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electron transport chain

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46

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15

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5

Isotope-Labeled Compounds

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-130055
    HQNO
    1 Publications Verification

    		 Mitochondrial Metabolism Infection
    HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III . HQNO is a potent inhibitor of mitochondrial NDH-2 in many species .
    HQNO
  • HY-112177
    Myxothiazol

    		Fungal Mitochondrial Metabolism Antibiotic Infection
    Myxothiazol, an antifungal antibiotic, is a mitochondrial electron transport chain complex III (bc1 complex) inhibitor. Myxothiazol inhibits the growth of many yeasts and fungi at concentrations between 0.01 and 3 μg/ml .
    Myxothiazol
  • HY-N6782
    Oligomycin
    65+ Cited Publications

    		 Oxidative Phosphorylation ATP Synthase Fungal Antibiotic Infection Cancer
    Oligomycin, an antifungal antibiotic, is an inhibitor of H +-ATP-synthase. Oligomycin blocks oxidative phosphorylation and the electron transport chain. Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells .
    Oligomycin
  • HY-101415
    Coenzyme Q9

    Ubiquinone Q9; CoQ9; Ubiquinone 9

    		 Apoptosis Endogenous Metabolite Cardiovascular Disease
    Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis .
    Coenzyme Q9
  • HY-126222A
    MitoTam iodide, hydriodide

    		Apoptosis Mitochondrial Metabolism Cancer
    MitoTam iodide, hydriodide is a Tamoxifen derivative , an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells . MitoTam iodide, hydriodide causes apoptosis .
    MitoTam iodide, hydriodide
  • HY-B1849
    Hexazinone

    		Herbicide Infection
    Hexazinone is a nonselective herbicide from the triazine family. Hexazinone binds to the D-1 quinone protein of the electron transport chain in photosystem II to inhibit the photosynthesis .
    Hexazinone
  • HY-130055R
    HQNO (Standard)

    		Reference Standards Mitochondrial Metabolism Infection
    HQNO (Standard) is the analytical standard of HQNO. This product is intended for research and analytical applications. HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2].
    HQNO (Standard)
  • HY-B1849R
    Hexazinone (Standard)

    		Herbicide Reference Standards Infection
    Hexazinone (Standard) is the analytical standard of Hexazinone. This product is intended for research and analytical applications. Hexazinone is a nonselective herbicide from the triazine family. Hexazinone binds to the D-1 quinone protein of the electron transport chain in photosystem II to inhibit the photosynthesis .
    Hexazinone (Standard)
  • HY-126222
    MitoTam bromide, hydrobromide

    		Apoptosis Mitochondrial Metabolism Cancer
    MitoTam bromide, hydrobromide, a Tamoxifen derivative , is an electron transport chain (ETC) inhibitor. MitoTam bromide, hydrobromide reduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam bromide, hydrobromide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells .
    MitoTam bromide, hydrobromide
  • HY-101415R
    Coenzyme Q9 (Standard)

    Ubiquinone Q9 (Standard); CoQ9 (Standard); Ubiquinone 9 (Standard)

    		 Reference Standards Apoptosis Endogenous Metabolite Cardiovascular Disease
    Coenzyme Q9 (Standard) is the analytical standard of Coenzyme Q9. This product is intended for research and analytical applications. Coenzyme Q9 (Ubiquinone Q9), the major form of ubiquinone in rodents, is an amphipathic molecular component of the electron transport chain that functions as an endogenous antioxidant. Coenzyme Q9 attenuates the diabetes-induced decreases in antioxidant defense mechanisms. Coenzyme Q9 improves left ventricular performance and reduces myocardial infarct size and cardiomyocyte apoptosis .
    Coenzyme Q9 (Standard)
  • HY-126222B
    (E/Z)-MitoTam iodide, hydriodide

    MitoTax iodide, hydriodide

    		 Mitochondrial Metabolism Apoptosis Cancer
    (E/Z)-MitoTam (iodide, hydriodide) (MitoTam (iodide, hydriodide)) is the E/Z mixture of MitoTam iodide, hydriodide. MitoTam iodide, hydriodide is a Tamoxifen derivative , an electron transport chain (ETC) inhibitor, spreduces mitochondrial membrane potential in senescent cells and affects mitochondrial morphology . MitoTam iodide, hydriodide is an effective anticancer agent, suppresses respiratory complexes (CI-respiration) and disrupts respiratory supercomplexes (SCs) formation in breast cancer cells . MitoTam iodide, hydriodide causes apoptosis .
    (E/Z)-MitoTam iodide, hydriodide
  • HY-N0111
    Coenzyme Q10
    5+ Cited Publications

    CoQ10; Ubiquinone-10; Ubidecarenone

    		 Endogenous Metabolite Reactive Oxygen Species (ROS) Ferroptosis Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
    Coenzyme Q10
  • HY-121242
    Buthidazole

    VEL-5026

    		 Photosystem II Others
    Buthidazole is a selective herbicide for weed control in corn. Buthidazole inhibits photosynthetic electron transport at two distinct sites in the photosynthetic electron transport chain. The major site of inhibition was on the reducing side of photosystem II. Another site of electron transport inhibition is on the oxidizing side of photosystem II. Buthidazole inhibits corn photosynthesis and prevents starch accumulation in bundle sheath chloroplasts and some ultrastructural disruption of mesophyl chloroplasts of corn plants .
    Buthidazole
  • HY-B1756
    Rotenone
    Maximum Cited Publications
    115 Publications Verification

    		 Mitochondrial Metabolism Autophagy Apoptosis Neurological Disease Cancer
    Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
    Rotenone
  • HY-120338
    RYL-552

    		Mitochondrial Metabolism Parasite Infection
    RYL-552, a mitochondrial electron transport chain (ETC) inhibitor, is a P. falciparum NADH dehydrogenase 2 (PfNDH2) inhibtor .
    RYL-552
  • HY-174393
    Gamhepathiopine

    		Parasite Mitochondrial Metabolism Infection
    Gamhepathiopine is a thienopyrimidinone compound. Gamhepathiopine exerts antimalarial effects by targeting the Qo site of Plasmodium falciparum cytochrome b and inhibiting the activity of complex III in the electron transport chain .
    Gamhepathiopine
  • HY-162515
    8-OAc

    		Mitochondrial Metabolism Cancer
    8-OAc is a potent and selective mitochondrial electron transport chain (ETC) complex I inhibitor. 8-OAc exhibits cytotoxicity against cancer cell lines .
    8-OAc
  • HY-N0111S2
    Coenzyme Q10-d9

    CoQ10-d9; Ubiquinone-10-d9

    		 Isotope-Labeled Compounds Endogenous Metabolite Reactive Oxygen Species (ROS) Ferroptosis Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Coenzyme Q10-d9 is the deuterium labeled Coenzyme Q10. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
    Coenzyme Q10-d9
  • HY-N0111S
    Coenzyme Q10-d6

    CoQ10-d6; Ubiquinone-10-d6

    		 Isotope-Labeled Compounds Endogenous Metabolite Reactive Oxygen Species (ROS) Ferroptosis Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Coenzyme Q10-d6 is deuterium labeled Coenzyme Q10. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
    Coenzyme Q10-d6
  • HY-136406
    Bongkrekic acid

    		ATP Synthase Infection Cancer
    Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans . Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .
    Bongkrekic acid
  • HY-119984
    DNP-INT

    		Cytochrome P450 Others
    DNP-INT is a potent photosynthetic electron transport chain (PETC) inhibitor. DNP-INT competently inhibits the oxidation of plastid quinoline by binding to the Q0 site of Cyt-b6f (Kd=1.4 nM), thereby inhibiting electron transfer in plants .
    DNP-INT
  • HY-158421
    MS-L6

    		Oxidative Phosphorylation Mitochondrial Metabolism Cancer
    MS-L6 is a potent inhibitor of oxidative phosphorylation (OXPHOS) that can acts as electron transport chain complexes I (ETC-I) combining inhibition of NADH oxidation and uncoupling effect .
    MS-L6
  • HY-N0111R
    Coenzyme Q10 (Standard)

    CoQ10 (Standard); Ubiquinone-10 (Standard); Ubidecarenone (Standard)

    		 Reference Standards Endogenous Metabolite Reactive Oxygen Species (ROS) Ferroptosis Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Coenzyme Q10 (Standard) is the analytical standard of Coenzyme Q10. This product is intended for research and analytical applications. Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
    Coenzyme Q10 (Standard)
  • HY-119687
    Bifenazate

    		GABA Receptor Mitochondrial Metabolism Na+/K+ ATPase Reactive Oxygen Species (ROS) Insecticide Infection Cardiovascular Disease
    Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .
    Bifenazate
  • HY-B1756R
    Rotenone (Standard)

    		Reference Standards Mitochondrial Metabolism Autophagy Apoptosis Neurological Disease Cancer
    Rotenone (Standard) is the analytical standard of Rotenone. This product is intended for research and analytical applications. Rotenone is a mitochondrial electron transport chain complex I inhibitor. Rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production.
    Rotenone (Standard)
  • HY-N2024A
    Maltose monohydrate
    1 Publications Verification

    		 Endogenous Metabolite Cancer
    Maltose monohydrate is the energy source for bacteria. Maltose is increased in leaves when starch breakdown is induced during the day under photorespiratory conditions. Maltose has the ability to protect proteins, membranes and the photosynthetic electron transport chain .
    Maltose monohydrate
  • HY-B1849S
    Hexazinone-d6

    		Isotope-Labeled Compounds Infection
    Hexazinone-d6 is the deuterium labeled Hexazinone . Hexazinone is a nonselective herbicide from the triazine family. Hexazinone binds to the D-1 quinone protein of the electron transport chain in photosystem II to inhibit the photosynthesis .
    Hexazinone-d6
  • HY-136406S
    Bongkrekic acid-13C28

    		Isotope-Labeled Compounds ATP Synthase Cancer
    Bongkrekic acid- 13C28 is the 13C labeled Bongkrekic acid (HY-136406). Bongkrekic acid is a mitochondrial toxin secreted by the bacteria Pseudomonas cocovenenans. Bongkrekic acid specific ligand for mitochondrial adenine nucleotide translocase (ANT) rather than the electron transport chain. Bongkrekic acid has to cross the mitochondrial inner membrane to produce its inhibitory effect on ADP/ATP transport .
    Bongkrekic acid-13C28
  • HY-149998
    Antimycobacterial agent-5

    		Bacterial Reactive Oxygen Species (ROS) Apoptosis Infection
    Antimycobacterial agent-5 (compound 27) is an imidazopyridine amide targeting mycobacterial electron transport chain (ETC) airway CIII2CIV2 supercomplexes. The IC50 value of Antimycobacterial agent-5 against Mycobacterium smegmatisCIII2CIV2 is 441 nM .
    Antimycobacterial agent-5
  • HY-121248
    Hydramethylnon

    AC217300

    		 Mitochondrial Metabolism Infection
    Hydramethylnon (AC217300) is an amidinohydrazone insecticide. Hydramethylnon's mechanism of action is through inhibition of mitochondrial respiration by inhibiting the electron transport chain at the cytochrome b-c1 complex. Hydramethylnon can be used to eliminate red imported fire ants, cockroaches, and other insects .
    Hydramethylnon
  • HY-B1848
    Hexaflumuron

    		Insecticide Others
    Hexaflumuron is an insect growth regulator (IGR) that inhibits chitin synthesis during insect molting .
    Hexaflumuron
  • HY-B1848R
    Hexaflumuron (Standard)

    		Reference Standards Insecticide Others
    Hexaflumuron (Standard) is the analytical standard of Hexaflumuron. This product is intended for research and analytical applications. Hexaflumuron is an insect growth regulator (IGR) that inhibits chitin synthesis during insect molting .
    Hexaflumuron (Standard)
  • HY-119687R
    Bifenazate (Standard)

    		Reference Standards GABA Receptor Mitochondrial Metabolism Na+/K+ ATPase Reactive Oxygen Species (ROS) Insecticide Infection Cardiovascular Disease
    Bifenazate (Standard) is the analytical standard of Bifenazate. This product is intended for research and analytical applications. Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .
    Bifenazate (Standard)
  • HY-W725476
    Bifenazate-d5

    		Reactive Oxygen Species (ROS) Infection
    Bifenazate-d5 is the deuterium labeled Bifenazate (HY-119687). Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm . Bifenazate is a positive allosteric modulator of GABA receptor . Bifenazate is the inhibitor for the mitochondrial electron transport chain complex III .
    Bifenazate-d5
  • HY-N2024AR
    Maltose monohydrate (Standard)

    		Reference Standards Endogenous Metabolite Cancer
    Maltose monohydrate (Standard) is the analytical standard of Maltose monohydrate. This product is intended for research and analytical applications. Maltose monohydrate is the energy source for bacteria. Maltose is increased in leaves when starch breakdown is induced during the day under photorespiratory conditions. Maltose has the ability to protect proteins, membranes and the photosynthetic electron transport chain .
    Maltose monohydrate (Standard)
  • HY-176246
    Antitubercular agent-52

    		Bacterial Infection
    Antitubercular agent-52 (Compound 7k) is an antitubercular agent targeting Mycobacterium tuberculosis (Mtb). Antitubercular agent-52 selectively inhibits the cytochrome bcc (cyt-bcc) electron transport chain of Mtb and also acts on cytochrome bd (cyt-bd). Antitubercular agent-52 blocks electron transfer and ATP production by interfering with the key energy metabolism pathway of Mtb. Antitubercular agent-52 is promising for research of tuberculosis .
    Antitubercular agent-52
  • HY-125283
    IM176OUT05

    2-Me-Phen hydrochloride; 2-Me-Phenformin hydrochloride

    		 Mitochondrial Metabolism Metabolic Disease
    IM176OUT05 is a high solubility biguanide. IM176OUT05 activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process. IM176OUT0 inhibits mitochondrial electron transport chain (ETC) activity with an IC50 of 3.2 μM .
    IM176OUT05
  • HY-170369
    SHO1122147

    		Mitochondrial Metabolism Metabolic Disease
    SHO1122147 (Compound 7m) affects the mitochondrial electron transport chain, exhibits mitochondrial uncoupling activity (EC50=3.6 μM), and increases the oxygen consumption rate (OCR=69%) and promotes cellular respiration. SHO1122147 is orally active, and can be used in reaearch of obesity and metabolic dysfunction-associated steatohepatitis (MASH) .
    SHO1122147
  • HY-19877
    GSK932121

    		Parasite Infection
    GSK932121 is an antimalarial drug with activity that inhibits the electron transport chain of P. falciparum. GSK932121 acts selectively on this pathogen at the level of cytochrome bc1 (complex III). The synthesis method of GSK932121 is highly efficient, and the final structure can be obtained in only 5 steps. The synthesis of GSK932121 can be prepared atKilog scale to support clinical studies .
    GSK932121
  • HY-N1839
    3-Hydroxybakuchiol

    		Apoptosis Glycosidase Cancer
    3-Hydroxybakuchiol can be isolated from Otholobium mexicanum J. W. Grimes. 3-Hydroxybakuchiol is an electron transport chain (ETC) inhibitor. 3-Hydroxybakuchiol has antitumor activity, and induces tumor cell apoptosis. 3-Hydroxybakuchiol also has moderate inhibitory activity against α-glucosidase (IC50: 345 μM) .
    3-Hydroxybakuchiol
  • HY-N12887
    Mycothiazole

    		Mitochondrial Metabolism Others Cancer
    Mycothiazole is an inhibitor for mitochondrial electron transport chain (ETC) complex I. Mycothiazole exhibits cytotoxicity in cancer cells Huh7 (IC50 is 55.8 μM), U87 and MCF7. Mycothiazole induces apoptosis in Huh7. Mycothiazole utilizes the unfolded protein response (UPR) and heat shock response (HSR) pathway involved transcription factors ATFS-1 and HSF1, to extend the lifespan of C. elegans .
    Mycothiazole
  • HY-W014684
    Lilial

    		Keap1-Nrf2 Reactive Oxygen Species (ROS) Mitochondrial Metabolism Endocrinology
    Lilial is a widely used synthetic fragrance and ester in consumer products. Lilial possesses estrogenic activity in vitro. Lilial can induce a toxic effect on mitochondria that causes a decrease in the viability of HaCaT cells. Lilial can increase NRF2 protein level in vitro. Lilial is able to target respiratory chain complexes, inhibit complexes I and II of the electron transport chain, increase the generation of reactive oxygen species, and decrease the level of intracellular ATP. Lilial can induce systemic toxicity in vivo. Lilial induces significant DNA strand breaks .
    Lilial
  • HY-176253
    Antitrypanosomal agent 26

    		Parasite Infection
    Antitrypanosomal agent 26 (Compound 1) is an allosteric trypanosome alternative oxidase (TAO) inhibitor. Antitrypanosomal agent 26 exhibits potent activity against African animal trypanosomes (e.g., Trypanosoma brucei, etc.) with an IC50 value of 1.3 nM for recombinant TAO. Antitrypanosomal agent 26 blocks the mitochondrial electron transport chain of trypanosomes and inhibits glucose-dependent respiration. Antitrypanosomal agent 26 is promising for research of African animal trypanosomiasis, such as bovine trypanosomiasis .
    Antitrypanosomal agent 26
  • HY-W014684R
    Lilial (Standard)

    		Reference Standards Keap1-Nrf2 Reactive Oxygen Species (ROS) Mitochondrial Metabolism Endocrinology
    Lilial (Standard) is the analytical standard of Lilial. This product is intended for research and analytical applications. Lilial is a widely used synthetic fragrance and ester in consumer products. Lilial possesses estrogenic activity in vitro. Lilial can induce a toxic effect on mitochondria that causes a decrease in the viability of HaCaT cells. Lilial can increase NRF2 protein level in vitro. Lilial is able to target respiratory chain complexes, inhibit complexes I and II of the electron transport chain, increase the generation of reactive oxygen species, and decrease the level of intracellular ATP. Lilial can induce systemic toxicity in vivo. Lilial induces significant DNA strand breaks .
    Lilial (Standard)
  • HY-N0354
    Anthraquinone

    		Virus Protease Topoisomerase Apoptosis Infection Metabolic Disease Inflammation/Immunology Cancer
    Anthraquinone is used as a precursor for dye formation and agrochemicals, existing in different organisms, such as bacteria, fungi, plants, and some animals. Anthraquinone has biological activities: anticancer, antiinflammatory, diuretic, antiarthritic, antifungal, antibacterial, antimalarial and antioxidant. Anthraquinone also plays an important role in the primary metabolism of plants by acting on the electron transport chain through the inhibition of energy transfer in the photosynthetic process. Anthraquinone can intercalates into DNA and inhibits the topoisomerase II (topo II) enzyme, resulting in cell death via Apoptosis .
    Anthraquinone
  • HY-17516R
    Tolfenpyrad (Standard)

    		Reference Standards Insecticide Bacterial Mitochondrial Metabolism Infection
    Tolfenpyrad (Standard) is the analytical standard of Tolfenpyrad (HY-17516). This product is intended for research and analytical applications. Tolfenpyrad is an orally active insecticide, acaricide and antibacterial agent. Tolfenpyrad inhibits Complex I in the mitochondrial respiratory electron transport chain, interfering with the cell respiration process. Tolfenpyrad has significant insecticidal activity against a variety of insect pests such as H. contortus, Coccinella septempunctata. Tolfenpyrad has antibacterial activity against Francisella novicida, with an IC50 of 1.2 µM or 1.5 µM .
    Tolfenpyrad (Standard)

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