Cofilin Antibody (YA5414)

Cofilin Antibody (YA5414) is a mouse-derived and non-conjugated monoclonal antibody, targeting to Cofilin. It can be applicated for IHC-P, WB assays, in the background of human, mouse, rat.

Cofilin binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. In conjunction with the subcortical maternal complex (SCMC), it plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics. It is required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Cofilin plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells. It is also required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. Additionally, Cofilin is involved in neural tube morphogenesis and neural crest cell migration (By similarity).

P23528

Observed band size: 19 kDa

affinity chromatography.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Rat

IHC1:50-200; WB: 1:1000-2000

IHC-P, WB

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Synthesized peptide derived from human Cofilin