QPRTase Protein, Human (His)

QPRTase Protein, Human (His) is the recombinant human-derived QPRTase protein, expressed by E. coli, with N-6*His labeled tag.

QPRT is a key enzyme encoding the catabolism of quinoline, which is an intermediate of the tryptophane-nicotinamide adenine dinucleotide pathway and is one of the most effective endogenous exotoxins against neurons. Elevated levels of quinoline in the brain have been linked to the pathogenesis of neurodegenerative diseases such as epilepsy, Alzheimer's disease and Huntington's disease. QPRT may affect the occurrence and progression of breast cancer through activation of PI3K-AKT signaling pathway, Wnt signaling pathway and cell cycle-related molecules. QPRT may play an important role in the pathogenesis of ASD in Chr16p11.2 deficient carriers. Reducing QPRT expression in gliomas reverses drug resistance in cells. The high expression of QPRT in follicular thyroid cancer can be used as a new screening marker^[1][2][3][4].

The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.

Human

E. coli

N-6*His

AAH05060.1 (M1-H297)

23475  [NCBI]

Full Length

MDAEGLALLLPPVTLAALVDSWLREDCPGLNYAALVSGAGPSQAALWAKSPGILAGQPFFDAIFTQLNCQVSWFLPEGSKLVPVARVAEVRGPAHCLLLGERVALNTLARCSGIASAAAAAVEAARGAGWTGHVAGTRKTTPGFRLVEKYGLLVGGAASHRYDLGGLVMVKDNHVVAAGGVEKAVRAARQAADFALKVEVECSSLQEAVQAAEAGADLVLLDNFKPEELHPTATVLKAQFPSVAVEASGGITLDNLPQFCGPHIDVISMGMLTQAAPALDFSLKLFAKEVAPVPKIH

Approximately 34.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Solution.

Supplied as a 0.22 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.