Search Result

Results for "

fungal pathogen

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Fungal (34) Antibiotic (5) Apoptosis (2) Bacterial (10) Carbonic Anhydrase (1) Endogenous Metabolite (1) Isotope-Labeled Compounds (4) Mitochondrial Metabolism (4) NF-κB (2) NOD-like Receptor (NLR) (2) Parasite (4) Phosphatase (1) Reference Standards (8) Succinate Dehydrogenase (2) TMV (1)
By Research Areas:	Cancer (7) Infection (36) Inflammation/Immunology (6)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Fungal

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W031471A

Pyrazine-2-amidoxime	Bacterial Fungal	Infection
Pyrazine-2-amidoxime is a structural analogue of pyrazine-2-carboxamide with antimicrobial activity. Pyrazine-2-amidoxime shows killing and inhibiting properties against Candida albicans, fungal pathogen and Gram-positive bacteria .

HY-B0850

Difenoconazole 1 Publications Verification	Fungal	Infection
Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth .

HY-B0221

Amphotericin B Maximum Cited Publications 19 Publications Verification	Fungal Antibiotic Bacterial Parasite	Infection Cancer
Amphotericin B is a polyene antifungal agent against a wide variety of *fungal* pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

HY-118149A

(±)9-HpODE	Bacterial Fungal Parasite	Infection
(±)9-HpODE is a long chain lipid hydroperoxide, is a product of linoleic acid peroxidation. (±)9-HpODE can induce oxidation of intracellular glutathione (GSH). (±)9-HpODE also exhibits antimicrobial activity against various fungal and bacterial pathogens .

HY-B1474

Alexidine	Fungal	Infection Cancer
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis .

HY-N14856

Verlamelin	Antibiotic Fungal	Infection
Verlamelin is a depsipeptide antibiotic. Verlamelin has anti-fungal activity against plant pathogens .

HY-129493

Lateropyrone	Bacterial Antibiotic Endogenous Metabolite	Infection
Lateropyrone is a type of pyranone antibiotic that can inhibit Gram-negative bacteria, and it's a secondary metabolite produced by the oat fungal pathogen .

HY-P2318

Bac2A TFA	Fungal	Infection
Bac2A TFA is an antimicrobial and immunomodulatory peptide. Bac2A TFA is a linear variant of bactenecin and is very effective against fungal pathogens.

HY-126117

(+)-Xylariamide A	Fungal Carbonic Anhydrase	Infection
(+)-Xylariamide A (compound 6b) is a mycobacterial and fungal carbonic anhydrase probe with inhibitory activity against pathogen β-carbonic anhydrases .

HY-P4327

Hispidalin	Bacterial	Infection
Hispidalin is a novel antimicrobial peptide with broad and efficient antibacterial activity against various bacterial and fungal pathogens, and can be used as an antibacterial agent and food preservative .

HY-B0850S

Difenoconazole-d6 hydrochloride	Isotope-Labeled Compounds Fungal	Infection
Difenoconazole-d₆ (hydrochloride) is deuterium labeled Difenoconazole. Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth .

HY-B0850R

Difenoconazole (Standard)	Reference Standards Fungal	Infection
Difenoconazole (Standard) is the analytical standard of Difenoconazole. This product is intended for research and analytical applications. Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth .

HY-W743674

Difenoconazole-d6	Isotope-Labeled Compounds Fungal	Infection
Difenoconazole-d₆ is the deuterium labeled Difenoconazole (HY-B0850). Difenoconazole is a sterol demethylation inhibitor, as a fungicide. Difenoconazole binds the heme portion of the fungal cytochrome P450 51, interferes the mycelial growth and inhibits the spore germination of pathogens, suppressing fungal growth .

HY-N0363

(+)-Columbianetin 1 Publications Verification (S)-Columbianetin	Fungal	Infection Inflammation/Immunology
(+)-Columbianetin is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity .

HY-B2053

Tolclofos-methyl	Bacterial	Infection
Tolclofos-methyl is a broad-spectrum aromatic hydrocarbon fungicide that is used as a see treatment for protection against soil-borne and seed borne fungal pathogens that caused seed decay and seedling blights.

HY-N0363A

(+)-Columbianetin acetate 1 Publications Verification (S)-Columbianetin acetate	Fungal	Infection Inflammation/Immunology
(S)-Columbianetin acetate is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity .

HY-E70119

Pectate Lyase	Fungal	Infection
Pectate Lyase is an important enzyme secreted by plant pathogens. Pectate Lyase plays a critical role in pectin degradation and fungal virulence. Pectate Lyase induces plant immune responses and contributes to virulence .

HY-108547

Alexidine dihydrochloride 3 Publications Verification	Fungal Apoptosis	Infection Cancer
Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens .

HY-B0221R

Amphotericin B (Standard)	Reference Standards Fungal Antibiotic Bacterial Parasite	Infection Cancer
Amphotericin B (Standard) is the analytical standard of Amphotericin B. This product is intended for research and analytical applications. Amphotericin B is a polyene antifungal agent against a wide variety of *fungal* pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

HY-W115529

Geranic acid Geranate; NSC 229335; GAGE	Fungal	Infection Cancer
Geranic acid is a monoterpenemainly used in flavor, fragrance, cosmetics and agro-industries . In vitro studies show that geranic acid exhibits strong inhibitory activity against Fusarium graminearum and Colletotrichum graminicola, the two main fungal pathogens of maize . It also exhibits antitumor activity .

HY-134215

cis-11-Methyl-2-dodecenoic acid	Bacterial Fungal	Infection
cis-11-Methyl-2-dodecenoic acid is a quorum sensing (QS) signal that acts as a diffusion signaling factor (DSF) in extracellular microbial and fungal communication systems. DSF is involved in the regulation of virulence and biofilm formation of a variety of bacterial pathogens .

HY-N0363R

(+)-Columbianetin (Standard) (S)-Columbianetin (Standard)	Reference Standards Fungal	Infection Inflammation/Immunology
(+)-Columbianetin (Standard) is the analytical standard of (+)-Columbianetin. This product is intended for research and analytical applications. (+)-Columbianetin is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity .

HY-B0221S

Amphotericin B-13C6	Isotope-Labeled Compounds Antibiotic Fungal Parasite Bacterial	Cancer
Amphotericin B- ¹³C₆ is ¹³C labeled Amphotericin B (HY-B0221). Amphotericin B is a polyene antifungal agent against a wide variety of *fungal* pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

HY-N0363AR

(+)-Columbianetin acetate (Standard) (S)-Columbianetin acetate (Standard)	Reference Standards Fungal	Infection Inflammation/Immunology
(+)-Columbianetin acetate (Standard) is the analytical standard of (+)-Columbianetin acetate. This product is intended for research and analytical applications. (S)-Columbianetin acetate is an isomer of Columbianetin. Columbianetin is a phytoalexin associated with celery (Apium graveolens) resistance to pathogens during storage. Columbianetin exhibits excellent anti-fungal and anti-inflammatory activity .

HY-A0277

Cyproconazole	Fungal	Others
Cyproconazole is a triazole fungicide used to protect crops, fruits and vegetables against a wide range of *fungal* pathogens. Cyproconazole can cause hepatocellular adenomas and carcinomas in CD-1 mice. Cyproconazole also exhibits low toxicity to zebrafish embryos and affects locomotor activity .

HY-108547R

Alexidine dihydrochloride (Standard)	Fungal Apoptosis	Infection Cancer
Alexidine (dihydrochloride) (Standard) is the analytical standard of Alexidine (dihydrochloride). This product is intended for research and analytical applications. Alexidine dihydrochloride is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis. Alexidine dihydrochloride has antifungal and antibiofilm activity against a diverse range of fungal pathogens .

HY-B2011

Flutolanil	Fungal Mitochondrial Metabolism Succinate Dehydrogenase	Infection
Flutolanil is a broad-spectrum fungicide. Flutolanil inhibits mycelial oxygen consumption and succinate dehydrogenase in mitochondria Complex II. Flutolanil causes endocrine disruption and reproductive disorders in zebrafish after long-term exposure. Flutolanil can be used to control the fungal pathogens induced plant disease .

HY-125776

Kresoxim-methyl BAS 490 F	Fungal Mitochondrial Metabolism	Infection
Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent K_d of 0.07 μM proving a high affinity for this enzyme .

HY-125776R

Kresoxim-methyl (Standard) BAS 490 F (Standard)	Reference Standards Fungal Mitochondrial Metabolism	Infection
Kresoxim-methyl (Standard) is the analytical standard of Kresoxim-methyl. This product is intended for research and analytical applications. Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme .

HY-N6051

(-)-Maackiain	Fungal NOD-like Receptor (NLR) NF-κB	Infection Inflammation/Immunology
(-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .

HY-15660

Efinaconazole 2 Publications Verification KP-103	Fungal	Infection
Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively . Efinaconazole has a potent in vitro activity against *fungal* pathogens including dermatophytes, Candida and Malassezia species .

HY-A0277R

Cyproconazole (Standard)	Reference Standards Fungal	Others
Cyproconazole (Standard) is the analytical standard of Cyproconazole. This product is intended for research and analytical applications. Cyproconazole is a triazole fungicide used to protect crops, fruits and vegetables against a wide range of *fungal* pathogens. Cyproconazole can cause hepatocellular adenomas and carcinomas in CD-1 mice. Cyproconazole also exhibits low toxicity to zebrafish embryos and affects locomotor activity .

HY-B2011R

Flutolanil (Standard)	Reference Standards Fungal Mitochondrial Metabolism Succinate Dehydrogenase	Infection
Flutolanil (Standard) is the analytical standard of Flutolanil. This product is intended for research and analytical applications. Flutolanil is a broad-spectrum fungicide. Flutolanil inhibits mycelial oxygen consumption and succinate dehydrogenase in mitochondria Complex II. Flutolanil causes endocrine disruption and reproductive disorders in zebrafish after long-term exposure. Flutolanil can be used to control the fungal pathogens induced plant disease .

HY-15660S

Efinaconazole-d4 KP-103-d₄	Isotope-Labeled Compounds Fungal	Infection
Efinaconazole-d₄ is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively . Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species .

HY-N6051R

(-)-Maackiain (Standard)	Reference Standards Fungal NOD-like Receptor (NLR) NF-κB	Infection Inflammation/Immunology
(-)-Maackiain (Standard) is the analytical standard of (-)-Maackiain. This product is intended for research and analytical applications. (-)-Maackiain is a pterocarpan phytoalexin produced from Sophora flavescens. (-)-Maackiain is toxic to several genera of fungal pathogens of legume and non legume hosts. (-)-Maackiain enhances the activation of NLRP3 inflammasome, inhibits the activation of NF-κB pathway, exhibiting thereby immunostimulatory and anti-inflammatory activities. (-)-Maackiain is orally active .

HY-149492

Phosphatase-IN-1	Phosphatase Fungal	Infection
Phosphatase-IN-1 (compound II-8), a propranolol (HY-B0573B) derivative, is a phosphatidate phosphatase (Pah) inhibitor. Phosphatase-IN-1 can binds to MoPah1, with an affinity constant of 19.8 μM. Phosphatase-IN-1 inhibits growth of plant pathogens and shows anti-fungal ability. Phosphatase-IN-1 is not toxic to rice seedlings and wheat heads .

HY-N13196

Arcopilin A	Bacterial	Infection
Arcopilin A (compound Arcopilin A(1))is an antibacterial agent. Arcopilin A has weak inhibitory effects on fungal pathogens and Gram-positive bacteria, with IC₅₀ values of 8.9 μg/mL and 14 μg/mL for cells KB-3-1 and L929, but it can effectively destroy preformed biofilms of Staphylococcus aureus. Arcopilin A can enhance the activities of gentamicin (GM; HY-K1050) and vancomycin (Vac; HY-B0671) by 115 and 31 times, respectively .

HY-N1836

3-Acetonyl-3-hydroxyoxindole 3-Hydroxy-3-acetonyloxindole	TMV	Infection
3-Acetonyl-3-hydroxyoxindole (AHO) is a potent systemic acquired resistance (SAR) inducer in plants. 3-Acetonyl-3-hydroxyoxindole induces resistance in tobacco plants against infection with tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole increases the level of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation and phenylalanine ammonia-lyase activity .

HY-117089

Tetraconazole	Fungal	Infection
Tetraconazole is a selective irreversible inhibitor of 14-α-sterol demethylase (CYP51) with antifungal activity. Tetraconazole competitively binds to the enzyme to block fungal ergosterol synthesis, resulting in cell membrane damage. The EC₅₀ of tetraconazole against wheat pathogens is 0.382-0.802 mg/L, and the EC₅₀ against onion root tip meristem cell growth is 6.7 mg/L, and (R)-(+)-Tetraconazole is 1.49-1.98 times more active than (S)-(-)-Tetraconazole. Tetraconazole can also induce oxidative stress and chromosomal aberrations in plant cells .

Cat. No.	Product Name

HY-L059

Pyroptosis Compound Library	1,459 compounds
Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc. MCE designs a unique collection of 1,459 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Pyroptosis Compound Library

1,459 compounds

Programmed cell death pathways, including apoptosis, pyroptosis and necroptosis, are regulated by unique sets of host proteins that coordinate a variety of biological outcomes. Pyroptosis is a highly inflammatory form of programmed cell death that occurs most frequently upon infection with intracellular pathogens and is likely to form part of the antimicrobial response. This process promotes the rapid clearance of various bacterial, viral, fungal and protozoan infections by removing intracellular replication niches and enhancing the host's defensive responses. Pyroptosis has been widely studied in inflammatory and infection disease models. Recently, there are growing evidences that pyroptosis also plays an important role in the development of cancer, cardiovascular diseases and Metabolic disorder, etc.

MCE designs a unique collection of 1,459 pyroptosis-related compounds mainly focusing on the key targets in the pyroptosis signaling pathway and can be used in the research of pyroptosis signal pathway and related diseases.

Cat. No.	Product Name	Target	Research Area