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Results for "

neuroprotective and anti-cancer effects

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Amyloid-β (12) Antibiotic (8) Apoptosis (30) Aryl Hydrocarbon Receptor (1) Autophagy (4) Bacterial (20) Bcl-2 Family (2) Calcium Channel (7) Caspase (3) Cathepsin (1) Cholinesterase (ChE) (2) COX (2) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Metabolite (1) Endogenous Metabolite (4) ERK (5) Fluorescent Dye (4) Fungal (7) GSK-3 (5) HBV (3) HDAC (2) HIF/HIF Prolyl-Hydroxylase (7) Histone Acetyltransferase (1) IAP (1) Isotope-Labeled Compounds (10) JNK (1) KMO (2) MDM-2/p53 (7) MMP (2) NF-κB (9) NO Synthase (3) Opioid Receptor (4) P-glycoprotein (1) p38 MAPK (5) Parasite (2) PARP (1) Potassium Channel (8) Proteasome (5) Reactive Oxygen Species (ROS) (6) Reference Standards (18) RUNX (2) Src (2) STAT (3) Survivin (1) Toll-like Receptor (TLR) (1) VEGFR (1) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (63) Cardiovascular Disease (18) Endocrinology (5) Infection (24) Inflammation/Immunology (48) Metabolic Disease (18) Neurological Disease (57)

By Targets:

Akt (2)

Amyloid-β (12)

Antibiotic (8)

Apoptosis (30)

Aryl Hydrocarbon Receptor (1)

Autophagy (4)

Bacterial (20)

Bcl-2 Family (2)

Calcium Channel (7)

Caspase (3)

Cathepsin (1)

Cholinesterase (ChE) (2)

COX (2)

Cytochrome P450 (1)

DNA/RNA Synthesis (1)

Drug Metabolite (1)

Endogenous Metabolite (4)

ERK (5)

Fluorescent Dye (4)

Fungal (7)

GSK-3 (5)

HBV (3)

HDAC (2)

HIF/HIF Prolyl-Hydroxylase (7)

Histone Acetyltransferase (1)

IAP (1)

Isotope-Labeled Compounds (10)

JNK (1)

KMO (2)

MDM-2/p53 (7)

MMP (2)

NF-κB (9)

NO Synthase (3)

Opioid Receptor (4)

P-glycoprotein (1)

p38 MAPK (5)

Parasite (2)

PARP (1)

Potassium Channel (8)

Proteasome (5)

Reactive Oxygen Species (ROS) (6)

Reference Standards (18)

RUNX (2)

Src (2)

STAT (3)

Survivin (1)

Toll-like Receptor (TLR) (1)

VEGFR (1)

Wnt (2)

β-catenin (2)

By Research Areas:

Cancer (63)

Cardiovascular Disease (18)

Endocrinology (5)

Infection (24)

Inflammation/Immunology (48)

Metabolic Disease (18)

Neurological Disease (57)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: BCRP Fat Mass and Obesity-associated Protein (FTO)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100350

CA-074 methyl ester 30+ Cited Publications CA-074Me	Cathepsin	Neurological Disease Cancer
CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.

HY-N0401

Ligustilide	Autophagy Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects .

HY-N0820

Catalpol 5+ Cited Publications Catalpinoside	HBV	Infection Neurological Disease Inflammation/Immunology Cancer
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0013

Vitexin 5+ Cited Publications	Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-N5086

Picroside IV	HBV	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820) . Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0006

Demethoxycurcumin 3 Publications Verification Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin	Apoptosis Bacterial Cholinesterase (ChE) NO Synthase	Infection Neurological Disease Inflammation/Immunology Cancer
Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-N14021

Petasites japonicus extract	DNA/RNA Synthesis	Neurological Disease Inflammation/Immunology Cancer
Petasites japonicus extract is the extract from Petasites japonicus with antioxidant, anti-inflammatory, anti-obesity, neuroprotective and anti-cancer effects. Petasites japonicus extract promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells .

HY-176305S

Neurofilament, U-15N	Isotope-Labeled Compounds	Neurological Disease
Neurofilament, U- ¹⁵N is the ¹⁵N-labeled Neurofilament.

HY-N7044

Vitexin arginine	Others	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Vitexin arginine is a c-glycosylated flavone, and is found in various medicinal plants species such as Ficus deltoid and Spirodela polyrhiza. Vitexin arginine has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-N0820R

Catalpol (Standard) Catalpinoside (Standard)	Reference Standards HBV	Infection Neurological Disease Inflammation/Immunology Cancer
Catalpol (Standard) is the analytical standard of Catalpol. This product is intended for research and analytical applications. Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0013R

Vitexin (Standard)	Reference Standards Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Vitexin (Standard) is the analytical standard of Vitexin. This product is intended for research and analytical applications. Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-W230975

(E/Z)-Piperine (E/Z)-Bioperine; (E/Z)-1-Piperoylpiperidine	Cytochrome P450 P-glycoprotein	Neurological Disease Inflammation/Immunology Cancer
(E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease .

HY-129566

Withanolide B	ERK Wnt β-catenin RUNX	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N0664

Aucubin 5+ Cited Publications	Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .

HY-N0006R

Demethoxycurcumin (Standard) Curcumin II (Standard); Desmethoxycurcumin (Standard); Monodemethoxycurcumin (Standard)	Reference Standards Apoptosis Bacterial Cholinesterase (ChE) NO Synthase	Infection Neurological Disease Inflammation/Immunology Cancer
Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-N0664R

Aucubin (Standard)	Reference Standards Bacterial	Infection Neurological Disease Inflammation/Immunology Cancer
Aucubin (Standard) is the analytical standard of Aucubin. This product is intended for research and analytical applications. Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .

HY-129566R

Withanolide B (Standard)	Reference Standards ERK Wnt β-catenin RUNX	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-W011641

(±)-Naringenin 4 Publications Verification	Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BK_Ca channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .

HY-17412A

Minocycline Maximum Cited Publications 48 Publications Verification	Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows *anti-cancer, anti-inflammatory, and glutamate* antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412

Minocycline hydrochloride Maximum Cited Publications 48 Publications Verification	Bacterial Antibiotic HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows *anti-cancer, anti-inflammatory, and glutamate* antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-121362

Evernic Acid	Bacterial Endogenous Metabolite	Inflammation/Immunology Cancer
Evernic Acid is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. Neuroprotective and anti-inflammatory effects .

HY-W654013

Minocycline-d7	Isotope-Labeled Compounds Apoptosis Potassium Channel Antibiotic Bacterial MDM-2/p53 HIF/HIF Prolyl-Hydroxylase Calcium Channel	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Minocycline-d₇ is deuterium labeled Minocycline. Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows *anti-cancer, anti-inflammatory, and glutamate* antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412S

Minocycline-d6 hydrochloride	Isotope-Labeled Compounds Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Minocycline-d₆ hydrochloride is deuterated labeled Minocycline hydrochloride (HY-17412). Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows *anti-cancer, anti-inflammatory, and glutamate* antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412S1

Minocycline-d6 sulfate	Isotope-Labeled Compounds Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Minocycline-d₆ sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows *anti-cancer, anti-inflammatory, and glutamate* antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412R

Minocycline hydrochloride (Standard)	Reference Standards Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Minocycline (hydrochloride) (Standard) is the analytical standard of Minocycline (hydrochloride). This product is intended for research and analytical applications. Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows *anti-cancer, anti-inflammatory, and glutamate* antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412AS

Minocycline-d6	Isotope-Labeled Compounds Antibiotic Bacterial HIF/HIF Prolyl-Hydroxylase Apoptosis MDM-2/p53 Potassium Channel Calcium Channel	Infection Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Minocycline-d₆ is deuterium labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows *anti-cancer, anti-inflammatory, and glutamate* antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-B1619

Cromolyn 5+ Cited Publications Cromoglycate; Cromoglicic acid; FPL-670 free acid	GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-17412B

4-Epiminocycline	Drug Metabolite	Others
4-Epiminocycline is a Minocycline (HY-17412A) degradation product. Minocycline (HY-17412A) is an antibiotic that has anti-inflammatory, anticancer, antibacterial, immunomodulatory and neuroprotective effects .

HY-B0320A

Cromolyn disodium 5+ Cited Publications Cromoglycate disodium; Cromoglicic acid disodium; FPL-670	GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-B1619R

Cromolyn (Standard)	GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Standard) is the analytical standard of Cromolyn. This product is intended for research and analytical applications. Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-W748591

Cannflavin A	Apoptosis Amyloid-β KMO	Neurological Disease Inflammation/Immunology Cancer
Cannflavin A can be isolated from Cannabis sativa L.. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ_1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO) (IC₅₀ = 29.4 μM). Cannflavin A activates apoptosis via caspase-3 cleavage. Cannflavin A exerts anti-inflammatory effects by inhibiting pro-inflammatory enzymes, including prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line .

HY-B1619S

Cromolyn-d5 Cromoglycate-d₅; Cromoglicic acid-d₅; FPL-670-d₅ free acid	Isotope-Labeled Compounds GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn-d₅ (Cromoglycate-d₅) is the deuterium labeled Cromolyn (HY-B1619). Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-111954

(+)-Erinacin A Erinacine A	Apoptosis JNK NF-κB Histone Acetyltransferase NO Synthase Bcl-2 Family p38 MAPK Caspase	Neurological Disease Inflammation/Immunology Cancer
(+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage .

HY-N8572

3',4'-Dimethoxyflavone	PARP Reactive Oxygen Species (ROS) Aryl Hydrocarbon Receptor	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .

HY-W748591R

Cannflavin A (Standard)	Amyloid-β Apoptosis Reference Standards KMO	Neurological Disease Inflammation/Immunology Cancer
Cannflavin A (Standard) is the analytical standard of Cannflavin A. This product is intended for research and analytical applications. Cannflavin A can be isolated from Cannabis sativa L.. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ_1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO) (IC₅₀ = 29.4 μM). Cannflavin A activates apoptosis via caspase-3 cleavage. Cannflavin A exerts anti-inflammatory effects by inhibiting pro-inflammatory enzymes, including prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line .

HY-B0320AR

Cromolyn disodium (Standard) Cromoglycate disodium (Standard); Cromoglicic acid disodium (Standard); FPL-670 (Standard)	Reference Standards GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn disodium (Standard) (Cromoglycate disodium (Standard)) is the analytical standard of Cromolyn disodium (HY-B0320A). This product is intended for research and analytical applications. Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-N0188

Esculin 4 Publications Verification	p38 MAPK	Inflammation/Immunology Cancer
Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-N0573

Umbelliferone 3 Publications Verification 7-Hydroxycoumarin; Hydrangin; NSC 19790	Apoptosis Fluorescent Dye	Neurological Disease Inflammation/Immunology Cancer
Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-N0188R

Esculin (Standard)	Reference Standards p38 MAPK	Inflammation/Immunology Cancer
Esculin (Standard) is the analytical standard of Esculin. This product is intended for research and analytical applications. Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-142026

Vitisin A (+)-Vitisin A	NF-κB ERK	Inflammation/Immunology
Vitisin A has antioxidative, anticancer, antiapoptotic, neuroprotective and anti-inflammatory effects. Vitisin A inhibits LPS-induced NO and iNOS production via down-regulation of ERK1/2 and p38 and the NF-κB signal pathway. Vitisin A also inhibits adipocyte differentiation. Vitisin A is a resveratrol tetramer that can be isolated from Vitis vinifera roots .

HY-B0914

10-Undecenoic acid,98% (stabilized with TBC) 2 Publications Verification Undecylenic acid	Fungal Amyloid-β Reactive Oxygen Species (ROS) Proteasome Bacterial	Infection Neurological Disease Endocrinology Cancer
10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-12354

SB-3CT 20+ Cited Publications	MMP	Cancer
SB-3CT is a potent and competitive matrix metalloproteinase MMP-2 and MMP-9 inhibitor with K_i values of 13.9 and 600 nM, respectively. SB-3CT has high selectivity for gelatinases. SB-3CT shows blood-brain barrier permeability and has neuroprotective effects and anticancer activity .

HY-13716

Noscapine 1 Publications Verification (S,R)-Noscapine	Opioid Receptor Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-13716A

Noscapine hydrochloride 1 Publications Verification (S,R)-Noscapine hydrochloride	Opioid Receptor Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Noscapine ((S,R)-Noscapine) hydrochloride is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine hydrochloride exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine hydrochloride disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine hydrochloride possesses anticancer, neuroprotective, anti-inflammatory activities, and can crosse the blood-brain barrier .

HY-N6746

Citrinin NSC 186	Bacterial Fungal Endogenous Metabolite Apoptosis	Infection Neurological Disease Cancer
Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-N0573R

Umbelliferone (Standard) 7-Hydroxycoumarin (Standard); Hydrangin (Standard); NSC 19790 (Standard)	Reference Standards Apoptosis Fluorescent Dye	Neurological Disease Inflammation/Immunology Cancer
Umbelliferone (Standard) (7-Hydroxycoumarin (Standard)) is the analytical standard of Umbelliferone (HY-N0573). This product is intended for research and analytical applications. Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats.

HY-N0573S

Umbelliferone-d5 7-Hydroxycoumarin-d₅; Hydrangin-d₅; NSC 19790-d₅	Isotope-Labeled Compounds Apoptosis Fluorescent Dye	Neurological Disease Inflammation/Immunology Cancer
Umbelliferone-d₅ (7-Hydroxycoumarin-d₅) is the deuterium labeled Umbelliferone (HY-N0573 ). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-N0202

Atractylenolide II 3 Publications Verification Asterolide	ERK Apoptosis p38 MAPK Akt Src STAT	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Atractylenolide II (Asterolide) is a sesquiterpenoid compound. Atractylenolide II can induce G1 phase cell cycle arrest and apoptosis in B16 melanoma cells. Atractylenolide II is an orally effective anticancer agent that can exert anti-melanoma effects by inhibiting the STAT3 signaling pathway. In addition, Atractylenolide II has been shown to ameliorate myocardial fibrosis, oxidative stress, and neuroprotective activity .

HY-B0914A

10-Undecenoic acid zinc salt 2 Publications Verification Zinc undecylenate	Fungal Bacterial Amyloid-β Reactive Oxygen Species (ROS) Proteasome	Infection Neurological Disease Endocrinology Cancer
10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-N0194

Asiatic acid 3 Publications Verification	Apoptosis Parasite	Inflammation/Immunology Cancer
Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0401

Ligustilide	Cardiovascular Disease Structural Classification Natural Products Neurological Disease Classification of Application Fields Source classification Dicerothamnus rhinocerotis Umbelliferae Plants Inflammation/Immunology Disease Research Fields Echinacea angustifolia DC.	Autophagy Apoptosis
Ligustilide is is a bioactive phthalide derivative isolated from Angelica sinensis and Chuanxiong. Ligustilide exhibits neuroprotective, anti-cancer, anti-inflammatory, and vasodilator effects .

HY-N0820

Catalpol Maximum Cited Publications 10 Publications Verification Catalpinoside	Structural Classification Neurological Disease Classification of Application Fields Anti-aging Source classification Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey Infection Iridoids Terpenoids Scrophulariaceae Inflammation/Immunology Disease Research Fields Cancer	HBV
Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0013

Vitexin 5+ Cited Publications	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Flavones Anti-aging Source classification Metabolic Disease Plants Flavonoids Leguminosae Phenols Polyphenols Trigonella foenum-graecum Linn. Disease Research Fields Cancer	Autophagy
Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-N5086

Picroside IV	Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Plants Monophenols Iridoids Terpenoids Phenols Scrophulariaceae Picrorhiza scrophulariiflora Pennell Inflammation/Immunology Disease Research Fields	HBV
Picroside IV is an iridoid glycoside found in the underground parts of Picrorhiza scrophulariiflora. Picroside IV is a derivative of Catalpol (HY-N0820) . Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0006

Demethoxycurcumin 3 Publications Verification Curcumin II; Desmethoxycurcumin; Monodemethoxycurcumin	Zingiber officinale Roscoe Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Zingiberaceae Cancer	Apoptosis Bacterial Cholinesterase (ChE) NO Synthase
Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-W230975

(E/Z)-Piperine (E/Z)-Bioperine; (E/Z)-1-Piperoylpiperidine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants Piper nigrum Linn.	Cytochrome P450 P-glycoprotein
(E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease .

HY-N14021

Petasites japonicus extract	Structural Classification Natural Products Source classification Plants Compositae Piptadenia Benth.	DNA/RNA Synthesis
Petasites japonicus extract is the extract from Petasites japonicus with antioxidant, anti-inflammatory, anti-obesity, neuroprotective and anti-cancer effects. Petasites japonicus extract promotes osteoblast differentiation via up-regulation of Runx2 and Osterix in MC3T3-E1 cells .

HY-N7044

Vitexin arginine	Cardiovascular Disease Flavonoids other families Classification of Application Fields Neurological Disease Flavones Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	Others
Vitexin arginine is a c-glycosylated flavone, and is found in various medicinal plants species such as Ficus deltoid and Spirodela polyrhiza. Vitexin arginine has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-N0820R

Catalpol (Standard) Catalpinoside (Standard)	Structural Classification Iridoids Terpenoids Source classification Scrophulariaceae Plants Rehmannia glutinosa (Gaert.) Libosch. ex Fisch. et Mey	Reference Standards HBV
Catalpol (Standard) is the analytical standard of Catalpol. This product is intended for research and analytical applications. Catalpol (Catalpinoside), an iridoid glycoside found in Rehmannia glutinosa. Catalpol has neuroprotective, hypoglycemic, anti-inflammatory, anti-cancer, anti-spasmodic, anti-oxidant effects and anti-HBV effects .

HY-N0013R

Vitexin (Standard)	Structural Classification Flavonoids Flavones Leguminosae Source classification Phenols Polyphenols Plants Trigonella foenum-graecum Linn.	Reference Standards Autophagy
Vitexin (Standard) is the analytical standard of Vitexin. This product is intended for research and analytical applications. Vitexin is a c-glycosylated flavone, and is found in various medicinal plants species such as Trigonella foenum-graecum Linn. Vitexin has a wide range of pharmacological effects, including anti-oxidant, anti-cancer, anti-inflammatory, anti-hyperalgesic, and neuroprotective effects .

HY-129566

Withanolide B	Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Withania somnifera Solanaceae Plants Inflammation/Immunology Disease Research Fields Steroids	ERK Wnt β-catenin RUNX
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-N0664

Aucubin 5+ Cited Publications	Infection Structural Classification Eucommia ulmoides Oliver Iridoids Neurological Disease Classification of Application Fields Terpenoids Source classification Eucommiaceae Plants Inflammation/Immunology Disease Research Fields	Bacterial
Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .

HY-N0006R

Demethoxycurcumin (Standard) Curcumin II (Standard); Desmethoxycurcumin (Standard); Monodemethoxycurcumin (Standard)	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Reference Standards Apoptosis Bacterial Cholinesterase (ChE) NO Synthase
Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research .

HY-N0664R

Aucubin (Standard)	Structural Classification Eucommia ulmoides Oliver Iridoids Terpenoids Source classification Eucommiaceae Plants	Reference Standards Bacterial
Aucubin (Standard) is the analytical standard of Aucubin. This product is intended for research and analytical applications. Aucubin, an iridoid glucoside, is isolated from Plantago asiatica, Eucommia ulmoides, the leaves of Aucuba japonica and more recently from butterfly larva. Aucubin has many biological activities, such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, anti-fibrotic, anti-cancer, hepatoprotective, neuroprotective and osteoprotective effects .

HY-129566R

Withanolide B (Standard)	Structural Classification Source classification Withania somnifera Solanaceae Plants Steroids	Reference Standards ERK Wnt β-catenin RUNX
Withanolide B (Standard) is the analytical standard of Withanolide B. This product is intended for research and analytical applications. Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects .

HY-W011641

(±)-Naringenin 4 Publications Verification	Cardiovascular Disease Structural Classification Flavonoids other families Classification of Application Fields Flavonones Source classification Phenols Polyphenols Plants Disease Research Fields	Potassium Channel Toll-like Receptor (TLR) NF-κB Apoptosis Caspase
(±)-Naringenin is an orally available anti-inflammatory agent that can regulate both acute and chronic inflammation responses, while also showing antioxidant, neuroprotective, liver-protective, and anti-cancer effects. (±)-Naringenin promotes vasodilation in endothelial cells by activating BK_Ca channels in muscle cells. It also exerts protective effects against experimental colitis by inhibiting Toll-like receptor 4/NF-κB signaling, making it useful in studies related to sepsis, fulminant hepatitis, fibrosis, and cancer research .

HY-121362

Evernic Acid	Structural Classification other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Inflammation/Immunology Disease Research Fields	Bacterial Endogenous Metabolite
Evernic Acid is a secondary metabolite generated by lichens, including Ramalina, Evernia, and Hypogymnia, and several studies have described its anticancer, antifungal, and antimicrobial effects. Neuroprotective and anti-inflammatory effects .

HY-W748591

Cannflavin A	Structural Classification Flavonoids Cannabis sativa L Flavones Source classification Plants Moraceae	Apoptosis Amyloid-β KMO
Cannflavin A can be isolated from Cannabis sativa L.. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ_1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO) (IC₅₀ = 29.4 μM). Cannflavin A activates apoptosis via caspase-3 cleavage. Cannflavin A exerts anti-inflammatory effects by inhibiting pro-inflammatory enzymes, including prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line .

HY-111954

(+)-Erinacin A Erinacine A	Structural Classification Microorganisms Terpenoids Diterpenoids	Apoptosis JNK NF-κB Histone Acetyltransferase NO Synthase Bcl-2 Family p38 MAPK Caspase
(+)-Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+)-Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+)-Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage .

HY-N8572

3',4'-Dimethoxyflavone	Structural Classification Flavonoids other families Flavones Coniogramme japonica (Thunb.) Diels Plants	PARP Reactive Oxygen Species (ROS) Aryl Hydrocarbon Receptor
3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects .

HY-W748591R

Cannflavin A (Standard)	Structural Classification Flavonoids Cannabis sativa L Flavones Source classification Plants Moraceae	Amyloid-β Apoptosis Reference Standards KMO
Cannflavin A (Standard) is the analytical standard of Cannflavin A. This product is intended for research and analytical applications. Cannflavin A can be isolated from Cannabis sativa L.. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ_1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO) (IC₅₀ = 29.4 μM). Cannflavin A activates apoptosis via caspase-3 cleavage. Cannflavin A exerts anti-inflammatory effects by inhibiting pro-inflammatory enzymes, including prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line .

HY-N0188

Esculin 4 Publications Verification	Structural Classification Monophenols other families Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Cancer	p38 MAPK
Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-N0573

Umbelliferone 3 Publications Verification 7-Hydroxycoumarin; Hydrangin; NSC 19790	Structural Classification Monophenols Classification of Application Fields Source classification Coumarins Phenols Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer	Apoptosis Fluorescent Dye
Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-N0188R

Esculin (Standard)	Structural Classification Monophenols other families Source classification Coumarins Phenols Phenylpropanoids Plants	Reference Standards p38 MAPK
Esculin (Standard) is the analytical standard of Esculin. This product is intended for research and analytical applications. Esculin is a fluorescent coumarin glucoside, the active ingredient in ash bark. Esculin has antidiabetic effects, improves cognitive impairment in experimental diabetic nephropathy (DN) via the MAPK signaling pathway, and exerts antioxidant stress and anti-inflammatory effects. Esculin also has anticancer, antibacterial, antiviral, neuroprotective, antithrombotic, and therapeutic properties for eye diseases .

HY-142026

Vitisin A (+)-Vitisin A	Structural Classification Microorganisms Source classification Vitis vinifera cv. Zalema Phenols Polyphenols Plants Vitaceae	NF-κB ERK
Vitisin A has antioxidative, anticancer, antiapoptotic, neuroprotective and anti-inflammatory effects. Vitisin A inhibits LPS-induced NO and iNOS production via down-regulation of ERK1/2 and p38 and the NF-κB signal pathway. Vitisin A also inhibits adipocyte differentiation. Vitisin A is a resveratrol tetramer that can be isolated from Vitis vinifera roots .

HY-B0914

10-Undecenoic acid,98% (stabilized with TBC) 2 Publications Verification Undecylenic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Fungal Amyloid-β Reactive Oxygen Species (ROS) Proteasome Bacterial
10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-13716

Noscapine 1 Publications Verification (S,R)-Noscapine	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Source classification Quinoline Alkaloids Papaver somniferum Linn. Plants Inflammation/Immunology Disease Research Fields Papaveraceae	Opioid Receptor Apoptosis
Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

HY-N6746

Citrinin NSC 186	Infection Structural Classification Microorganisms Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Bacterial Fungal Endogenous Metabolite Apoptosis
Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-N0573R

Umbelliferone (Standard) 7-Hydroxycoumarin (Standard); Hydrangin (Standard); NSC 19790 (Standard)	Structural Classification Monophenols Source classification Coumarins Phenols Phenylpropanoids Endogenous metabolite	Reference Standards Apoptosis Fluorescent Dye
Umbelliferone (Standard) (7-Hydroxycoumarin (Standard)) is the analytical standard of Umbelliferone (HY-N0573). This product is intended for research and analytical applications. Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats.

HY-N0202

Atractylenolide II 3 Publications Verification Asterolide	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Astragalus caprinus L. Plants Compositae Disease Research Fields Cancer	ERK Apoptosis p38 MAPK Akt Src STAT
Atractylenolide II (Asterolide) is a sesquiterpenoid compound. Atractylenolide II can induce G1 phase cell cycle arrest and apoptosis in B16 melanoma cells. Atractylenolide II is an orally effective anticancer agent that can exert anti-melanoma effects by inhibiting the STAT3 signaling pathway. In addition, Atractylenolide II has been shown to ameliorate myocardial fibrosis, oxidative stress, and neuroprotective activity .

HY-B0914A

10-Undecenoic acid zinc salt 2 Publications Verification Zinc undecylenate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease Research Fields	Fungal Bacterial Amyloid-β Reactive Oxygen Species (ROS) Proteasome
10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-N0194

Asiatic acid 3 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Tagetes lucida Cav. Umbelliferae Plants Inflammation/Immunology Disease Research Fields	Apoptosis Parasite
Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

HY-N3001

Isolinderalactone	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm. Disease Research Fields Cancer	STAT VEGFR Bcl-2 Family Survivin IAP NF-κB Apoptosis Caspase
Isolinderalactone is a sesquiterpene that exhibits anti-cancer, anti-inflammatory, and neuroprotective effects. Isolinderalactone inhibits VEGF expression and tyrosine phosphorylation of VEGFR2. Isolinderalactone decreases viability and induces apoptosis in U-87 glioblastoma (GBM) cells and colorectal cancer (CRC) cells. Isolinderalactone induces G2/M phase cell cycle arrest, ROS generation, pJNK/p38 MAPK activation, in colorectal cancer (CRC) cells. Isolinderalactone blocks LPS (HY-D1056)-induced NF-κB activation while activating Nrf2-HMOX1 signaling in RAW264.7 macrophages. Isolinderalactone improves cognitive dysfunction in APP/PS1 mice. Isolinderalactone can be used for the study of Glioblastoma multiforme (GBM), colorectal cancer, Alzheimer’s disease and acute lung injury .

HY-13716R

Noscapine (Standard) (S,R)-Noscapine (Standard)	Structural Classification Alkaloids Source classification Quinoline Alkaloids Papaver somniferum Linn. Plants Papaveraceae	Reference Standards Opioid Receptor Apoptosis
Noscapine (Standard) is the analytical standard of Noscapine. This product is intended for research and analytical applications. Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier [4] .

HY-W005255R

3-(3-Hydroxyphenyl)propionic acid (Standard)	Structural Classification Monophenols Microorganisms Ketones, Aldehydes, Acids Source classification Phenols Endogenous metabolite	Reference Standards Endogenous Metabolite
Citrinin (Standard) is the analytical standard of Citrinin. This product is intended for research and analytical applications. Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-N6746R

Citrinin (Standard) NSC 186 (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Reference Standards Bacterial Fungal Endogenous Metabolite Apoptosis
Citrinin (Standard) is the analytical standard of Citrinin. This product is intended for research and analytical applications. Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-B0914R

10-Undecenoic acid (Standard) Undecylenic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Fungal Amyloid-β Reactive Oxygen Species (ROS) Proteasome Bacterial
10-Undecenoic acid (Standard) is the analytical standard of 10-Undecenoic acid. This product is intended for research and analytical applications. 10-Undecenoic acid (Undecylenic acid) is an antifungal agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-N0194R

Asiatic acid (Standard)	Triterpenes Structural Classification Terpenoids Source classification Tagetes lucida Cav. Umbelliferae Plants	Reference Standards Apoptosis Parasite
Asiatic acid (Standard) is the analytical standard of Asiatic acid. This product is intended for research and analytical applications. Asiatic acid, a pentacyclic triterpene found in Centella asiatica (Centella asiatica), has anticancer activity. Asiatic acid induces apoptosis in melanoma cells and has barrier protective effects on human aortic endothelial cells (HAEC). Asiatic acid also has anti-inflammatory activity and inhibits tumor necrosis factor (TNF)-α-induced endothelial barrier dysfunction. Asiatic acid also inhibits NLRP3 inflammasome activation and NF-κB pathway, effectively inhibits inflammation in rats, and has neuroprotective effects in rat spinal cord injury (SCI) model .

HY-N3017

Artemitin	Flavonols Structural Classification Monophenols Flavonoids other families Classification of Application Fields Source classification Phenols Plants Inflammation/Immunology Disease Research Fields	Antibiotic
Artemitin is a flavonoid neuroanesthetic agent with moderate cytotoxicity. Artemitint has selective inhibitory activity against Meth-A sarcoma cells with an ED₅₀ of 5-10 μg/mL, and has no significant effect on LLC lung cancer cells. Artemitin exerts anticancer activity by affecting cell proliferation signaling pathways, and also has potential anti-inflammatory and neuroprotective effects. Artemitin exhibits a dose-dependent antinociceptive effect in the mouse hot plate test, with an ED₅₀ of 1.6 μg/kg, and has analgesic activity .

HY-B1890

(±)-Catechin 1 Publications Verification rel-Cianidanol; rel-Catechuic acid	Cardiovascular Disease Structural Classification Neurological Disease Classification of Application Fields Source classification Camellia sinensis (L.) O. Ktze. Plants Infection Phenols Polyphenols Inflammation/Immunology Disease Research Fields Theaceae	COX
(±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC₅₀ of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects .

HY-N0202R

Atractylenolide II (Standard) Asterolide (Standard)	Structural Classification Terpenoids Sesquiterpenes Source classification Astragalus caprinus L. Plants Compositae	ERK Reference Standards Apoptosis p38 MAPK Src Akt STAT
Atractylenolide II (Standard) is the analytical standard of Atractylenolide II. This product is intended for research and analytical applications. Atractylenolide II (Asterolide) is a sesquiterpenoid compound. Atractylenolide II can induce G1 phase cell cycle arrest and apoptosis in B16 melanoma cells. Atractylenolide II is an orally effective anticancer agent that can exert anti-melanoma effects by inhibiting the STAT3 signaling pathway. In addition, Atractylenolide II has been shown to ameliorate myocardial fibrosis, oxidative stress, and neuroprotective activity .

HY-B0914AR

10-Undecenoic acid zinc salt (Standard) Zinc undecylenate (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Reference Standards Fungal Amyloid-β Reactive Oxygen Species (ROS) Proteasome Bacterial
10-Undecenoic acid (zinc salt) (Standard) is the analytical standard of 10-Undecenoic acid (zinc salt). This product is intended for research and analytical applications. 10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an antifungal agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-B1890R

(±)-Catechin (Standard) rel-Cianidanol (Standard); rel-Catechuic acid (Standard)	Structural Classification Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Theaceae	Reference Standards COX
(±)-Catechin (Standard) is the analytical standard of (±)-Catechin. This product is intended for research and analytical applications. (±)-Catechin (rel-Cianidanol) is the racemate of the green tea polyphenol Catechin. Catechin has anticancer activity and induces apoptosis. (±)-Catechin has two forms, (+)-Catechin and its enantiomer (-)-Catechin. (+)-Catechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. (-)-Catechin can effectively promote hBM-MSC adipocyte differentiation and increase adiponectin and PPARγ levels. (±)-Catechin has anti-tumor, anti-obesity, anti-diabetic, anti-cardiovascular, anti-infectious, hepatoprotective and neuroprotective effects .

Cat. No.	Product Name	Chemical Structure

HY-W654013

Minocycline-d7

Minocycline-d₇ is deuterium labeled Minocycline. Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412S1

Minocycline-d6 sulfate

Minocycline-d₆ sulfate is deuterated labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-176305S

Neurofilament, U-15N
Neurofilament, U- ¹⁵N is the ¹⁵N-labeled Neurofilament.

HY-17412S

Minocycline-d6 hydrochloride

Minocycline-d₆ hydrochloride is deuterated labeled Minocycline hydrochloride (HY-17412). Minocycline hydrochloride is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline hydrochloride is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline hydrochloride shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline hydrochloride reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline hydrochloride inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-17412AS

Minocycline-d6

Minocycline-d₆ is deuterium labeled Minocycline (HY-17412A). Minocycline is an orally active, potent and BBB-penetrated semi-synthetic tetracycline antibiotic. Minocycline is a hypoxia-inducible factor (HIF)-1α inhibitor. Minocycline shows anti-cancer, anti-inflammatory, and glutamate antagonist effects. Minocycline reduces glutamate neurotransmission and shows neuroprotective properties and antidepressant effects. Minocycline inhibits bacterial protein synthesis through binding with the 30S subunit of the bacterial ribosome, resulting in a bacteriostatic effect .

HY-B1619S

Cromolyn-d5

Cromolyn-d₅ (Cromoglycate-d₅) is the deuterium labeled Cromolyn (HY-B1619). Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-N0573S

Umbelliferone-d5

Umbelliferone-d₅ (7-Hydroxycoumarin-d₅) is the deuterium labeled Umbelliferone (HY-N0573 ). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-W777393

Umbelliferone-13C6

Umbelliferone- ¹³C₆ (7-Hydroxycoumarin- ¹³C₆) is the ¹³C-labeled Umbelliferone (HY-N0573). Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats .

HY-N6746S1

Citrinin-13C13

Citrinin- ¹³C₁₃ (NSC 186- ¹³C₁₃) is the ¹³C labeled Citrinin (HY-N6746). Citrinin (NSC 186) is a mycotoxin that causes food contamination and has different toxic effects. Citrinin is an effective oral anticancer agent. Citrinin has various regulatory effects on mouse immune system, including regulating the number of immune cells, inducing apoptosis and autophagy of immune cells, altering toll-like receptor expression and cytokine production. Citrinin can induce oxidative stress and lead to early apoptosis of oocytes. Low doses of Citrinin have neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. In addition, Citrinin also has antibacterial activity .

HY-13716S

Noscapine-13C,d3

Noscapine- ¹³C,d₃ is a ¹³C- labeled and deuterated labeled Noscapine . Noscapine ((S,R)-Noscapine) is an orally active phthalideisoquinoline alkaloid with potent antitussive. Noscapine exerts its antitussive effects by activating sigma opioid receptors and is a non-competitive Bradykinin inhibitor. Noscapine disrupts microtubule dynamics, induces mitotic arrest and apoptosis. Noscapine possesses anticancer, neuroprotective, anti-inflammatory activities, and can cross the blood-brain barrier .

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