lim kinase

By Targets:	LIM Kinase (LIMK) (11) Aurora Kinase (1) PKA (2) Reference Standards (1) Reverse Transcriptase (1) ROCK (5)
By Research Areas:	Cancer (7) Endocrinology (2) Infection (1) Neurological Disease (2)

Targets Recommended: LIM Kinase (LIMK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16563

Narciclasine Maximum Cited Publications 15 Publications Verification Lycoricidinol	ROCK	Cancer
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-19353

SR7826 1 Publications Verification	LIM Kinase (LIMK)	Neurological Disease Cancer
SR7826 is a class of bis-aryl urea derived potent, selective and orally active LIM kinase (LIMK) inhibitor with an IC₅₀ of 43 nM for LIMK1. SR7826 is >100-fold more selective for LIMK1 than ROCK and JNK kinases .

HY-151539

TH470	LIM Kinase (LIMK)	Neurological Disease
TH470 is a highly selective LIMK1/2 (LIM *kinase1/2) inhibitor (LIMK1 IC₅₀=9.8 nM; LIMK2 IC₅₀*=13 nM), and can be used in orphan disease research .

HY-120097

R-10015	LIM Kinase (LIMK) Reverse Transcriptase	Infection
R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC₅₀ of 38 nM for human LIMK1 .

HY-14227

LIMK-IN-1	LIM Kinase (LIMK) ROCK	Others
LIMK-IN-1 (Compound 14) is an inhibitor of LIM-Kinase (LIMK), with IC₅₀s of 0.5 nM and 0.9 nM for LIMK1 and LIMK2, respectively. LIMK-IN-1 can be used for ocular hypertension and associated glaucoma research .

HY-128062

LIMK1 inhibitor BMS-4	LIM Kinase (LIMK)	Cancer
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells .

HY-144438

*Aurora/LIM* kinase-IN-1**	Aurora Kinase LIM Kinase (LIMK)	Cancer
Aurora/LIM kinase-IN-1 (Compound F114) is a potent and dual inhibitor of aurora and *lim* kinase. Aurora kinases and lim kinases are involved in neoplastic cell division and cell motility, respectively. Aurora/LIM kinase-IN-1 inhibits GBM proliferation and invasion. Aurora/LIM kinase-IN-1 is a promising new scaffold for dual aurora/lim kinase inhibitors that may be used in future agent development efforts for GBM, and potentially other cancers .

HY-N8669

Curcolonol	LIM Kinase (LIMK)	Cancer
Curcolonol is a furan type sesquiterpene. Curcolonol can be isolated from several medical herbs. Curcolonol has inhibitory activity for LIM kinase 1. Curcolonol can be used for the research of breast cancer .

HY-W070753

LIMK1 inhibitor 2 WAY-248134	LIM Kinase (LIMK)	Cancer
LIMK1 inhibitor 2 (compound 41) is a LIMK1 inhibitor with the IC₅₀ of 9 μM .

HY-16563R

Narciclasine (Standard) Lycoricidinol (Standard)	Reference Standards ROCK	Cancer
Narciclasine (Standard) is the analytical standard of Narciclasine. This product is intended for research and analytical applications. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-12659

LX7101 2 Publications Verification	LIM Kinase (LIMK) ROCK PKA	Endocrinology
LX7101 is a potent *LIM-kinase, ROCK* and PKA inhibitor with IC₅₀s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 proves significantly selective for LIMK2 with IC₅₀ values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 has the potential for ocular hypertension and associated glaucoma research .

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

HY-12659B

LX7101 monohydrochloride	LIM Kinase (LIMK) ROCK PKA	Endocrinology
LX7101 monohydrochloride is a potent *LIM-kinase, ROCK* and PKA inhibitor with IC₅₀s of 24 nM, 1.6 nM, 10 nM and <1 nM for LIMK1, LIMK2, ROCK2 and PKA, respectively. LX7101 monohydrochloride proves significantly selective for LIMK2 with IC₅₀ values of 4.3 nM and 32 nM for LIMK2 and LIMK1 at 2 μM ATP, respectively. LX7101 monohydrochloride has the potential for ocular hypertension and associated glaucoma research .

Cat. No.	Product Name	Target	Research Area

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16563

Narciclasine 10+ Cited Publications Lycoricidinol	Structural Classification Alkaloids Classification of Application Fields Narcissus tazetta Linn. var. chinensis M.Roemer Source classification Plants Isoquinoline Alkaloids Amaryllidaceae Disease Research Fields Cancer Agricultural Research	ROCK
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-N8669

Curcolonol	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Curcuma phaeocaulis Valeton Zingiberaceae	LIM Kinase (LIMK)
Curcolonol is a furan type sesquiterpene. Curcolonol can be isolated from several medical herbs. Curcolonol has inhibitory activity for LIM kinase 1. Curcolonol can be used for the research of breast cancer .

HY-16563R

Narciclasine (Standard) Lycoricidinol (Standard)	Structural Classification Alkaloids Narcissus tazetta Linn. var. chinensis M.Roemer Source classification Plants Isoquinoline Alkaloids Amaryllidaceae	Reference Standards ROCK
Narciclasine (Standard) is the analytical standard of Narciclasine. This product is intended for research and analytical applications. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

Species:	Human (2)
Tag:	His (1) Tag Free (1)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P701792

	LIMK1 Protein, Human (D460N, sf9) limK1; lim domain kinase 1; limK-1	Human	Sf9 insect cells
	The LIMK1 protein is an important serine/threonine protein kinase that controls actin dynamics downstream of Rho GTPases. Activation of ROCK1, PAK1, and PAK4 phosphorylates LIMK1, allowing it to phosphorylate and inhibit actin depolymerizing factors, including cofilin-1/CFL1 and destrin/DSTN. LIMK1 Protein, Human (D460N, sf9) is the recombinant human-derived LIMK1 protein, expressed by sf9 insect cells , with tag free.

HY-P701793

	LIMK1 Protein, Human (D460N, sf9, His) limK1; lim domain kinase 1; limK-1	Human	Sf9 insect cells
	The LIMK1 protein is an important serine/threonine protein kinase that controls actin dynamics downstream of Rho GTPases. Activation of ROCK1, PAK1, and PAK4 phosphorylates LIMK1, allowing it to phosphorylate and inhibit actin depolymerizing factors, including cofilin-1/CFL1 and destrin/DSTN. LIMK1 Protein, Human (D460N, sf9, His) is the recombinant human-derived LIMK1 protein, expressed by sf9 insect cells , with N-8*His labeled tag.

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HY-P81941

	LIM Kinase 1 Antibody (YA1686) limK1; limK; lim domain kinase 1; limK-1	WB	Human, Mouse
	LIM Kinase 1 Antibody (YA1686) is a non-conjugated IgG antibody, targeting LIM Kinase 1, with a predicted molecular weight of 73 kDa (observed band size: 73 kDa). LIM Kinase 1 Antibody (YA1686) can be used for WB experiment in human, mouse background.

HY-P85864

	LIMK-1/2 Antibody (YA5556) lim domain kinase 1; limK-1;	WB, ICC/IF, ELISA	Human, Mouse, Rat
	LIMK-1/2 Antibody (YA5556) is a mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to LIMK-1/2. It can be applicated for WB, ICC/IF, ELISA assays, in the background of human, mouse, rat.

HY-P86944

	LIMK2 Antibody (YA6637) lim domain kinase 2 antibody; lim kinase 2 antibody; limK 2 antibody; limK-2 antibody; limk2 antibody; limK2_HUMAN antibody	WB, ICC/IF, IHC-P, IP	Human, Mouse, Rat, Monkey

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lim kinase

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