Search Result
Results for "
monoamine neurotransmitters
" in MedChemExpress (MCE) Product Catalog:
6
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-14472
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NS-2330
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Dopamine Transporter
Serotonin Transporter
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Metabolic Disease
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Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC50=6.5 nM), norepinephrine (NE;IC50=1.7 nM), and serotonin (5-HT;IC50=11 nM), and with potentials as an anti-obesity agent . Tesofensine is a CNS acting anti-obesity agent .
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- HY-B1473A
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- HY-B1473
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5-Hydroxytryptamine hydrochloride; 5-HT hydrochloride
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5-HT Receptor
COMT
Endogenous Metabolite
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Neurological Disease
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Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
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- HY-174833
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Monoamine Oxidase
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Neurological Disease
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MAO-A-IN-2 (Compound 4l) is a selective monoamine oxidase A (MAO-A) inhibitor with an IC50 value of 0.4 μM. MAO-A-IN-2 reduces the degradation of monoamine neurotransmitters (e.g., serotonin, norepinephrine). MAO-A-IN-2 is promising for research of neurological diseases related to monoamine neurotransmitter imbalance such as depression and anxiety disorders .
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- HY-158555
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4-Ethyl-N,N-Dmc hydrochloride
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Others
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Others
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4-Ethyl-N,N-Dimethylcathinone hydrochloride is an analog of Methedrone. Methedrone is a cathinone-related compound, which act as a non-selective substrate for monoamine transporters, facilitating a neurotransmitter release .
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- HY-110019
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Lu 19-005
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Serotonin Transporter
Dopamine Transporter
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Neurological Disease
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Indatraline hydrochloride (Lu 19-005) is a non-selective monoamine transporter inhibitor that blocks the reuptake of neurotransmitters (dopamine, serotonin, and norepinephrine). Indatraline hydrochloride can be used for the research of antidepressive. Indatraline hydrochloride induces autophagy while simultaneously inhibiting cell proliferation. Indatraline hydrochloride may also serve to direct the development of new agents for autophagy-related diseases such as atherosclerosis or restenosis .
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- HY-14472R
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Dopamine Transporter
Serotonin Transporter
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Metabolic Disease
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Tesofensine (Standard) is the analytical standard of Tesofensine. This product is intended for research and analytical applications. Tesofensine (NS-2330) is a triple monoamine reuptake inhibitor inducing a potent inhibition of the re-uptake process in the synaptic cleft of the neurotransmitters dopamine (DA; IC50=6.5 nM), norepinephrine (NE;IC50=1.7 nM), and serotonin (5-HT;IC50=11 nM), and with potentials as an anti-obesity agent . Tesofensine is a CNS acting anti-obesity agent .
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- HY-122271
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Endogenous Metabolite
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Neurological Disease
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Safrazine Hydrochloride is a monoamine oxidase inhibitor with irreversible activity. It is mainly used to inhibit depression and other mood disorders. As a compound, its mechanism is to increase the level of monoamine neurotransmitters in the body by blocking the activity of monoamine oxidase, thereby improving mood and psychological state .
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- HY-B2132S
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Isotope-Labeled Compounds
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Neurological Disease
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Tryptamine-d2 (hydrochloride) is a deuterium labeled Tryptamine hydrochloride. Tryptamine hydrochloride is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter .
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- HY-136800
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Thyroid Hormone Receptor
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Endocrinology
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Posatirelin, a TRH analog, increases monoamine metabolites in the cerebral cortex, nucleus accumbens,
and striatum, and possibly exerts CNS activating effects through a modification of several neurotransmitter systems .
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- HY-B2132R
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3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine (Standard)
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Endogenous Metabolite
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Others
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Tryptamine (Standard) is the analytical standard of Tryptamine. This product is intended for research and analytical applications. Tryptamine is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter.
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- HY-169611
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5-Hydroxytryptamine maleate; 5-HT maleate
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5-HT Receptor
COMT
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Neurological Disease
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Serotonin hydrogen maleate is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrogen maleate is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .
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- HY-B1473AS
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- HY-173336
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Monoamine Oxidase
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Neurological Disease
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MAO-B-IN-42 (Compound 4f) is a selective and reversible inhibitor of monoamine oxidase-B (MAO-B) with an IC50 value of 0.184 μM. MAO-B-IN-42 helps maintain the levels of neurotransmitters by blocking the oxidative deamination of monoamines catalyzed by MAO-B. MAO-B-IN-42 is promising for research of Parkinson's disease .
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- HY-B1473S1
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5-Hydroxytryptamine-13C2,15N hydrochloride; 5-HT-13C2,15N hydrochloride
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Isotope-Labeled Compounds
5-HT Receptor
COMT
Endogenous Metabolite
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Neurological Disease
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Serotonin- 13C2, 15N hydrochloride is the 13C- and 15N-labeled Serotonin hydrochloride (HY-B1473). Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .
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- HY-14197
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M&B 9302
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Monoamine Oxidase
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Neurological Disease
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Clorgyline (M&B 9302) is an orally active, blood-brain barrier permeable and selective monoamine oxidase A (MAO-A) inhibitor. Clorgyline's selective inhibition of MAO-A leads to reduced metabolism of neurotransmitters such as serotonin (5-hydroxytryptamine), which accumulates in the brain. Clorgyline can be used in the study of depression and neurodegenerative diseases .
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- HY-B1473S
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5-Hydroxytryptamine-d4 hydrochloride; 5-HT-d4 hydrochloride
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Isotope-Labeled Compounds
5-HT Receptor
Endogenous Metabolite
COMT
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Others
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Serotonin-d4 (5-Hydroxytryptamine-d4) hydrochloride is the deuterium labeled Serotonin (hydrochloride) (HY-B1473) . Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .
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- HY-16731
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EVT 302; RG1577; RO4602522
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Monoamine Oxidase
Reactive Oxygen Species (ROS)
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Neurological Disease
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Sembragiline (EVT 302) is a potent, selective and reversible monoamine oxidase B (MAO-B) inhibitor. Sembragiline reduces the metabolism of dopamine and other amine neurotransmitters by inhibiting the activity of the MAO-B enzyme, thereby potentially increasing the concentration of these neurotransmitters in the brain. Inhibition of the MAO-B enzyme also reduces the formation of toxic reactive oxygen species (ROS) that play a role in the pathological process of AD. Sembragiline has good oral activity and blood-brain barrier permeability. Sembragiline can be used in studies of AD, especially in patients with AD who show increased MAO-B activity .
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- HY-116062
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Monoamine Transporter
Dopamine Transporter
Adrenergic Receptor
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Others
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JNJ-7925476 (hydrochloride) is a triple monoamine uptake inhibitor with the ability to regulate neurotransmitter levels and antidepressant activity. JNJ-7925476 (hydrochloride) can be rapidly absorbed into the plasma in rats, with a higher concentration in the brain than in plasma. It can induce an increase in the levels of extracellular serotonin, dopamine, and norepinephrine in the rat cerebral cortex, and exhibits antidepressant activity in the mouse tail suspension test.
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- HY-B0528
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Adrenergic Receptor
Endogenous Metabolite
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Neurological Disease
Endocrinology
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Octopamine is a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
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- HY-141554A
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(2S,3S,11bR)-DHTBZ
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Monoamine Transporter
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Neurological Disease
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(2S,3S,11bR)-Dihydrotetrabenazine ((2S,3S,11bR)-DHTBZ) is a highly selective inhibitor of vesicular monoamine transporter 2 (VMAT2) with a Ki value of 593 nM. (2S,3S,11bR)-Dihydrotetrabenazine inhibits vesicular transport of monoamine neurotransmitters like dopamine and serotonin, reducing their synaptic release. (2S,3S,11bR)-Dihydrotetrabenazine is promising for research of Huntington's chorea and other hyperkinetic disorders .
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- HY-103465
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Monoamine Transporter
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Others
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FFN511 is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices .
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- HY-103465B
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Monoamine Transporter
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Others
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FFN511 (hydrochloride) is a potent fluorescent false neurotransmitters (FFNs) that targets neuronal vesicular monoamine transporter 2 (VMA T2). FFN511 (hydrochloride) inhibits serotonin binding to VMA T2-containing membranes with an IC50 of 1 µM. FFN511 (hydrochloride) directly images the dynamics of release during exocytosis, can be used to label dopamine terminals in live cortical-striatalacute slices .
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- HY-B0528A
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(±)-p-Octopamine hydrochloride
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Adrenergic Receptor
Endogenous Metabolite
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Neurological Disease
Endocrinology
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Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
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- HY-174834
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Monoamine Oxidase
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Neurological Disease
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MAO-B-IN-44 (Compound 4n) is a selective monoamine oxidase B (MAO-B) inhibitor targetin with an IC50 value of 1.01 μM, showing weak inhibition on MAO-A (IC50=14.4 μM). MAO-B-IN-44 reduces degradation of neurotransmitters like dopamine. MAO-B-IN-44 is promising for research of neurodegenerative diseases related to MAO-B abnormalities such as Parkinson’s disease .
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- HY-B0528AS
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(±)-p-Octopamine-d4 hydrochloride
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Adrenergic Receptor
Endogenous Metabolite
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Neurological Disease
Endocrinology
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Octopamine-d4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
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- HY-117542
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Histone Methyltransferase
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Neurological Disease
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D595 is a phenylethylamine calcium channel blocker with potent negative inotropic activity. D595 has shown significant efficacy in its corresponding pharmacological studies, especially in inhibiting the uptake of monoamine neurotransmitters. D595 has high affinity in binding to the dopamine transporter (DAT), serotonin transporter (SERT), and norepinephrine transporter (NET). Structural adjustments of D595, especially changes in the hydroxyl stereochemistry, significantly affect its interaction with the transporters, showing a specific preference for stereoisomers .
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- HY-B0528AR
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(±)-p-Octopamine hydrochloride (Standard)
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Reference Standards
Adrenergic Receptor
Endogenous Metabolite
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Neurological Disease
Endocrinology
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Octopamine (hydrochloride) (Standard) is the analytical standard of Octopamine (hydrochloride). This product is intended for research and analytical applications. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
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- HY-N2554
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Ostenol
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Monoamine Oxidase
PI3K
Akt
Apoptosis
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Infection
Neurological Disease
Cancer
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Osthenol (Ostenol) is a reversible, selective, competitive inhibitor of hMAO-A (IC50=0.74 μM, Ki=0.26 μM), with antifungal and antibacterial activity. Osthenol inhibits the oxidative deamination of hMAO-A and regulates the metabolism of monoamine neurotransmitters. Osthenol also inhibits the PI3K/AKT signaling pathway to induce apoptosis of colon cancer cells, arrest the cell cycle at the G1 phase, and inhibit cell proliferation. Osthenol is mainly used in the study of neurological diseases and cancer, especially depression-related MAO-A targeted intervention and colon cancer .
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HY-L186
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57 compounds
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Neurotransmitters are chemical messengers that allows a neuron's electrical signal to pass to a postsynaptic neuron or effect target. Neurotransmitters include amino acids, monoamines, and peptides, while other neurotransmitters are composed of metabolites such as nitric oxide and carbon monoxide. The function of neurotransmitters is closely related to the disease of life, helping to regulate the body's heartbeat, blood pressure, breathing, sleep, aging and muscle activity. Therefore, research based on neurotransmitters can help to increase human understanding of diseases.
MCE collects and organizes 57 neurotransmitters and is a tool library for drug screening and mechanism research.
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
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- HY-B2132S1
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Tryptamine-d4 (hydrochloride) is the deuterium labeled Tryptamine hydrochloride. Tryptamine hydrochloride, a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter .
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- HY-B1473S
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Serotonin-d4 (5-Hydroxytryptamine-d4) hydrochloride is the deuterium labeled Serotonin (hydrochloride) (HY-B1473) . Serotonin (5-Hydroxytryptamine) hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .
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- HY-B0528AS
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Octopamine-d4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. Octopamine hydrochloride increased glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure .
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- HY-B2132S
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Tryptamine-d2 (hydrochloride) is a deuterium labeled Tryptamine hydrochloride. Tryptamine hydrochloride is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter .
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- HY-B1473AS
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Serotonin-d4 is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
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- HY-B1473S1
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Serotonin- 13C2, 15N hydrochloride is the 13C- and 15N-labeled Serotonin hydrochloride (HY-B1473). Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM .
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