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marine fungus

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Bacterial (5) Caspase (1) Endogenous Metabolite (6) ERK (1) Fungal (1) Interleukin Related (3) JNK (1) MMP (1) NO Synthase (1) p38 MAPK (2) PPAR (1) Reference Standards (1) Ser/Thr Protease (2) Sirtuin (1) Thrombin (2) TNF Receptor (1)
By Research Areas:	Cancer (8) Endocrinology (1) Infection (8) Inflammation/Immunology (3)

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Peptides

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113972

Methyl mycophenolate	Others	Inflammation/Immunology
Methyl mycophenolate is a methyl ester of mycophenolic acid and is also found in marine-derived fungus Phaeosphaeria spartinae .

HY-N8571

6-Methoxyflavonol	Others	Others
6-Methoxyflavonol (Compound 15) is a natural flavone isolated from the marine-derived fungus Aspergillus candidus .

HY-N7569

Demethoxyfumitremorgin C	Apoptosis Caspase PPAR	Cancer
Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to PARP/ cleavage .

HY-N10256

Varioxepine A	Endogenous Metabolite	Infection
Varioxepine A is a 3H-oxepine-containing alkaloid with a new oxa-cage found in the marine algal-derived endophytic fungus Paecilomyces variotii. Varioxepine A inhibits plant pathogenic fungus Fusarium graminearum .

HY-N8520

Variculanol	Bacterial	Infection Cancer
Variculanol is an antimicrobial, anticancer and anti-HCV NS3/4A Protease agent which can be extracted from marine fungus Aspergillus versicolor .

HY-N12901

Fiscalin C Ficalin C	Others	Others
Fiscalin C (Ficalin C) is an alkaloid and can be isolated from Stentrophomonas maltophilia .

HY-N10203

Rostratin A	Endogenous Metabolite	Cancer
Rostratin A is a cytotoxic disulfide found in the marine-derived fungus Exserohilum rostratum. Rostratin A shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC₅₀ of 8.5 μg/mL .

HY-N12179

Brevianamide M	Bacterial	Others
Brevianamide M (compound 4) is a metabolite of Aspergillus versicolor. This is an endophytic fungus isolated from the marine brown alga Sargassum. Brevianamide M has antimicrobial activity against Escherichia coli and Staphylococcus aureus .

HY-N12165

1,3,5,6-Tetrahydroxy-8-methylxanthone	Others	Others
1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .

HY-N6181

Terrelumamide A	Others	Endocrinology
Terrelumamide A is a lumazine-containing peptide. Terrelumamide A is isolated from the culture broth of the marine-derived fungus Aspergillus terreus. Terrelumamide A exhibits pharmacological activity by improving insulin sensitivity. Terrelumamide A has the potential in the application of DNA sequence recognition .

HY-N8908

2α,9α,11-Trihydroxy-6-oxodrim-7-ene	Others	Infection
2α,9α,11-Trihydroxy-6-oxodrim-7-ene is a natural product that can be isolated from the culture medium of the marine-derived fungus Aspergillus insuetus .

HY-N15359

Germicidin C	Bacterial	Infection
Germicidin C is a microbial metabolite with antibacterial activity, which is found in the marine sponge-derived fungus Aspergillus niger. Germicidin C can inhibit the growth of various pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, and Bacillus subtilis with MIC values ranging from 32 to 64 µg/mL .

HY-N15651

Asperflavin	NO Synthase TNF Receptor Interleukin Related	Inflammation/Immunology
Asperflavin is an anti-inflammatory compound that can be produced by the marine fungus Eurotium amstelodami. Asperflavin inhibits the production of NO, PGE₂, and proinflammatory cytokines, as well as the expression of inducible NOS (iNOS) in RAW 264.7 cells treated with LPS (HY-D1056). Asperflavin can be used in the study of inflammatory diseases .

HY-135422

Nidulin Methylustin	Bacterial Fungal	Infection
Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candida albicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp .

HY-N15348

Aphidicolins B32	Others	Cancer
Aphidicolins B32 is a diterpenoid compound discovered in the marine fungus Botryotinia fuckeliana, exhibiting cytotoxic activity against human bladder cancer cells. It inhibits the proliferation of T24 cells in the G0/G1 phase, with an IC₅₀ of 27.6 μM. Aphidicolins B32 holds potential for research in the field of cancer therapy .

HY-N10208

Aspericin C	Endogenous Metabolite	Cancer
Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC₅₀=14.6, 7.1, 61.4, and 24.2 μM, respectively) .

HY-N12726

Halociline	p38 MAPK MMP	Infection Inflammation/Immunology Cancer
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum. Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities .

HY-N12386

SIRT1 activator 1	Sirtuin	Cancer
SIRT1 activator 1(compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing SIRT1 expression levels and balancing the AMPK/Akt signaling pathway .

HY-W004261

Nonadecanoic acid	Endogenous Metabolite Interleukin Related Ser/Thr Protease Thrombin	Others
Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis. Nonadecanoic acid can be isolated from several sources, including fungus, plant, and marine sponge. Nonadecanoic acid exhibits inhibitory effects on fibrinolysis and plasmin activity. Nonadecanoic acid produced from Streptomyces is an anti-tumor agent and inhibits IL-12 production .

HY-119387

Chevalone B	Bacterial	Infection
Chevalone B was isolated from the ethyl acetate extract of the marine sponge-associated fungus Aspergillus similanensis. The structure of Chevalone B was confirmed by 1D and 2D NMR spectroscopy. Chevalone B showed antimicrobial activity against Gram-positive and Gram-negative bacteria, Candida albicans, and multidrug-resistant strains from the environment. Studies on Chevalone B have shown its potential value in antimicrobial applications.

HY-W004261R

Nonadecanoic acid (Standard)	Reference Standards Endogenous Metabolite Interleukin Related Ser/Thr Protease Thrombin	Others
Nonadecanoic acid (Standard) is the analytical standard of Nonadecanoic acid. This product is intended for research and analytical applications. Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis. Nonadecanoic acid can be isolated from several sources, including fungus, plant, and marine sponge. Nonadecanoic acid exhibits inhibitory effects on fibrinolysis and plasmin activity. Nonadecanoic acid produced from Streptomyces is an anti-tumor agent and inhibits IL-12 production .

HY-N12561

Pestanoid A	ERK p38 MAPK JNK	Others
Pestanoid A is a rearranged pimarane diterpenoid osteoclastogenesis inhibitor with an IC₅₀ of 4.2 μM. Pestanoid A can be isolated from the marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145. Pestanoid A inhibits the receptor activator of NF-kB ligand-induced MAPK and NF-κB signaling by suppressing the phosphorylation of ERK1/2-JNK1/2-p38 MAPKs and NF-κB nuclear translocation. Pestanoid A can be used for the study of osteoporosis .

HY-138098

Sartorypyrone B	Endogenous Metabolite	Cancer
Sartorypyrone B is a 2β-acetoxyl analogue of chevalone C. Sartorypyrone B is yielded from the ethyl acetate extract of the culture of the marine sponge-associated fungus Neosartorya tsunodae (KUFC 9213). Sartorypyrone B exhibits strong growth inhibitory activity, having GI₅₀s of 17.8, 20.5, and 25.0 μM, respectively, for MCF-7, NCI-H460, and A375-C5. Sartorypyrone B has the potential for the research of breast adenocarcinoma, non-small cell lung cancer, and melanoma diseases .

HY-N1791

3,5-Diprenyl-4-hydroxybenzaldehyde	Others	Infection
3, 5-diprenyl-4-hydroxybenzaldehyde is an isoprene phenyl butyl aldehyde. 3, 5-diprenyl-4-hydroxybenzaldehyde had the ability to inhibit biofilm formation in strains. 3, 5-diprenyl-4-hydroxybenzaldehyde can be used to study the potential synergistic effect of clinically relevant antibiotics .

Cat. No.	Product Name	Target	Research Area

HY-133801

Unguisin A	Peptides	Others
Unguisin A s a cyclic peptides that can be isolated from the marine-derived fungus Emericella unguis .

HY-125488

Unguisin B	Peptides	Others
Unguisin B s a cyclic peptides that can be isolated from the marine-derived fungus Emericella unguis .

Methyl mycophenolate	Structural Classification Monophenols Microorganisms Classification of Application Fields Marine natural products Phenols Inflammation/Immunology Disease Research Fields Marine microorganism	Others
Methyl mycophenolate is a methyl ester of mycophenolic acid and is also found in marine-derived fungus Phaeosphaeria spartinae .

6-Methoxyflavonol	Structural Classification Flavonols Flavonoids Microorganisms Source classification	Others
6-Methoxyflavonol (Compound 15) is a natural flavone isolated from the marine-derived fungus Aspergillus candidus .

Demethoxyfumitremorgin C	Structural Classification Alkaloids Microorganisms Source classification Marine natural products Other marine organisms Indole Alkaloids	Apoptosis Caspase PPAR
Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to PARP/ cleavage .

Varioxepine A	Infection Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Endogenous Metabolite
Varioxepine A is a 3H-oxepine-containing alkaloid with a new oxa-cage found in the marine algal-derived endophytic fungus Paecilomyces variotii. Varioxepine A inhibits plant pathogenic fungus Fusarium graminearum .

Variculanol	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Bacterial
Variculanol is an antimicrobial, anticancer and anti-HCV NS3/4A Protease agent which can be extracted from marine fungus Aspergillus versicolor .

Fiscalin C Ficalin C	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Others
Fiscalin C (Ficalin C) is an alkaloid and can be isolated from Stentrophomonas maltophilia .

Rostratin A	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Source classification Marine natural products Disease Research Fields Marine microorganism Cancer	Endogenous Metabolite
Rostratin A is a cytotoxic disulfide found in the marine-derived fungus Exserohilum rostratum. Rostratin A shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC₅₀ of 8.5 μg/mL .

Brevianamide M	Structural Classification Alkaloids Human Gut Microbiota Metabolites Microorganisms Other Alkaloids Source classification Endogenous metabolite	Bacterial
Brevianamide M (compound 4) is a metabolite of Aspergillus versicolor. This is an endophytic fungus isolated from the marine brown alga Sargassum. Brevianamide M has antimicrobial activity against Escherichia coli and Staphylococcus aureus .

1,3,5,6-Tetrahydroxy-8-methylxanthone	Structural Classification Flavonoids Microorganisms Xanthones Source classification Phenols Other Flavonoids	Others
1,3,5,6-Tetrahydroxy-8-methylxanthone (compound 8) is a dimeric 1,4-benzoquinone derivative isolated from the marine-derived fungus Penicillium genus .

Terrelumamide A	Alkaloids Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Marine natural products Endogenous metabolite Disease Research Fields Marine microorganism Endocrinology	Others
Terrelumamide A is a lumazine-containing peptide. Terrelumamide A is isolated from the culture broth of the marine-derived fungus Aspergillus terreus. Terrelumamide A exhibits pharmacological activity by improving insulin sensitivity. Terrelumamide A has the potential in the application of DNA sequence recognition .

2α,9α,11-Trihydroxy-6-oxodrim-7-ene	Other Terpenoids Structural Classification Microorganisms Terpenoids Source classification	Others
2α,9α,11-Trihydroxy-6-oxodrim-7-ene is a natural product that can be isolated from the culture medium of the marine-derived fungus Aspergillus insuetus .

Germicidin C	Structural Classification Natural Products Microorganisms Source classification	Bacterial
Germicidin C is a microbial metabolite with antibacterial activity, which is found in the marine sponge-derived fungus Aspergillus niger. Germicidin C can inhibit the growth of various pathogenic bacteria such as Staphylococcus aureus, Escherichia coli, and Bacillus subtilis with MIC values ranging from 32 to 64 µg/mL .

Asperflavin	Structural Classification Natural Products Microorganisms Source classification	NO Synthase TNF Receptor Interleukin Related
Asperflavin is an anti-inflammatory compound that can be produced by the marine fungus Eurotium amstelodami. Asperflavin inhibits the production of NO, PGE₂, and proinflammatory cytokines, as well as the expression of inducible NOS (iNOS) in RAW 264.7 cells treated with LPS (HY-D1056). Asperflavin can be used in the study of inflammatory diseases .

Nidulin Methylustin	Structural Classification Natural Products Microorganisms Source classification	Bacterial Fungal
Nidulin (Methylustin) is a depsidone isolated from a marine fungus Aspergillus unguis. Nidulin shows antifungal and antibacterial against pathogenetic strains, Pseudomonas aeruginosa, Methicillin-resistant Staphylococcus aureus and Candida albicans with inhibition zones of 9.5 mm, 9.0 mm and 9.0 mm, respectively. Nidulin exhibits potent larvicidality against brine shrimp .

Aphidicolins B32	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Others
Aphidicolins B32 is a diterpenoid compound discovered in the marine fungus Botryotinia fuckeliana, exhibiting cytotoxic activity against human bladder cancer cells. It inhibits the proliferation of T24 cells in the G0/G1 phase, with an IC₅₀ of 27.6 μM. Aphidicolins B32 holds potential for research in the field of cancer therapy .

Aspericin C	Natural Products Microorganisms Classification of Application Fields Source classification Marine natural products Disease Research Fields Marine microorganism Cancer	Endogenous Metabolite
Aspericin C is a pyran derivative found in the marine-derived fungus Rhizopus sp. 2-PDA-61. Aspericin C shows cytotoxic activities against P388, A549, HL-60, and BEL-7420 cell lines (IC₅₀=14.6, 7.1, 61.4, and 24.2 μM, respectively) .

Halociline	Structural Classification Microorganisms Marine natural products Source classification Phenols Marine microorganism	p38 MAPK MMP
Halociline, a derivative of alkaloids, that can be isolated from the marine fungus Penicillium griseofulvum. Halociline targets MAPK1, MMP-9, and PIK3CA in gastric cancer cells, potentially mediated by diverse pathways including cancer, lipid metabolism, atherosclerosis, and EGFR tyrosine kinase inhibitor resistance. Halociline possesses antimicrobial, antioxidant and biofilm inhibitory activities .

SIRT1 activator 1	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification Marine natural products Marine microorganism	Sirtuin
SIRT1 activator 1(compound 3) is a derivative of marine compound xyloallenoide A isolated from the mangrove fungus Xylaria sp.SIRT1 activator 1 shows angiogenic activities in zebrafish. SIRT1 activator 1 protects hEPC against AngII-induced senescence by increasing SIRT1 expression levels and balancing the AMPK/Akt signaling pathway .

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marine fungus

Inhibitors & Agonists

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