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Results for "

caspase 3-Gsdme

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Peptides

1

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111770
    2-Bromohexadecanoic acid
    2 Publications Verification

    2-Bromopalmitic acid; 2-Bromopalmitate

    		 Pyroptosis Infection Inflammation/Immunology Cancer
    2-Bromohexadecanoic acid (2-Bromopalmitate; 2-BP) is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-Bromohexadecanoic acid inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis .
    2-Bromohexadecanoic acid
  • HY-P10939
    Ac-DMLD-CMK

    		Caspase Pyroptosis Inflammation/Immunology Cancer
    Ac-DMLD-CMK is a polypeptide targeting the mouse caspase 3-Gsdme signaling pathway. Ac-DMLD-CMK can specifically inhibit the activation of caspase 3 and Gsdme. Ac-DMLD-CMK blocks the cleavage of Gsdme by caspase 3, inhibits the occurrence of pyroptosis, thereby reducing renal tubular epithelial cell injury and the secretion of inflammatory cytokines. Ac-DMLD-CMK reduces the levels of serum creatinine and blood urea nitrogen in mice induced by Cisplatin (HY-17394) and alleviates the deterioration of kidney function. Ac-DMLD-CMK is promising for research of chemotherapy drug-induced nephrotoxicity .
    Ac-DMLD-CMK
  • HY-N15380
    4,4′-Secalonic acid D

    		PARP Reactive Oxygen Species Caspase Apoptosis Pyroptosis Cancer
    4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the caspase-3/GSDME pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity .
    4,4′-Secalonic acid D

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