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phosphoglycerate

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By Targets:	Phosphoglycerate Dehydrogenase (PHGDH) (9) Akt (1) Apoptosis (2) CDK (2) Endogenous Metabolite (3) Enolase (1) ERK (1) Fluorescent Dye (1) Keap1-Nrf2 (1) MDM-2/p53 (1) Phosphatase (6) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (16) Endocrinology (1) Infection (2) Metabolic Disease (3) Neurological Disease (1)

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Targets Recommended: Phosphoglycerate Kinase (PGK) Phosphoglycerate Dehydrogenase (PHGDH)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2822

Phosphoglycerate kinase, yeast PGK	Endogenous Metabolite	Infection Endocrinology Cancer
Phosphoglycerate kinase, yeast (PGK), namely phosphoglycerate kinase, is a glycolytic enzyme commonly used in biochemical research. Phosphoglycerate kinase can catalyze the reversible transfer of phosphate groups from 1,3-bisphosphoglycerate (1,3-BPG) to ADP to generate 3-phosphoglycerate (3-PG) and ATP. At the same time, it can also participate in gluconeogenesis, catalyzing the opposite reaction to produce 1,3BPGA and ADP. Phosphoglycerate kinase is involved in energy metabolism, interaction with nucleic acid, tumor progression, cell death and virus replication and other related processes .

HY-148570

PHGDH-IN-3 1 Publications Verification	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-3 inhibits PHGDH with an IC₅₀ value of 2.8 μM. PHGDH-IN-3 can be used for the research of cancer .

HY-134205A

CBR-470-1 2 Publications Verification	Keap1-Nrf2	Neurological Disease Metabolic Disease
CBR-470-1 is an inhibitor of the *glycolytic enzyme phosphoglycerate* kinase 1 (PGK1). CBR-470-1 is also a non-covalent Nrf2** activator. CBR-470-1 protects SH-SY5Y neuronal cells against MPP ⁺-induced cytotoxicity through activation of the Keap1-Nrf2 cascade .

HY-101966

NCT-503 Maximum Cited Publications 21 Publications Verification	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
NCT-503 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC₅₀ of 2.5 µM.

HY-101143

PGMI-004A	Phosphatase	Cancer
PGMI-004A is a potent phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC₅₀ of 13.1 μM.

HY-W552257

Hydroxypyruvic acid phosphate	Phosphatase	Others
Hydroxypyruvic acid phosphate serves as a crucial metabolic intermediate in the biosynthesis of L-Serine, being formed from the conversion of the glycolytic intermediate 3-phosphoglycerate through the action of 3-phosphoglycerate dehydrogenase. Subsequently, it is transformed into phosphoserine by phosphohydroxypyruvate aminotransferase, and finally, via the action of phosphoserine phosphatase, it is converted into L-Serine. This pathway not only highlights the significance of hydroxypyruvic acid phosphate in cellular proliferation but also emphasizes its role in providing essential one-carbon groups necessary for the synthesis of purine nucleotides and deoxythymidine monophosphate, thereby underscoring its metabolic importance in the central nervous system and various physiological conditions.

HY-164642

Ribulose 1,5-bisphosphate RuBP	Endogenous Metabolite	Metabolic Disease
Ribulose 1,5-bisphosphate (RuBP) is an intermediate in photosynthesis that can be metabolized to 3-phosphoglycerate by ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), a key enzyme in the Calvin-Benson-Bassham cycle .

HY-126278

Z1609609733	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
Z1609609733 (Compound 18) is a non-covalent *3-Phosphoglycerate* dehydrogenase (PHGDH) inhibitor with an IC₅₀** of 1.46 μM. Z1609609733 significantly inhibits serine synthesis and cancer metabolism with complete abrogation of cell proliferation .

HY-125273

DNS-pE	Fluorescent Dye	Others
DNS-pE is a vinyl sulfone-based fluorescent probe that has the activity to selectively label 3-phosphoglycerate dehydrogenase (PHGDH) in living mammalian cells and generate fluorescence after labeling, while having inhibitory properties comparable to those of known inhibitors.

HY-160252

PHGDH-IN-4	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
PHGDH-IN-4 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-4 can be used for the research of cancer .

HY-128682

PGAM1-IN-2	Phosphatase	Cancer
PGAM1-IN-2 is a phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC₅₀ of 2.1 μM .

HY-128681

PGAM1-IN-1 1 Publications Verification	Phosphatase	Cancer
PGAM1-IN-1 is a phosphoglycerate mutase 1 (PGAM1) inhibitor with an IC₅₀ of 6.4 μM .

HY-113002

α-D-Glucose 1,6-bisphosphate	Endogenous Metabolite	Metabolic Disease
α-D-Glucose 1,6-bisphosphate is a bis-phosphorylated derivative of α-D-glucose that has roles in carbohydrate metabolism . It is the product of the reaction of glucose-1- or 6-phosphate with glucose-1,6-bisphosphate synthase (PGM2LI) in the conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate . It is also a cofactor for the bacterial enzyme phosphopentomutase ^[3][4].

HY-123269

PKUMDL-WQ-2101	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
PKUMDL-WQ-2101 is a non-NAD ⁺-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC₅₀ of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity .

HY-117240

NCT-502 5+ Cited Publications	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
NCT-502 is a human phosphoglycerate dehydrogenase (PHGDH) inhibitor, cytotoxic to PHGDH-dependent cancer cells, and reduces glucose-derived serine production, with an IC₅₀ of 3.7 μM against PHGDH .

HY-138877A

Phosphoglycolic acid lithium	Phosphatase	Cancer
Phosphoglycolic acid (lithium) is a competitive inhibitor of phosphoglycerate mutase (PGAM)-B, an enzyme of the glycolytic pathway. Phosphoglycolic acid increases basal and fMLF-induced levels of G6P in intact neutrophils. Phosphoglycolic acid thereby increases upstream intermediates in neutrophils, thereby amplifying the respiratory oxidative burst .

HY-126254

BI-4924 1 Publications Verification	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
BI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC₅₀=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC₅₀ of 2200 nM at 72 h .

HY-100012

CBR-5884 15+ Cited Publications	Phosphoglycerate Dehydrogenase (PHGDH)	Cancer
CBR-5884 is an active, selective inhibitor of phosphoglycerate dehydrogenase (PHGDH) with an IC₅₀ of 33 μM. CBR-5884 inhibits de novo serine synthesis in cancer cells and is selectively toxic to cancer cell lines with high serine biosynthetic activity. CBR-5884 selectively inhibits the proliferation of melanoma and breast cancer lines that have a high propensity for serine synthesis .

HY-148510

HKB99	Phosphatase Apoptosis Akt ERK Reactive Oxygen Species (ROS)	Cancer
HKB99 is an allosteric inhibitor of phosphoglycerate mutase 1 (PGAM1). HKB99 induces apoptosis. HKB99 inhibits the formation of invasive pseudopodia and inhibits migration. HKB99 increases the oxidative stress, activates JNK/c-Jun and suppresses AKT and ERK. HKB99 can be used for the research of non-small-cell lung cancer (NSCLC) .

HY-141412

D-(-)-3-Phosphoglyceric acid disodium 3-Phospho-D-glyceric acid disodium	Enolase Phosphoglycerate Dehydrogenase (PHGDH) MDM-2/p53 Apoptosis	Infection
D-(-)-3-Phosphoglyceric acid (3-Phospho-D-glyceric acid) disodium is an important intermediate in the enzyme-catalyzed glycolysis process. D-(-)-3-Phosphoglyceric acid disodium competitively inhibits yeast enolase (enolase). D-(-)-3-Phosphoglyceric acid disodium can regulate the activity of phosphoglycerate dehydrogenase (PHGDH) to modulate p53 protein and apoptosis .

HY-15154

NG 52 5+ Cited Publications Compound 52	CDK	Cancer
NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC₅₀s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC₅₀ of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p .

HY-15154R

NG 52 (Standard)	CDK	Cancer
NG 52 (Standard) is the analytical standard of NG 52. This product is intended for research and analytical applications. NG 52 is a potent, cell-permeable, selective, ATP-compatible and orally active Cdc28p and Pho85p kinase inhibitor with IC50s of 7 μM and 2 μM, respectively. NG 52 also inhibits the activity of phosphoglycerate kinase 1 (PGK1) with an IC50 of 2.5 μM. NG 52 is inactive against yeast kinases Kin28p, Srb10, and Cak1p .

Ribulose 1,5-bisphosphate RuBP	Structural Classification Natural Products Source classification Endogenous metabolite	Endogenous Metabolite
Ribulose 1,5-bisphosphate (RuBP) is an intermediate in photosynthesis that can be metabolized to 3-phosphoglycerate by ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), a key enzyme in the Calvin-Benson-Bassham cycle .

Species:	Human (6) Mouse (1)
Tag:	His (6) Tag Free (1) Strep (1)
Source:	HEK293 (1) Sf9 insect cells (2) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P701962

	PGAM1 Protein, Human PGAM1; phosphoglycerate mutase 1; BPG-dependent PGAM 1; phosphoglycerate mutase isozyme B; PGAM-B	Human	E. coli
	PGAM1 protein plays a pivotal role in glycolysis by catalyzing the vital interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Additionally, it is instrumental in the conversion of (2R)-2,3-bisphosphoglycerate to (2R)-3-phospho-glyceroyl phosphate, further contributing to the intricate metabolic processes associated with glycolytic pathways. PGAM1 Protein, Human is the recombinant human-derived PGAM1 protein, expressed by E. coli , with tag free.

HY-P74633A

	PHGDH Protein, Human (C-His) D-3-phosphoglycerate dehydrogenase; 3-PGDH; 2-oxoglutarate reductase; PGDH3	Human	E. coli
	PHGDH protein plays a key role in cellular metabolism by catalyzing the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, marking the first step in the phosphorylated L-serine biosynthetic pathway.PHGDH Protein, Human (C-His) is the recombinant human-derived PHGDH protein, expressed by E.coli , with C-6*His labeled tag.

HY-P702869

	PGAM5 Protein, Human (His) Bcl-XL-binding protein v68; phosphoglycerate mutase family member 5	Human	E. coli
	PGAM5 Protein, Human (His) is the recombinant human-derived PGAM5, expressed by E. coli , with C-6*His labeled tag. ,

HY-P74634

	PGK1 Protein, Mouse (sf9, His) phosphoglycerate kinase 1; Primer recognition protein 2; PGK1; PGKA	Mouse	Sf9 insect cells
	The PGK1 protein catalyzes the conversion of 1,3-bisphosphoglycerate into 3-phosphoglycerate and plays a central role in ATP production.It also acts as a polymerase alpha cofactor protein and may be involved in primer recognition.PGK1 Protein, Mouse (sf9, His) is the recombinant mouse-derived PGK1 protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P71049

	PGK1 Protein, Human (HEK293, His) phosphoglycerate kinase 1; Cell migration-inducing gene 10 protein; Primer recognition protein 2; PGK1; PGKA	Human	HEK293
	The PGK1 protein plays a key role in the glycolysis pathway by catalyzing one of two ATP-generating reactions, promoting the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate. In addition to its glycolytic function, PGK1 appears to act as a cofactor protein for polymerase α, playing a role in primer recognition. PGK1 Protein, Human (HEK293, His) is the recombinant human-derived PGK1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P701963

	PGAM1 Protein, Human (His, StrepⅡ) PGAM1; phosphoglycerate mutase 1; BPG-dependent PGAM 1; phosphoglycerate mutase isozyme B; PGAM-B	Human	E. coli
	PGAM1 protein plays a pivotal role in glycolysis by catalyzing the vital interconversion of 2-phosphoglycerate and 3-phosphoglycerate. Additionally, it is instrumental in the conversion of (2R)-2,3-bisphosphoglycerate to (2R)-3-phospho-glyceroyl phosphate, further contributing to the intricate metabolic processes associated with glycolytic pathways. PGAM1 Protein, Human (His, Strep) is the recombinant human-derived PGAM1 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

HY-P75972

	PGK2 Protein, Human (sf9, His) phosphoglycerate kinase 2; PGK2; PGKB	Human	Sf9 insect cells
	The PGK2 protein is indispensable for sperm motility and male fertility, and studies have confirmed the critical role of the PGK2 protein in these processes. Its presence is essential to ensure the normal movement and function of sperm. PGK2 Protein, Human (sf9, His) is the recombinant human-derived PGK2 protein, expressed by Sf9 insect cells , with N-His labeled tag.

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HY-P87008

	PGAM5 Antibody (YA6701) Bcl-XL-binding protein v68 antibody; BXLBv68 antibody; MGC5352 antibody; mitochondrial antibody; PGAM5 antibody; PGAM5_HUMAN antibody; phosphoglycerate mutase family member 5 antibody; Serine/threonine protein phosphatase PGAM5 mitochondrial antibody; Serine/threonine-protein phosphatase PGAM5 antibody	WB	Human, Mouse, Rat

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phosphoglycerate

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