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cystine

" in MedChemExpress (MCE) Product Catalog:

45

Inhibitors & Agonists

1

Fluorescent Dye

3

Biochemical Assay Reagents

12

Peptides

13

Natural
Products

1

Recombinant Proteins

8

Isotope-Labeled Compounds

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W001941
    D-Cystine

    		Drug Isomer Bacterial Antibiotic Others
    D-Cystine is the D-enantiomer of L-Cystine. D-Cystine inhibits L-aspartate-β-semialdehyde dehydrogenase (ASADH) from Escherichia coli .
    D-Cystine
  • HY-W009203
    L-Cystine dihydrochloride
    2 Publications Verification

    		 Endogenous Metabolite Apoptosis Keap1-Nrf2 Reactive Oxygen Species (ROS) Ferroptosis Metabolic Disease Inflammation/Immunology Cancer
    L-Cystine dihydrochloride is the dihydrochloride salt form of L-Cystine (HY-N0394). L-Cystine dihydrochloride elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine dihydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine dihydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine dihydrochloride is promising for research of cystinuria and kidney stones
    L-Cystine dihydrochloride
  • HY-W013940S1
    DL-Cystine-d6

    		Isotope-Labeled Compounds Others
    DL-Cystine-d6 is the deuterium labeled DL-Cystine (HY-W013940). DL-Cystine is a cysteine derivative .
    DL-Cystine-d6
  • HY-N0394R
    L-Cystine (Standard)

    		Reference Standards Endogenous Metabolite Ferroptosis ROS Kinase Keap1-Nrf2 Metabolic Disease Inflammation/Immunology Cancer
    L-Cystine (Standard) is the analytical standard of L-Cystine. This product is intended for research and analytical applications. L-Cystine, the extracellular form of L-Cysteine (HY-Y0337), is a nutritionally dispensable semiessential sulfur-containing amino acid, occurring in proteins of plants and animals. L-Cystine induces Nrf2 protein elevation in a Keap1 (HY-P75897)-dependent manner and activates Nrf2 transcription factor. L-cystine can elicit cytoprotection by reducing ROS generation and protecting against oxidant- or doxorubicin-induced apoptosis. The reduced reabsorption of L-Cystine in renal tubules and its poor solubility in urine are the important causes of cystine precipitation and cystine crystal formation eventually leading to kidney stones. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and cystinosis
    L-Cystine (Standard)
  • HY-N0394S1
    L-Cystine-d4
    1 Publications Verification

    		 Isotope-Labeled Compounds Endogenous Metabolite Ferroptosis Others
    L-Cystine-d4 is the deuterium labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.
    L-Cystine-d4
  • HY-W013940
    DL-Cystine

    		Amino Acid Derivatives Others
    DL-Cystine is a cysteine derivative .
    DL-Cystine
  • HY-W009356
    L-Cystine hydrochloride

    		Endogenous Metabolite Ferroptosis ROS Kinase Keap1-Nrf2 Reactive Oxygen Species (ROS) Others
    L-Cystine hydrochloride is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine hydrochloride elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-Cystine hydrochloride reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine hydrochloride combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine hydrochloride is promising for research of cystinuria and kidney stones
    L-Cystine hydrochloride
  • HY-N0394
    L-Cystine
    2 Publications Verification

    		 Endogenous Metabolite Ferroptosis ROS Kinase Keap1-Nrf2 Reactive Oxygen Species (ROS) Metabolic Disease Inflammation/Immunology Cancer
    L-Cystine is an orally active extracellular form of L-Cysteine (HY-Y0337), occurring in proteins of plants and animals. L-Cystine elevates Nrf2 protein expression and activates Nrf2 transcription factor. L-cystine reduces ROS generation and protects against oxidant- or Doxorubicin (HY-15142A)-induced apoptosis. L-Cystine combined with L-theanine (HY-15121) enhances the production of antigen-specific IgG by increasing glutathione (GSH) levels and T helper 2 (Th2) mediated responses in mice. L-Cystine is promising for research of cystinuria and kidney stones
    L-Cystine
  • HY-W013940S
    DL-Cystine-d4

    		Isotope-Labeled Compounds Others
    DL-Cystine-d4 is the deuterium labeled DL-Cystine (HY-W013940). DL-Cystine is a cysteine derivative .
    DL-Cystine-d4
  • HY-W009356A
    L-Cystine monohydrochloride

    		Biochemical Assay Reagents Others
    L-Cystine monohydrochloride is an amino acid. L-Cystine is converted to L-Cysteine in the body. Moreover, L-Cystine/L-Cysteine conversion system is a channel on the cell membrane, which can maintain the internal REDOX homeostasis of E. coli .
    L-Cystine monohydrochloride
  • HY-N0394S3
    L-Cystine-34S2

    		Endogenous Metabolite Ferroptosis Others
    L-Cystine- 34S2 is the 34S-labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.
    L-Cystine-34S2
  • HY-N0394S2
    (S)-L-Cystine-15N2

    		Endogenous Metabolite Ferroptosis Others
    (S)-L-Cystine- 15N2 is the 15N-labeled L-Cystine. L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes.
    (S)-L-Cystine-15N2
  • HY-N0394S4
    L-Cystine-3,3'-13C2

    		Ferroptosis Endogenous Metabolite Others
    L-Cystine-3,3'- 13C2 is the 13C labeled L-Cystine . L-Cystine is an amino acid and intracellular thiol, which plays a critical role in the regulation of cellular processes .
    L-Cystine-3,3'-13C2
  • HY-D1605
    BODIPY FL L-Cystine

    		Fluorescent Dye Others
    BODIPY FL L-Cystine is a thiol-reactive, green-fluorescent dye. BODIPY FL L-Cystine can be the labeling of membrane proteins, proteins with hydrophobic binding sites, or hydrophobic ligands. (λex=504 nm, λem=511 nm) .
    BODIPY FL L-Cystine
  • HY-44680
    L-Cystine N-carboxyanhydride

    		Drug Intermediate Cancer
    L-Cystine N-carboxyanhydride can be used for synthesis of polyamino acid carrier for anti-tumor agent delivery .
    L-Cystine N-carboxyanhydride
  • HY-W013734
    N,N'-Di-BOC-L-cystine

    		Amino Acid Derivatives Others
    N,N'-Di-BOC-L-cystine is a cysteine derivative .
    N,N'-Di-BOC-L-cystine
  • HY-114348R
    N,N'-Diacetyl-L-cystine (Standard)

    DiNAC (Standard); (Ac-Cys-OH)2 (Standard)

    		 Amino Acid Derivatives Reference Standards Cardiovascular Disease
    N,N'-Diacetyl-L-cystine (Standard) is the analytical standard of N,N'-Diacetyl-L-cystine. This product is intended for research and analytical applications. N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits .
    N,N'-Diacetyl-L-cystine (Standard)
  • HY-114348
    N,N'-Diacetyl-L-cystine

    DiNAC; (Ac-Cys-OH)2

    		 Amino Acid Derivatives Cardiovascular Disease
    N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits .
    N,N'-Diacetyl-L-cystine
  • HY-W701625
    N,N'-Diacetyl-L-cystine bis(tert-butyl) diester-d6

    		Isotope-Labeled Compounds Others
    N,N'-Diacetyl-L-cystine bis(tert-butyl) diester-d6 is the deuterium labeled N,N'-Diacetyl-L-cystine bis(tert-butyl) diester.
    N,N'-Diacetyl-L-cystine bis(tert-butyl) diester-d6
  • HY-100787
    L-Cysteine S-sulfate sodium

    		iGluR Endogenous Metabolite Neurological Disease
    L-Cysteine S-sulfate sodium is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate sodium hydrate is the substrate for cystine lyase, it can be used in mass spectrometry operations .
    L-Cysteine S-sulfate sodium
  • HY-45609
    L-Cysteine S-sulfate sodium hydrate

    		iGluR Endogenous Metabolite Neurological Disease
    L-Cysteine S-sulfate sodium hydrate is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate sodium hydrate is the substrate for cystine lyase, it can be used in mass spectrometry operations .
    L-Cysteine S-sulfate sodium hydrate
  • HY-113084
    L-Cysteine S-sulfate

    		iGluR Endogenous Metabolite Neurological Disease
    L-Cysteine S-sulfate is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptor agonist. L-Cysteine S-sulfate is the substrate for cystine lyase, and can be used in mass spectrometry operations .
    L-Cysteine S-sulfate
  • HY-45609R
    L-Cysteine S-sulfate sodium hydrate (Standard)

    		iGluR Endogenous Metabolite Neurological Disease
    L-Cysteine S-sulfate (sodium hydrate) (Standard) is the analytical standard of L-Cysteine S-sulfate (sodium hydrate). This product is intended for research and analytical applications. L-Cysteine S-sulfate sodium hydrate is a potent N-methyl-d-aspartate (NMDA) glutamatergic receptors agonist. L-Cysteine S-sulfate sodium hydrate is the substrate for cystine lyase, it can be used in mass spectrometry operations .
    L-Cysteine S-sulfate sodium hydrate (Standard)
  • HY-114481
    Imidazole ketone erastin
    30+ Cited Publications

    IKE

    		 Ferroptosis Cancer
    Imidazole ketone erastin is a potent, selective, and metabolically stable inhibitor of the cystine-glutamate antiporter, system xc - and an activator of ferroptosis. Imidazole ketone erastin has anti-tumor activity .
    Imidazole ketone erastin
  • HY-P5793
    GTx1-15

    		Sodium Channel Calcium Channel Neurological Disease
    GTx1-15 is an inhibitor cystine knot (ICK) peptide that inhibits the voltage-dependent calcium channel Cav3.1 and the voltage-dependent sodium channels Nav1.3 and Nav1.7 .
    GTx1-15
  • HY-P5184
    Hainantoxin-IV

    HNTX-IV

    		 Sodium Channel Neurological Disease
    Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif .
    Hainantoxin-IV
  • HY-124009A
    L-Cysteic acid monohydrate

    		Endogenous Metabolite Metabolic Disease
    L-Cysteic acid monohydrate is the oxidation product of L-cystine. L-Cysteic acid monohydrate is a substrate of GADCase/CADCaseII .
    L-Cysteic acid monohydrate
  • HY-124009
    L-Cysteic acid

    		Endogenous Metabolite Others
    L-Cysteic acid is the oxidation product of L-cystine. L-Cysteic acid is a substrate of GADCase/CADCaseII .
    L-Cysteic acid
  • HY-120446
    Thiocystine

    		Biochemical Assay Reagents Others
    Thiocystine is a relatively stable trisulfide analog of Cystine. Thiocystine functions as a persullide in transferring its sulfane sulfur to thiophilic acceptors .
    Thiocystine
  • HY-161715
    LH708

    		Others Others
    LH708 is an orally active L-cystine crystallization inhibitor with an EC50 of 59.8 nM. LH708 can be used for Cystinuria research .
    LH708
  • HY-161716
    LH1753

    		Others Others
    LH1753 is an orally active L-cystine crystallization inhibitor with an EC50 of 29.5 nM. LH1753 can be used for Cystinuria research .
    LH1753
  • HY-W008876
    Fmoc-Pen(Trt)-OH

    		Amino Acid Derivatives Others
    Fmoc-Pen(Trt)-OH is an amino acid derivative with an Fmoc protecting group that can be used to synthesize the inhibitory cystine knot (ICK) peptide ProTx-II .
    Fmoc-Pen(Trt)-OH
  • HY-139087
    Erastin2
    2 Publications Verification

    		 Ferroptosis Metabolic Disease
    Erastin2, an Erastin (HY-15763) analog, is a ferroptosis inducer and a potent, selective inhibitor of the system xc(-) cystine/glutamate transporter
    Erastin2
  • HY-W327808
    DL-Lanthionine

    		Antibiotic Infection
    DL-Lanthionine is a distinctive amino acid and a monosulfide counterpart to cystine, playing a vital role as a component of peptide antibiotics known as lantiobiotics, which encompass well-known examples such as nisin and subtilin.
    DL-Lanthionine
  • HY-P10132
    PRDX3(103-112), human

    		Ferroptosis Metabolic Disease
    PRDX3(103-112), human is a marker for ferroptosis. PRDX3 is hyperoxidated by mitochondrial lipid peroxides. PRDX3 inhibits cystine uptake after hyperoxidization .
    PRDX3(103-112), human
  • HY-B0373
    Tiopronin
    1 Publications Verification

    		 Biochemical Assay Reagents Metabolic Disease
    Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders .
    Tiopronin
  • HY-N15156
    Thiotaurine

    		Endogenous Metabolite Inflammation/Immunology
    Thiotaurine is the metabolite of Cystine. Thiotaurine is a sulfur donor, which may probably modulates the activity of GAPDH, followed by the pparticipation in neutrophil activation and leukocytes energy metabolism. Thiotaurine is a potential anti-inflammatory agent and immunomodulator .
    Thiotaurine
  • HY-W101954
    (Fmoc-Cys-OtBu)2 (disulfide bridge)

    		Biochemical Assay Reagents Others
    (Fmoc-Cys-OtBu)2 (Disulfide bond) is a cystine dipeptide which is linked through an oxidized disulfide bond. (Fmoc-Cys-OtBu)2 (disulfide bridge) can be used in the synthesis of cleavable disulfide linkers.
    (Fmoc-Cys-OtBu)2 (disulfide bridge)
  • HY-B0373S1
    Tiopronin-d3

    		Isotope-Labeled Compounds Metabolic Disease
    Tiopronin-d3 is the deuterium labeled Tiopronin. Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders .
    Tiopronin-d3
  • HY-B0373R
    Tiopronin (Standard)

    		Biochemical Assay Reagents Metabolic Disease
    Tiopronin (Standard) is the analytical standard of Tiopronin. This product is intended for research and analytical applications. Tiopronin is a diffusible antioxidant, an antidote to heavy metal poisoning and a radioprotective agent. Tiopronin can control the rate of cystine precipitation and excretion and has the potential for cystinuria, rheumatoid arthritis and hepatic disorders .
    Tiopronin (Standard)
  • HY-P5153
    ProTx-III

    μ-TRTX-Tp1a

    		 Sodium Channel Neurological Disease
    ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK). ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia .
    ProTx-III
  • HY-Y1147
    Diethyl maleate
    1 Publications Verification

    Maleic acid diethyl ester

    		 Biochemical Assay Reagents Others
    Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter XO -. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].
    Diethyl maleate
  • HY-15763
    Erastin
    Maximum Cited Publications
    566 Publications Verification

    		 VDAC Ferroptosis Disulfidptosis Cancer
    Erastin is a ferroptosis inducer. Erastin exhibits the mechanism of ferroptosis induction related to ROS and iron-dependent signaling. Erastin inhibits voltage-dependent anion channels (VDAC2/VDAC3) and accelerates oxidation, leading to the accumulation of endogenous reactive oxygen species. Erastin also disrupts mitochondrial permeability transition pore (mPTP) with anti-tumor activity. Furthermore, Erastin can block the uptake of cystine mediated by SLC7A11 and also spares UMRC6-EV and -C91A cells from disulfidptosis under glucose starvation .
    Erastin
  • HY-P5917
    Vm24-toxin

    Vaejovis mexicanus peptide 24

    		 Potassium Channel Inflammation/Immunology Cancer
    Vm24-toxin (Vaejovis mexicanus peptide 24), a 36-residue peptide, is a potent and selective Kv1.3 blocker with a Kd of ~3 pM in lymphocytes. Vm24-toxin shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin attenuates the CD4 + effector memory T cell response to T cell receptor (TCR) stimulation .
    Vm24-toxin
  • HY-P5917A
    Vm24-toxin TFA

    Vaejovis mexicanus peptide 24 TFA

    		 Potassium Channel Inflammation/Immunology Cancer
    Vm24-toxin (Vaejovis mexicanus peptide 24) TFA, a 36-residue peptide, is a potent and selective Kv1.3 blocker with a Kd of ~3 pM in lymphocytes. Vm24-toxin TFA shows >1500-fold affinity for Kv1.3 over other assayed potassium channels. Vm24-toxin TFA folds into a distorted cystine-stabilized α/β motif consisting of a single-turn α-helix and a three-stranded antiparallel β-sheet, stabilized by four disulfide bridges. Vm24-toxin TFA attenuates the CD4 + effector memory T cell response to T cell receptor (TCR) stimulation .
    Vm24-toxin TFA

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