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pancreas

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56

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1

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14

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Isotope-Labeled Compounds

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2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P3863

    Ser/Thr Protease Inflammation/Immunology
    Pancreastatin (swine) is a 49-residue peptide which strongly inhibits glucose-induced insulin release. Pancreastatin (swine) can be isolated and characterized from porcine pancreas .
    Pancreastatin (swine)
  • HY-129046C

    Ribonuclease B, Bovine pancreas

    DNA/RNA Synthesis Others
    RNase B, Bovine Pancreas is an N-glycosylated form of bovine pancreatic ribonuclease, which is structurally analogous to RNase A. RNase B, Bovine Pancreas promotes the folding of polypeptide chains and performs a chaperone-like function .
    RNase B, Bovine Pancreas
  • HY-E70192

    Ser/Thr Protease Others
    Acetyltrypsin, Bovine pancreas is a stable trypsin derivative that can catalyze the hydrolysis of alpha-N-benzoyl-L-argininamide .
    Acetyltrypsin, Bovine pancreas
  • HY-P2974
    Elastase, Porcine pancreas
    1 Publications Verification

    EC 3.4.21.36; Pancreatopeptidase E

    Elastase Metabolic Disease
    Elastase, Porcine pancreas (EC 3.4.21.36) is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase, Porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters .
    Elastase, Porcine pancreas
  • HY-P2795

    kininogenase; SK-827

    Endogenous Metabolite Others
    Kallikrein, Porcine pancreas (kininogenase) is capable of forming the kallikrenase kalinin system (KKS) in plasma and tissues, producing bradykinin and kalin peptides, respectively .
    Kallikrein, Porcine pancreas
  • HY-P2879A

    Endogenous Metabolite Metabolic Disease
    Cholesterol esterase, Porcine pancreas is an enzyme that hydrolyzes cholesterol ester to cholesterol and free fatty acid in the intestinal lumen. Cholesterol synthesized in the acinar cells and is stored in zymogen granules. Cholesterol esterase is also known as bile salt-stimulated lipase and carboxy ester lipasea, acts function for acceleration of cholesterol absorption.
    Cholesterol esterase, Porcine pancreas
  • HY-129046
    RNase A, Bovine pancreas
    1 Publications Verification

    Ribonuclease A; EC 4.6.1.18; RNase A

    DNA/RNA Synthesis Others
    RNase A, Bovine pancreas (Ribonuclease A) cleaves the 3' end of RNA to pyrimidine and actively cleaves RNA at each pyrimidine residue. RNase A, bovine pancreas catalyzes the hydrolysis of single-stranded RNA in the absence of metal ions or cofactors .
    RNase A, Bovine pancreas
  • HY-129046E

    Ribonuclease A (DNase & Protease Free), Recombinant

    DNA/RNA Synthesis Others
    RNase A (DNase & Protease Free), Recombinant is an endonuclease, that can be found in bovine pancreas. RNase A (DNase & Protease Free), Recombinant purifies DNA by hydrolyzing cytosine or uracil residues in RNA. RNase A (DNase & Protease Free), Recombinant regulates cell growth, proliferation, differentiation, and migration, and exhibits antitumor efficacy .
    RNase A (DNase & Protease Free), Recombinant
  • HY-W011240

    Methforylthiazidine; Rontyl

    Sodium Channel Chloride Channel Metabolic Disease Endocrinology
    Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas .
    Hydroflumethiazide
  • HY-129046B

    Ribonuclease A DNase & Protease Free

    DNA/RNA Synthesis Others
    RNase A, Bovine Pancreas (Ribonuclease A) (DNase & Protease Free) is a ribonuclease, a widely used endonuclease that acts by specifically hydrolyzing cytosine or uracil residues in RNA. RNase A, Bovine Pancreas (DNase & Protease Free) is commonly used in cell cycle assays .
    RNase A, Bovine Pancreas DNase & Protease Free
  • HY-P2980

    EC 3.4.2.1

    Endogenous Metabolite Others
    Carboxypeptidase A, Bovine pancreas (EC 3.4.2.1) is a zinc-containing metalloprotease, is often used in biochemical studies. Carboxypeptidase A catalyzes the hydrolysis of the peptide bonds that are adjacent to the C-terminal end of a polypeptide chain. Carboxypeptidase A is a prototypical enzyme for metalloproteases that plays important roles in biological systems .
    Carboxypeptidase A, Bovine pancreas
  • HY-P2746

    EC 3.4.2.2

    Endogenous Metabolite Metabolic Disease
    Carboxypeptidase B, Porcine pancreas (EC 3.4.2.2) is a peptide exonuclease that can specifically degrade peptide chains. Carboxypeptidase B is progressively degraded from the C-terminal to release free amino acids. Carboxypeptidase B hydrolyzes only peptide bonds with basic amino acids (such as arginine and lysine) as C-terminal residues .
    Carboxypeptidase B, Porcine pancreas
  • HY-B2193B

    Amylase, a-Amylase, 1,4-a-D-glucan glucanohydrolase, glycogenase

    Biochemical Assay Reagents Others
    α-Amylase, Human Pancreas (Amylase, a-Amylase, 1,4-a-D-glucan glucanohydrolase, glycogenase) is a biological material or organic compound that can be used in life science research .
    α-Amylase, Human Pancreas
  • HY-W011240R

    Methforylthiazidine (Standard); Rontyl (Standard)

    Sodium Channel Chloride Channel Reference Standards Metabolic Disease Endocrinology
    Hydroflumethiazide (Standard) is the analytical standard of Hydroflumethiazide. This product is intended for research and analytical applications. Hydroflumethiazide (Methforylthiazidine) is an orally active and potent thiazide diuretic. Hydroflumethiazide possesses the ability to directly stimulate A cell secretion in the normal and alloxan diabetic pancreas .
    Hydroflumethiazide (Standard)
  • HY-116844

    Glidiazine

    Drug Derivative Insulin Receptor Metabolic Disease
    Glymidine (Glidiazine) is a hypoglycaemic agent. Glymidine is a lipid soluble sulphapyrimidine derivative. Glymidine appears to stimulate insulin release from pancreas. Glymidine is a possible alternative to the sulphonylureas and biguanides for the research of diabetes mellitus .
    Glymidine
  • HY-108882
    DNase I, Bovine pancreas
    Maximum Cited Publications
    15 Publications Verification

    DNase

    Others Inflammation/Immunology Cancer
    DNase I (EC 3.1.21.1) is an enzyme that degrade DNA, it plays a key role in the cleavage of extracellular DNA is crucial for limiting the inflammatory response and maintaining homeostasis. Exogenous deoxyribonuclease shows beneficial effects in inflammatory diseases and cancer .
    DNase I, Bovine pancreas
  • HY-W703629

    Isotope-Labeled Compounds Potassium Channel Metabolic Disease
    Acetohexamide-d11 is the deuterium labeled Acetohexamide (HY-B0881). Acetohexamide is a first-generation sulfonylurea agent used in research related to type 2 diabetes; it stimulates the pancreas to secrete insulin.Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas .
    Acetohexamide-d11
  • HY-B2118
    Pancreatin
    3 Publications Verification

    Biochemical Assay Reagents Endocrinology
    Pancreatin is the porcine pancreas extract (PPE) which contains the main pancreatic digestive enzymes.
    Pancreatin
  • HY-P2942

    Ser/Thr Protease Inflammation/Immunology
    Chymotrypsinogen is an inactive precursor of Chymotrypsin (HY-108910). Chymotrypsin is a serine protease produced by the pancreas .
    Chymotrypsinogen
  • HY-108910
    Chymotrypsin
    2 Publications Verification

    EC 3.4.21.1; Chymotrypsin A

    Ser/Thr Protease Others
    Chymotrypsin (Chymotrypsin A) is a serine protease produced by the pancreas. Chymotrypsin cleaves protein chains at the carboxyl side of aromatic amino acids .

    Chymotrypsin
  • HY-P1244

    Secretin (rat)

    Secretin Receptor Neurological Disease
    Secretin (33-59), rat is a 27-aa peptide, acts on secretin receptor, enhances the secretion of bicarbonate, enzymes, and K + from the pancreas.
    Secretin (33-59), rat
  • HY-B2192

    Amylases Metabolic Disease Cancer
    Amylase is an enzyme produced by pancreas and salivary glands, catalyzing the hydrolysis of starch into sugars. Amylase are broadly classified into α, β, and γ subtypes .
    Amylase
  • HY-P1025

    Neuropeptide Y Receptor Cardiovascular Disease Neurological Disease
    M40 is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .
    M40
  • HY-P4060

    Neuropeptide Y Receptor Metabolic Disease Endocrinology
    Pancreatic polypeptide is a peptide secreted by the endocrine PP cells of the pancreas that regulates pancreatic secretory activity and also affects hepatic glycogen stores and gastrointestinal secretion .
    Pancreatic polypeptide
  • HY-108910A
    Chymotrypsin (MS grade)
    2 Publications Verification

    EC 3.4.21.1 (MS grade); Chymotrypsin A (MS grade)

    Ser/Thr Protease Others
    Chymotrypsin (Chymotrypsin A) (MS grade) is a serine protease produced by the pancreas. Chymotrypsin (MS grade) cleaves protein chains at the carboxyl side of aromatic amino acids .
    Chymotrypsin (MS grade)
  • HY-P1244A

    Secretin (rat) (TFA)

    Secretin Receptor Neurological Disease
    Secretin (33-59), rat (TFA) is a 27-aa peptide, which acts on secretin receptor, and enhances the secretion of bicarbonate, enzymes, and K + from the pancreas .
    Secretin (33-59), rat TFA
  • HY-W017227

    Proteasome Metabolic Disease
    Alloxan hydrate is a diabetogenic agent to induce diabetes. Alloxan hydrate is a proteasome inhibitor. Alloxan causes diabetes in experimental animals through its ability to destroy the insulin-secreting B-cells of the pancreas .
    Alloxan hydrate
  • HY-176763

    Sec61 Apoptosis Caspase Cancer
    KZR-261 is a Sec61 inhibitor. KZR-261 directly binds to the Sec61 channel to potently inhibit the biogenesis of a subset of Sec61 client proteins. KZR-261 has a broad antitumor activity (such as colorectal pancreas and prostate cancer), along with the activation of an endoplasmic reticulum stress response, with minimal adverse effects on normal cells. KZR-261 significantly induces apoptosis of H929 cells. KZR-261 potently inhibits tumor growth in multiple xenograft tumor mice models with good tolerance .
    KZR-261
  • HY-P3621

    GCGR Metabolic Disease
    Biotinyl-Glucagon (1-29), human, bovine, porcine is a biotinylated glucagon. Glucagon is a peptide hormone, produced by α-cells of the pancreas, can increase concentration of glucose and fatty acids in the bloodstream .
    Biotinyl-Glucagon (1-29), human, bovine, porcine
  • HY-B0881
    Acetohexamide
    1 Publications Verification

    Potassium Channel Metabolic Disease Cancer
    Acetohexamide is an orally active first-generation sulfonylurea agent used in research related to type 2 diabetes and cancer. Acetohexamide exerts reductase activity in human erythrocytes. Acetohexamide stimulates the pancreas to secrete insulin. Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. Acetohexamide can inhibit the formation of circular chemorepellent induced defects (CCIDs) in lymphendothelial cell (LEC) monolayers. Acetohexamide inhibits markers of epithelial-to-mesenchymal-transition and migration. Acetohexamide suppresses the synthesis of 12(S)-HETE. Acetohexamide can potentiate hypoglycaemic action .
    Acetohexamide
  • HY-P1025A

    Neuropeptide Y Receptor Cardiovascular Disease Neurological Disease
    M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas .
    M40 TFA
  • HY-P1537

    Neuropeptide Y Receptor Metabolic Disease Endocrinology
    Pancreatic Polypeptide, bovine, a 36-amino acid, straight chain polypeptide derived primarily from the pancreas, inhibits secretin- and cholecystokinin-stimulated pancreatic secretion; Pancreatic Polypeptide, bovine acts as an agonist of NPY receptor, with high affinity at NPYR4.
    Pancreatic Polypeptide, bovine
  • HY-B1493R

    Biochemical Assay Reagents Reference Standards Endocrinology
    Bentiromide (Standard) is the analytical standard of Bentiromide. This product is intended for research and analytical applications. Bentiromide is a peptide that is broken down in the pancreas by chymotrypsin. The bentiromide test is an excellent means of confirming the diagnosis of pancreatic exocrine insufficiency by outpatient test of chymotrypsin function .
    Bentiromide (Standard)
  • HY-B0881R

    Reference Standards Potassium Channel Metabolic Disease Cancer
    Acetohexamide (Standard) is the analytical standard of Acetohexamide. This product is intended for research and analytical applications. Acetohexamide is an orally active first-generation sulfonylurea agent used in research related to type 2 diabetes and cancer. Acetohexamide exerts reductase activity in human erythrocytes. Acetohexamide stimulates the pancreas to secrete insulin. Acetohexamide inhibits ATP-sensitive potassium channels in the β cells of the pancreas. Acetohexamide can inhibit the formation of circular chemorepellent induced defects (CCIDs) in lymphendothelial cell (LEC) monolayers. Acetohexamide inhibits markers of epithelial-to-mesenchymal-transition and migration. Acetohexamide suppresses the synthesis of 12(S)-HETE. Acetohexamide can potentiate hypoglycaemic action .
    Acetohexamide (Standard)
  • HY-107482

    Nicotinoyl-GABA; Nicotinoyl-γ-aminobutyric acid

    GABA Receptor Neurological Disease
    Picamilon is an orally active derivative of γ-aminobutyric acid that has nootropic effect. Picamilon improves the epilepsy model in rats and promotes correction of functional disorders of the pancreas during Alloxan (HY-W017227)-induced diabetes mellitus in rats .
    Picamilon
  • HY-107482A

    Nicotinoyl-GABA sodium; Nicotinoyl-γ-aminobutyric acid sodium; Sodium 4-(nicotinamido)butanoate

    GABA Receptor Neurological Disease
    Picamilon sodium is an orally active derivative of γ-aminobutyric acid that has nootropic effect. Picamilon sodium improves the epilepsy model in rats and promotes correction of functional disorders of the pancreas during Alloxan (HY-W017227)-induced diabetes mellitus in rats .
    Picamilon sodium
  • HY-142118A
    Trabedersen sodium
    1 Publications Verification

    AP 12009 sodium

    TGF-beta/Smad Cancer
    Trabedersen sodium is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen sodium can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon .
    Trabedersen sodium
  • HY-P1096

    Cholecystokinin Receptor Metabolic Disease
    A71623, a CCK-4-based peptide, is a potent and highly selective CCK-A full agonist. The IC50s for A-71623 are 3.7 nM in guinea pig pancreas (CCK-A) and 4500 nM in cerebral cortex (CCK-B) in radioligand binding assays, respectively .
    A71623
  • HY-112052
    Aminomalonic acid
    1 Publications Verification

    Endogenous Metabolite Cancer
    Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis .
    Aminomalonic acid
  • HY-142118
    Trabedersen
    1 Publications Verification

    AP 12009

    TGF-beta/Smad Cancer
    Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits TGF-β2 (TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon .
    Trabedersen
  • HY-129046I

    DNA/RNA Synthesis Others
    RNase A, Recombinant (animal free) cleaves the 3' end of RNA to pyrimidine and actively cleaves RNA at each pyrimidine residue. RNase A, RNase A, Recombinant (animal free) catalyzes the hydrolysis of single-stranded RNA in the absence of metal ions or cofactors. Recombinant bovine pancreas RNase A, free of animal-derived components .
    RNase A, Recombinant (animal free)
  • HY-117839

    Cholecystokinin Receptor Neurological Disease
    PD-135666 is a dipeptide inhibitor of cholecystokinin B (CCK B) receptors, binding to CCK B receptors in mouse cerebral cortex with IC50 of 0.1 nM. Its enantiomer, PD-140548, preferentially binds to CCK A receptors with IC50 of 2.8 nM in rat pancreas. PD-135666 exhibits anxiolytic effects in animal models .
    PD-135666
  • HY-19694

    Insulin Receptor Endocrinology
    BRD7552, a potent PDX1 transcription factor inducer, upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases insulin expression. PDX1 is a key transcription factor involved in pancreas development and β cell function .
    BRD7552
  • HY-129046H

    DNA/RNA Synthesis Others
    RNase A, Recombinant (Protease & DNase free, animal free) cleaves the 3' end of RNA to pyrimidine and actively cleaves RNA at each pyrimidine residue. RNase A, Recombinant (Protease & DNase free, animal free) catalyzes the hydrolysis of single-stranded RNA in the absence of metal ions or cofactors. Recombinant bovine pancreas RNase A, chromatographically purified, free of animal-derived components, DNases, and proteases .
    RNase A, Recombinant Protease & DNase free, animal free
  • HY-12461

    PI3K EGFR GABA Receptor FLT3 IKK Neurological Disease Metabolic Disease Inflammation/Immunology
    WS6 is an IkB kinase and EBP1 inhibitor, with IC50 values of 0.24 nM, 0.21 nM, and 40.48 nM in MV4-11, MOLM13, and K562 cells, respectively. WS6 promotes the proliferation of alpha and beta cells in the pancreas, has antioxidant and anti-inflammatory activities, and can alleviate depression like behavior in rats [1][2][4].
    WS6
  • HY-107372S4

    UTP-15N2 dilithium; Uridine 5'-triphosphate-15N2 dilithium

    Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Cardiovascular Disease Inflammation/Immunology Cancer
    Uridine triphosphate- 15N2 (UTP- 15N2 dilithium; Uridine 5'-triphosphate- 15N2) dilithium is 15N labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
    Uridine triphosphate-15N2 dilithium
  • HY-107372S3

    UTP-d13 dilithium; Uridine 5'-triphosphate-d13 dilithium

    Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Cardiovascular Disease Inflammation/Immunology Cancer
    Uridine triphosphate-d13 (UTP-d13 dilithium; Uridine 5'-triphosphate-d13) dilithium is deuterium labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
    Uridine triphosphate-d13 dilithium
  • HY-112052R

    Reference Standards Endogenous Metabolite Cancer
    Aminomalonic acid (Standard) is the analytical standard of Aminomalonic acid. This product is intended for research and analytical applications. Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis[1][2][3].
    Aminomalonic acid (Standard)
  • HY-107372S2

    UTP-13C9 dilithium; Uridine 5'-triphosphate-13C9 dilithium

    Isotope-Labeled Compounds Endogenous Metabolite DNA/RNA Synthesis Cardiovascular Disease Inflammation/Immunology Cancer
    Uridine triphosphate- 13C9 (UTP- 13C9 dilithium; Uridine 5'-triphosphate- 13C9) dilithium is 13C-labeled Uridine triphosphate (HY-107372). Uridine triphosphate (UTP;Uridine 5'-triphosphate) is a nucleotide that regulates the functions of the pancreas in endocrine and exocrine secretion, proliferation, channels, transporters, and intracellular signaling under normal and disease states.
    Uridine triphosphate-13C9 dilithium
  • HY-P99662

    MLN0264; TAK-264

    Antibody-Drug Conjugates (ADCs) Guanylate Cyclase Apoptosis Cancer
    Indusatumab vedotin (MLN-0264; AKT-264) is an antibody-drug conjugate (ADC) consisting of the human anti-guanylate cyclase C (GCC) antibody linked to a microtubule-disruptor Monomethyl auristatin (HY-15162). Indusatumab vedotin has anti-proliferative effects on pancreas cancer cell lines. Indusatumab vedotin arrests cell cycle at G2/M phase, and induces apoptosis .
    Indusatumab vedotin

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