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cytotoxicity-assay

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By Targets:	ADC Linker (1) Adrenergic Receptor (1)
By Research Areas:	Cancer (2)

2

Inhibitors & Agonists

2

MCE Kits

Targets Recommended: Biochemical Assay Reagents

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Mc-Val-Cit-PAB-Cl	ADC Linker	Cancer
Mc-Val-Cit-PAB-Cl is a cleavable ADC linker. Mc-Val-Cit-PAB-Cl can be used to conjugate MMAE and antibody to form antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE with IC₅₀s of 3.3 and 0.95 nM for BJAB and WSU cell lines in cytotoxicity assay).

(-)-Domesticine	Adrenergic Receptor	Cancer
(-)-Domesticine is an anti-α-1D-adrenoceptor compound with cytotoxic activity. (-)-Domesticine showed activity in MTS cytotoxicity assays against human colon cancer cell lines HCT-116 and Caco-2. (-)-Domesticine tolerates alkoxy substituents and benzoate functional groups at the C1 position in modifications of its chemical structure. The most potent compounds of (-)-Domesticine have IC50 values in the range of 23-38 μM, similar to the known cytotoxic compound etoposide .

Cat. No.	Product Name

Cell Counting Kit-8 3320+ Cited Publications
Cell Counting Kit-8 (CCK-8) allows sensitive colorimetric assays for the determination of cell viability in cell proliferation and cytotoxicity assays.

*Viability/Cytotoxicity Assay* Kit for Live & Dead Cells (Calcein/PI)** 1 Publications Verification
MCE Viability/Cytotoxicity Assay Kit for Live & Dead Cells (Calcein/PI) enables dual fluorescent staining of both live and dead cells, making it suitable for assessing cell viability and cytotoxicity.

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