Search Result

Results for "

paraquat

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Apoptosis (3) Biochemical Assay Reagents (2) Drug Derivative (1) Drug Intermediate (2) Endogenous Metabolite (1) Interleukin Related (1) Isotope-Labeled Compounds (1) JAK (1) NF-κB (1) Nuclear Hormone Receptor 4A/NR4A (1) PI3K (2) Reactive Oxygen Species (ROS) (1) Reference Standards (2) ROS Kinase (1) SARS-CoV (1) STAT (1) VEGFR (2) Virus Protease (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (6) Neurological Disease (5)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1063

Terpin hydrate Terpin monohydrate; cis-Terpin hydrate	Biochemical Assay Reagents	Inflammation/Immunology
Terpin hydrate (cis-Terpin hydrate) is an expectorant, commonly used in the research of mucus associated with acute and chronic bronchitis. Terpin hydrate ameliorates Paraquat dichloride (HY-B0864A)-induced lung damage .

HY-W017289

4,4′-Dipyridyl	Drug Intermediate	Others
4,4′-Dipyridyl is a heterocyclic compound. 4,4′-Dipyridyl is utilized as an electronic and photosensitive building block and bidentate ligand in supramolecular chemistry. 4,4′-Dipyridyl can also be used as a drug intermediate in the synthesis of paraquat, a widely used herbicide .

HY-P3042

Chymostatin	SARS-CoV Virus Protease NF-κB Interleukin Related	Inflammation/Immunology
Chymostatin is a SARS-CoV-2 M ^pro inhibitor. Chymostatin up-regulates endocan and inhibits NF-κBp65 activity. Chymostatin reduces proinflammatory cytokines (IL-1β and IL-6) and HMGB1. Chymostatin shows protective effects against Paraquat-induced acute lung injury. Chymostatin exhibits anticancer activity against lung cancer .

HY-130278

MitoPQ 5 Publications Verification Mitoparaquat	ROS Kinase	Cancer
MitoPQ is a mitochondria-targeted redox cycler. MitoPQ produces superoxide by redox cycling at the flavin site of complex I, selectively increasing superoxide production within mitochondria. MitoPQ can be used in antioxidant study .

HY-D0803

Thymoquinone Maximum Cited Publications 11 Publications Verification	Apoptosis VEGFR PI3K Akt	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .

HY-N8730

7,8,3′,4′-Tetramethoxyflavone	Others	Neurological Disease
7,8,3 ',4 '-Tetramethoxyflavone is an extract isolated from natural pomegranate juice and seeds. 7,8,3 ',4' -Tetramethoxyflavone has a protective effect on the neurotoxicity of paraquat-induced Parkinson's disease mouse model .

HY-N10283

Neoechinulin C	Endogenous Metabolite	Neurological Disease
Neoechinulin C, an echinulin-related indolediketopiperazine alkaloid, protects the neuronal cells against paraquat-induced damage in a Parkinson’s disease model .

HY-B1063R

Terpin hydrate (Standard) Terpin monohydrate (Standard); cis-Terpin hydrate (Standard)	Biochemical Assay Reagents Reference Standards	Inflammation/Immunology
Terpin (hydrate) (Standard) is the analytical standard of Terpin (hydrate). This product is intended for research and analytical applications. Terpin hydrate (cis-Terpin hydrate) is an expectorant, commonly used to remove mucus in patients with acute and chronic bronchitis. Terpin hydrate ameliorates Paraquat dichloride (HY-B0864A)-induced lung damage.

HY-W017289S

4,4′-Dipyridyl-d8	Isotope-Labeled Compounds Drug Intermediate	Others
4,4′-Dipyridyl-d₈ is the deuterium labeled 4,4'-Dipyridyl (HY-017289). 4,4′-Dipyridyl is a heterocyclic compound. 4,4′-Dipyridyl is utilized as an electronic and photosensitive building block and bidentate ligand in supramolecular chemistry. 4,4′-Dipyridyl can also be used as a drug intermediate in the synthesis of paraquat, a widely used herbicide.

HY-173025

Nurr1 agonist 12	Nuclear Hormone Receptor 4A/NR4A	Neurological Disease
Nurr1 agonist 12 (Compound 37) is the agonist for nuclear receptor-associated protein 1 (Nurr1) that activates the transcriptional activity of Nurr1 with an EC₅₀ of 0.06 μM. Nurr1 agonist 12 activates the human response elements NBRE, NurRE, and DR5 with EC₅₀ of 0.07 μM, 0.027 μM, and 0.014 μM, respectively. Nurr1 agonist 12 induces the expression of Nurr1-regulated neurotrophic genes, such as tyrosine hydroxylase (TH), SOD1/2, BDNF, Sestrin 3, and BIRC5 (Survivin). Nurr1 agonist 12 exhibits neuroprotective efficacy against Paraquat-induced neurotoxicity .

HY-D0803R

Thymoquinone (Standard)	Reference Standards Apoptosis VEGFR PI3K Akt	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Thymoquinone (Standard) is the analytical standard of Thymoquinone. This product is intended for research and analytical applications. Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .

HY-125938

Cycloartenyl ferulate 1 Publications Verification Cycloartenol ferulate; Cycloartenol ferulic acid ester	Drug Derivative Apoptosis Reactive Oxygen Species (ROS) JAK STAT	Inflammation/Immunology Cancer
Cycloartenyl ferulate (Cycloartenol ferulate; Cycloartenol ferulic acid ester) is a derivative of γ-oryzanol (HY-B2194) with multiple biological activities including antioxidant, anti-inflammatory, and anti-tumor properties. Cycloartenyl ferulate selectively binds to IFNγR1 (binding affinity K_d = 0.5 μM) to activate the canonical JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate inhibits paraquat (PQ)-triggered apoptosis and ROS in HK2 cells. Cycloartenyl ferulate enhances the activation and cytolytic activity of natural killer (NK) cells by upregulating the expression of NK cell activation receptors (NKG2D, NKp30, NKp44) and the release of cytotoxic molecules and cytokine IFNγ. Cycloartenyl ferulate exerts anti-cancer effects in tumor mice models. Cycloartenyl ferulate can be used for the study of cancer and allergic inflammation intervention .

Cat. No.	Product Name	Type

HY-W017289

4,4′-Dipyridyl	Biochemical Assay Reagents
4,4′-Dipyridyl is a heterocyclic compound. 4,4′-Dipyridyl is utilized as an electronic and photosensitive building block and bidentate ligand in supramolecular chemistry. 4,4′-Dipyridyl can also be used as a drug intermediate in the synthesis of paraquat, a widely used herbicide .

Cat. No.	Product Name	Target	Research Area

HY-P3042

Chymostatin	SARS-CoV Virus Protease NF-κB Interleukin Related	Inflammation/Immunology
Chymostatin is a SARS-CoV-2 M ^pro inhibitor. Chymostatin up-regulates endocan and inhibits NF-κBp65 activity. Chymostatin reduces proinflammatory cytokines (IL-1β and IL-6) and HMGB1. Chymostatin shows protective effects against Paraquat-induced acute lung injury. Chymostatin exhibits anticancer activity against lung cancer .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-D0803

Thymoquinone 10+ Cited Publications	Quinones Classification of Application Fields Nigella sativa L. Ranunculaceae Benzene Quinones Plants Inflammation/Immunology Disease Research Fields	Apoptosis VEGFR PI3K Akt
Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .

HY-125938

Cycloartenyl ferulate 1 Publications Verification Cycloartenol ferulate; Cycloartenol ferulic acid ester	Triterpenes Monophenols other families Classification of Application Fields Terpenoids Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Drug Derivative Apoptosis Reactive Oxygen Species (ROS) JAK STAT
Cycloartenyl ferulate (Cycloartenol ferulate; Cycloartenol ferulic acid ester) is a derivative of γ-oryzanol (HY-B2194) with multiple biological activities including antioxidant, anti-inflammatory, and anti-tumor properties. Cycloartenyl ferulate selectively binds to IFNγR1 (binding affinity K_d = 0.5 μM) to activate the canonical JAK1/2-STAT1 signaling pathway. Cycloartenyl ferulate inhibits paraquat (PQ)-triggered apoptosis and ROS in HK2 cells. Cycloartenyl ferulate enhances the activation and cytolytic activity of natural killer (NK) cells by upregulating the expression of NK cell activation receptors (NKG2D, NKp30, NKp44) and the release of cytotoxic molecules and cytokine IFNγ. Cycloartenyl ferulate exerts anti-cancer effects in tumor mice models. Cycloartenyl ferulate can be used for the study of cancer and allergic inflammation intervention .

HY-N8730

7,8,3′,4′-Tetramethoxyflavone	Flavonoids Punica granatum L. Flavones Source classification Punicaceae Plants	Others
7,8,3 ',4 '-Tetramethoxyflavone is an extract isolated from natural pomegranate juice and seeds. 7,8,3 ',4' -Tetramethoxyflavone has a protective effect on the neurotoxicity of paraquat-induced Parkinson's disease mouse model .

HY-N10283

Neoechinulin C	Alkaloids Microorganisms Source classification Indole Alkaloids	Endogenous Metabolite
Neoechinulin C, an echinulin-related indolediketopiperazine alkaloid, protects the neuronal cells against paraquat-induced damage in a Parkinson’s disease model .

HY-D0803R

Thymoquinone (Standard)	Quinones Nigella sativa L. Ranunculaceae Benzene Quinones Plants	Reference Standards Apoptosis VEGFR PI3K Akt
Thymoquinone (Standard) is the analytical standard of Thymoquinone. This product is intended for research and analytical applications. Thymoquinone is an orally active natural product isolated from N. sativa Thymoquinone down-regulates the VEGFR2-PI3K-Akt pathway. Thymoquinone has antioxidant, anti-inflammatory, anticancer, antiviral, anticonvulsant, antifungal, antiviral, antiangiogenic activity and hepatoprotective effects. Thymoquinone can be used to study Alzheimer's disease, cancer, cardiovascular disease, infectious disease and inflammation .

Cat. No.	Product Name	Chemical Structure

HY-W017289S

4,4′-Dipyridyl-d8
4,4′-Dipyridyl-d₈ is the deuterium labeled 4,4'-Dipyridyl (HY-017289). 4,4′-Dipyridyl is a heterocyclic compound. 4,4′-Dipyridyl is utilized as an electronic and photosensitive building block and bidentate ligand in supramolecular chemistry. 4,4′-Dipyridyl can also be used as a drug intermediate in the synthesis of paraquat, a widely used herbicide.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.

paraquat

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products