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Results for "

locked nucleic acid

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Biochemical Assay Reagents (1) DNA/RNA Synthesis (4) E1/E2/E3 Enzyme (2) HCV (1) Isotope-Labeled Compounds (1) MicroRNA (2) Nucleoside Antimetabolite/Analog (5) PCSK9 (4)
By Research Areas:	Cancer (1) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (1) Metabolic Disease (4)
Oligonucleotides:	Adenosine (1) Nucleoside Phosphoramidites (4) Guanosine (1) Nucleoside Analogs (3) Adenine (1) Thymidine (1) Cytosine (1) Antisense Oligonucleotides (8) Uracil (1) Guanine (1)

Inhibitors & Agonists

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: Amino acid Transporter Amino Acid Derivatives Amino Acid Decarboxylase Hydroxycarboxylic Acid Receptor (HCAR) Amino Acid Oxidase Free Fatty Acid Receptor Fatty Acid Synthase (FASN) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110407

2'-O,4'-C-Methyleneadenosine LNA-A	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Metabolic Disease
2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog .

HY-46317

DMT-5Me-dC(Bz)-CE Phosphoramidite	DNA/RNA Synthesis	Others
DMT-5Me-dC(Bz)-CE Phosphoramidite is used in the preparation of locked nucleic acids (LNAs) for optimization of fluorescent oligonucleotide probes with improved spectral properties and target binding .

HY-148506

5'-ODMT cEt m5U Phosphoramidite (Amidite)	Nucleoside Antimetabolite/Analog	Cardiovascular Disease
5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice .

HY-132598A

Miravirsen sodium SPC-3649 sodium	MicroRNA	Infection
Miravirsen sodium is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen sodium is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen sodium inhibits HCV replication, and can be used in research of HCV infection .

HY-111807

Locked nucleic acid 1	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Metabolic Disease
Locked nucleic acid 1 is a derivative of LNA-type nucleoside.

HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2	Isotope-Labeled Compounds	Cancer
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

HY-148689

SPC4061	PCSK9	Metabolic Disease
SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases .

HY-148689A

SPC4061 sodium	PCSK9	Metabolic Disease
SPC4061 an antisense nucleotide, sodium is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases .

HY-W800446

LNA-Guanosine 3'-CE phosphoramidite Lna-g amidite	Biochemical Assay Reagents	Others
LNA-Guanosine 3'-CE phosphoramidite (Lna-g amidite) is an essential building block to Locked Nucleic Acid (LNA) oligonucleotide synthesis, which includes a ribonucleoside linked by a methylene unit between the 2’-oxygen and 4’-carbon atoms, paralleling DNA polymer assembly.

HY-148687

SPC5001	PCSK9	Cardiovascular Disease
SPC5001 is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′ .

HY-148687A

SPC5001 sodium	PCSK9	Cardiovascular Disease
SPC5001 sodium is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 sodium can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′ .

HY-132598

Miravirsen SPC-3649	MicroRNA HCV	Infection Inflammation/Immunology
Miravirsen (SPC-3649) is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen inhibits HCV replication. Miravirsen can be used in research of HCV infection .

HY-W406070

2'-O,4'-C-Methyleneguanosine LNA-G	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Others
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analog, where LNA (locked nucleic acid) is a nucleic acid analog. LNA modification can be widely used in various fields, such as effective binding affinity with complementary sequences and stronger nuclease resistance than natural nucleotides, providing great potential for application in disease diagnosis and research. LNA-G can also be incorporated into the DNA chain by KOD DNA polymerase .

HY-148130A

Rugonersen sodium RG6091 sodium; RO7248824 sodium	E1/E2/E3 Enzyme	Others
Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-148130

Rugonersen RG6091; RO7248824	E1/E2/E3 Enzyme	Others
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-148503

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)	Nucleoside Antimetabolite/Analog	Others
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

Cat. No.	Product Name		Classification

HY-110407

2'-O,4'-C-Methyleneadenosine LNA-A		Nucleoside Analogs Adenosine
2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog .

HY-46317

DMT-5Me-dC(Bz)-CE Phosphoramidite		Nucleoside Phosphoramidites Cytosine
DMT-5Me-dC(Bz)-CE Phosphoramidite is used in the preparation of locked nucleic acids (LNAs) for optimization of fluorescent oligonucleotide probes with improved spectral properties and target binding .

HY-148506

5'-ODMT cEt m5U Phosphoramidite (Amidite)		Nucleoside Phosphoramidites Uracil
5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice .

HY-132598A

Miravirsen sodium SPC-3649 sodium		Antisense Oligonucleotides
Miravirsen sodium is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen sodium is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen sodium inhibits HCV replication, and can be used in research of HCV infection .

HY-148687A

SPC5001 sodium		Antisense Oligonucleotides
SPC5001 sodium is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 sodium can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′ .

HY-111807

Locked nucleic acid 1		Nucleoside Analogs Thymidine
Locked nucleic acid 1 is a derivative of LNA-type nucleoside.

HY-148689

SPC4061		Antisense Oligonucleotides
SPC4061 an antisense nucleotide, is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases .

HY-148689A

SPC4061 sodium		Antisense Oligonucleotides
SPC4061 an antisense nucleotide, sodium is a potent PCSK9 inhibitor. SPC4061 targets the lock-in nucleic acid (LNA) of PCSK9 for the study of hypercholesterolemia and related diseases .

HY-W800446

LNA-Guanosine 3'-CE phosphoramidite Lna-g amidite		Nucleoside Phosphoramidites Guanine
LNA-Guanosine 3'-CE phosphoramidite (Lna-g amidite) is an essential building block to Locked Nucleic Acid (LNA) oligonucleotide synthesis, which includes a ribonucleoside linked by a methylene unit between the 2’-oxygen and 4’-carbon atoms, paralleling DNA polymer assembly.

HY-148687

SPC5001		Antisense Oligonucleotides
SPC5001 is a locked nucleic acid (LNA)-modifed antisense oligonucleotide (ASO) complementary to human PCSK9 (proprotein convertase subtilisin/kexin type 9) mRNA. SPC5001 can be used for the research of hypercholesterolemia. SPC5001 sequence: 5′-TGmCTACAAAACmCmCA-3′ .

HY-132598

Miravirsen SPC-3649		Antisense Oligonucleotides
Miravirsen (SPC-3649) is a potent miR-122 inhibitor and inhibits the biogenesis of miR-122. Miravirsen is a 15-nucleotide locked nucleic acid-modified phosphorothioate antisense oligonucleotide. Miravirsen inhibits HCV replication. Miravirsen can be used in research of HCV infection .

HY-W406070

2'-O,4'-C-Methyleneguanosine LNA-G		Nucleoside Analogs Guanosine
2′-O,4′-C-Methyleneguanosine (LNA-G) is a reverse guanine analog, where LNA (locked nucleic acid) is a nucleic acid analog. LNA modification can be widely used in various fields, such as effective binding affinity with complementary sequences and stronger nuclease resistance than natural nucleotides, providing great potential for application in disease diagnosis and research. LNA-G can also be incorporated into the DNA chain by KOD DNA polymerase .

HY-148130A

Rugonersen sodium RG6091 sodium; RO7248824 sodium		Antisense Oligonucleotides
Rugonersen sodium is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) sodium is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-148130

Rugonersen RG6091; RO7248824		Antisense Oligonucleotides
Rugonersen (RG6091; RO7248824) is a locked-nucleic acid (LNA)- modified antisense oligonucleotides (ASOs), and results in reduction of ubiquitin-protein ligase E3A (UBE3A) silencing. Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of neuronal E3 ligase UBE3A, Rugonersen has been used for AS reasearch .

HY-148503

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)		Nucleoside Phosphoramidites Adenine
5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment .

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