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opiate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cathepsin (1) Dopamine Receptor (1) Endogenous Metabolite (3) iGluR (1) Isotope-Labeled Compounds (1) Mas-related G-protein-coupled Receptor (MRGPR) (1) MMP (1) Neuropeptide FF Receptor (1) Neuropeptide Y Receptor (1) Opioid Receptor (16) Parasite (1) Reference Standards (1)
By Research Areas:	Cancer (1) Endocrinology (1) Infection (2) Inflammation/Immunology (4) Metabolic Disease (3) Neurological Disease (16)

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Biochemical Assay Reagents

Peptides

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Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Dopamine Receptor	Neurological Disease
L-Stepholidine (Stepholidine) is an alkaloid. L-Stepholidine exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect. L-Stepholidine can be used for the researches of neurological disease, such as Parkinson disease, Alzheimer's disease and opiate addiction .

HY-B0505

Moguisteine 1 Publications Verification BBR-2173	Opioid Receptor	Neurological Disease Cancer
Moguisteine???(BBR-2173) is an antitussive compound but has no significant affinity for opiate receptors.

HY-168366

R-6890	Opioid Receptor	Neurological Disease
R-6890 is an opiate compound with analgesic potencies .

HY-P3874

Peptide E	Opioid Receptor	Neurological Disease
Peptide E is a potent *kappa opiate* receptor** agonist. Peptide E has opiate receptor binding activity with IC₅₀ value of 0.39 μM. Peptide E can be used for the research of central nervous system .

HY-P3087

Tyr-W-MIF-1	Opioid Receptor	Neurological Disease
Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia .

HY-123492

Kentsin	Opioid Receptor	Neurological Disease Endocrinology
Kentsin (Thr-Pro-Arg-Lys), a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation, without binding to opioid receptors. Kentsin has opiate properties on gastrointestinal motility .

HY-120846

CHIR 4531	Opioid Receptor	Neurological Disease
CHIR 4531, a trimer peptide, is a opiate ligand that binds to the *mu-opiate* receptor with a K_i** of 6 nM .

HY-P2572

Deltakephalin	Opioid Receptor	Neurological Disease
Deltakephalin is a potent, selective opiate δ-receptor agonist. Deltakephalin has analgesic properties .

HY-P3555

D-Ala-Gly-Phe-Met-NH2	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-P3555A

D-Ala-Gly-Phe-Met-NH2 monoacetate	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2 monoacetate, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-137180

Naloxonazine	Opioid Receptor Parasite	Infection Neurological Disease
Naloxonazine is a potent and selective opiate mu-1 antagonist that can also affect leishmania by regulating host coding function .

HY-P3547

(D-Met2,Pro5)-Enkephalinamide	Opioid Receptor	Others
(D-Met2,Pro5)-Enkephalinamide is a highly potent *opiate* agonist, and shows antinociceptive activity .

HY-124680

AC-263093 free base AC-093	Neuropeptide FF Receptor	Inflammation/Immunology
AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pK_is of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research . .

HY-W019151

Meconine	Endogenous Metabolite	Metabolic Disease
Meconine is an endogenous metabolite of Noscapine (HY-13716). Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use .

HY-148905

p-Aminophenylmercuric acetate 4 Publications Verification	Cathepsin MMP	Infection
p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor .

HY-P1335

CTAP 1 Publications Verification	Opioid Receptor	Neurological Disease
CTAP is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC₅₀ of 3.5 nM. CTAP displays over 1200-fold selectivity over δ opioid (IC₅₀=4500 nM) and somatostatin receptors. CTAP can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction .

HY-P1335A

CTAP TFA 1 Publications Verification	Opioid Receptor	Neurological Disease
CTAP TFA is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC₅₀ of 3.5 nM. CTAP TFA displays over 1200-fold selectivity over δ opioid (IC₅₀=4500 nM) and somatostatin receptors. CTAP TFA can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction .

HY-W019151S

Meconin-d3	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Meconin-d₃ is the deuterium labeled Meconine (HY-W019151). Meconine is an endogenous metabolite of Noscapine (HY-13716). Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use.

HY-W019151R

Meconine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
Meconine (Standard) is the analytical standard of Meconine (HY-W019151). This product is intended for research and analytical applications. Meconine is an endogenous metabolite of Noscapine (HY-13716). Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use.

HY-171844

CX1739	iGluR	Neurological Disease
CX1739 is a low impact enhancer of AMPA-glutamate receptors (AMPARs). CX1739 enhances long-term potentiation dose-dependently in mouse model. CX1739 also abrogates amphetamine-induced locomotor activity. CX1739 rapidly reverses opioid-induced respiratory depression. CX1739 can be studied in research for dementia, neuropsychiatric disorders, and severe complication of opiate-induced suppression of endogenous inspiratory breathing rhythms .

HY-18618

SB-612111	Opioid Receptor	Neurological Disease Inflammation/Immunology
SB-612111 is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (K_i=0.33 nM). SB-612111 exhibits selectivity for μ-, κ- and δ-receptors with K_i values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model .

HY-18618A

SB-612111 hydrochloride 1 Publications Verification	Opioid Receptor	Neurological Disease Inflammation/Immunology
SB-612111 hydrochloride hydrochloride is a novel and potent opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (K_i=0.33 nM). SB-612111 hydrochloride exhibits selectivity for μ-,?κ- and?δ-receptors with K_i values of?57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 hydrochloride effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model .

HY-18617

rel-SB-612111 hydrochloride	Opioid Receptor	Neurological Disease Inflammation/Immunology
rel-SB-612111 hydrochloride is a novel and potent *human opiate* receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (K_i=0.33 nM). rel-SB-612111 hydrochloride exhibits selectivity for μ-, κ- and δ-receptors with K_i** values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. rel-SB-612111 hydrochloride effectively antagonizes the pronociceptive action of Nociceptin (HY-P0183) in an acute pain model .

HY-P3843

Neuropeptide AF (cattle)	Mas-related G-protein-coupled Receptor (MRGPR) Neuropeptide Y Receptor	Neurological Disease
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC₅₀ of ~60 nM) and MrgprC11 (EC₅₀ of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC₅₀ of ~25-325 nM) and NPFF2 (EC₅₀ of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects .

Cat. No.	Product Name	Type

HY-148905

p-Aminophenylmercuric acetate 4 Publications Verification	Cell Assay Reagents
p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor .

p-Aminophenylmercuric acetate

4 Publications Verification

Cell Assay Reagents

p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor .

Cat. No.	Product Name	Target	Research Area

HY-P1335

CTAP 1 Publications Verification	Opioid Receptor	Neurological Disease
CTAP is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC₅₀ of 3.5 nM. CTAP displays over 1200-fold selectivity over δ opioid (IC₅₀=4500 nM) and somatostatin receptors. CTAP can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction .

HY-P1335A

CTAP TFA 1 Publications Verification	Opioid Receptor	Neurological Disease
CTAP TFA is a potent, highly selective, and BBB penetrant μ opioid receptor antagonist, with an IC₅₀ of 3.5 nM. CTAP TFA displays over 1200-fold selectivity over δ opioid (IC₅₀=4500 nM) and somatostatin receptors. CTAP TFA can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction .

HY-P3874

Peptide E	Opioid Receptor	Neurological Disease
Peptide E is a potent *kappa opiate* receptor** agonist. Peptide E has opiate receptor binding activity with IC₅₀ value of 0.39 μM. Peptide E can be used for the research of central nervous system .

HY-P3087

Tyr-W-MIF-1	Opioid Receptor	Neurological Disease
Tyr-W-MIF-1 is an opioid tetrapeptide with opiate and antiopiate activity. Tyr-W-MIF-1 can induce analgesia .

HY-123492

Kentsin	Opioid Receptor	Neurological Disease Endocrinology
Kentsin (Thr-Pro-Arg-Lys), a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation, without binding to opioid receptors. Kentsin has opiate properties on gastrointestinal motility .

HY-P2572

Deltakephalin	Opioid Receptor	Neurological Disease
Deltakephalin is a potent, selective opiate δ-receptor agonist. Deltakephalin has analgesic properties .

HY-P3555

D-Ala-Gly-Phe-Met-NH2	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-P3555A

D-Ala-Gly-Phe-Met-NH2 monoacetate	Opioid Receptor	Others
D-Ala-Gly-Phe-Met-NH2 monoacetate, an opioid peptide, is a potent opiate δ-receptor agonist .

HY-P3547

(D-Met2,Pro5)-Enkephalinamide	Opioid Receptor	Others
(D-Met2,Pro5)-Enkephalinamide is a highly potent *opiate* agonist, and shows antinociceptive activity .

HY-P3843

Neuropeptide AF (cattle)	Mas-related G-protein-coupled Receptor (MRGPR) Neuropeptide Y Receptor	Neurological Disease
Neuropeptide AF (cattle), an amidated octadecapeptide, is RFamide neuropeptide. Neuropeptide AF (cattle) acts as a ligand of Mas-related gene receptor A4 (MrgprA4) (Mas-related G-protein-coupled Receptor (MRGPR)) (EC₅₀ of ~60 nM) and MrgprC11 (EC₅₀ of ~300 nM). Neuropeptide AF (cattle) also activate to the G protein-coupled receptors NPFF1 (Neuropeptide Y Receptor) (EC₅₀ of ~25-325 nM) and NPFF2 (EC₅₀ of ~1-5 nM). Neuropeptide AF (cattle) shows anti-opiate and related pain modulation effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Alkaloids Stephania intermedia Source classification Plants Isoquinoline Alkaloids Menispermaceae	Dopamine Receptor
L-Stepholidine (Stepholidine) is an alkaloid. L-Stepholidine exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect. L-Stepholidine can be used for the researches of neurological disease, such as Parkinson disease, Alzheimer's disease and opiate addiction .

HY-W019151

Meconine	Natural Products Classification of Application Fields Source classification Metabolic Disease Papaver somniferum Linn. Plants Endogenous metabolite Disease Research Fields Papaveraceae	Endogenous Metabolite
Meconine is an endogenous metabolite of Noscapine (HY-13716). Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use .

HY-W019151R

Meconine (Standard)	Natural Products Source classification Papaver somniferum Linn. Plants Endogenous metabolite Papaveraceae	Reference Standards Endogenous Metabolite
Meconine (Standard) is the analytical standard of Meconine (HY-W019151). This product is intended for research and analytical applications. Meconine is an endogenous metabolite of Noscapine (HY-13716). Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use.

Cat. No.	Compare	Product Name	Species	Source

HY-P702403

	OPRM1 Protein, Human (Cell-Free, His) Mu-type opioid receptor; Mu opiate receptor; Mu opioid receptor; MOP; hMOP	Human	E. coli Cell-free
	The OPRM1 protein serves as a receptor for endogenous and synthetic opioids and undergoes conformational changes upon agonist binding, activating downstream signaling pathways. This includes coupling to G proteins, thereby regulating adenylyl cyclase, calcium channels, potassium channels, and intracellular signaling pathways. OPRM1 Protein, Human (Cell-Free, His) is the recombinant human-derived OPRM1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

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HY-W019151S

Meconin-d3
Meconin-d₃ is the deuterium labeled Meconine (HY-W019151). Meconine is an endogenous metabolite of Noscapine (HY-13716). Meconine is the major metabolite in all three species, accounting for about 3, 8 and 2% of the dose in the first 24 h urines of rats, rabbits and humans, respectively. Meconine can be used as a marker to detect illicit opiate use.

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opiate

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Natural
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