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gout disease

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

2

Biochemical Assay Reagents

3

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-163358
    SLC3037
    1 Publications Verification

    		 NOD-like Receptor (NLR) NEKs Cardiovascular Disease Neurological Disease Inflammation/Immunology
    SLC3037 is a NLRP3 inhibitor which blocks NLRP3 from binding to NEK7 or oligomerization, inhibiting inflammasome caused by MSU and other inflammasome activators. SLC3037 can be used for research of gout, cardiovascular diseases, metabolic syndrome or neurodegenerative diseases .
    SLC3037
  • HY-126382
    Hesperidin methylchalcone
    1 Publications Verification

    		 NF-κB Inflammation/Immunology
    Hesperidin methylchalcone (Hesperidin methyl chalcone) is an orally active flavonoid that has analgesic, anti-inflammatory and antioxidant properties. Hesperidin methylchalcone exhibits vasoprotective activity. Hesperidin methylchalcone inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone can be used for the research of gout disease .
    Hesperidin methylchalcone
  • HY-148187
    NLRP3-IN-11

    		NOD-like Receptor (NLR) Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
    NLRP3-IN-11 is a NLR family pyrin domain containing 3 (NLRP3) proteins inhibitor. NLRP3-IN-11 has biological activity for NLRP3 with an IC50 value of <0.3 μM. NLRP3-IN-11 can be used for the researh of inflammatory and degenerative diseases including NASH, atherosclerosis and other cardiovascular diseases, Alzheimer's disease, Parkinson's disease, diabetes, gout, and numerous other autoinflammatory diseases .
    NLRP3-IN-11
  • HY-P2921C
    Uricase (Recombinant)

    Uox (Recombinant)

    		 Endogenous Metabolite Metabolic Disease
    Uricase, Arthrobacter globiformis is a peroxidase enzyme responsible for catalyzing the oxidative reaction of uric acid, converting it into the soluble product allantoin. Uricase, Arthrobacter globiformis can be used for the determination of uric acid levels in serum. The lack of uricase in mammals can lead to kidney diseases caused by the accumulation of uric acid. Uricase, Arthrobacter globiformis can be utilized in research on gout and hyperuricemia .
    Uricase (Recombinant)
  • HY-163498
    NLRP3-IN-37

    		NOD-like Receptor (NLR) Neurological Disease Inflammation/Immunology
    NLRP3-IN-37 (Compound 23) is a NLRP3 inhibitor (EC50: 5 nM). NLRP3-IN-37 can be used for NLRP3 related research, such as gout, pseudogout, CAPS, NASH fibrosis, heart failure, idiophathic pericarditis, atopic dermatitis, inflammatory bowel disease, Alzheimer's Disease, Parkinson's Disease and traumatic brain injury .
    NLRP3-IN-37
  • HY-126382R
    Hesperidin methylchalcone (Standard)

    		NF-κB Inflammation/Immunology
    Hesperidin methylchalcone (Standard) is the analytical standard of Hesperidin methylchalcone. This product is intended for research and analytical applications. Hesperidin methylchalcone (Hesperidin methyl chalcone) is an orally active flavonoid that has analgesic, anti-inflammatory and antioxidant properties. Hesperidin methylchalcone exhibits vasoprotective activity. Hesperidin methylchalcone inhibits oxidative stress, cytokine production and NF-κB activation. Hesperidin methylchalcone can be used for the research of gout disease .
    Hesperidin methylchalcone (Standard)
  • HY-W104467
    (+/-)-Epicatechin

    (+/-)-Epicatechol; (+/-)-epi-Catechin

    		 Xanthine Oxidase Metabolic Disease
    (+/-)-Epicatechin is a xanthine oxidase inhibitor with an IC50 of 982.14 μM, and can be found in Semen Plantaginis (Plantago seed). (+/-)-Epicatechin can be used in research on diseases such as hyperuricemia and gout .
    (+/-)-Epicatechin
  • HY-P2921B
    Uricase, Arthrobacter globiformis

    Uox, Arthrobacter globiformis

    		 Endogenous Metabolite Metabolic Disease
    Uricase, Arthrobacter globiformis is a peroxidase enzyme. It catalyzes the oxidation of uric acid, converting it into the soluble product allantoin. Uricase, Arthrobacter globiformis can be used for the determination of uric acid levels in serum. A deficiency of uricase in mammals can lead to kidney diseases caused by the accumulation of uric acid. Uricase, Arthrobacter globiformis can be utilized in research on gout and hyperuricemia .
    Uricase, Arthrobacter globiformis
  • HY-P2921D
    Uricase, candida utilis

    		Endogenous Metabolite Metabolic Disease
    Uricase, candida utilis is a peroxidase enzyme. It catalyzes the oxidation of uric acid, converting it into the soluble product allantoin. Uricase, candida utilis can be used for the determination of uric acid levels in serum. A deficiency of uricase in mammals can lead to kidney diseases caused by the accumulation of uric acid. Uricase, candida utilis can be utilized in research on gout and hyperuricemia .
    Uricase, candida utilis
  • HY-P2921A
    Uricase, Bacillus fastidious

    Uox, Bacillus fastidious

    		 Endogenous Metabolite Metabolic Disease
    Uricase, Arthrobacter globiformis is a peroxidase enzyme responsible for catalyzing the oxidative reaction of uric acid, converting it into the soluble product allantoin. Uricase, Arthrobacter globiformis can be used for the determination of uric acid levels in serum. The lack of uricase in mammals can lead to kidney diseases caused by the accumulation of uric acid. Uricase, Arthrobacter globiformis can be utilized in research on gout and hyperuricemia .
    Uricase, Bacillus fastidious
  • HY-173231
    hURAT1 inhibitor 2

    		URAT1 Metabolic Disease
    hURAT1 inhibitor 2 (Compound 5) is an inhibitor of hURAT1 (uric acid transporter 1, SLC22A12) with an IC50 of 18 nM. hURAT1 inhibitor 2 also has a certain inhibitory effect on OATP1B1, with an IC50 value of 0.73 μM. hURAT1 inhibitor 2 can be used in the research of diseases related to abnormal uric acid metabolism, such as hyperuricemia and gout .
    hURAT1 inhibitor 2
  • HY-151173
    XO/COX/LOX-IN-1

    		Xanthine Oxidase Lipoxygenase COX Metabolic Disease Inflammation/Immunology Cancer
    XO/COX/LOX-IN-1 (compound 7i) is a potent xanthine oxidase/cyclooxygenases/lipoxygenases (XO/COX/LOX) inhibitor. XO/COX/LOX-IN-1 can be used in studies of inflammation, cancer and metabolic diseases .
    XO/COX/LOX-IN-1
  • HY-163497
    NLRP3-IN-38

    		NOD-like Receptor (NLR) Neurological Disease Inflammation/Immunology
    NLRP3-IN-38 (Compound 18) is an inhibitor for NOD-like receptor protein 3 (NLRP3), that inhibits NLRP3 inflammasome activation with an EC50 of 23 nM .
    NLRP3-IN-38
  • HY-D0837
    Imidazole
    2 Publications Verification

    Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene

    		 Ser/Thr Protease Thrombopoietin Receptor Neurological Disease Inflammation/Immunology
    Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .
    Imidazole
  • HY-W699983
    Imidazole-15N2

    Glyoxaline-15N2; 1,3-Diaza-2,4-cyclopentadiene-15N2

    		 Isotope-Labeled Compounds Thrombopoietin Receptor Ser/Thr Protease Xanthine Oxidase Neurological Disease Inflammation/Immunology
    Imidazole- 15N2 (Glyoxaline- 15N2) is 15N labeled Imidazole. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CL Pro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .
    Imidazole-15N2
  • HY-D0837R
    Imidazole (Standard)

    Glyoxaline (Standard); 1,3-Diaza-2,4-cyclopentadiene (Standard)

    		 Xanthine Oxidase Reference Standards Ser/Thr Protease Thrombopoietin Receptor Neurological Disease Inflammation/Immunology
    Imidazole (Standard) is the analytical standard of Imidazole. This product is intended for research and analytical applications. Imidazole (Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene) is a heterocyclic aromatic compound. Imidazole bearing molecules have been used as corrosion, acetylcholinesterase (AChEI) and xanthine oxidase (XO) inhibitors, performing biological activities such as antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic, amongst many others. Imidazole inhibits the enzymatic conversion of the endoperoxides (PGG2 and PGH2) to thromboxane A2 by platelet microsomes. Imidazole derivatives exhibits inhibition on SARS-CoV-2 3CLPro enzyme, which is promising for research in the field of Alzheimer’s disease, gout, COVID-19 and thrombo-embolic disease .
    Imidazole (Standard)

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