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Results for "

coronavirus replication

" in MedChemExpress (MCE) Product Catalog:

By Targets:	SARS-CoV (19) 5-HT Receptor (1) Apoptosis (3) Calcium Channel (1) Casein Kinase (1) Cathepsin (1) HIV (4) Influenza Virus (1) Parasite (3) PROTACs (1) Sodium Channel (2) Virus Protease (4)
By Research Areas:	Cancer (3) Infection (21) Inflammation/Immunology (2)

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Targets Recommended: SARS-CoV

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-155016

SARS-CoV-2-IN-46	SARS-CoV	Infection
SARS-CoV-2-IN-46 is a novel coronavirus (SARS-CoV-2) replication inhibitor with an EC₅₀ of 0.9 μM in Calu-3 cells. SARS-CoV-2-IN-46 has antiviral activity and can be used in novel coronavirus (COVID-19) research .

HY-138067

SSAA09E2	SARS-CoV	Inflammation/Immunology
SSAA09E2 is an inhibitor of SARS-CoV (Severe acute respiratory syndrome-Coronavirus) replication, acting by blocking early interactions of SARS-S with the receptor for SARS-CoV, Angiotensin Converting Enzyme-2 (ACE2) .

HY-139442

RdRP-IN-2	SARS-CoV	Infection
RdRP-IN-2 is a RNA dependent RNA polymerase (RdRp) inhibitor. RdRP-IN-2 significantly inhibits SARS-CoV-2 RdRp with an IC₅₀ of 41.2 μM.RdRP-IN-2 also inhibits Feline coronavirus (FIPV) replication .

HY-13433

Thapsigargin Maximum Cited Publications 92 Publications Verification	Calcium Channel SARS-CoV Apoptosis	Infection Cancer
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

HY-172553

AS-0017445	Virus Protease SARS-CoV	Infection
AS-0017445 is an inhibitor targeting the main protease of both the current *coronavirus* and the virus that caused the Middle East Respiratory Syndrome (MERS) outbreak. AS-0017445 inhibits the viral protein processing in host cells and thus prevents viral replication .

HY-161114

MDOLL-0229	SARS-CoV	Infection
MDOLL-0229 (compound 27) is an antiviral agent that targets SARS-CoV-2 Mac1 and repress coronavirus replication. MDOLL-0229 inhibits SARS-CoV-2 Mac1 with an IC₅₀ of 2.1 µM .

HY-122668

K22	SARS-CoV	Infection
K22 is an inhibitor of coronavirus RNA synthesis that specifically targets membrane-associated coronavirus RNA synthesis. K22 effectively blocks replication of multiple coronaviruses by inhibiting the critical step of viral replication complex anchoring to host cell membranes to form double-membrane vesicles (DMVs). K22 exhibits broad-spectrum antiviral activity against diverse coronaviruses, including Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), Feline Coronavirus (FCoV), Mouse Hepatitis Virus (MHV), and Avian Infectious Bronchitis Virus (IBV) .

HY-158322

nsp12-IN-1	SARS-CoV	Infection
Nsp12-IN-1 is a nucleoside analogue. Nsp12-IN-1 can block the synthesis of viral RNA and inhibit viral replication. Nsp12-IN-1 can be used in the study of pan-coronavirus .

HY-162151

SARS-CoV-2-IN-74	SARS-CoV	Infection
SARS-CoV-2-IN-74 (compound 30) is a epoxide inhibitor, which inhibits cellular SARS-CoV-2 replication with an EC₆₈ of 5 μM. SARS-CoV-2-IN-74 can be used for the research of coronavirus .

HY-155097

SARS-CoV-2-IN-53	SARS-CoV	Infection
ARS-CoV-2-IN-53 (Compd 5d) can inhibit the replication of SARS-CoV-2 with an EC₅₀ value of 14.3 μM. ARS-CoV-2-IN-5 shows significant antiviral activity against human coronavirus 229E (HCoV-229E) .

HY-156655

Olgotrelvir STI-1558	SARS-CoV Virus Protease Cathepsin	Infection
Olgotrelvir (STI-1558) is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L). Olgotrelvir is readily converted to its active form, AC1115, in full blood and/or plasma. Olgotrelvir can effectively inhibit both SARS-CoV-2 replication and entry into host cells .

HY-156655A

Olgotrelvir sodium STI-1558 sodium
Olgotrelvir (STI-1558) sodium is an orally active dual inhibitor of coronavirus main protease (Mpro) and human cell cathepsin (Cathepsin L). Olgotrelvir sodium is readily converted to its active form, AC1115, in full blood and/or plasma. Olgotrelvir sodium can effectively inhibit both SARS-CoV-2 replication and entry into host cells .

HY-163067

SARS-CoV-2-IN-71	SARS-CoV	Infection
SARS-CoV-2-IN-71 (compound 8h) is a potent inhibitor of SARS-CoV-2. SARS-CoV-2-IN-71 inhibits coronavirus replication at multiple stages. SARS-CoV-2-IN-71 displays anti-coronaviral effect by simultaneously acting on 3CL ^pro and TMPRSS2 .

HY-174350

CK2-IN-15	Casein Kinase SARS-CoV	Infection
CK2-IN-15 (Compound Biv5) is a selective and potent bivalent protein kinase CK2 inhibitor with an IC₅₀ value of 51 pM. CK2-IN-15 significantly reduces the replication of SARS-CoV-2 in HEK-ACE2-TMPRSS2 and Vero cells, and also reduces viral replication in an ex vivo model of human nasal epithelial cells. CK2-IN-15 is promising for research of β-coronavirus infection-related diseases .

HY-128067

5-(N,N-Hexamethylene)-amiloride 2 Publications Verification Hexamethylene amiloride; HMA	Sodium Channel HIV Apoptosis	Infection Cancer
5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na ⁺/H ⁺ exchanger inhibitor, which decreases the intracellular pH (pH_i) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC₅₀s of 3.91 μM and 1.34 μM, respectively .

HY-W760546

SARS-CoV-2 3CLpro-IN-15	SARS-CoV Virus Protease	Infection
SARS-CoV-2 3CLpro-IN-15 (compound a) is a beta-nitrostyrene coronavirus SARS-CoV-2 inhibitor that targets the SARS-CoV-2 3CL protease (3CLpro). SARS-CoV-2 3CLpro-IN-15 inhibits viral replication and transcription and plays a key role in the discovery of anti-COVID-19 lead compounds .

HY-100943

Cinanserin hydrochloride 1 Publications Verification SQ 10643	5-HT Receptor Influenza Virus	Infection Inflammation/Immunology
Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT₂ receptor antagonist with a K_i of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT₂ than for the 5-HT₁ receptor (K_i of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro .

HY-135855

SARS-CoV-IN-1 1 Publications Verification	SARS-CoV Parasite	Infection
SARS-CoV-IN-1 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-1 shows anti-Coronavirus activity with an EC₅₀ of 4.9 μM in Vero cells. SARS-CoV-IN-1 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 15.4 and 133.2 nM; and IC₉₀s of 25.7 and 459.1 nM; respectively. Antimalarial and antiviral activities .

HY-128067R

5-(N,N-Hexamethylene)-amiloride (Standard)	Sodium Channel HIV Apoptosis	Infection Cancer
5-(N,N-Hexamethylene)-amiloride (Standard) is the analytical standard of 5-(N,N-Hexamethylene)-amiloride. This product is intended for research and analytical applications. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively .

HY-135858

SARS-CoV-IN-3 1 Publications Verification	SARS-CoV Parasite HIV	Infection
SARS-CoV-IN-3 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-3 shows anti-Coronavirus activity with an EC₅₀ of 3.6 μM in Vero cells. SARS-CoV-IN-3 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 11.7 and 20.4 nM; and IC₉₀s of 29.19 and 56 nM; respectively. SARS-CoV-IN-3 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 10 μM in MT-4 cells .

HY-135856

SARS-CoV-IN-2 1 Publications Verification	SARS-CoV Parasite HIV	Infection
SARS-CoV-IN-2 is an effective inhibitor of SARS-CoV replication. SARS-CoV-IN-2 shows anti-Coronavirus activity with an EC₅₀ of 1.9 μM in Vero cells. SARS-CoV-IN-2 inhibits the 3D7 and W2 strains of P. falciparum with IC₅₀s of 21.5 and 30 nM; and IC₉₀s of 51.0 and 99.9 nM; respectively. SARS-CoV-IN-2 reduces HIV-1-induced cytopathic effect with an EC₅₀ of 2.9 μM in MT-4 cells. Antimalarial and Antiviral Activities .

HY-174233

PROTAC SARS-CoV-2 Degrader-1	PROTACs SARS-CoV Virus Protease	Infection
PROTAC SARS-CoV-2 Degrader-1 (Compound LLP019) is a SARS-CoV-2 M ^Pro PROTAC degrader with a DC₅₀ value of 4.7 μM. PROTAC SARS-CoV-2 Degrader-1 induces M ^Pro ubiquitination and proteasomal degradation to inhibit SARS-CoV-2 replication. PROTAC SARS-CoV-2 Degrader-1 is promising for research of COVID-19 and related coronavirus infections. (Pink: DH03 (HY-32717); Black: linker (HY-42149); Blue: Thalidomide-4-O-CH2-COO(t-Bu) (HY-42771) .

HY-163913

SARS-CoV-IN-5	SARS-CoV	Infection
SARS-CoV-IN-5 (compound 49) is a highly selective, nonpeptidic and noncovalent 3CL ^pro inhibitor with IC₅₀s of 38 nM, 21.1 nM and 86 nM for 3CL ^pro of SARS-CoV-1, SARS-CoV-2, Bat coronavirus WIV1, respectively. SARS-CoV-IN-5 inhibits the replication of the SARS-CoV-2 delta variant with an EC₅₀ of 0.272 μM. SARS-CoV-IN-5 significantly reduces the lung viral copies in a K18-hACE2 transgenic mouse model. SARS-CoV-IN-5 has good target-specific and potential broad-spectrum anticoronavirus activities against SARS-CoV-1, WIV1, MERS, HCoV-OC43, HCoV-229E, and HKU9 .

Thapsigargin 90+ Cited Publications	Infection Classification of Application Fields Terpenoids Source classification Diterpenoids Umbelliferae Plants Disease Research Fields Thapsia garganica L. Cancer	Calcium Channel SARS-CoV Apoptosis
Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca ²⁺-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types .

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coronavirus replication

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