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Results for "

histamine release inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Histamine Receptor (33) 5-HT Receptor (4) Adrenergic Receptor (1) Akt (2) Amyloid-β (5) Autophagy (3) Calcium Channel (3) Caspase (1) Cholinesterase (ChE) (2) Dengue Virus (4) Dopamine Receptor (4) Drug Derivative (1) Drug Intermediate (1) Enterovirus (3) Flavivirus (4) GABA Receptor (1) GnRH Receptor (1) GPR35 (1) GSK-3 (5) Influenza Virus (1) Interleukin Related (2) Isotope-Labeled Compounds (7) Leukotriene Receptor (4) Lipoxygenase (1) Mas-related G-protein-coupled Receptor (MRGPR) (1) NF-κB (8) p38 MAPK (1) Phosphodiesterase (PDE) (1) Phospholipase (1) PI3K (2) Prostaglandin Receptor (2) Reference Standards (6) Ser/Thr Protease (1) TNF Receptor (3) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (12) Endocrinology (10) Infection (10) Inflammation/Immunology (42) Metabolic Disease (6) Neurological Disease (16)

By Targets:

Histamine Receptor (33)

5-HT Receptor (4)

Adrenergic Receptor (1)

Akt (2)

Amyloid-β (5)

Autophagy (3)

Calcium Channel (3)

Caspase (1)

Cholinesterase (ChE) (2)

Dengue Virus (4)

Dopamine Receptor (4)

Drug Derivative (1)

Drug Intermediate (1)

Enterovirus (3)

Flavivirus (4)

GABA Receptor (1)

GnRH Receptor (1)

GPR35 (1)

GSK-3 (5)

Influenza Virus (1)

Interleukin Related (2)

Isotope-Labeled Compounds (7)

Leukotriene Receptor (4)

Lipoxygenase (1)

Mas-related G-protein-coupled Receptor (MRGPR) (1)

NF-κB (8)

p38 MAPK (1)

Phosphodiesterase (PDE) (1)

Phospholipase (1)

PI3K (2)

Prostaglandin Receptor (2)

Reference Standards (6)

Ser/Thr Protease (1)

TNF Receptor (3)

Transmembrane Glycoprotein (1)

By Research Areas:

Cancer (12)

Endocrinology (10)

Infection (10)

Inflammation/Immunology (42)

Metabolic Disease (6)

Neurological Disease (16)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Histamine Receptor CRAC Channel

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-U00027

Quinotolast sodium FR71021	Histamine Receptor Leukotriene Receptor Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Quinotolast sodium in the concentration range of 1-100 μg/mL inhibits *histamine, LTC₄* and PGD₂ release in a concentration-dependent manner.

HY-N10182

Spinacetin	Histamine Receptor	Inflammation/Immunology
Spinacetin is a natural product that can be isolated from Inula japonica. Spinacetin inhibits the release of *histamine*. Spinacetin has anti-inflammatory activity .

HY-12206A

Thioperamide maleate 3 Publications Verification MR-12842 maleate	Histamine Receptor	Neurological Disease
Thioperamide maleate (MR-12842 maleate) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a K_i of 4.3 nM for inhibition of [ ³H]histamine release. Thioperamide maleate inhibits [ ³H]histamine synthesis with a K_i of 31 nM .

HY-12206

Thioperamide 3 Publications Verification MR-12842	Histamine Receptor	Neurological Disease
Thioperamide (MR-12842) is a potent, orally available, brain penetrant and selective H3 receptor antagonist with a K_i of 4.3 nM for inhibition of [ ³H]histamine release. Thioperamide inhibits [ ³H]histamine synthesis with a K_i of 31 nM .

HY-13405

Tiaramide hydrochloride RHC 2592-A	Histamine Receptor	Inflammation/Immunology
Tiaramide (RHC 2592-A) hydrochloride is an analgesic agent with antiallergic activity, and is also a non-steroidal, anti-inflammatory compound. Tiaramide hydrochloride inhibits histamine release .

HY-13218

Acitazanolast WP-871	Histamine Receptor	Inflammation/Immunology
Acitazanolast is an orally active antiallergic agent, can inhibit histamine release. Acitazanolast can be used in study of type I anaphylaxis (immediate) caused by IgE antibodies .

HY-109544

Repirinast MY-5116	Histamine Receptor	Inflammation/Immunology
Repirinast (MY-5116) is an orally active anti-allergic agent. Repirinast inhibits histamine release. Repirinast can be used in the research of bronchial asthma .

HY-14271

Acreozast TYB-2285	Histamine Receptor	Inflammation/Immunology
Acreozast (TYB-2285) is a histamine release inhibitor. Acreozast inhibits the histamine release primed with IL-3. Acreozast might regulate allergic inflammation in vivo by the suppression of mediator release primed with IL-3 .

HY-106076

REV 2871 Eclazolast; CHBZ	Histamine Receptor	Inflammation/Immunology
REV 2871 (Eclazolast; CHBZ) is a potent and oral activity antiallergic agent. REV 2871 also is an irreversibility histamine release (HR) inhibitor .

HY-N12295

Ciwujianoside D1	Others	Inflammation/Immunology
Ciwujianoside D1 is a natural product that can inhibit histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells .

HY-N15704

Cassiaside C2	Histamine Receptor	Inflammation/Immunology
Cassiaside C2 is a naphthopyrone with a strong antiallergic activity. Cassiaside C2 inhibits the histamine release from rat peritoneal exudate mast cells induced by antigen-antibody reaction .

HY-137941

Roxatidine	Histamine Receptor Caspase NF-κB p38 MAPK	Inflammation/Immunology
Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is an orally active histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect. Roxatidine is promising for research of gastric and duodenal ulcers .

HY-137941R

Roxatidine (Standard)	Reference Standards Histamine Receptor	Inflammation/Immunology
Roxatidine (Standard) is the analytical standard of Roxatidine. This product is intended for research and analytical applications. Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is a histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect .

HY-137787R

Cyanosafracin B (Standard)	Drug Intermediate Reference Standards	Others
Nylidrin (hydrochloride) (Standard) is the analytical standard of Nylidrin (hydrochloride). This product is intended for research and analytical applications. Nylidrin hydrochloride is an inhibitor of IgE-mediated histamine release in passive sensitized rat peritoneal mast cells, and it has anti-allergic effects.

$Cyanosafracin B (Standard)$

HY-U00364

CI-949	Histamine Receptor Prostaglandin Receptor Leukotriene Receptor	Inflammation/Immunology Endocrinology
CI-949 is an allergic mediator release inhibitor, which inhibits *histamine, leukotriene C₄/D₄ (LTC₄/LTD₄), and thromboxane B₂ (TXB₂)* release with IC₅₀s of 11.4 μM, 0.5 μM and 0.1 μM, respectively.

HY-P3317

Azaline Azaline A	GnRH Receptor	Endocrinology
Azaline (Azaline A) is a gonadotropin-releasing hormone (GnRH) receptor antagonist with a K_D value of 0.48 nM. Azaline can effectively induce histamine release, with an effect comparable to that of GnRH, and it can completely inhibit ovulation at a dose of 2.0-3.0 μg per female rat. Azaline has potential applications in regulating reproductive functions .

HY-105999A

APC 366 hydrochloride	Ser/Thr Protease	Inflammation/Immunology
APC 366 hydrochloride is a selective inhibitor of mast cell trypsin activity. APC 366 hydrochloride is able to inhibit trypsin-induced histamine release in human tonsil and lung cells. APC 366 hydrochloride may have important applications in regulating allergic reactions and inflammation .

HY-W754020

Elbanizine	Histamine Receptor	Others
Elbanizine inhibits histamine, bradykinin, histamin-release from rat mast cells (IC₅₀ of 0.26 μM) and the IgE-mediated passive cutaneous anaphylaxis (PCA) reaction. Elbanizine exhibits antiallergic and antiasthmatic in guinea pig model .

HY-123103

Linetastine	Lipoxygenase Histamine Receptor	Inflammation/Immunology
Linetastine is an orally active and potent 5-Lipoxygenase inhibitor. Linetastine shows antihistamine activity. Linetastine inhibits leukotriene production and antagonizes the effect of histamine. Linetastine inhibits the release of leukotrienes B4 and C4 from calcium ionophore-stimulated human leukocytes .

HY-123432

AHR-13268D	Histamine Receptor	Inflammation/Immunology
AHR-13268D is an oral active antiallergic and antihistaminic agent, with bioavailable approximately 88%. AHR-13268D is a potent inhibitor of histamine release from rat peritoneal mast cells, with the IC₅₀ of 0.51 nM .

HY-17043

Loratadine 10+ Cited Publications Loratidine; SCH 29851	Flavivirus Dengue Virus Histamine Receptor	Infection Inflammation/Immunology Endocrinology Cancer
Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-113802

VUF 8328	Histamine Receptor	Neurological Disease
VUF 8328 is a potent histamine H(3) receptor agonist. VUF 8328 inhibits the electrically-evoked [ ³H]-no-radrenaline release from rat cortical slices. VUF 8328 is promising for research of central nervous system disorders .

HY-N3622

Corchoionoside C (6S,9S)-Roseoside	Others	Inflammation/Immunology
Corchoionoside C ((6S,9S)-Roseoside), an ionone glucoside, can be isolated from Capparis spinosa. Corchoionoside C inhibits the antigen-antibody reaction induced histamine release from rat peritoneal exudate cells .

HY-106064A

Piriprost potassium U 60257B	Leukotriene Receptor	Inflammation/Immunology
Piriprost (U-60,257B) potassium is an inhibitor of leukotriene synthesis. Piriprost potassium inhibits the release of both leukotriene and histamine with an IC₅₀ of 0.11 μM from isolated porcine lung cells. Piriprost potassium increases alkaline phosphatase (ALP) activity in cultured endometrial stromal cells .

HY-N3421

Koaburaside	Interleukin Related TNF Receptor Influenza Virus	Infection Inflammation/Immunology Cancer
Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC₅₀ of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits *histamine* release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .

HY-N3007A

(E)-Naringenin chalcone	Others	Inflammation/Immunology
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell .

HY-17043S

Loratadine-d4 Loratidine-d₄; SCH 29851-d₄	Isotope-Labeled Compounds Histamine Receptor	Infection Inflammation/Immunology Endocrinology
Loratadine-d₄ is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-17043S1

Loratadine-d5 Loratidine-d₅; SCH 29851-d₅	Isotope-Labeled Compounds Histamine Receptor	Infection Inflammation/Immunology Endocrinology
Loratadine-d₅ is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-130592

Compound 48/80 trihydrochloride 1 Publications Verification C48/80 trihydrochloride	Phospholipase	Neurological Disease
Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a *histamine* releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .

HY-17043R

Loratadine (Standard) Loratidine (Standard); SCH 29851 (Standard)	Dengue Virus Flavivirus Reference Standards Histamine Receptor	Infection Inflammation/Immunology Endocrinology Cancer
Loratadine (Standard) is the analytical standard of Loratadine. This product is intended for research and analytical applications. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-23188

Loratadine-d5-1 Loratidine-d₅-1; SCH 29851-d₅-1	Isotope-Labeled Compounds	Others
Loratadine-d₅-1 is a deuterated labeled Loratadine (HY-17043). Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC₅₀ of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-17043S2

Loratadine-d4-1 Loratidine-d₄-1; SCH 29851-d₄-1	Isotope-Labeled Compounds Histamine Receptor Dengue Virus Flavivirus	Infection Inflammation/Immunology Endocrinology Cancer
Loratadine-d₄-1 (Loratidine-d₄-1) is deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators .

HY-17043S3

Loratadine-13C6 SCH 29851-¹³C₆	Isotope-Labeled Compounds Histamine Receptor Dengue Virus Flavivirus	Infection Inflammation/Immunology Endocrinology Cancer
Loratadine- ¹³C₆ (SCH 29851- ¹³C₆) is ¹³C labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-B0640S

Epinastine-13C,d3 hydrobromide WAL801-¹³C,d₃ hydrobromide	Isotope-Labeled Compounds Histamine Receptor Transmembrane Glycoprotein Interleukin Related	Inflammation/Immunology Endocrinology
Epinastine- ¹³C,d₃ (hydrobromide) is the ¹³C- and deuterium labeled Epinastine. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action .

HY-172458

Z-3578	Mas-related G-protein-coupled Receptor (MRGPR) TNF Receptor	Neurological Disease
Z-3578 is a small-molecule antagonist targeting MrgX2 (Mas-related G protein-coupled receptor X2) with significant anti-pseudoallergic activity and a K_D value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppressing the release of β-hexosaminidase with IC₅₀ values of 4.90 µM and 6.18 µM, respectively. It also markedly reduces the release of histamine and TNF-α, along with intracellular calcium flux. In a murine pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation and lowers serum histamine levels, indicating potent in vivo anti-allergic effects. Z-3578 holds promise as a lead compound for the treatment of allergic diseases, especially pseudoallergic reactions .

HY-167715

Traxanox	Histamine Receptor Phosphodiesterase (PDE)	Inflammation/Immunology
Traxanox is an orally available diuretic that enhances phagocytosis of yeast granules by mouse peritoneal macrophages and rat peritoneal polymorphonuclear leukocytes in vitro. Traxanox inhibits IgE-mediated histamine release and cyclic AMP phosphodiesterase activity.Traxanox exhibits anti-inflammatory activity, as it inhibits the anaphylactoid reaction and reduces pleural fluid accumulation in experimental models of inflammation. Traxanox also demonstrates a synergistic effect when combined with hydrocortisone or indomethacin in suppressing adjuvant arthritis in rats.

HY-126127

BRL 22321 free base	Histamine Receptor	Inflammation/Immunology
BRL 22321 free base is a stabilizer with similar mast cell stabilizing activity to Cromolyn sodium (HY-B0320A) and also has some smooth muscle relaxant activity. BRL 22321 free base is more potent than Cromolyn sodium (HY-B0320A) in inhibiting rat passive cutaneous and peritoneal anaphylaxis and antigen-induced histamine release from passively sensitized rat peritoneal cells .

HY-106481

Bufrolin	GPR35 Histamine Receptor	Inflammation/Immunology
Bufrolin is a Cromoglycate (histamine release inhibitor) analog and a high potency agonist of GPR35. Bufrolin promotes interactions between β-arrestin-2 and either human GPR35a or rat GPR35. Bufrolin also serves as antiallergic mast cell stabilizer and inhibit an anti-inflammatory response inducible by the internalization peptide. Bufrolin acts as an anti-inflammatory agent to be used in research of delivering pharmacol linked with internalization peptide .

HY-B1619

Cromolyn 5+ Cited Publications Cromoglycate; Cromoglicic acid; FPL-670 free acid	GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-B0320A

Cromolyn disodium 5+ Cited Publications Cromoglycate disodium; Cromoglicic acid disodium; FPL-670	GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-N15663

(-)-Epigallocatechin-3-O-(4-O-methyl)gallate EGCG4′′Me	Drug Derivative	Inflammation/Immunology
(-)-Epigallocatechin-3-O-(4-O-methyl)gallate is an orally active catechin derivative found in Taiwanese oolong tea. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can inhibit histamine release and exhibits anti-inflammation and anti-allergic effect. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can be used for the researches of immunology and inflammation, such as type I allergic .

HY-B0539

Desloratadine Maximum Cited Publications 13 Publications Verification Sch34117	Histamine Receptor TNF Receptor Leukotriene Receptor	Inflammation/Immunology
Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (K_i=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria .

HY-B1619R

Cromolyn (Standard)	GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn (Standard) is the analytical standard of Cromolyn. This product is intended for research and analytical applications. Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-B1619S

Cromolyn-d5 Cromoglycate-d₅; Cromoglicic acid-d₅; FPL-670-d₅ free acid	Isotope-Labeled Compounds GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn-d₅ (Cromoglycate-d₅) is the deuterium labeled Cromolyn (HY-B1619). Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-137312A

Carbuterol hydrochloride SKF 40383-A hydrochloride	Adrenergic Receptor	Inflammation/Immunology
Carbuterol (SKF 40383-A) hydrochloride is a selective β₂-adrenergic receptor agonist that primarily targets bronchial smooth muscle, exhibiting significant bronchodilatory and anti-allergic activity. Carbuterol hydrochloride can directly inhibit the immunologically induced release of histamine and slow-reacting substance of anaphylaxis (SRS-A), thereby alleviating allergic responses. In addition, it exerts mild β₁-mediated cardiac stimulation and is applicable to studies related to respiratory and immune-related diseases such as asthma and allergic disorders .

HY-B1693

Levomepromazine 1 Publications Verification Methotrimeprazine	5-HT Receptor Dopamine Receptor Histamine Receptor Autophagy Enterovirus Calcium Channel	Infection Neurological Disease Inflammation/Immunology
Levomepromazine (Methotrimeprazine) is an orally active antipsychotic compound and Ca ²⁺ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca ²⁺ levels. Levomepromazine has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine can induce adaptive ER stress and autophagy. In addition, Levomepromazine has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine can be used in the study psychiatric disorders and relieving nausea and vomiting .

HY-B1693A

Levomepromazine hydrochloride Methotrimeprazine hydrochloride	5-HT Receptor Dopamine Receptor Histamine Receptor Autophagy Enterovirus Calcium Channel	Infection Neurological Disease Inflammation/Immunology
Levomepromazine (Methotrimeprazine) hydrochloride is an orally active antipsychotic compound and Ca ²⁺ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca ²⁺ levels. Levomepromazine hydrochloride has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine hydrochloride can induce adaptive ER stress and autophagy. In addition, Levomepromazine hydrochloride has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine hydrochloride can be used in the study psychiatric disorders and relieving nausea and vomiting .

HY-B1693R

Levomepromazine (Standard) Methotrimeprazine (Standard)	Reference Standards 5-HT Receptor Dopamine Receptor Autophagy Histamine Receptor Enterovirus Calcium Channel	Infection Neurological Disease Inflammation/Immunology
Levomepromazine (Standard) is the analytical standard of Levomepromazine. This product is intended for research and analytical applications. Levomepromazine (Methotrimeprazine) is an orally active antipsychotic compound and Ca ²⁺ release inducer. Levomepromazine inhibits SERCA pump and induces an increase in cytoplasmic Ca ²⁺ levels. Levomepromazine has antagonistic effects on a variety of neurotransmitter receptors, including dopamine, cholinergic, serotonin, and histamine receptors. Levomepromazine can induce adaptive ER stress and autophagy. In addition, Levomepromazine has antiviral, anti-inflammatory, neuroprotective and analgesic, sedative and anti-injurious activities. Levomepromazine can be used in the study psychiatric disorders and relieving nausea and vomiting .

HY-B0320AR

Cromolyn disodium (Standard) Cromoglycate disodium (Standard); Cromoglicic acid disodium (Standard); FPL-670 (Standard)	Reference Standards GSK-3 NF-κB Amyloid-β	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Cromolyn disodium (Standard) (Cromoglycate disodium (Standard)) is the analytical standard of Cromolyn disodium (HY-B0320A). This product is intended for research and analytical applications. Cromolyn (Cromoglycate) disodium is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn disodium is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn disodium can be used in the research of bronchial asthma. In addition, Cromolyn disodium has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

HY-12191

A-331440	Histamine Receptor	Metabolic Disease
A-331440 is a potent and selective histamine H3 receptor antagonist that regulates neurotransmitter release by inhibiting presynaptic H3 receptors. In preclinical studies involving mice on a high-fat diet, A-331440 demonstrated dose-dependent effects on weight reduction and fat loss. At 5 mg/kg, it effectively decreased body weight comparable to dexfenfluramine, while at 15 mg/kg, it significantly reduced body fat and improved insulin tolerance, similar to mice on a low-fat diet. These findings suggest that A-331440 holds promise as an antiobesity agent by modulating histaminergic pathways involved in food intake and metabolic regulation .

Cat. No.	Product Name	Target	Research Area

HY-P3317

Azaline Azaline A	GnRH Receptor	Endocrinology
Azaline (Azaline A) is a gonadotropin-releasing hormone (GnRH) receptor antagonist with a K_D value of 0.48 nM. Azaline can effectively induce histamine release, with an effect comparable to that of GnRH, and it can completely inhibit ovulation at a dose of 2.0-3.0 μg per female rat. Azaline has potential applications in regulating reproductive functions .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N10182

Spinacetin	Phyllodium pulchellum (L.) Desv. Flavonols Flavonoids Source classification Plants Compositae	Histamine Receptor
Spinacetin is a natural product that can be isolated from Inula japonica. Spinacetin inhibits the release of *histamine*. Spinacetin has anti-inflammatory activity .

HY-N3007A

(E)-Naringenin chalcone	Phenols Polyphenols Solanum lycopersicum L. Solanaceae Plants	Others
(E)-Naringenin chalcone is an orally active anti-allergic agent. (E)-Naringenin chalcone also has antioxidant, anti-inflammatory activities. (E)-Naringenin chalcone can improve adipocyte functions. (E)-Naringenin chalcone inhibits histamine release from rat peritoneal mast cell .

HY-N15663

(-)-Epigallocatechin-3-O-(4-O-methyl)gallate EGCG4′′Me	Structural Classification Source classification Phenols Polyphenols Camellia sinensis (L.) O. Ktze. Plants Theaceae	Drug Derivative
(-)-Epigallocatechin-3-O-(4-O-methyl)gallate is an orally active catechin derivative found in Taiwanese oolong tea. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can inhibit histamine release and exhibits anti-inflammation and anti-allergic effect. (-)-Epigallocatechin-3-O-(4-O-methyl)gallate can be used for the researches of immunology and inflammation, such as type I allergic .

HY-B0539

Desloratadine 10+ Cited Publications Sch34117	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology	Histamine Receptor TNF Receptor Leukotriene Receptor
Desloratadine (Sch34117) is an orally active and selective H1 receptor antagonist (K_i=0.9 nM) with anti-inflammatory and anti-allergic activities. Desloratadine inhibits the release of histamine and LTC4 from human basophils and targets the regulatory signals of IL-4 and IL-13 production in basophils. Desloratadine significantly alleviates SAR symptoms in patients with concurrent asthma and can be used in the study of seasonal allergic rhinitis and chronic idiopathic urticaria .

HY-N2081

Skimmianine 3 Publications Verification	Alkaloids Classification of Application Fields Source classification Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort. Inflammation/Immunology Disease Research Fields	Cholinesterase (ChE) PI3K Akt NF-κB
Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC₅₀ = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca ²⁺ signaling and protein kinase C signaling .

HY-N12295

Ciwujianoside D1	Triterpenes Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Others
Ciwujianoside D1 is a natural product that can inhibit histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells .

HY-N15704

Cassiaside C2	Polysaccharides Source classification Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Saccharides	Histamine Receptor
Cassiaside C2 is a naphthopyrone with a strong antiallergic activity. Cassiaside C2 inhibits the histamine release from rat peritoneal exudate mast cells induced by antigen-antibody reaction .

HY-137787R

Cyanosafracin B (Standard)	Microorganisms Marine natural products Source classification	Drug Intermediate Reference Standards
Nylidrin (hydrochloride) (Standard) is the analytical standard of Nylidrin (hydrochloride). This product is intended for research and analytical applications. Nylidrin hydrochloride is an inhibitor of IgE-mediated histamine release in passive sensitized rat peritoneal mast cells, and it has anti-allergic effects.

$Cyanosafracin B (Standard)$

HY-N3622

Corchoionoside C (6S,9S)-Roseoside	Capparis spinosa L. Source classification Plants Capparidaceae Saccharides Monosaccharides	Others
Corchoionoside C ((6S,9S)-Roseoside), an ionone glucoside, can be isolated from Capparis spinosa. Corchoionoside C inhibits the antigen-antibody reaction induced histamine release from rat peritoneal exudate cells .

HY-N3421

Koaburaside	Eucommia ulmoides Oliver Source classification Eucommiaceae Plants Saccharides Monosaccharides	Interleukin Related TNF Receptor Influenza Virus
Koaburaside is a cytoprotective and anti-inflammatory natural compound. Koaburaside shows antioxidant activity with an IC₅₀ of 9.0 μM for DPPH-free radical scavenging assay. Koaburaside inhibits *histamine* release and expressions of IL-6 and TNF-α in human mast cells. Koaburaside also effectively inhibits influenza A neuraminidase .

HY-N2081R

Skimmianine (Standard)	Alkaloids Source classification Rutaceae Quinoline Alkaloids Plants Skimmia reevesiana Fort.	Reference Standards Cholinesterase (ChE) PI3K Akt NF-κB
Skimmianine (Standard) is the analytical standard of Skimmianine. This product is intended for research and analytical applications. Skimmianine is an orally active furoquiniline alkaloid present mainly in the Rutaceae family. Skimmianine has analgesic, antispastic, sedative, and anti-inflammatory properties. Skimmianine inhibits acetylcholinesterase (AChE) (IC₅₀ = 8.6 μg/mL). Skimmianine exhibits cytotoxicity against a variety of cancer cell lines and genotoxicity. Skimmianine has antioxidant and anti-inflammatory effects on ischemia-reperfusion (IR) injury. Skimmianine exerts anti-inflammatory effects through activation of the phosphatidylinositol-3-kinase (PI3K)-protein kinase B (AKT) pathway. Skimmianine is neuroprotective by targeting the NF-κB activation pathway to prevent neuroinflammation. Skimmianine inhibits the release of histamine, intracellular Ca ²⁺ signaling and protein kinase C signaling .

Cat. No.	Product Name	Chemical Structure

HY-17043S1

Loratadine-d5
Loratadine-d₅ is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-17043S

Loratadine-d4
Loratadine-d₄ is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-23188

Loratadine-d5-1
Loratadine-d₅-1 is a deuterated labeled Loratadine (HY-17043). Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC₅₀ of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-17043S2

Loratadine-d4-1
Loratadine-d₄-1 (Loratidine-d₄-1) is deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators .

HY-17043S3

Loratadine-13C6
Loratadine- ¹³C₆ (SCH 29851- ¹³C₆) is ¹³C labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.

HY-B0640S

Epinastine-13C,d3 hydrobromide
Epinastine- ¹³C,d₃ (hydrobromide) is the ¹³C- and deuterium labeled Epinastine. Epinastine (WAL801) is an antihistamine and mast cell stabilizer. Epinastine is a potent, selective and orally-active histamine H1 receptor antagonist. Epinastine also inhibits IL-8 release and has an antiallergic action .

HY-B1619S

Cromolyn-d5

Cromolyn-d₅ (Cromoglycate-d₅) is the deuterium labeled Cromolyn (HY-B1619). Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC₅₀ of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects .

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