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nicotinate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (2) Arf Family GTPase (1) Bacterial (1) Biochemical Assay Reagents (1) BMX Kinase (1) Drug Derivative (3) Drug Metabolite (1) Endogenous Metabolite (7) Isotope-Labeled Compounds (4) Liposome (2) NAMPT (1) PDGFR (2) Reactive Oxygen Species (3)
By Research Areas:	Cancer (5) Cardiovascular Disease (13) Infection (1) Inflammation/Immunology (4) Metabolic Disease (4)

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Biochemical Assay Reagents

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Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-133027

Myristyl nicotinate Tetradecyl nicotinate	Biochemical Assay Reagents	Cancer
Myristyl nicotinate (Tetradecyl nicotinate) is an ester proagent and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier .

HY-122365R

*Inositol nicotinate* (Standard)**	Drug Derivative	Cardiovascular Disease
Inositol nicotinate (Standard) is the analytical standard of Inositol nicotinate. This product is intended for research and analytical applications. Inositol nicotinate, with vasodilatory effect, is used in the study of Peripheral arterial disease (PAD) .

HY-B1695S

*Methyl nicotinate-d4*	Isotope-Labeled Compounds	Inflammation/Immunology
Methyl nicotinate-d₄ is the deuterium labeled Methyl nicotinate . Methyl nicotinate, the methyl ester of Niacin found in alcoholic beverages, that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain .

HY-B0757A

(±)-α-Tocopherol nicotinate rel-Vitamin E nicotinate	Reactive Oxygen Species Endogenous Metabolite	Cardiovascular Disease
(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases .

HY-121660

Hexyl nicotinate	Drug Derivative	Others
Hexyl nicotinate, a nicotinic acid ester with vasodilatory effect. Hexyl nicotinate improves blood circulation, usually serves as an active ingredient in topical preparations, such as creams and lotions .

HY-B0132B

*Norfloxacin (nicotinate)* MK-0366 (nicotinate)	Bacterial Antibiotic	Infection
Norfloxacin nicotinate (MK-0366 nicotinate) is a fluoroquinolones antibiotic, an adduct of Norfloxacin (NOR) and nicotinic acid. Norfloxacin nicotinate has been widely used for replacing NOR in animal husbandry and fishery industry. Norfloxacin nicotinate can induce innate immune response at a high concentration .

HY-B1695R

*Methyl nicotinate* (Standard)**	Others	Cardiovascular Disease Inflammation/Immunology
Methyl nicotinate (Standard) is the analytical standard of Methyl nicotinate. This product is intended for research and analytical applications. Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-B1555R

*Benzyl nicotinate* (Standard)**	Liposome	Cardiovascular Disease
Benzyl nicotinate (Standard) is the analytical standard of Benzyl nicotinate. This product is intended for research and analytical applications. Benzyl nicotinate is a vasodilator that increases skin oxygenation levels by increasing skin blood flow .

HY-B0757AR

*(±)-α-Tocopherol nicotinate* (Standard)** rel-Vitamin E nicotinate (Standard)	Reactive Oxygen Species Endogenous Metabolite	Cardiovascular Disease
(±)-α-Tocopherol nicotinate (Standard) is the analytical standard of (±)-α-Tocopherol nicotinate. This product is intended for research and analytical applications. (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].

HY-B1815R

*Xanthinol Nicotinate* (Standard)**	PDGFR	Cardiovascular Disease
Xanthinol Nicotinate (Standard) is the analytical standard of Xanthinol Nicotinate. This product is intended for research and analytical applications. Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance .

HY-B0757

Vitamin E nicotinate	Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
Vitamin E nicotinate is the derivative of Vitamin E. Vitamin E nicotinate exhibits antioxidant activity and prevents lipid peroxidation. Vitamin E nicotinate upregulates levels of CD4+ T cells and IL-2, exhibits immunomodulatory activity. Vitamin E nicotinate exhibits antiplatelet and antihypertensive activities, that can be used in atherosclerosis and thrombosis ressearch .

HY-144241S

*DL-Alpha-tocopherol nicotinate-d9*	Isotope-Labeled Compounds	Others
DL-Alpha-tocopherol nicotinate-d₉ is the deuterium labeled DL-Alpha-tocopherol nicotinate .

HY-10079A

*CHS-828 (nicotinate)* GMX1778 (nicotinate)	NAMPT Apoptosis	Cancer
CHS-828 nicotinate is a competitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), with an IC₅₀ less than 25 nM. CHS-828 nicotinate (GMX1778) exerts a cytotoxic effect by decreasing the cellular level of NAD ⁺ and exhibits a potent anticancer activity .

HY-B1695

Methyl nicotinate Nicotinic acid methyl ester	Others	Cardiovascular Disease Inflammation/Immunology
Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-B1555

Benzyl nicotinate	Liposome	Cardiovascular Disease
Benzyl nicotinate is a vasodilator that increases skin oxygenation levels by increasing skin blood flow .

HY-B1815

Xanthinol Nicotinate Xanthinol Niacinate	PDGFR	Cardiovascular Disease
Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance .

HY-122365

Inositol nicotinate Inositol niacinate; Hexanicit	Drug Derivative	Cardiovascular Disease
Inositol nicotinate (Hexanicit) has vasodilating effects and can be used in research on peripheral arterial disease, showing efficacy when taken orally. Inositol nicotinate does not significantly improve triglyceride levels in mice induced by biphenyl esters .

HY-138118

Propyl nicotinate Nicotinic acid propyl ester	Endogenous Metabolite	Others
Propyl nicotinate (Nicotinic acid propyl ester), the propyl ester of niacin, occurs in various animal and plant tissues, where it contributes to the formation of the coenzymes NAD and NADP.

HY-117029

NAAD sodium Deamido nad sodium	Endogenous Metabolite	Metabolic Disease
NAAD sodium (Deamido nad sodium), a functional NAD ⁺ precursor, is the substrate of glutamine-dependent NAD ⁺ synthetase. NAAD sodium is used to study the structure of nicotinate mononucleotide adenylyltransferases .

HY-173280

Brefeldin A 4-O-nicotinate CHNQD-01228	Arf Family GTPase BMX Kinase	Cancer
Brefeldin A 4-O-nicotinate (CHNQD-01228) is a dual inhibitor of Arf1 and BMX proteins. The IC₅₀ value for the proliferation of T24 cells is 0.22 μM. It can also dose-dependently inhibit the migration and colony formation of T24 cells, induce G1 phase arrest and trigger Apoptosis. Brefeldin A 4-O-nicotinate exerts its anti-cancer activity by targeting the BMX protein to inhibit the AKT/p-AKT and STAT3/p-STAT3 signaling pathways, as well as by inhibiting the Arf1 protein to eliminate bladder cancer stem cells and activate anti-tumor immunity. Brefeldin A 4-O-nicotinate can be used in the research related to bladder cancer .

HY-125665R

Pheophorbide A (Standard)	Apoptosis	Cardiovascular Disease Cancer
Xanthinol Nicotinate (Standard) is the analytical standard of Xanthinol Nicotinate. This product is intended for research and analytical applications. Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance .

HY-128700

Nicotinic acid mononucleotide	Endogenous Metabolite	Metabolic Disease
Nicotinic acid mononucleotide (NAMN) is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD ⁺. Nicotinate mononucleotide is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase .

HY-128700A

Nicotinic acid mononucleotide triethylamine 1 Publications Verification	Endogenous Metabolite	Metabolic Disease
Nicotinic acid mononucleotide triethylamine is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD ⁺. Nicotinate mononucleotide triethylamine is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase .

HY-W719560S

Flupyrsulfuron-methyl-d6	Isotope-Labeled Compounds	Others
Flupyrsulfuron-methyl-d₆ is deuterium labeled Methyl 2-(N-((4,6-dimethoxypyrimidin-2-yl)carbamoyl)sulfamoyl)-6-(trifluoromethyl)nicotinate .

HY-124124

N-Methylnicotinamide 1 Publications Verification	Endogenous Metabolite Drug Metabolite	Cardiovascular Disease Metabolic Disease Cancer
N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway. N-Methylnicotinamide is a potential biomarker in miR-1291-altered pancreatic cell metabolism and tumorigenesis .

HY-W246043

3-Pyridine-2,4,5,6-d4-carboxylic acid, ethyl ester Ethyl nicotinate-d₄	Isotope-Labeled Compounds	Others
3-Pyridine-2,4,5,6-d₄ -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-carboxylic acid, ethyl ester .

Cat. No.	Product Name	Type

HY-B0757A

(±)-α-Tocopherol nicotinate rel-Vitamin E nicotinate	Biochemical Assay Reagents
(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases .

HY-B0757AR

*(±)-α-Tocopherol nicotinate* (Standard)** rel-Vitamin E nicotinate (Standard)	Biochemical Assay Reagents
(±)-α-Tocopherol nicotinate (Standard) is the analytical standard of (±)-α-Tocopherol nicotinate. This product is intended for research and analytical applications. (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].

(±)-α-Tocopherol nicotinate (Standard)

rel-Vitamin E nicotinate (Standard)

Biochemical Assay Reagents

(±)-α-Tocopherol nicotinate (Standard) is the analytical standard of (±)-α-Tocopherol nicotinate. This product is intended for research and analytical applications. (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0757A

(±)-α-Tocopherol nicotinate rel-Vitamin E nicotinate	Cardiovascular Disease Structural Classification Alkaloids Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Disease Research Fields	Reactive Oxygen Species Endogenous Metabolite
(±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases .

HY-B1695

Methyl nicotinate Nicotinic acid methyl ester	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Others
Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-122365

Inositol nicotinate Inositol niacinate; Hexanicit	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Drug Derivative
Inositol nicotinate (Hexanicit) has vasodilating effects and can be used in research on peripheral arterial disease, showing efficacy when taken orally. Inositol nicotinate does not significantly improve triglyceride levels in mice induced by biphenyl esters .

HY-117029

NAAD sodium Deamido nad sodium	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NAAD sodium (Deamido nad sodium), a functional NAD ⁺ precursor, is the substrate of glutamine-dependent NAD ⁺ synthetase. NAAD sodium is used to study the structure of nicotinate mononucleotide adenylyltransferases .

HY-124124

N-Methylnicotinamide 1 Publications Verification	Alkaloids Structural Classification Classification of Application Fields Source classification Pyridine Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite Drug Metabolite
N-Methylnicotinamide is an endogenous metabolite with antithrombotic effect. N-Methylnicotinamide via production/release of prostacyclin inhibits arterial thrombosis development. N-Methylnicotinamide is also the N-methylation product from nicotinamide catalyzed by N-methyltransferase within nicotinate and nicotinamide metabolism pathway. N-Methylnicotinamide is a potential biomarker in miR-1291-altered pancreatic cell metabolism and tumorigenesis .

HY-B1695R

*Methyl nicotinate* (Standard)**	Structural Classification Natural Products Microorganisms Source classification	Others
Methyl nicotinate (Standard) is the analytical standard of Methyl nicotinate. This product is intended for research and analytical applications. Methyl nicotinate (Nicotinic acid methyl ester) is an orally active vasodilator. Methyl nicotinate has analgesic activity. Methyl nicotinate causes local skin erythema when applied topically to the skin. Methyl nicotinate is used as an active ingredient in over-the-counter topical preparations for the study of muscle and joint pain .

HY-B0757AR

*(±)-α-Tocopherol nicotinate* (Standard)** rel-Vitamin E nicotinate (Standard)	Structural Classification Alkaloids Source classification Pyridine Alkaloids Endogenous metabolite	Reactive Oxygen Species Endogenous Metabolite
(±)-α-Tocopherol nicotinate (Standard) is the analytical standard of (±)-α-Tocopherol nicotinate. This product is intended for research and analytical applications. (±)-α-Tocopherol nicotinate, vitamin E - nicotinate, is an orally active fat-soluble antioxidant that prevents lipid peroxidation in cell membranes. (±)-α-Tocopherol nicotinate is hydrolysed in the blood to α -tocopherol and niacin and may be used in studies of related vascular diseases[1][2].

HY-125665R

Pheophorbide A (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Apoptosis
Xanthinol Nicotinate (Standard) is the analytical standard of Xanthinol Nicotinate. This product is intended for research and analytical applications. Xanthinol Nicotinate (Xanthinol Niacinate), a vasodilator, can act directly on the smooth muscle of small arteries and capillaries. Xanthinol Nicotinate expands blood vessels, improves blood rheology and reduces peripheral vascular resistance .

HY-128700

Nicotinic acid mononucleotide	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Nicotinic acid mononucleotide (NAMN) is formed from nicotinic acid (NA) via the nicotinic acid phosphoribosyltransferase in the biosynthesis of NAD ⁺. Nicotinate mononucleotide is a substrate for nicotinamide mononucleotide/Nicotinic acid mononucleotide adenylyltransferase .

Cat. No.	Compare	Product Name	Species	Source

HY-P70971

	QPRTase Protein, Human (His) nicotinate-Nucleotide Pyrophosphorylase [Carboxylating]; Quinolinate Phosphoribosyltransferase [Decarboxylating]; QAPRTase; QPRTase; QPRT	Human	E. coli
	QPRTase Protein, Human (His) is the recombinant human-derived QPRTase protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-B1695S

*Methyl nicotinate-d4*
Methyl nicotinate-d₄ is the deuterium labeled Methyl nicotinate . Methyl nicotinate, the methyl ester of Niacin found in alcoholic beverages, that is used as an active ingredient as a rubefacient in over-the-counter topical preparations indicated for muscle and joint pain .

HY-144241S

*DL-Alpha-tocopherol nicotinate-d9*
DL-Alpha-tocopherol nicotinate-d₉ is the deuterium labeled DL-Alpha-tocopherol nicotinate .

HY-W719560S

Flupyrsulfuron-methyl-d6
Flupyrsulfuron-methyl-d₆ is deuterium labeled Methyl 2-(N-((4,6-dimethoxypyrimidin-2-yl)carbamoyl)sulfamoyl)-6-(trifluoromethyl)nicotinate .

HY-W246043

3-Pyridine-2,4,5,6-d4-carboxylic acid, ethyl ester
3-Pyridine-2,4,5,6-d₄ -carboxylic acid, ethyl ester is the deuterium labeled 3-Pyridine-2,4,5,6-carboxylic acid, ethyl ester .

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nicotinate

Inhibitors & Agonists

Biochemical Assay Reagents

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Isotope-Labeled Compounds

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