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clonic seizure

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101708
    N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea

    		Biochemical Assay Reagents Neurological Disease
    N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent with potential for the treatment of generalized tonic-clonic and partial seizures.
    N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea
  • HY-103181
    N6-Cyclopentyladenosine

    CPA; UK-80882

    		 Adenosine Receptor Apoptosis Cardiovascular Disease Neurological Disease Cancer
    N6-Cyclopentyladenosine (CPA) is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively. N6-cyclopentyladenosine increases Apoptosis. N6-Cyclopentyladenosine has antitumor activity against leukemia. N6-cyclopentyladenosine improves 5-fluorouracil (HY-90006)-induced hematopoietic damage, regulates sleep, and delays Aminophylline-induced clonic epileptic seizures .
    N6-Cyclopentyladenosine
  • HY-179215
    OV329 hydrochloride

    		GABA Receptor Neurological Disease
    OV329 (hydrochloride) is a potent GABA aminotransferase inactivator. OV329 (hydrochloride) is a Vigabatrin (HY-15399) analogue. OV329 (hydrochloride) can increase brain GABA levels and block abnormal intracerebral hyperexcitability. OV329 (hydrochloride) exhibits anticonvulsant and antiepileptic activities. OV329 (hydrochloride) can be used for the research of neurological disease, such as seizure .
    OV329 hydrochloride
  • HY-179215A
    OV329

    		GABA Receptor Neurological Disease
    OV329 is a potent GABA aminotransferase inactivator. OV329 is a Vigabatrin (HY-15399) analogue. OV329 can increase brain GABA levels and block abnormal intracerebral hyperexcitability. OV329 exhibits anticonvulsant and antiepileptic activities. OV329 can be used for the research of neurological disease, such as seizure .
    OV329
  • HY-105236
    (Rac)-Enadoline

    (Rac)-CI-977 free base

    		 Opioid Receptor Neurological Disease
    (Rac)-Enadoline ((Rac)-CI-977 free base) is a selective K-opioid receptor agonist that stereoselectively antagonizes clonic seizures induced by slow intravenous injection of N-methyl-DL-aspartate in mice .
    (Rac)-Enadoline
  • HY-10420
    ZK-93426

    		Drug Derivative Neurological Disease
    ZK-93426 is a benzodiazepine receptor antagonist. ZK-93426 does not alter the dogs' motility but induces generalized myoclonic jerks and tonic-clonic seizures. ZK-93426 can be used to study the mechanism of withdrawal reactions in the state of benzodiazepine dependence .
    ZK-93426
  • HY-171182
    D3017

    		Endogenous Metabolite Neurological Disease
    D3017 is the main metabolite of D2624, which has oral bioactivity and anti-convulsant effects. D3017 ED50 value is 1.5 mg/kg in mice, and it can be used for research on severe generalized tonic-clonic seizures (grand mal) and complex partial epilepsy .
    D3017
  • HY-120146
    NNC 05-2090

    		GABA Receptor Neurological Disease
    NNC 05-2090 is aGABA uptake inhibitor and inhibitor of the β-GABA transporter (BGT-1) (IC50 sub>: 10.6 μM). NNC 05-2090 also inhibits mGAT2 with a Ki value of 1.4 μM. NNC 05-2090 has anticonvulsant activity and can be used in the study of epilepsy and neurological diseases .
    NNC 05-2090
  • HY-175263
    Aminochalcone 4AAF

    		GABA Receptor 5-HT Receptor Reactive Oxygen Species (ROS) Neurological Disease Metabolic Disease
    Aminochalcone 4AAF is a neuroprotective agent that exerts anxiolytic effects through GABAA and 5-HT receptors. Aminochalcone 4AAF has high selectivity for 5-HT3A and 5-HT2C receptors, and stimulates allosteric behavior toward the 5-HT2A receptor. Aminochalcone 4AAF shows hypoglycemic effects and reduces the level of ROS in the liver. Aminochalcone 4AAF delays the clonic stage of the epileptic seizures . Aminochalcone 4AAF can be used in the study of anxiety, hyperglycemia, and seizures .
    Aminochalcone 4AAF

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