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Results for "

renal clearance

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0235
    Trichlormethiazide

    		Carbonic Anhydrase Metabolic Disease
    Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model .
    Trichlormethiazide
  • HY-N2263
    Skimmin
    1 Publications Verification

    Umbelliferone glucoside

    		 Interleukin Related TGF-β Receptor TNF Receptor Parasite Inflammation/Immunology
    Skimmin (Umbelliferone glucoside) is a major pharmacologically active and orally active molecule present in Hydrangea paniculata, a medical herb used in traditional Chinese medicine as an anti-inflammatory agent. Skimmin has renal protective activity. Skimmin can improve creatinine clearance, and reduce plasma creatinine, and kidney injuries. Skimmin has good anti-amoebic activity against the HM1:IMMS strain of Entamoeba histolytica. Skimmin has anti-cancer and neuroprotective activities. Skimmin reduces cardiac fibrosis as well as decreasing TNF-α, IL-6, IL1β, and TGFβ1 in cardiac tissues. Skimmin can be studied in research for diabetes and diabetes-related diseases .
    Skimmin
  • HY-DN7075F
    FITC-inulin

    		Fluorescent Dye Others
    FITC-inulin is a FITC (HY-66019)-labled inulin (Ex/Em=488/525 nm). FITC-inulin can be used for monitoring renal clearance .
    FITC-inulin
  • HY-B0235A
    Trichlormethiazide sodium

    		Carbonic Anhydrase Metabolic Disease
    Trichlormethiazide sodium is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide sodium increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model .
    Trichlormethiazide sodium
  • HY-B0235R
    Trichlormethiazide (Standard)

    		Carbonic Anhydrase Metabolic Disease
    Trichlormethiazide (Standard) is the analytical standard of Trichlormethiazide. This product is intended for research and analytical applications. Trichlormethiazide is an orally active thiazide diuretic, with antihypertensive effect. Trichlormethiazide increases urine volume (UV), Na and K excretion and tends to improve the depressed creatinine clearance (CCRE) in acute renal failure rats model .
    Trichlormethiazide (Standard)
  • HY-150502
    Poly(styrenyl acetal trehalose)

    pSAT

    		 Biochemical Assay Reagents Others
    Poly(styrenyl acetal trehalose) (pSAT) is composed of trehalose side chains linked to a polystyrene backbone via acetals. Poly(styrenyl acetal trehalose) stabilizes a variety of proteins and enzymes against fluctuations in temperature, and does not trigger the innate immune response. Poly(styrenyl acetal trehalose) can be used in synthesis of protein-polymer conjugates for reduced renal clearance of the biomolecule .
    Poly(styrenyl acetal trehalose)
  • HY-120270
    PF-06679142

    		AMPK Metabolic Disease
    PF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC50 of 22 nM against α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research .
    PF-06679142
  • HY-102093A
    ZD 7155

    		Angiotensin Receptor Others
    ZD 7155 is an AT1R selective antagonist with renal function modulating activity. The effects of ZD 7155 on glomeruli and tubules were measured in 1- (N = 9) and 6-week-old (N = 13) lambs. Pretreatment with ZD 7155 after L-NAME infusion did not alter glomerular function in 1- or 6-week-old lambs. During postnatal development, Ang II modulates the effects of NO on electrolyte handling via AT1R and AT2R. In 6-week-old lambs, selective inhibition of AT1R and AT2R increased the excretion of Na+, K+, and Cl-. In 6-week-old lambs, pretreatment with ZD 7155 and PD 123319 followed by the addition of L-NAME increased urine flow rate by 200%, free water clearance by 50%, and decreased urine osmolality by 40%. The same trends of changes in these variables were also observed when L-NAME was added to ZD 7155 or PD 123319, although to a lesser extent.
    ZD 7155

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