of poly (ADP-ribose) in the ileum and colon of treated rats. These results suggest GPI 15427 could be useful for treating intestinal ischemia and inflammation .

HY-143881

FGFR4-IN-6	FGFR	Cancer
FGFR4-IN-6 (Compound 9ka) is a covalently reversible FGFR4 inhibitor with an IC₅₀ value of 5.4 nM. FGFR4-IN-6 also exhibits good oral pharmacokinetic properties. FGFR4-IN-6 induces significant tumor regressions in a xenograft mouse model of Hep3B2.1-7 HCC cell line without an obvious sign of toxicity . FGFR4-IN-6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Target	Research Area

HY-P2459

MOG (35-55), human	MHC	Neurological Disease
MOG (35-55), human is a component of CNS myelin. MOG (35-55), human is different from mMOG (35-55) by a proline for serine substitution at position 42. MOG (35-55), human is also immunogenic via bind to H-2b class II MHC and recognized by T cells, but not encephalitogenic, and is only partially cross-reactive with mMOG35–55. MOG (35-55), human induces minimal clinical signs of EAE relative to the rodent peptide .

HY-P3628

Dynorphin (2-17) (porcine)	Peptides	Neurological Disease
Dynorphin (2-17) (porcine) is a peptide derived from Prodynorphin, can improve somatic signs of Morphine-dependent withdrawal .

Cat. No.	Product Name	Target	Research Area

HY-P990398

*Anti-DC-SIGN/CD209 Antibody*	Integrin	Inflammation/Immunology
Anti-DC-SIGN/CD209 Antibody is a CHO-expressed humanized antibody that targets *DC-SIGN/CD209. Anti-DC-SIGN/CD209 Antibody is composed of huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-DC-SIGN*/CD209 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991400

GSK1995057	TNF Receptor	Inflammation/Immunology
GSK1995057 is a human monoclonal antibody (mAb) targeting TNFRSF1A. GSK1995057 attenuates pulmonary neutrophilia, inflammatory cytokine release and signs of endothelial injury in bronchoalveolar lavage and serum samples. GSK1995057 can be used in Acute lung injury and Adult respiratory distress syndrome research. Recommended isotype control: dAb (VHH-His) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113405

21-Deoxycortisol	Structural Classification Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Endocrinology Steroids	Endogenous Metabolite
21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-107818

4-Hydroxychalcone	Cardiovascular Disease Structural Classification Chalcones Monophenols Flavonoids other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields	NF-κB
4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity . 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice .

HY-113405R

21-Deoxycortisol (Standard)	Structural Classification Source classification Endogenous metabolite Steroids	Endogenous Metabolite
21-Deoxycortisol (Standard) is the analytical standard of 21-Deoxycortisol. This product is intended for research and analytical applications. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-150177

Mannose 6 phosphate	Human Gut Microbiota Metabolites Microorganisms Source classification Endogenous metabolite	Endogenous Metabolite
Mannose 6 phosphate is a source of energy for cellular metabolism through their involvement in glycolysis. Mannose 6 phosphate can protect proteins in the dermis scaffold against oxidation and degradation. Mannose 6 phosphate can reverse the visible signs of aging .

HY-107818R

4-Hydroxychalcone (Standard)	Structural Classification Chalcones Monophenols Flavonoids other families Source classification Phenols Plants	NF-κB
4-Hydroxychalcone (Standard) is the analytical standard of 4-Hydroxychalcone. This product is intended for research and analytical applications. 4-Hydroxychalcone is a chalcone metabolite with anti-angiogenic and anti-inflammatory activities. 4-Hydroxychalcone suppresses angiogenesis by suppression of growth factor pathway with no signs of cytotoxicity . 4-Hydroxychalcone inhibits TNF-α induced NF-κB pathway activation and activates BMP signaling, reduces resistant hypertension (RH) by attenuating hyperaldosteronism and renal injury in mice .

Species:	Human (5) Rhesus Macaque (2) Mouse (1)
Tag:	His (4) Fc (4) Flag (1)
Source:	HEK293 (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P76643

	*DC-SIGN/CD209 Protein, Mouse (HEK293, His)* CD209 antigen; DC-sign1; CD209	Mouse	HEK293
	DC-SIGN/CD209 Protein, a probable pathogen-recognition receptor, mediates the endocytosis and lysosomal degradation of pathogens. It recognizes high mannose N-linked oligosaccharides in pathogen antigens in a calcium-dependent manner and functions as a receptor for ICAM3, potentially through binding to mannose-like carbohydrates. DC-SIGN/CD209 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DC-SIGN/CD209 protein, expressed by HEK293 , with N-His labeled tag.

HY-P74205

	*DC-SIGN/CD209 Protein, Rhesus Macaque (HEK293, His)* CD209 antigen; DC-sign1; CD209	Rhesus Macaque	HEK293
	DC-SIGN/CD209 Protein, is a C-type lectin receptor present on the surface of both macrophages and dendritic cells (DCs), serves as a pivotal pathogen-recognition receptor, playing a crucial role in initiating the primary immune response. It mediates endocytosis and subsequent degradation of pathogens within lysosomal compartments. On DCs, it acts as a high-affinity receptor for ICAM2 and ICAM3, binding to mannose-like carbohydrates. DC-SIGN/CD209 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived DC-SIGN/CD209 protein, expressed by HEK293 , with N-His labeled tag.

HY-P70110

	*DC-SIGN/CD209 Protein, Human (HEK293, Fc)* rHuCD209 antigen/CD209, Fc; CD209 molecule; CD209; CDsignHIV gpl20-binding protein; CLEC4L; DCsign; DC-sign; DC-sign1; CD209 Antigen	Human	HEK293
	The DC-SIGN/CD209 protein is expressed on immature dendritic cells (DC) and is an important pathogen recognition receptor that initiates primary immune responses. It mediates endocytosis and subsequent degradation of pathogens within the lysosomal compartment. DC-SIGN/CD209 Protein, Human (HEK293, Fc) is the recombinant human-derived DC-SIGN/CD209 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P76219

	CD299 Protein, Human (HEK293, Fc) C-type lectin domain family 4 member M; DC-signR; DC-sign2; L-sign; CD299; CLEC4M; CD209L	Human	HEK293
	The CD299 protein is an important C-type lectin that plays a role in cell adhesion and pathogen recognition. It can identify pathogens such as Mycobacterium tuberculosis, Ebola virus, hepatitis C, HIV-1, influenza A, West Nile virus and SARS-CoV. CD299 Protein, Human (HEK293, Fc) is the recombinant human-derived CD299 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P76219A

	CD299 Protein, Human (HEK293, hFc) C-type lectin domain family 4 member M; DC-signR; DC-sign2; L-sign; CD299; CLEC4M; CD209L	Human	HEK293
	The CD299 protein is an important C-type lectin that plays a role in cell adhesion and pathogen recognition. It can identify pathogens such as Mycobacterium tuberculosis, Ebola virus, hepatitis C, HIV-1, influenza A, West Nile virus and SARS-CoV. CD299 Protein, Human (HEK293, Fc) is the recombinant human-derived CD299 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P72739

	CD299 Protein, Human (HEK293, His-Flag) C-type lectin domain family 4 member M; DC-signR; DC-sign2; L-sign; CD299; CLEC4M; CD209L	Human	HEK293
	CD299 protein showcases an unconventional genetic architecture with a non-canonical intron-exon splice junction, highlighting unique structural features. CD299 Protein, Human (HEK293, His-Flag) is the recombinant human-derived CD299 protein, expressed by HEK293 , with N-Flag, N-8*His labeled tag.

HY-P74206

	*DC-SIGN/CD209 Protein, Rhesus Macaque (HEK293, Fc)* CD209 antigen; DC-sign1; CD209	Rhesus Macaque	HEK293
	DC-SIGN/CD209 Protein, is a C-type lectin receptor present on the surface of both macrophages and dendritic cells (DCs), serves as a pivotal pathogen-recognition receptor, playing a crucial role in initiating the primary immune response. It mediates endocytosis and subsequent degradation of pathogens within lysosomal compartments. On DCs, it acts as a high-affinity receptor for ICAM2 and ICAM3, binding to mannose-like carbohydrates. DC-SIGN/CD209 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived DC-SIGN/CD209 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P704561

	*DC-SIGN/CD209 Protein, Human (HEK293, His)* rHuCD209 antigen/CD209, Fc; CD209 molecule; CD209; CDsignHIV gpl20-binding protein; CLEC4L; DCsign; DC-sign; DC-sign1; CD209 Antigen	Human	HEK293

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Cat. No.	Product Name	Chemical Structure

HY-113405S1

21-Deoxycortisol-d8
21-Deoxycortisol-d₈ is the deuterium labeled 21-Deoxycortisol. 21-Deoxycortisol is an endogenous metabolite. 21-Deoxycortisol is a sign of congenital adrenal hyperplasia .

HY-B0389S19

D-Glucose-13C,d
D-Glucose- ¹³C,d is the deuterium and ¹³C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical sign

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P84813

	CD209 Antibody (YA4510) CDsign; CLEC4L; DC-sign; DC-sign1	WB, FC, ELISA	Human

HY-P84794

	CD299 Antibody (YA4491) CLEC4M; Lsign; CD209L; L-sign; DCsignR; HP10347; DC-sign2; DC-signR	WB, FC, ELISA	Human

HY-P83614

	CD209 Antibody (YA3359) CD209; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; DC-sign; DC-sign1; CD209	WB	Human
	CD209 Antibody (YA3359) is a non-conjugated IgG antibody, targeting CD209, with a predicted molecular weight of 46 kDa (observed band size: 50 kDa). CD209 Antibody (YA3359) can be used for WB experiment in human background.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-153489A

ISIS 329993 sodium ISIS-CRPRx sodium		Antisense Oligonucleotides
ISIS 329993 sodium is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx sodium has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis

HY-153489

ISIS 329993 ISIS-CRPRx		Antisense Oligonucleotides
ISIS 329993 (ISIS-CRPRx) is an antisense oligonucleotide targeting to C-reactive protein (CRP). ISIS-CRPRx has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis

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sign

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Natural
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