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Results for "

inositol phosphates

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (5) Amyloid-β (1) Apoptosis (2) Autophagy (1) Bradykinin Receptor (1) Calcium Channel (3) CaSR (2) DAPK (1) DNA/RNA Synthesis (1) DYRK (1) EGFR (1) Endogenous Metabolite (3) Guanylate Cyclase (1) IPK Superfamily (2) Isotope-Labeled Compounds (2) MEK (1) mGluR (1) Mitosis (2) P2Y Receptor (2) PDGFR (3) Phospholipase (2) Prostaglandin Receptor (1) Protease Activated Receptor (PAR) (1) Reference Standards (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (6) Endocrinology (2) Inflammation/Immunology (1) Metabolic Disease (5) Neurological Disease (7)

By Targets:

5-HT Receptor (5)

Amyloid-β (1)

Apoptosis (2)

Autophagy (1)

Bradykinin Receptor (1)

Calcium Channel (3)

CaSR (2)

DAPK (1)

DNA/RNA Synthesis (1)

DYRK (1)

EGFR (1)

Endogenous Metabolite (3)

Guanylate Cyclase (1)

IPK Superfamily (2)

Isotope-Labeled Compounds (2)

MEK (1)

mGluR (1)

Mitosis (2)

P2Y Receptor (2)

PDGFR (3)

Phospholipase (2)

Prostaglandin Receptor (1)

Protease Activated Receptor (PAR) (1)

Reference Standards (1)

By Research Areas:

Cancer (6)

Cardiovascular Disease (6)

Endocrinology (2)

Inflammation/Immunology (1)

Metabolic Disease (5)

Neurological Disease (7)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: IRE1 Sodium Phosphate Cotransporter Carbamoyl Phosphate Synthetase (CPS) Glucose-6-Phosphate Isomerase (GPI)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2581

Phytic acid sodium salt 1 Publications Verification myo-inositol, hexakis(dihydrogen phosphate) sodium salt; inositol hexaphosphate sodium salt	Endogenous Metabolite Amyloid-β Autophagy	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphate) is an orally active compound derived from the seeds of legumes. Phytic acid sodium salt is a [PO4] ³- storage depot and precursor for other **inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant. Phytic acid sodium salt attenuates Aβ oligomers and upregulates autophagy** protein. Phytic acid sodium salt can be used in cardiovascular disease, metabolic disease, nervous system disease and cancer research .

HY-P3061

[Hyp3]-Bradykinin	Bradykinin Receptor	Cardiovascular Disease Endocrinology
[Hyp3]-Bradykinin, naturally occurring peptide hormone, is a bradykinin receptor agonist. [Hyp3]-Bradykinin interacts with B2-bradykinin receptors and stimulates inositol phosphate production in cultured human fibroblasts .

HY-118010A

(+)-Norfenfluramine hydrochloride	5-HT Receptor	Cardiovascular Disease
(+)-Norfenfluramine hydrochloride, a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT_2B receptor agonist (K_i: 11.2 nM). (+)-Norfenfluramine hydrochloride potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca ²⁺. (+)-Norfenfluramine hydrochloride can be used for the research of primary pulmonary hypertension and valvular heart disease .

HY-P10270

PDGFR Y1021 peptide (phosphorylation)	PDGFR Mitosis	Others
PDGFR Y1021 peptide (phosphorylation) is the phosphorylated fragment of platelet-derived growth factor receptor (PDGFR). PDGFR Y1021 peptide (phosphorylation) supports association of PLCγ to PDGFR through PLCγSH2 domains, and thus promotes the production of inositol phosphates and mitogenic response .

HY-137608A

Uridine 5'-O-thiodiphosphate trisodium UDP-β-S trisodium	P2Y Receptor DNA/RNA Synthesis	Cardiovascular Disease
Uridine 5'-O-thiodiphosphate (trisodium) (UDP-β-S (trisodium)) is a purinergic P2Y6 receptor agonist. Uridine 5'-O-thiodiphosphate (trisodium) selectively induces accumulation of inositol phosphates in 1321N1 cells expressing P2Y6 receptors (EC₅₀ = 28 nM). Uridine 5'-O-thiodiphosphate (trisodium) induces DNA synthesis in rat aortic smooth muscle cells .

HY-172573

D-myo-Inositol-2,3,5,6-tetraphosphate tetrasodium 2,3,5,6-IP4 tetrasodium; Ins(2,3,5,6)-P4 tetrasodium	Calcium Channel	Others
D-myo-Inositol-2,3,5,6-tetraphosphate (2,3,5,6-IP4) tetrasodium is a inositol phosphate. D-myo-Inositol-2,3,5,6-tetraphosphate tetrasodium can be used for the study of calcium channels .

HY-N2581R

Phytic acid sodium salt (Standard) myo-inositol, hexakis(dihydrogen phosphate) sodium salt (Standard); inositol hexaphosphate sodium salt (Standard)	Reference Standards Endogenous Metabolite	Others
Phytic acid (sodium salt) (Standard) is the analytical standard of Phytic acid (sodium salt). This product is intended for research and analytical applications. Phytic acid sodium salt (myo-Inositol; hexakis dihydrogen phosphate; Inositol hexaphosphat) is often present in legume seeds with antinutritional effects. Phytic acid sodium salt is a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. phytic acid is hydrolyzed by phytases in a stepwise manner in the plant .

HY-P10119

PDGFR Y1021 peptide (non-phosphorylation)	PDGFR Mitosis	Others
PDGFR Y1021 peptide (non-phosphorylation) is the non-phosphorylated fragment of platelet-derived growth factor receptor (PDGFR). PDGFR Y1021 peptide (non-phosphorylation) blocks the PLCγ association to PDGFR through PLCγSH2 domain, and thus inhibits mitogenic response .

HY-175476

UNC7437	IPK Superfamily	Cancer
UNC7437 is a inositol phosphate multikinase (IPMK) inhibitor, with an IC₅₀ value of 26.2 nM. UNC7437 exhibits anti-proliferative activity against glioblastoma cells. UNC7437 decreases the accumulation of InsP₄, InsP₅, and InsP₆ in cells. UNC7437 can be used for the study of TEN-negative glioblastoma models .

HY-125150

AL-3138 11-Deoxy-16-fluoro PGF2α	Prostaglandin Receptor Endogenous Metabolite	Endocrinology
AL-3138 (11-Deoxy-16-fluoro PGF2α) is a prostaglandin F2 alpha (PGF2alpha) analogue that antagonises FP prostaglandin receptor-mediated inositol phosphate production .

HY-W131725

(+)-Norfenfluramine	5-HT Receptor	Cardiovascular Disease
(+)-Norfenfluramine a major hepatic metabolite of (+)-fenfluramine, is a selective 5-HT_2B receptor agonist (K_i: 11.2 nM). (+)-Norfenfluramine potently stimulates the hydrolysis of inositol phosphates and increases intracellular Ca ²⁺. (+)-Norfenfluramine can be used for the research of primary pulmonary hypertension and valvular heart disease .

HY-120985

Araguspongin B	Calcium Channel	Neurological Disease
Xestospongins and araguspongins are marine natural products first isolated from Pacific basin sponges, and noted to have vasodilatory properties.1 Inositol phosphates (IP) are important signal transduction messengers acting via IP3 receptors to promote the mobilization of Ca2+ from intracellular stores.2 Araguspongin B antagonizes the calcium-releasing action of inositol 1,4,5-trisphosphate at the receptor level in cerebral microsomes, with an IC₅₀ of 0.6 μM. It is nearly as potent as xestospongin C as an antagonist of the IP3 receptor.

HY-146874S

D-myo-Inositol, 1-[(2R)-3-[(1-oxoheptadecyl)oxy]-2-[[(9Z)-1-oxo-9-hexadecen-1-yl]oxy]propyl hydrogen phosphate], ammonium salt (1:1)	Isotope-Labeled Compounds	Others
D-myo-Inositol, 1-[(2R)-3-[(1-oxoheptadecyl)oxy]-2-[[(9Z)-1-oxo-9-hexadecen-1-yl]oxy]propyl hydrogen phosphate]-d₅, ammonium salt (1:1) is an isotopically labeled compound.

HY-146873S

D-myo-Inositol, 1-[(2R)-3-[(1-oxoheptadecyl)oxy]-2-[[(9Z)-1-oxo-9-tetradecen-1-yl]oxy]propyl hydrogen phosphate], ammonium salt (1:1)	Isotope-Labeled Compounds	Others
D-myo-Inositol, 1-[(2R)-3-[(1-oxoheptadecyl)oxy]-2-[[(9Z)-1-oxo-9-tetradecen-1-yl]oxy]propyl hydrogen phosphate]-d₅, ammonium salt (1:1) is an isotopically labeled compound.

HY-103320

Calhex 231	CaSR	Metabolic Disease
Calhex 231 is a potent negative allosteric modulator that blocks (IC₅₀ = 0.39 μM) increases in [ ³H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca ²⁺-sensing receptor. Calhex 231 can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM) .

HY-103320A

Calhex 231 hydrochloride Maximum Cited Publications 7 Publications Verification	CaSR	Metabolic Disease
Calhex 231 hydrochloride is a potent negative allosteric modulator that blocks (IC₅₀ = 0.39 μM) increases in [ ³H]inositol phosphates elicited by activating the human wild-type CaSR transiently Ca ²⁺-sensing receptor. Calhex 231 hydrochloride can be used in the study of traumatic hemorrhagic shock (THS) and diabetic cardiomyopathy (DCM) .

HY-P4987

TRAP-7	Protease Activated Receptor (PAR)	Cardiovascular Disease
TRAP-7 is a thrombin receptor (PAR) activating peptide. TRAP-7 stimulates total inositol phosphate (IP) accumulation and phosphorylation of a specific endogenous substrate for activated PKC. TRAP-7 can be used in cardiovascular disease research .

HY-172570

D-myo-Inositol-1,2,3,5-tetraphosphate tetrasodium Ins(1,2,3,5,6)-P5 tetrasodium; 1,2,3,5,6-IP5 tetrasodium	Calcium Channel	Others
D-myo-inositol-1,2,3,5-tetraphosphate (Ins(1,2,3,5,6)-P5) tetrasodium is one of the Inositol phosphate isomers and can act as a soluble second messenger to participate in cellular calcium signaling .

HY-175477

UNC9750	DAPK DYRK PDGFR IPK Superfamily	Cancer
UNC9750 is an inositol phosphate multikinase (IPMK) inhibitor with IC₅₀ values of 31.6 and 374 nM for IPMK and IP6K2, respectively.. UNC9750 inhibits cellular accumulation of InsP₅, the direct product of IPMK kinase activity, while having no effect on either InsP6 or InsP₇ levels. UNC9750 has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR). UNC9750 can be used for the study of glioblastoma .

HY-125641A

AL-34662 formate	5-HT Receptor	Neurological Disease
AL-34662 (formate) is a 5-HT₂ receptor agonist (IC₅₀: 0.8-1.5 nM). AL-34662 (formate) stimulates inositol phosphate turnover and Ca ²⁺ release in human ciliary muscle cells (h-CM) (E₅₀: 289 nM) and human trabecular meshwork cells (h-TM) (E₅₀: 254 nM). AL-34662 (formate) can be used in studies to lower intraocular pressure (IOP) .

HY-114667

Lavendustin C6	EGFR	Others
Lavendustin C6 is a specific inhibitor of tyrosine kinase. Lavendustin C6 inhibits epidermal growth factor (EGF) receptor tyrosine kinase with an EC₅₀ value of 0.05 μg/mL. Lavendustin C6 inhibits platelet-derived growth factor (PDGF)-induced inositol phosphate formation .

HY-19619R

m-3M3FBS (Standard)	Phospholipase Apoptosis	Cancer
m-3M3FBS (Standard) is the analytical standard of m-3M3FBS. This product is intended for research and analytical applications. m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .

HY-103138

(Rac)-WAY-161503 hydrochloride	5-HT Receptor	Neurological Disease Metabolic Disease
(Rac)-WAY-161503 hydrochloride is a potent, selective, high affinity 5-HT_2C receptor agonist with a K_i of 4 nM and an EC₅₀ of 12 nM. (Rac)-WAY-161503 hydrochloride displays higher affinity for 5-HT_2C than 5-HT_2A and 5-HT_2B receptors. (Rac)-WAY-161503 hydrochloride has anti-obesity and antidepressant effects .

HY-103138A

(Rac)-WAY-161503	5-HT Receptor	Neurological Disease Metabolic Disease
(Rac)-WAY-161503 is a potent, selective, highly affinity 5-HT_2C receptor agonist with a K_i of 4 nM and an EC₅₀ of 12 nM. (Rac)-WAY-161503 displays higher affinity for 5-HT_2C than 5-HT_2A and 5-HT_2B receptors. (Rac)-WAY-161503 has anti-obesity and antidepressant effects .

HY-19619

m-3M3FBS 5 Publications Verification	Phospholipase Apoptosis	Cancer
m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .

HY-107510

YM-230888	mGluR	Neurological Disease
YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a K_i of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC₅₀ of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin (HY-13753)-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant (HY-153808)-induced arthritic pain models .

HY-137325

2-Chloro-ATP	Guanylate Cyclase	Others
2-Chloro-ATP is a soluble guanylate cyclase inhibitor that increases intracellular calcium concentration at low concentrations through a mechanism independent of inositol phosphate production .

HY-108662

PIT 2,2'-Pyridylisatogen tosylate	P2Y Receptor	Inflammation/Immunology Cancer
PIT (2,2'-Pyridylisatogen tosylate) is a selective and non-competitive antagonist of P2Y1 receptor with an IC₅₀ value of 0.14 μM for human P2Y1 receptor. PIT antagonizes P2Y1 receptor signaling without affecting nucleotide binding. PIT is an irreversible antagonist of responses to ATP at metabotropic purinoceptors (of the P2Y family) in some smooth muscles. PIT can be used for the research of chronic bronchitis and asthma .

HY-107620

PD 198306	MEK	Neurological Disease
PD 198306 is a selective MAPK/ERK-kinase (MEK) inhibitor. PD 198306 results in an observable reduction in the Streptozocin induced increase in the level of active ERK1 and 2. Antihyperalgesic effects .

Cat. No.	Product Name	Target	Research Area