cofilin

By Targets:	Antibiotic (1) Arp2/3 Complex (1) Isotope-Labeled Compounds (1) LIM Kinase (LIMK) (5) PAK (1) Reference Standards (1) ROCK (3) Small Interfering RNA (siRNA) (1) YAP (1)
By Research Areas:	Cancer (9) Infection (1) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110335

OXA-06 hydrochloride	ROCK	Cancer
OXA-06 hydrochloride is an ATP-competitive ROCK inhibitor that blocks anchorage-dependent growth and invasion of non-small cell lung cancer cell lines. OXA-06 hydrochloride inhibits cofilin phosphorylation but does not stimulate apoptosis .

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

HY-N6682

Cytochalasin D Maximum Cited Publications 75 Publications Verification Zygosporin A; NSC 209835	Arp2/3 Complex Antibiotic YAP	Infection Cancer
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

HY-16563

Narciclasine 15+ Cited Publications Lycoricidinol	ROCK	Cancer
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-128062

LIMK1 inhibitor BMS-4	LIM Kinase (LIMK)	Cancer
LIMK1 inhibitor BMS-4 is a LIM Kinase (LIMK) inhibitor targeting to LIMK1/2. LIMK1 inhibitor BMS-4 inhibits phosphorylation of cofilin, the LIMK substrate. However, LIMK1 inhibitor BMS-4 is noncytotoxic on A549 cells .

HY-RS02568

CFL1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CFL1 Human Pre-designed siRNA Set A contains three designed siRNAs for CFL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CFL1 Human Pre-designed siRNA Set A CFL1 Human Pre-designed siRNA Set A

HY-16563R

Narciclasine (Standard) Lycoricidinol (Standard)	Reference Standards ROCK	Cancer
Narciclasine (Standard) is the analytical standard of Narciclasine. This product is intended for research and analytical applications. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-170781

MDI-114215	LIM Kinase (LIMK)	Metabolic Disease
MDI-114215 (compound 85) is an allosteric LIMK1/2 dual inhibitor with good in vivo tolerance. MDI-114215 can inhibit cofilin phosphorylation in mouse brain region-induced pluripotent stem cells (iPSCs), which can be used for Fragile X Syndrome (FXS) research .

HY-174229

SM311	LIM Kinase (LIMK)	Neurological Disease Cancer
SM311 (Compound 10) is a potent selective irreversible LIMK1 inhibitor (EC₅₀=0.045 μM, >30-fold selective over LIMK2). SM311 blocks cofilin phosphorylation and actin cytoskeleton regulation. SM311 is promising for research of neurodegenerative diseases like Fragile X syndrome (FXS) and Alzheimer’s disease, as well as tumor invasion .

HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2	Isotope-Labeled Compounds	Cancer
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

HY-19353

SR7826 1 Publications Verification	LIM Kinase (LIMK)	Neurological Disease Cancer
SR7826 is a class of bis-aryl urea derived potent, selective and orally active LIM kinase (LIMK) inhibitor with an IC₅₀ of 43 nM for LIMK1. SR7826 is >100-fold more selective for LIMK1 than ROCK and JNK kinases .

HY-164374

AK963/40708899	PAK	Cancer
AK963/40708899 is a potent PAK1 inhibitor. AK963/40708899 suppresses the proliferation of human gastric cancer cells by downregulation of PAK1-NF-κB-cyclinB1 pathway. AK963/40708899 induces cell cycle arrest at G2 phase and reduces the migration and invasion. AK963/40708899 inhibits the formation of filopodia and promots cell adhesion which in turn inhibits invasive potential of gastric cells by negatively regulating PAK1-LIMKl-cofilin and PAK1-ERK-FAK pathways .

Cat. No.	Product Name	Target	Research Area

HY-P5455

S3 Fragment	LIM Kinase (LIMK)	Others
S3 Fragment is a biological active peptide. (This peptide contains the unique amino-terminal phosphorylation site of Xenopus ADF/cofilin, the LIM kinase (LIMK) phosphorylation site. LIMK1 is a key regulator of the actin cytoskeleton through its phosphorylation of ADF/cofilin at serine-3 for inactivation. This peptide is a fragment of the S3 peptide containing the serine-3 sequence of ADF/cofilin that has been widely used as an effective competitive inhibitor of LIMK1.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6682

Cytochalasin D 70+ Cited Publications Zygosporin A; NSC 209835	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Arp2/3 Complex Antibiotic YAP
Cytochalasin D (Zygosporin A) is a potent actin polymerization inhibitor, could be derived from fungus. Cytochalasin D has cell-permeable activity. Cytochalasin D inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells. Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of Yap .

HY-16563

Narciclasine 15+ Cited Publications Lycoricidinol	Structural Classification Alkaloids Classification of Application Fields Narcissus tazetta Linn. var. chinensis M.Roemer Source classification Plants Isoquinoline Alkaloids Amaryllidaceae Disease Research Fields Cancer Agricultural Research	ROCK
Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

HY-16563R

Narciclasine (Standard) Lycoricidinol (Standard)	Structural Classification Alkaloids Narcissus tazetta Linn. var. chinensis M.Roemer Source classification Plants Isoquinoline Alkaloids Amaryllidaceae	Reference Standards ROCK
Narciclasine (Standard) is the analytical standard of Narciclasine. This product is intended for research and analytical applications. Narciclasine is a plant growth modulator. Narciclasine modulates the Rho/Rho kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity as well as inducing actin stress fiber formation in a RhoA-dependent manner.

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P74234

	Cofilin-2 Protein, Human (His) cofilin-2; CFL2	Human	E. coli
	Cofilin-2 protein controls actin polymerization and depolymerization in a pH-sensitive manner. Cofilin-2 Protein, Human (His) is the recombinant human-derived Cofilin-2 protein, expressed by E. coli , with N-His labeled tag.

HY-P75682

	Cofilin-1 Protein, Human (His) cofilin-1; 18 kDa phosphoprotein; p18; CFL1; CFL	Human	E. coli
	Cofilin-1 protein has pH-sensitive F-actin depolymerizing activity and can bind to F-actin. It cooperates with the subcortical maternal complex (SCMC) to guide the fertilized egg through initial embryonic cell division by regulating actin dynamics. Cofilin-1 Protein, Human (His) is the recombinant human-derived Cofilin-1 protein, expressed by E. coli , with N-6*His labeled tag.

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HY-176347S

Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2
Alpha Feto Protein, Arg- ¹³C₃₆, ¹⁵N₄, Lys- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled Alpha Feto Protein.

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P83077

	Cofilin Antibody (YA2822) CFL1; CFL; cofilin-1; 18 kDa phosphoprotein; p18; cofilin; non-muscle isoform	WB, IHC-F, IHC-P, ICC/IF	Human
	Cofilin Antibody (YA2822) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA2822), targeting Cofilin, with a predicted molecular weight of 19 kDa (observed band size: 19 kDa). Cofilin Antibody (YA2822) can be used for WB, IHC-F, IHC-P, ICC/IF experiment in human background.

HY-P85722

	Cofilin Antibody (YA5414) cofilin-1; 18 kDa phosphoprotein; p18; cofilin, non-muscle isoform;	IHC-P, WB	Human, Mouse, Rat
	Cofilin Antibody (YA5414) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Cofilin.

HY-P81566

	Cofilin Antibody (YA1311) 18 kDa phosphoprotein antibody; CFL 1 antibody; CFL antibody; CFL1 antibody; COF1_HUMAN antibody; cofilin 1 antibody; cofilin 1 non muscle antibody; cofilin antibody; cofilin non muscle isoform antibody; cofilin-1 antibody; epididymis secretory protein Li 15 antibody; HEL-S-15 antibody; non-muscle isoform antibody; p18 antibody	WB, ICC/IF, FC	Human, Mouse, Rat, Monkey
	Cofilin Antibody (YA1311) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Cofilin.

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Cat. No.	Product Name		Classification

HY-RS02568

CFL1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CFL1 Human Pre-designed siRNA Set A contains three designed siRNAs for CFL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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cofilin

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