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Results for "

cytotoxicity reduction

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (1) Aldose Reductase (1) Apoptosis (1) Bacterial (5) COX (1) Cytochrome P450 (1) Dengue Virus (1) DNA/RNA Synthesis (3) E1/E2/E3 Enzyme (1) EGFR (1) Endogenous Metabolite (1) Ferroptosis (1) Fluorescent Dye (1) Fungal (1) HDAC (1) Interleukin Related (1) NO Synthase (1) Nucleoside Antimetabolite/Analog (1) p38 MAPK (1) p62 (1) PIN1 (1) Ras (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) SARS-CoV (1) STAT (1) VD/VDR (1)
By Research Areas:	Cancer (9) Infection (6) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)

By Targets:

17β-HSD (1)

Aldose Reductase (1)

Apoptosis (1)

Bacterial (5)

COX (1)

Cytochrome P450 (1)

Dengue Virus (1)

DNA/RNA Synthesis (3)

E1/E2/E3 Enzyme (1)

EGFR (1)

Endogenous Metabolite (1)

Ferroptosis (1)

Fluorescent Dye (1)

Fungal (1)

HDAC (1)

Interleukin Related (1)

NO Synthase (1)

Nucleoside Antimetabolite/Analog (1)

p38 MAPK (1)

p62 (1)

PIN1 (1)

Ras (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (1)

SARS-CoV (1)

STAT (1)

VD/VDR (1)

By Research Areas:

Cancer (9)

Infection (6)

Inflammation/Immunology (2)

Metabolic Disease (1)

Neurological Disease (1)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153675

BCPA	PIN1	Metabolic Disease
BCPA is a Pin1 regulator without cytotoxicity. BCPA attenuates the reduction of Pin1 protein to inhibit receptor activator of RANKL-induced osteoclastogenesis. BCPA regulates osteoclast activation, used to osteoporosis research .

HY-15924

Thiazolyl Blue 155+ Cited Publications MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide	Fluorescent Dye	Others
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

HY-155035

S07-1066	17β-HSD	Cancer
S07-1066 is an aldo-keto reductase 1C3 (AKR1C3) inhibitor, synergizing doxorubicin (DOX) cytotoxicity. S07-1066 selectively blocks AKR1C3-mediated reduction of DOX, and reverses the DOX resistance in overexpressing AKR1C3 cells .

HY-135470

Nifurpirinol P-7138	Bacterial	Infection
Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS) .

HY-116170

SN34037	Aldose Reductase	Cancer
SN34037 is a specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) with the ability to inhibit the cytotoxic activity of PR-104A. SN34037-sensitive coumberone reduction provides a rapid and specific assay for AKR1C3 activity. SN34037 inhibits the aerobic cytotoxicity of PR-104A in TF1 erythroleukemia cells with high AKR1C3 expression, but not in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression .

HY-N10307

Anserinone B	Fungal Bacterial Endogenous Metabolite	Infection Cancer
Anserinone B is an antifungal and antibacterial benzoquinone. Anserinone B causes radial growth reductions of 50% and 37% against S.fimicola and A. furfuraceus, respectively. Anserinones B also displays moderate cytotoxicity in the NCI’s 60 human tumor cell line panel (GI₅₀=4.4 µg/mL) .

HY-144341

DprE1-IN-1	Bacterial	Infection
DprE1-IN-1 is a potent, orally active DprE1 inhibitor with favorable hepatocyte stability, low cytotoxicity and low hERG channel inhibition. DprE1-IN-1 displays potent activity against both agent-susceptible and clinically isolated drug-resistant Tuberculosis strains with MICs10 CFU reduction in macrophages.

HY-U00279B

Nitracrine hydrochloride	DNA/RNA Synthesis	Cancer
Nitracrine hydrochloride is a platinum-based antineoplastic drug with selective toxicity to hypoxic cells. Nitracrine hydrochloride exhibits significant cytotoxicity against the Chinese hamster ovary cell line AA8 under hypoxic conditions. Nitracrine hydrochloride exerts its effect by binding to the insertion of DNA and forming covalent adducts. The cytotoxicity of Nitracrine hydrochloride under hypoxic conditions is related to its reductive metabolism to form alkylated substances. At the same time, it may enhance the reactivity to DNA through the insertion of DNA, thereby improving the efficacy. Nitracrine hydrochloride can also inhibit RNA synthesis, contributing to its anti-tumor effect .

HY-163880

EGFR-IN-119	EGFR Ras p38 MAPK Reactive Oxygen Species (ROS)	Cancer
EGFR-IN-119 (Compound 5l) is an inhibitor for EGFR with an IC₅₀ of 84.3 nM. EGFR-IN-119 inhibits the cytotoxicity in lung cancer cell A549 with an IC₅₀ of 1.34 μM. EGFR-IN-119 downregulates the expressions of EGFR, KRAS, and MAP2K genes, exhibits antioxidant activity through reduction of reactive oxygen species (ROS), and hyperpolarizes the mitochondrial membrane potential .

HY-118722

RB-90740	DNA/RNA Synthesis Cytochrome P450	Cancer
RB-90740 is a type of biological reducing agent. RB-90740 is activated through metabolic reduction and generates cytotoxic products, thereby selectively killing tumor cells (usually in a hypoxic environment). RB-90740 has selective toxicity towards hypoxic cells, which is mainly achieved by causing DNA strand breaks and activating reducing enzymes (such as Cytochrome P450). RB-90740 does not initially exhibit cytotoxicity similar to its in vitro properties in hypoxic cells in mouse models. RB-90740 can be used to study the tumor physiological environment

HY-178111

AcrB-IN-6	Bacterial	Infection
AcrB-IN-6 is an effective AcrB inhibitor. AcrB-IN-6 The compound inhibits the function of bacterial multidrug efflux pumps, thereby significantly enhancing the antibacterial activity of various antibiotics. AcrB-IN-6 achieves 32-fold MIC reductions in wild-type E. coli BW25113. AcrB-IN-6 exhibits excellent synergistic antibacterial effects, low cytotoxicity and hemolytic properties. AcrB-IN-6 can be used for researching anti-resistant bacteria .

HY-N15398

Chaetoglobosin E	Ferroptosis	Cancer
Chaetoglobosin E is a Ferroptosis inducer that exhibits significant cytotoxicity against human tumor cell lines MDA-MB231 and A549, with IC₅₀ values of 9.14 and 7.47 μM, respectively. By downregulating the expression of GPX4 in A549 cells, Chaetoglobosin E markedly increases intracellular levels of Fe ²⁺ and the lipid peroxidation product malondialdehyde (MDA), leading to mitochondrial shrinkage, reduction or disappearance of cristae, and subsequent induction of ferroptosis. Chaetoglobosin E can be used for research in the field of cancer .

HY-135470R

Nifurpirinol (Standard) P-7138 (Standard)	Reference Standards Bacterial	Infection
Nifurpirinol (P-7138) (Standard) is the analytical standard of Nifurpirinol (HY-135470). This product is intended for research and analytical applications. Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR). NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS) .

HY-161778

ZG-126	HDAC VD/VDR	Inflammation/Immunology Cancer
ZG-126 is an agonist for vitamin D receptor (VDR) and an inhibitor for histone deacetylase (HDAC) (IC₅₀=0.63-67.6 μM). ZG-126 exhibits cytotoxicity in cancer cells MDA-MB-231 and 4T1. ZG-126 exhibits antitumor and anti-metastatic efficacy against melanoma and triple-negative breast cancer (TNBC) in mouse models. ZG-126 also exhibits anti-inflammatory activity, through the reduction of macrophage infiltration and immunosuppressive M2-polarization .

HY-170621

STAT1/3-IN-1	STAT NO Synthase COX Interleukin Related	Neurological Disease Inflammation/Immunology
STAT1/3-IN-1 (Compound 6k) is a STAT1/3 phosphorylation inhibitor. STAT1/3-IN-1 inhibits the phosphorylation and nuclear translocation of STAT1/3. STAT1/3-IN-1 also inhibits inflammatory enzymes iNOS and COX-2. STAT1/3-IN-1 demonstrates anti-inflammatory effect (reduction of pro-inflammatory cytokines, including IL-1β, IL-6 and TNF-α) without significant cytotoxicity .

HY-151799

P62-RNF168 agonist-1	p62 E1/E2/E3 Enzyme Apoptosis	Cancer
P62-RNF168 agonist-1 (compound 5a) is a low cytotoxicity P62-RNF168 agonist that enhances the interaction between P62 and RNF168. P62-RNF168 agonist-1 induces a reduction in H2A ubiquitination mediated by RNF168 and impairs homologous recombination-mediated DNA repair. P62-RNF168 agonist-1 also inhibits the growth of xenograft tumors in mice in a dose-dependent manner .

HY-179249

Fluoroneplanocin A-8N	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog SARS-CoV Dengue Virus	Infection
Fluoroneplanocin A-8N (Compound 3a) is an inhibitor targeting SAH hydrolase (IC₅₀ = 1.51 μM) and viral RNA polymerase. Fluoroneplanocin A-8N exhibits broad-spectrum anti-SARS-CoV-2 and dengue virus activity, with EC₅₀ values of 12.2 and 37.4 μM respectively. Fluoroneplanocin A-8N has no cytotoxicity. Fluoroneplanocin A-8N can be used for anti-positive-strand viruses .

Cat. No.	Product Name	Type

HY-15924

Thiazolyl Blue 155+ Cited Publications MTT; Thiazolyl Blue Tetrazolium bromide; Methylthiazolyldiphenyl-tetrazolium bromide	Fluorescent Dye
Thiazolyl Blue (MTT) is a cell-permeable and positively charged tetrazolium dye that is used to detect reductive metabolism in cells. Thiazolyl Blue is taken up by cells through the plasma membrane and then reduced to formazan by intracellular NAD (P) H-oxidoreductases. Thiazolyl Blue is frequently used in colorimetric assays to measure cell proliferation, cytotoxicity, and apoptosis .

Anserinone B	Infection Quinones Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Benzene Quinones Endogenous metabolite Disease Research Fields	Fungal Bacterial Endogenous Metabolite
Anserinone B is an antifungal and antibacterial benzoquinone. Anserinone B causes radial growth reductions of 50% and 37% against S.fimicola and A. furfuraceus, respectively. Anserinones B also displays moderate cytotoxicity in the NCI’s 60 human tumor cell line panel (GI₅₀=4.4 µg/mL) .

Chaetoglobosin E	Alkaloids Microorganisms Source classification Indole Alkaloids	Ferroptosis
Chaetoglobosin E is a Ferroptosis inducer that exhibits significant cytotoxicity against human tumor cell lines MDA-MB231 and A549, with IC₅₀ values of 9.14 and 7.47 μM, respectively. By downregulating the expression of GPX4 in A549 cells, Chaetoglobosin E markedly increases intracellular levels of Fe ²⁺ and the lipid peroxidation product malondialdehyde (MDA), leading to mitochondrial shrinkage, reduction or disappearance of cristae, and subsequent induction of ferroptosis. Chaetoglobosin E can be used for research in the field of cancer .

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