Search Result
Results for "
iodine
" in MedChemExpress (MCE) Product Catalog:
5
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-W441271
-
-
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- HY-B2234
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iodopovidone
|
Bacterial
|
Infection
|
Povidone iodine (iodopovidone) displays excellent antibacterial activity which can against MRSA and MSSA strains with MICs of 31.25 mg/L and 7.82 mg/L, respectively.
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- HY-D1054
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Cyanine2 (iodine)
|
Fluorescent Dye
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Others
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Cy2 iodine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .
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- HY-D0826
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Cyanine2 Succinimidyl Ester (iodine)
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Fluorescent Dye
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Others
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Cy2-SE iodine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .
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- HY-108775A
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Sodium hyposulfite (99%, water≤1.0%)
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Biochemical Assay Reagents
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Others
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Sodium thiosulfate (99%, water≤1.0%) (Sodium hyposulfite (99%, water≤1.0%)) can be used for the titrimetric determination of elemental iodine and for the detection of trace cysteine. Sodium thiosulfate (99%, water≤1.0%) is a kind of biological materials or organic compounds that are widely used in life science research .
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- HY-130982
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620 (HY-133137). SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM .
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- HY-169395
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E3 Ligase Ligand-Linker Conjugates
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Cancer
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(S,R,S)-AHPC-CO-PEG-C2-iodine is an E3 ligase (VHL) ligand-linker conjugate, and can be used for synthesis of PROTACs, such as PROTAC FAK degrader 1 (HY-119932)
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- HY-N0224A
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(S)-Goitrin; L-5-Vinyl-2-thiooxazolidone
|
Influenza Virus
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Metabolic Disease
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Goitrin ((S)-Goitrin), a product of glucosinolate-myrosinase reactions, is a potent inhibitor of thyroid peroxidase. Goitrin can inhibit iodine utilization by the thyroid. Goitrin also exhibits anti-influenza virus (H1N1) activity .
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- HY-133846
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Thyroid Hormone Receptor
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Cancer
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Iodothiouracil exhibits high selectivity for melanoma, remains stable in the melanin in melanoma cells, and localizes remote secondary metastases of melanoma. Iodothiouracil can be used for melanoma imaging when labeled with iodine-123, and can be used for radiation therapy when labeled with iodine-131 .
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- HY-W348170
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Biochemical Assay Reagents
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Others
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tert-Butyl((5-iodopentyl)oxy)dimethylsilane is a silane compound with a terminal iodine group. The trimethylsilane is commonly used for surface modifications. The iodine (I) is a very good leaving group for nucleophilic substitution reactions.
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- HY-B1426
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- HY-W053842
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Biochemical Assay Reagents
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Others
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tert-Butyl 3-iodopropylcarbamate is a compound with a t-butyl and a terminal iodine. The iodine (I) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.
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- HY-W248726
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Biochemical Assay Reagents
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Others
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tert-Butyl (6-iodohexyl)carbamate is a six carbon linker containing an iodine group and a t-butyl ester. The iodine (I) acts as a good leaving group for nucleophilic substitution reactions. The t-butyl ester groups can be deprotected under acidic conditions.
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- HY-B1362
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- HY-W092078
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Biochemical Assay Reagents
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Others
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tert-Butyl (4-iodobutyl)carbamate is a four carbon linker containing a Boc-protected amino group and an iodine group. The Boc group can be deprotected under mild acidic conditions to form the free amine. Iodine (I) is a very good leaving group for nucleophilic substitution reactions.
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- HY-W460133
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Biochemical Assay Reagents
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Others
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tert-Butyl (2-(2-(2-iodoethoxy)ethoxy)ethyl)carbamate is a PEG linker containing a Boc protected amine and an iodine group. The protected amine can be deprotected under mild acidic conditions. Iodine (I) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.
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- HY-W586331
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Ligands for E3 Ligase
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Cancer
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Thalidomide-iodo is an iodinated E3 ligase activator. Thalidomide-iodo can be used for further derivitization by substitution of iodine.
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- HY-B1362S
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-
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- HY-B1362R
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Biochemical Assay Reagents
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Cardiovascular Disease
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Iopromide (Standard) is the analytical standard of Iopromide. This product is intended for research and analytical applications. Iopromide is a non-ionic, monomeric, iodine-based contrast medium for intravascular administration.
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- HY-B1620
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PVP K30; Polyvidone K30; Povidone K30
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Biochemical Assay Reagents
|
Infection
|
Polyvinylpyrrolidone K30 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds.
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- HY-W076313
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Ligands for E3 Ligase
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Cancer
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2-(2,6-Dioxopiperidin-3-yl)-4-iodoisoindoline-1,3-dione is a derivative of Thalidomide with an iodine atom on the benzyl ring
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- HY-B1620I
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PVP K120; Polyvidone K120; Povidone K120
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Biochemical Assay Reagents
|
Infection
|
Polyvinylpyrrolidone K120 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds .
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- HY-149132
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DDA
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LXR
|
Cancer
|
Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC50 of 4.1 and 6.2 µM. Dendrogenin A arrests the cell cycle at G0/G1 phase .
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- HY-131556
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p-Iodoamphetamine hydrochloride
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5-HT Receptor
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Neurological Disease
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4-Iodoamphetamine (p-Iodoamphetamine) hydrochloride is a halogenated amphetamine featuring an iodine atom at the para position of the phenyl group. 4-Iodoamphetamine hydrochloride selectively induces serotonin release and inhibits reuptake by rat brain synaptosomes.
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- HY-B1796
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Fungal
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Infection
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Thymol iodide is a compound of Iodide and Thymol. Thymol iodide acts as a substitute for iodoform . Thymol iodide is an iodine derivative of Thymol (a phenol derived from thyme oil), which is mostly used as mild antiseptic and fungicide .
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- HY-W075603
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2,6-Diiodo-Pyrromethene 546; 2,6-Diiodo-BDP 493/503 lipid stain
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Fluorescent Dye
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Others
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2,6-Diiodo-BODIPY 493/503 is an F-Bodipy fluorescent dye with diiodo substitution at the (pyrrole) 2,6 position. 2,6-Diiodo-BODIPY 493/503 has a pyrrole iodine substituent that turns it red .
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- HY-W251756
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Biochemical Assay Reagents
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Others
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3-(2-Iodoethoxy)prop-1-yne is a crosslinker that can be used in copper catalyzed azide-alkyne Click Chemistry to form a stable triazole linkage with azides. The iodine (I) acts as a good leaving group for nucleophilic substitution reactions.
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- HY-114918
-
|
TSH Receptor
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Endocrinology
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MS438 is a potent thyrotropin receptor (TSHR) agonist with an EC50 of 53 nM. MS438 binds to the serpentine portion of the TSHR. MS438 induces T4 secretion in mice .
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- HY-P99566
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ST2146
|
Transmembrane Glycoprotein
|
Cancer
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Tenatumomab (ST2146) is a murine monoclonal antibody against tenascin-C. And tenascin-C, the large extracellular glycoprotein, is overexpressed in cancer. Tenatumomab has been used for Pretargeted Antibody Guided Radioimmunoresearch (PAGRIT), and delivering radionuclides to tumors via PAGRIT and direct 131Iodine labeling approach .
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- HY-114994
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|
TSH Receptor
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Endocrinology
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MS437 is a potent TSH receptor (TSHR) stimulator with an EC50 value of 13x10 -8 M. MS437 shows potent activation of Gsα, Gαq and Gα12 and up-regulation of thyroglobulin (Tg), sodium iodine symporter (NIS) and TSHR gene expressions .
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- HY-117953
-
|
Prostaglandin Receptor
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Endocrinology
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RU 59063 is an N-substituted arylthiohydantoin compound with antiandrogenic activity and high relative binding affinity for the rat androgen receptor. RU 59063 is a nonsteroidal androgen receptor that functions as a radioactive AR radioprobe (Ki: 0.71 nM, rAR) when its trifluoromethyl group is replaced by a similar hydrophobic iodine atom .
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- HY-107903
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Thyroglobulin from bovine
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Biochemical Assay Reagents
|
Cancer
|
Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle .
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- HY-W403732
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Biochemical Assay Reagents
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Others
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8-Iodooct-7-yn-1-ol comprises an iodo-propargyl group attached to a 6-carbon tail with a terminal hydroxyl group. The iodine (I) acts as a good leaving group for nucleophilic substitution reactions. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.
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- HY-W400574
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6-Iodo-1-Hexanol
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Biochemical Assay Reagents
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Others
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6-Iodohexan-1-ol (6-Iodo-1-Hexanol) comprises an Iodo group attached to a 6-carbon tail with a terminal hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The iodine (I) acts as a good leaving group for nucleophilic substitution reactions.
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- HY-B1620H
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PVP K90; Polyvidone K90; Povidone K90
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Biochemical Assay Reagents
|
Infection
|
Polyvinylpyrrolidone K90 can be used to prepare drug delivery systems, such as electrospun nanofibrous membranes. Polyvinylpyrrolidone K90 is widely used in human and veterinary medicine as an effective wound healing promoter and disinfectant when combined with iodine and other compounds. In addition, Polyvinylpyrrolidone K90 is also used to stabilize nanosuspensions, interact with the surface of drug crystals, and remain bound to the surface after drying .
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-
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- HY-155446
-
|
Others
|
Inflammation/Immunology
Cancer
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di-DTPA-LTL is a bivalent hapten based on tyrosine-containing polypeptide design. di-DTPA-LTL has good hydrophilia and biological distribution. di-DTPA-LTL is labeled with 111In (indium) and 131I (iodine). di-DTPA-LTL achieves tumor radioimmunoimaging in primary colorectal cancer patients with CEA by injecting a fixed low dose (5 mg) of bispecific antibody (anti-CEA x, anti-DTPA) and di-DTPA antigen peptide (labeled 111In) into the patients .
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- HY-14998
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MK 185
|
β-catenin
PPAR
Wnt
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Endocrinology
|
Halofenate, structurally akin to clofibrate, was evaluated in hypertriglyceridemic patients over 6-week periods in a controlled, double-blind crossover trial. It effectively reduced serum triglycerides by 50%, with minimal impact on serum cholesterol levels. Additionally, it lowered serum uric acid by 30% and exhibited uricosuric effects independent of glomerular filtration rate. Halofenate was associated with a significant increase in plasma thyroxine (T4), accompanied by a decrease in protein-bound iodine and T4 by column. In vitro studies confirmed its ability to displace T4 from thyroid-binding proteins, suggesting a thyroxine-displacing effect, which could influence thyroid function in vivo .
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-
Cat. No. |
Product Name |
Type |
-
- HY-D1054
-
Cyanine2 (iodine)
|
Fluorescent Dyes/Probes
|
Cy2 iodine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .
|
-
- HY-D0826
-
Cyanine2 Succinimidyl Ester (iodine)
|
Protein Labeling
|
Cy2-SE iodine is a CY dye. CY, short for Cyanine, is a compound consisting of two nitrogen atoms connected by an odd number of methyl units. Cyanine compounds have the characteristics of long wavelength, adjustable absorption and emission, high extinction coefficient, good water solubility and relatively simple synthesis . CY dyes are of en used for the labeling of proteins, antibodies and small molecular compounds. For the labeling of protein antibodies, the combination can be completed through a simple mixing reaction. Below, we introduce the labeling method of protein antibody labeling, which has certain reference significance .
|
-
- HY-W075603
-
2,6-Diiodo-Pyrromethene 546; 2,6-Diiodo-BDP 493/503 lipid stain
|
Fluorescent Dyes/Probes
|
2,6-Diiodo-BODIPY 493/503 is an F-Bodipy fluorescent dye with diiodo substitution at the (pyrrole) 2,6 position. 2,6-Diiodo-BODIPY 493/503 has a pyrrole iodine substituent that turns it red .
|
Cat. No. |
Product Name |
Type |
-
- HY-108775A
-
Sodium hyposulfite (99%, water≤1.0%)
|
Buffer Reagents
|
Sodium thiosulfate (99%, water≤1.0%) (Sodium hyposulfite (99%, water≤1.0%)) can be used for the titrimetric determination of elemental iodine and for the detection of trace cysteine. Sodium thiosulfate (99%, water≤1.0%) is a kind of biological materials or organic compounds that are widely used in life science research .
|
-
- HY-B1620
-
PVP K30; Polyvidone K30; Povidone K30
|
Thickeners
|
Polyvinylpyrrolidone K30 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds.
|
-
- HY-B1620I
-
PVP K120; Polyvidone K120; Povidone K120
|
Thickeners
|
Polyvinylpyrrolidone K120 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds .
|
-
- HY-107903
-
Thyroglobulin from bovine
|
Native Proteins
|
Thyroglobulin is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland. Thyroglobulin acts as a substrate for the synthesis of the thyroid hormones thyroxine (T4) and triiodothyronine (T3), as well as the storage of the inactive forms of thyroid hormone and iodine within the follicular lumen of a thyroid follicle .
|
-
- HY-B1620H
-
PVP K90; Polyvidone K90; Povidone K90
|
Thickeners
|
Polyvinylpyrrolidone K90 can be used to prepare drug delivery systems, such as electrospun nanofibrous membranes. Polyvinylpyrrolidone K90 is widely used in human and veterinary medicine as an effective wound healing promoter and disinfectant when combined with iodine and other compounds. In addition, Polyvinylpyrrolidone K90 is also used to stabilize nanosuspensions, interact with the surface of drug crystals, and remain bound to the surface after drying .
|
Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P99566
-
ST2146
|
Transmembrane Glycoprotein
|
Cancer
|
Tenatumomab (ST2146) is a murine monoclonal antibody against tenascin-C. And tenascin-C, the large extracellular glycoprotein, is overexpressed in cancer. Tenatumomab has been used for Pretargeted Antibody Guided Radioimmunoresearch (PAGRIT), and delivering radionuclides to tumors via PAGRIT and direct 131Iodine labeling approach .
|
Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N0224A
-
-
-
- HY-149132
-
DDA
|
Triterpenes
Structural Classification
Terpenoids
Source classification
Endogenous metabolite
|
LXR
|
Dendrogenin A (DDA) is a ligand for liver X receptor (LXR), that induces the expression of sodium/iodine symporter, and increases iodine uptake. Dendrogenin A induces cell differentiation of MCF-7, and reactivates the function of lactating cells. Dendrogenin A induces the expressions of the TSH receptor, thyroid peroxidase, and thyroglobulin, and affects thyroid hormone generation. Dendrogenin A exhibits cytotoxicity in cancer cell B-CPAP and 8505c with IC50 of 4.1 and 6.2 µM. Dendrogenin A arrests the cell cycle at G0/G1 phase .
|
-
Cat. No. |
Product Name |
Chemical Structure |
-
- HY-B1362S
-
|
Iopromide-d3 is the deuterium labeled Iopromide. Iopromide is a non-ionic, monomeric, iodine-based contrast medium for intravascular administration.
|
-
Cat. No. |
Product Name |
|
Classification |
-
- HY-B1620
-
PVP K30; Polyvidone K30; Povidone K30
|
|
Disintegrants
Suspending Agents
|
Polyvinylpyrrolidone K30 is a compound which has been widely tested and used in human and veterinary medicine as an effective wound healing accelerator and disinfectant when combined with iodine and other compounds.
|
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