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poison

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (2) Adrenergic Receptor (5) Antibiotic (2) Apoptosis (2) Bacterial (5) Biochemical Assay Reagents (8) Cholinesterase (ChE) (22) Cytochrome P450 (4) Drug Intermediate (1) Drug Isomer (1) Drug Metabolite (2) Endogenous Metabolite (5) GABA Receptor (2) Glutathione Peroxidase (2) HIV (2) IFNAR (1) Isotope-Labeled Compounds (2) mAChR (2) Microtubule/Tubulin (3) Molecular Glues (2) nAChR (2) Opioid Receptor (1) Parasite (8) Potassium Channel (2) Reference Standards (13) TNF Receptor (1) Topoisomerase (9)
By Research Areas:	Cancer (17) Cardiovascular Disease (7) Endocrinology (5) Infection (11) Inflammation/Immunology (3) Metabolic Disease (12) Neurological Disease (24)

By Targets:

ADC Payload (2)

Adrenergic Receptor (5)

Antibiotic (2)

Apoptosis (2)

Bacterial (5)

Biochemical Assay Reagents (8)

Cholinesterase (ChE) (22)

Cytochrome P450 (4)

Drug Intermediate (1)

Drug Isomer (1)

Drug Metabolite (2)

Endogenous Metabolite (5)

GABA Receptor (2)

Glutathione Peroxidase (2)

HIV (2)

IFNAR (1)

Isotope-Labeled Compounds (2)

mAChR (2)

Microtubule/Tubulin (3)

Molecular Glues (2)

nAChR (2)

Opioid Receptor (1)

Parasite (8)

Potassium Channel (2)

Reference Standards (13)

TNF Receptor (1)

Topoisomerase (9)

By Research Areas:

Cancer (17)

Cardiovascular Disease (7)

Endocrinology (5)

Infection (11)

Inflammation/Immunology (3)

Metabolic Disease (12)

Neurological Disease (24)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Pralidoxime iodide	Cholinesterase (ChE)	Neurological Disease
Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning .

Dequalinium Chloride	Potassium Channel nAChR Apoptosis Bacterial Parasite	Infection Cancer
Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity .

Chloroquinoxaline sulfonamide Chloroquinoxaline; NSC-339004	Molecular Glues Topoisomerase Parasite	Infection Cancer
Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle . Antitumor activity .

Succimer 1 Publications Verification Dimercaptosuccinic acid; DMSA	Biochemical Assay Reagents	Others Cancer
Succimer is a widely used chelating agent for the treatment of Pb poisoning.

Dimercaprol 2,3-Dimercapto-1-propanol; Dithioglycerol	HIV	Infection
Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning .

Benactyzine	Cholinesterase (ChE)	Neurological Disease
Benactyzine is a competitive BChE inhibitor with a K_i of 0.01 mM. Benactyzine is an anticholinergic drug. Benactyzine has the potential for organophosphate poisoning research .

Pralidoxime iodide (Standard)	Cholinesterase (ChE)	Neurological Disease
Pralidoxime (iodide) (Standard) is the analytical standard of Pralidoxime (iodide). This product is intended for research and analytical applications. Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning .

Dequalinium Chloride (Standard)	Reference Standards Potassium Channel nAChR Apoptosis Bacterial Parasite	Infection Cancer
Dequalinium (Chloride) (Standard) is the analytical standard of Dequalinium (Chloride). This product is intended for research and analytical applications. Dequalinium chloride is an Apamin (HY-P0256)-sensitive potassium channel selective blocker. Dequalinium chloride is a cationic, lipophilic mitochondrial poison. Dequalinium chloride is also an antagonist pf α7 nAChR, and an anti-microbial antiseptic agent with a broad bactericidal and fungicidal activity .

Chloroquinoxaline sulfonamide (Standard)	Molecular Glues Topoisomerase Parasite	Infection Cancer
Chloroquinoxaline sulfonamide (Standard) is the analytical standard of Chloroquinoxaline sulfonamide. This product is intended for research and analytical applications. Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle . Antitumor activity .

MB327	Others	Neurological Disease
MB327 is a bipyridine nonoxime compound that restores neuromuscular function. MB327 restores the activity of nicotinamide acetylcholine receptors (nAChRs) for carbachol desensitization in a typical type II PAM manner. MB327 can neutralize nerve agent poisoning .

Hydroxocobalamin 3 Publications Verification Vitamin B12a	Endogenous Metabolite	Neurological Disease Metabolic Disease
Hydroxocobalamin (Vitamin B12a) is a cyanide antidote. Hydroxocobalamin can decrease the cell and plasma cyanide concentrations and increase survival rate in acute cyanide poisoning. Hydroxocobalamin can improve newborn Cbl-C defect-induced metabolic profile and neurocognitive outcome. Hydroxocobalamin can normalize Vitamin B₁₂ deficiency. Hydroxocobalamin can induce acute kidney injury. Hydroxocobalamin can be used for the researches of metabolic and neurological disease .

Proscillaridin A 1 Publications Verification	Topoisomerase	Cancer
Proscillaridin A is a potent poison of topoisomerase I/II activity with IC₅₀ values of 30 nM and 100 nM, respectively .

Penniclavine	Biochemical Assay Reagents	Others
Penniclavine is a clavine ergot alkaloid that is present in some forages and can cause livestock poisoning .

Dimercaprol (Standard) 2,3-Dimercapto-1-propanol (Standard); Dithioglycerol (Standard)	Reference Standards HIV	Infection
Dimercaprol (Standard) is the analytical standard of Dimercaprol. This product is intended for research and analytical applications. Dimercaprol (2,3-Dimercapto-1-propanol) is an anti-heavy metal-poisoning agent, which exhibits anti-HIV activity. Dimercaprol can be used for the study for arsenic, mercury, gold, lead, antimony, and other toxic metal poisoning .

(R)-Camptothecin (R)-Campathecin; (R)-(+)-Camptothecin; (R)-CPT	Topoisomerase Drug Isomer	Others
(R)-Camptothecin is an enantiomer of Camptothecin (CPT), is inactive as an inhibitor of the DNA religation reaction and consequently do not poison Top1 .

Benactyzine hydrochloride 1 Publications Verification	Cholinesterase (ChE)	Neurological Disease
Benactyzine hydrochloride is a competitive BChE inhibitor with a K_i of 0.01 mM. Benactyzine hydrochloride is an anticholinergic drug. Benactyzine hydrochloride has the potential for organophosphate poisoning research .

Bemegride 3-Ethyl-3-methylglutarimide; Bemegrid	GABA Receptor	Neurological Disease
Bemegride (3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning .

Succimer (Standard)	Biochemical Assay Reagents	Others Cancer
Succimer (Standard) is the analytical standard of Succimer. This product is intended for research and analytical applications. Succimer is a widely used chelating agent for the treatment of Pb poisoning.

3,5-Dimethoxyphenol (Standard)	Endogenous Metabolite	Metabolic Disease
3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .

3,5-Dimethoxyphenol Phloroglucinol Dimethyl Ether	Endogenous Metabolite	Metabolic Disease
3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves .

Sabarubicin MEN 10755	Topoisomerase	Cancer
Sabarubicin is a doxorubicin disaccharide analogue with striking antitumor activity. Sabarubicin is more effective than doxorubicin as a topoisomerase II poison and stimulated DNA fragmentation at lower intracellular concentrations.

Guajadial C	Topoisomerase	Cancer
Guajadial C is a Top1 catalytic inhibitor that delays Top1 poison-mediated DNA damage. Guajadial C shows cytotoxicity against cancer cells .

1-Naphthyl acetate	Cholinesterase (ChE)	Others
1-Naphthyl acetate is an attractive chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity. 1-Naphthyl acetate has the potential to detect organophosphorus pesticide (OP) poisoning .

1-Naphthyl acetate (Standard)	Cholinesterase (ChE)	Others
1-Naphthyl acetate is an attractive chromogenic substrate for the detection of erythrocyte acetylcholinesterase (AChE) activity. 1-Naphthyl acetate has the potential to detect organophosphorus pesticide (OP) poisoning .

Eseramine	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
Eseramine is a weak acetylcholinesterase inhibitor with an IC₅₀ value of 9300 nM. Eseramine is promising for research of diseases involving the regulation of acetylcholinesterase, such as glaucoma, myasthenia gravis, and protection against organophosphate poisoning .

Proscillaridin A (Standard)	Reference Standards Topoisomerase	Cancer
Proscillaridin A (Standard) is the analytical standard of Proscillaridin A. This product is intended for research and analytical applications. Proscillaridin A is a potent poison of topoisomerase I/II activity with IC₅₀ values of 30 nM and 100 nM, respectively .

Amiprofos methyl BAY-NTN 6867	Microtubule/Tubulin	Others
Amiprofos methyl (BAY-NTN 6867) is a phosphoric amide herbicide. Amiprofos methyl is a specific and potent antimicrotubule agent. Amiprofos methyl directly poisons microtubule dynamics in plant cells .

Dinophysistoxin 1 DTX 1	Endogenous Metabolite	Cancer
Dinophysistoxin 1 (DTX 1, 35-methylokadaic acid) is a causative agent of diarrhetic shellfish poisoning. Dinophysistoxin 1 exerts tumor-promoting activity, serves as a skin irritant as well .

Tiopronin 1 Publications Verification	Others	Metabolic Disease
Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders .

Piperilate hydrochloride	Cholinesterase (ChE)	Cardiovascular Disease
Piperilate (Pipethanate) hydrochloride is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate hydrochloride also causes hypotension and rescues mice poisoned by the organophosphates .

Piperilate Pipethanate	Cholinesterase (ChE)	Cardiovascular Disease
Piperilate (Pipethanate) is one of the mixtures of hetrazepine derivative PAF antagonists with anticholinergics, can be used for bronchial asthma research. Piperilate also causes hypotension and rescues mice poisoned by the organophosphates .

Calcium Phytate 1 Publications Verification Phytin	Endogenous Metabolite	Metabolic Disease
Calcium phytate (Phytin) is an insoluble phosphorus-containing compound widely present in plant-based foods such as cereals and legumes. Calcium phytate can be found in feces and can alleviate lead poisoning .

Sulfanegen	Drug Intermediate	Others
Sulfanegen is a 3-mercaptopyruvate prodrug and cyanide antidote. Sulfanegen converts toxic cyanide into a relatively non-toxic substance. Sulfanegen, alone or in combination with Cobinamide, has detoxification effect in mouse models of cyanide poisoning .

Terbutaline (Standard)	Drug Metabolite Reference Standards Adrenergic Receptor Antibiotic	Endocrinology
Benactyzine hydrochloride (Standard) is the analytical standard of Benactyzine hydrochloride. This product is intended for research and analytical applications. Benactyzine hydrochloride is a competitive BChE inhibitor with a Ki of 0.01 mM. Benactyzine hydrochloride is an anticholinergic drug. Benactyzine hydrochloride has the potential for organophosphate poisoning research .

Jesaconitine	Drug Metabolite	Cardiovascular Disease
Jesaconitine is a toxic alkaloid. Jesaconitine can be derived from Aconitum. Jesaconitine is one of the major metabolites that can be detected in the blood of the right atrium after aconitum poisoning. Various types of arrhythimia are characteristic in aconitine intoxication .

Obidoxime dichloride	Cholinesterase (ChE)	Neurological Disease
Obidoxime dichloride is a non-full spectrum oxime agent and can be used as an antidote for organophosphate nerve agent poisoning. Obidoxime dichloride reactivates sarin-inhibited acetylcholinesterase (AChE) and reduces acute toxicity of sarin-evaluated .

Bemegride (Standard)	GABA Receptor	Neurological Disease
Bemegride (Standard) is the analytical standard of Bemegride. This product is intended for research and analytical applications. Bemegride (3-Ethyl-3-methylglutarimide) is a central nervous system stimulant and antidote for barbiturate poisoning .

Benactyzine hydrochloride (Standard)	Reference Standards Cholinesterase (ChE)	Neurological Disease
Benactyzine hydrochloride (Standard) is the analytical standard of Benactyzine hydrochloride. This product is intended for research and analytical applications. Benactyzine hydrochloride is a competitive BChE inhibitor with a Ki of 0.01 mM. Benactyzine hydrochloride is an anticholinergic drug. Benactyzine hydrochloride has the potential for organophosphate poisoning research .

Rebeccamycin	Topoisomerase ADC Payload Antibiotic	Cancer
Rebeccamycin, an antitumor antibiotic, inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I and has negligible effect on protein kinase C and topoisomerase II .

Pralidoxime	Cholinesterase (ChE)	Neurological Disease
Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning .

Pralidoxime chloride 2 Publications Verification 2-PAM chloride	Cholinesterase (ChE)	Neurological Disease
Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning .

Atropine oxide Atropine oxidation	Parasite	Neurological Disease
Atropine Oxide (Atropine oxidation), a derivative of Atropine, acts as a competitive antagonist to the muscarinic acetylcholine receptors M1, M2, M3, M4, and M5, and is utilized in the treatment of specific nerve agent and pesticide poisonings.

Atropine oxide hydrochloride Atropine oxidation hydrochloride	mAChR
Atropine Oxide (Atropine oxidation) hydrochloride, a derivative of Atropine, acts as a competitive antagonist to the muscarinic acetylcholine receptors M1, M2, M3, M4, and M5, and is utilized in the treatment of specific nerve agent and pesticide poisonings .

Coralyne chloride 1 Publications Verification	Topoisomerase	Cancer
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage . Coralyne chloride can be used for preparing?coralyne derivatives?as DNA binding fluorescent probes .

Pralidoxime methanesulfonate	Cholinesterase (ChE)	Neurological Disease
Pralidoxime methanesulfonate is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime methanesulfonate reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime methanesulfonate is an antidote for organophosphate poisoning .

Anisodamine 6-Hydroxyhyoscyamine	mAChR	Neurological Disease Cancer
Anisodamine (6-Hydroxyhyoscyamine), a belladonna alkaloid, is a non-subtype-selective muscarinic, and also a nicotinic cholinoceptor antagonist. Anisodamine employs in traditional Chinese medicine for many ailments, mainly to improve the microcirculation in states of shock, and also in organophosphate poisoning .

Cat. No.	Product Name

HY-L224

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

200 compounds

Diarrhea is a disease symptom, and the pathophysiologic basis of diarrhea is a disturbance in intestinal water and electrolyte balance, which may be due to increased secretion of osmotically active electrolytes (secretory diarrhea) or increased intake of osmotically active substances (osmotic diarrhea). Food poisoning, pathogenic bacterial infections, and intestinal-related diseases can all contribute to the development of diarrhea. Traditional Chinese Medicine (TCM) considers diarrhea to be a symptom of an imbalance in the body's systems, particularly related to the functions of the spleen and stomach. Spleen qi deficiency, dampness-heat, liver and spleen disharmony are closely related to diarrhea. Many types of Chinese herbs regulate the function of diarrhea, such as: Dysosmae Verspiellis Rhixoma Et Radix, Ginkgo Semen, Forsythiae Fructus, and Campsis Flos.

MCE can provide 200 active monomers that can be obtained from TCM herbs with diarrhea-regulating functions, which can be applied to drug development and disease mechanism research.

Cat. No.	Product Name	Type

HY-106594B

Prussian blue soluble Pigment blue 27	Fluorescent Dyes/Probes
Prussian blue soluble is a good adsorbent to be used as antidotes for poisoning with cesium or thallium ions. Prussian blue soluble has anticancerous and antibacterial properties. Prussian blue soluble can be used as a contrast agent in photoacoustic and magnetic resonance imaging (MRI) .

Cat. No.	Product Name	Type

HY-W749867

Ca(II)-EDTA disodium dihydrate Calcium disodium EDTA dihydrate	Chelators
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis . CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning .

HY-W018746

EDTA disodium

20+ Cited Publications

Ethylenediaminetetraacetic acid disodium

Chelators

EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.

HY-W018746R

EDTA disodium (Standard)

Ethylenediaminetetraacetic acid disodium (Standard)

Chelators

EDTA (disodium) (Standard) is the analytical standard of EDTA (disodium). This product is intended for research and analytical applications. EDTA disodium salt, also known as ethylenediaminetetraacetic acid disodium, belongs to the chelating agent category, which is formed by chelating a central metal ion with four carboxylate groups and two amine groups. This compound, with its ability to bind and chelate metal ions such as calcium, magnesium and iron, is commonly used in a variety of applications, including industrial, medical and research settings. It is used as a preservative in food and beverage, as a stabilizer in medicine, as a chelating agent in water treatment, and as a reagent in biochemical and biomedical research. In addition, EDTA disodium salt has been studied for potential research effects such as improving heavy metal poisoning and cardiovascular disease.

HY-NP024

*Snake poison* protein**	Native Proteins
Snake poison protein is a venom protein secreted by the salivary glands of venomous snakes .

Cat. No.	Product Name	Target	Research Area

HY-B1603S

Chlorophenothane-d8	Peptides	Others
Chlorophenothane-d8 is the deuterium labeled Chlorophenothane. Chlorophenothane has stomach poisoning and contact killing effects. Chlorophenothane has been widely used as an insecticide .

Cat. No.	Product Name	Chemical Structure

HY-B0373S1

Tiopronin-d3
Tiopronin-d₃ is the deuterium labeled Tiopronin. Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders .

HY-N6608S

Physostigmine-d3
Physostigmine-d₃ is the deuterium labeled Physostigmine. Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning .

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