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Results for "

let-7

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Isomer (1) MicroRNA (91) Molecular Glues (2) Parasite (2)
By Research Areas:	Cancer (73) Infection (2) Neurological Disease (1)
Oligonucleotides:	miRNA mimics (24) miRNA agomirs (20) miRNA antagomirs (20) MicroRNAs (84) miRNA inhibitors (20)

Inhibitors & Agonists

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112659

*Lin28-let-7* antagonist 1**	MicroRNA	Neurological Disease Cancer
Lin28-let-7 antagonist 1 (compound 1632) is a potent antagonist of Lin28/pre-let-7 interaction. Lin28-let-7 antagonist 1 inhibits Lin28A binding to pre-let-7a-2, with an IC₅₀ of 8 μM. Lin28-let-7 antagonist 1 inhibits proliferation in human cancer cells .

HY-100692

*Lin28-let-7a antagonist 1* 2 Publications Verification	MicroRNA	Cancer
Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28-let-7a interaction with an IC₅₀ of 4.03 μM for Lin28A-let-7a-1 interaction.

HY-123905

LIN28 inhibitor LI71	MicroRNA Parasite	Infection Cancer
LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC₅₀: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC₅₀: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum .

HY-R00003

*hsa-let-7a-5p mimic*	MicroRNA	Cancer
hsa-let-7a-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7a-5p mimic hsa-let-7a-5p mimic

HY-177733

MG-Lin3	Molecular Glues MicroRNA	Cancer
Lin28 degrader MG-Lin3 is a molecular glucose degrading agent that targets the Lin28 protein. Lin28 degrader MG-Lin3 significantly reduces the Renilla luciferase signal at 100 µM. Lin28 degrader MG-Lin3 inhibits the maturation of tumor microRNA let-7. Lin28 degrader MG-Lin3 can be used for cancer research .

HY-177731

MG-Lin1	Molecular Glues MicroRNA	Cancer
Lin28 degrader MG-Lin1 is a molecular glucose degrading agent that targets the Lin28 protein. Lin28 degrader MG-Lin1 can significantly reduce the mRNA levels of let-7 targeting oncogenes. Lin28 degrader MG-Lin1 can significantly inhibit the migration ability of cancer cells. Lin28 degrader MG-Lin1 has no obvious cytotoxicity. Lin28 degrader MG-Lin1 can be used for cancer research .

HY-155237

LIN28-IN-1	MicroRNA	Cancer
LIN28-IN-1 (compound 5) is an inhibitor of the RNA-binding and regulatory protein LIN28 and binds to the LIN28 cold shock domain (CSD). LIN28-IN-1 effectively inhibits the interaction between LIN28 and let-7 miRNA (IC₅₀: 5.4 μM), blocking the negative impact of LIN28 on epigenetic gene regulation. LIN28-IN-1 significantly inhibits the proliferation of JAR cancer cells expressing LIN28 (IC₅₀: 6.4 μM) .

HY-R02560

*mmu-let-7j mimic*	MicroRNA	Cancer
mmu-let-7j mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7j mimic mmu-let-7j mimic

HY-R02561

*mmu-let-7k mimic*	MicroRNA	Cancer
mmu-let-7k mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7k mimic mmu-let-7k mimic

HY-R00002

*hsa-let-7a-3p mimic*	MicroRNA	Cancer
hsa-let-7a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7a-3p mimic hsa-let-7a-3p mimic

HY-R04633

*hsa-let-7d-5p mimic*	MicroRNA	Others
hsa-let-7d-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7d-5p mimic hsa-let-7d-5p mimic

HY-R00008

*hsa-let-7d-3p mimic*	MicroRNA	Cancer
hsa-let-7d-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7d-3p mimic hsa-let-7d-3p mimic

HY-R00007

*hsa-let-7c-5p mimic*	MicroRNA	Cancer
hsa-let-7c-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7c-5p mimic hsa-let-7c-5p mimic

HY-R00014

*hsa-let-7i-5p mimic*	MicroRNA	Cancer
hsa-let-7i-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7i-5p mimic hsa-let-7i-5p mimic

HY-R04616

*mmu-let-7i-5p mimic*	MicroRNA	Others
mmu-let-7i-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7i-5p mimic mmu-let-7i-5p mimic

HY-R00013

*hsa-let-7i-3p mimic*	MicroRNA	Cancer
hsa-let-7i-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7i-3p mimic hsa-let-7i-3p mimic

HY-R00004

*hsa-let-7b-3p mimic*	MicroRNA	Cancer
hsa-let-7b-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7b-3p mimic hsa-let-7b-3p mimic

HY-R00005

*hsa-let-7b-5p mimic*	MicroRNA	Cancer
hsa-let-7b-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7b-5p mimic hsa-let-7b-5p mimic

HY-R00006

*hsa-let-7c-3p mimic*	MicroRNA	Cancer
hsa-let-7c-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7c-3p mimic hsa-let-7c-3p mimic

HY-R04617

*mmu-let-7f-5p mimic*	MicroRNA	Others
mmu-let-7f-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7f-5p mimic mmu-let-7f-5p mimic

HY-R04623

*rno-let-7i-5p mimic*	MicroRNA	Others
rno-let-7i-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

rno-let-7i-5p mimic rno-let-7i-5p mimic

HY-R00009

*hsa-let-7e-3p mimic*	MicroRNA	Cancer
hsa-let-7e-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7e-3p mimic hsa-let-7e-3p mimic

HY-R00012

*hsa-let-7g-5p mimic*	MicroRNA	Cancer
hsa-let-7g-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7g-5p mimic hsa-let-7g-5p mimic

HY-RI02561

*mmu-let-7k inhibitor*	MicroRNA	Cancer
mmu-let-7k inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-let-7k inhibitor mmu-let-7k inhibitor

HY-RI02560

*mmu-let-7j inhibitor*	MicroRNA	Cancer
mmu-let-7j inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-let-7j inhibitor mmu-let-7j inhibitor

HY-R02557

*mmu-let-7a-1-3p mimic*	MicroRNA	Cancer
mmu-let-7a-1-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7a-1-3p mimic mmu-let-7a-1-3p mimic

HY-R02558

*mmu-let-7a-2-3p mimic*	MicroRNA	Cancer
mmu-let-7a-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7a-2-3p mimic mmu-let-7a-2-3p mimic

HY-R00001

*hsa-let-7a-2-3p mimic*	MicroRNA	Cancer
hsa-let-7a-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7a-2-3p mimic hsa-let-7a-2-3p mimic

HY-R02559

*mmu-let-7f-2-3p mimic*	MicroRNA	Cancer
mmu-let-7f-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-let-7f-2-3p mimic mmu-let-7f-2-3p mimic

HY-R00010

*hsa-let-7f-1-3p mimic*	MicroRNA	Cancer
hsa-let-7f-1-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7f-1-3p mimic hsa-let-7f-1-3p mimic

HY-R04205

*rno-let-7f-1-3p mimic*	MicroRNA	Cancer
rno-let-7f-1-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

rno-let-7f-1-3p mimic rno-let-7f-1-3p mimic

HY-R00011

*hsa-let-7f-2-3p mimic*	MicroRNA	Cancer
hsa-let-7f-2-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-let-7f-2-3p mimic hsa-let-7f-2-3p mimic

HY-123905A

LIN28 inhibitor LI71 enantiomer	Drug Isomer MicroRNA Parasite	Infection Cancer
LIN28 inhibitor LI71 enantiomer is the less active enantiomer of LIN28 inhibitor LI71 (HY-123905). LIN28 inhibitor LI71 is a LIN28 inhibitor that effectively inhibits LIN28:let-7 binding (IC₅₀: 7 μM). LIN28 inhibitor LI71 can abolish LIN28-mediated oligouridylation of let-7 precursor (IC₅₀: 27 μM). LIN28 inhibitor LI71 has potential application value in LIN28-driven cancer research. LIN28 inhibitor LI71 inhibits the interaction of cold shock protein of Plasmodium falciparum (PfCoSP) with DNA and α/β tubulin and has an inhibitory effect on Plasmodium falciparum .

HY-R02561A

*mmu-let-7k agomir*	MicroRNA	Cancer
mmu-let-7k agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-let-7k agomir mmu-let-7k agomir

HY-R02560A

*mmu-let-7j agomir*	MicroRNA	Cancer
mmu-let-7j agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-let-7j agomir mmu-let-7j agomir

HY-RI00002

*hsa-let-7a-3p inhibitor*	MicroRNA	Cancer
hsa-let-7a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7a-3p inhibitor hsa-let-7a-3p inhibitor

HY-RI00003

*hsa-let-7a-5p inhibitor*	MicroRNA	Cancer
hsa-let-7a-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7a-5p inhibitor hsa-let-7a-5p inhibitor

HY-RI00014

*hsa-let-7i-5p inhibitor*	MicroRNA	Cancer
hsa-let-7i-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7i-5p inhibitor hsa-let-7i-5p inhibitor

HY-RI00012

*hsa-let-7g-5p inhibitor*	MicroRNA	Cancer
hsa-let-7g-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7g-5p inhibitor hsa-let-7g-5p inhibitor

HY-RI00005

*hsa-let-7b-5p inhibitor*	MicroRNA	Cancer
hsa-let-7b-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7b-5p inhibitor hsa-let-7b-5p inhibitor

HY-RI00004

*hsa-let-7b-3p inhibitor*	MicroRNA	Cancer
hsa-let-7b-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7b-3p inhibitor hsa-let-7b-3p inhibitor

HY-RI00009

*hsa-let-7e-3p inhibitor*	MicroRNA	Cancer
hsa-let-7e-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7e-3p inhibitor hsa-let-7e-3p inhibitor

HY-RI00008

*hsa-let-7d-3p inhibitor*	MicroRNA	Cancer
hsa-let-7d-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7d-3p inhibitor hsa-let-7d-3p inhibitor

HY-RI00006

*hsa-let-7c-3p inhibitor*	MicroRNA	Cancer
hsa-let-7c-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7c-3p inhibitor hsa-let-7c-3p inhibitor

HY-RI00013

*hsa-let-7i-3p inhibitor*	MicroRNA	Cancer
hsa-let-7i-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7i-3p inhibitor hsa-let-7i-3p inhibitor

HY-RI00007

*hsa-let-7c-5p inhibitor*	MicroRNA	Cancer
hsa-let-7c-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7c-5p inhibitor hsa-let-7c-5p inhibitor

HY-RI00001

*hsa-let-7a-2-3p inhibitor*	MicroRNA	Cancer
hsa-let-7a-2-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-let-7a-2-3p inhibitor hsa-let-7a-2-3p inhibitor

HY-RI02558

*mmu-let-7a-2-3p inhibitor*	MicroRNA	Cancer
mmu-let-7a-2-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-let-7a-2-3p inhibitor mmu-let-7a-2-3p inhibitor

HY-RI02557

*mmu-let-7a-1-3p inhibitor*	MicroRNA	Cancer
mmu-let-7a-1-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-let-7a-1-3p inhibitor mmu-let-7a-1-3p inhibitor

HY-RI02559

*mmu-let-7f-2-3p inhibitor*	MicroRNA	Cancer
mmu-let-7f-2-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-let-7f-2-3p inhibitor mmu-let-7f-2-3p inhibitor

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