Search Result

Results for "

cardiac oxidative stress

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (2) Akt (5) Amyloid-β (1) Apoptosis (11) ASK1 (1) Autophagy (7) Bacterial (2) CDK (2) Collagen (1) COX (1) Dopamine β-hydroxylase (2) ERK (5) Ferroptosis (1) GABA Receptor (2) GnRH Receptor (1) Histone Demethylase (1) HIV (1) Interleukin Related (1) JNK (1) Keap1-Nrf2 (1) LDLR (1) MEK (3) Mitochondrial Metabolism (2) MMP (1) Monoamine Oxidase (1) mTOR (2) NF-κB (6) PI3K (7) Potassium Channel (1) PTEN (3) Reactive Oxygen Species (ROS) (3) Reference Standards (4) Sirtuin (1) SOD (1) STAT (3) TGF-beta/Smad (2) Thrombopoietin Receptor (2) TNF Receptor (1) Toll-like Receptor (TLR) (1) Transmembrane Glycoprotein (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (18) Endocrinology (3) Infection (3) Inflammation/Immunology (15) Metabolic Disease (2) Neurological Disease (6)

By Targets:

Adrenergic Receptor (2)

Akt (5)

Amyloid-β (1)

Apoptosis (11)

ASK1 (1)

Autophagy (7)

Bacterial (2)

CDK (2)

Collagen (1)

COX (1)

Dopamine β-hydroxylase (2)

ERK (5)

Ferroptosis (1)

GABA Receptor (2)

GnRH Receptor (1)

Histone Demethylase (1)

HIV (1)

Interleukin Related (1)

JNK (1)

Keap1-Nrf2 (1)

LDLR (1)

MEK (3)

Mitochondrial Metabolism (2)

MMP (1)

Monoamine Oxidase (1)

mTOR (2)

NF-κB (6)

PI3K (7)

Potassium Channel (1)

PTEN (3)

Reactive Oxygen Species (ROS) (3)

Reference Standards (4)

Sirtuin (1)

SOD (1)

STAT (3)

TGF-beta/Smad (2)

Thrombopoietin Receptor (2)

TNF Receptor (1)

Toll-like Receptor (TLR) (1)

Transmembrane Glycoprotein (1)

By Research Areas:

Cancer (10)

Cardiovascular Disease (18)

Endocrinology (3)

Infection (3)

Inflammation/Immunology (15)

Metabolic Disease (2)

Neurological Disease (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Targets Recommended: Oxidative Phosphorylation

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116152

Cipepofol Ciprofol; HSK3486	GABA Receptor Sirtuin Keap1-Nrf2 Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Cipepofol (Ciprofol), a novel 2,6-disubstituted phenol derivative, is a positive allosteric modulator and direct agonist of the GABA_A receptor. Cipepofol can cause the central nerve inhibition and promote sleep based on the structural modification of Propofol (HY-B0649). Cipepofol can activate the sirtuin1 (Sirt1)/Nrf2 pathway. Cipepofol protects the heart against Isoproterenol (ISO; HY-B0468)-induced myocardial infarction by reducing cardiac oxidative stress, inflammatory response and cardiomyocyte apoptosis .

HY-107754

Cesium chloride	Potassium Channel	Cardiovascular Disease
Cesium chloride is a blocker of potassium channel. Cesium chloride prevents the decrease of Na ⁺ transport produced by Alloxan . Cesium chloride has induced cardiac arrhythmias, including torsade de pointes in animal models .

HY-W099479

Insect repellent M 3535 Ethyl butylacetylaminopropionate; IR-3535	Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease Inflammation/Immunology
Insect repellent M 3535 (Ethyl butylacetylaminopropionate; IR-3535) is a potent anthelmintic that is toxic to zebrafish with a lethal concentration 50 (LC₅₀) of 140 mg/L at 72 hours post fertilization (hpf). Insect repellent M 3535 causes morphological abnormalities and cardiac defects in early embryonic development of zebrafish by potentially inducing the production and accumulation of reactive oxygen species (Reactive Oxygen Species) and activating oxidative stress responses, thereby activating the endogenous apoptosis pathway .

HY-N1487

Oleanonic acid 1 Publications Verification 3-Oxooleanolic acid	HIV Autophagy Ferroptosis Amyloid-β	Infection Neurological Disease Inflammation/Immunology Cancer
Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats .

HY-W099479R

Insect repellent M 3535 (Standard) Ethyl butylacetylaminopropionate (Standard); IR-3535 (Standard)	Reference Standards Reactive Oxygen Species (ROS) Apoptosis	Cardiovascular Disease Inflammation/Immunology
Insect repellent M 3535 (Standard) is the analytical standard of Insect repellent M 3535. This product is intended for research and analytical applications. Insect repellent M 3535 (Ethyl butylacetylaminopropionate; IR-3535) is a novel potent anthelmintic that is toxic to zebrafish with a lethal concentration 50 (LC50) of 140 mg/L at 72 hours post fertilization (hpf). Insect repellent M 3535 causes morphological abnormalities and cardiac defects in early embryonic development of zebrafish by potentially inducing the production and accumulation of reactive oxygen species (Reactive Oxygen Species) and activating oxidative stress responses, thereby activating the endogenous apoptosis pathway .

HY-N1441

Afzelin 5+ Cited Publications Kaempferol-3-O-rhamnoside	Mitochondrial Metabolism PTEN Autophagy Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .

HY-N1508

Ecliptasaponin A	MMP Apoptosis Autophagy NF-κB TNF Receptor COX Toll-like Receptor (TLR) SOD ASK1 JNK	Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
Ecliptasaponin A is an orally active pentacyclic triterpenoid saponin. Ecliptasaponin A exerts anti-tumor activity by activating ASK1/JNK pathway, inducing apoptosis and autophagy in lung cancer cells. Ecliptasaponin A exerts anti-inflammatory/anti-fibrotic effects and protects the cardiovascular system by inhibiting the HMGB1/TLR4/NF-κB pathway, and the expression of COX-2 and MMP-9. Ecliptasaponin A can enhance SOD activity, reduce MDA levels, and alleviate oxidative stress damage. Ecliptasaponin A exerts chondroprotective effects by inhibiting the expression of MMP13 and regulating inflammatory factors. Ecliptasaponin A improves ovarian function and regulates sex hormones by upregulating the expression of ESR1 receptors .

HY-123260

S12340	LDLR	Cardiovascular Disease
S12340 is a a inhibitor of the oxidative modification of low-density lipoprotein and shows protective effect on cardiac cells exposed to oxidative stress .

HY-P5762A

Phoenixin-14 TFA PNX-14 TFA	GnRH Receptor	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Phoenixin-14 (PNX-14) TFA, a neuropeptide, has anxiolytic, cardioprotective and neuroprotective effect. Phoenixin-14 TFA can regulate pituitary gonadotrophin secretion by upregulating the GnRH receptor mRNA. Phoenixin-14 TFA stimulates insulin secretion. Phoenixin-14 TFA also protects mice from ischemia/reperfusion (IR) injury. PNX-14 TFA prevents oxidative stress by reducing ROS and increasing GSH .

HY-N8321R

5-O-Caffeoylshikimic acid (Standard)	Reference Standards Others	Cancer
Insect repellent M 3535 (Standard) is the analytical standard of Insect repellent M 3535. This product is intended for research and analytical applications. Insect repellent M 3535 (Ethyl butylacetylaminopropionate; IR-3535) is a novel potent anthelmintic that is toxic to zebrafish with a lethal concentration 50 (LC50) of 140 mg/L at 72 hours post fertilization (hpf). Insect repellent M 3535 causes morphological abnormalities and cardiac defects in early embryonic development of zebrafish by potentially inducing the production and accumulation of reactive oxygen species (Reactive Oxygen Species) and activating oxidative stress responses, thereby activating the endogenous apoptosis pathway .

HY-122620

Rafutrombopag (tautomerism) Hetrombopag (tautomerism); SHR-8735 (tautomerism)	Thrombopoietin Receptor STAT PI3K ERK Apoptosis CDK	Cardiovascular Disease Inflammation/Immunology
Rafutrombopag (tautomerism) (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR‐expressing cells, including 32D‐ MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .

HY-145589

Rafutrombopag Hetrombopag; SHR-8735	Thrombopoietin Receptor STAT PI3K ERK Apoptosis CDK	Cardiovascular Disease Inflammation/Immunology
Rafutrombopag (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR‐expressing cells, including 32D‐ MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease .

HY-N1441R

Afzelin (Standard) Kaempferol-3-O-rhamnoside (Standard)	Mitochondrial Metabolism PTEN Autophagy Bacterial Reference Standards	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology
Afzelin (Standard) is the analytical standard of Afzelin. This product is intended for research and analytical applications. Afzelin (Kaempferol-3-O-rhamnoside)It is a flavonol glycoside that has anti-inflammatory, anti-oxidative stress response, anti-apoptotic, and anti-cardiac cytotoxic effects. AfzelinIt can reduce mitochondrial damage, enhance mitochondrial biosynthesis, and reduce mitochondria-related proteins. Parkinand PTENinduced putative kinase 1 (putative kinase 1)s level. AfzelinCan be improved D-galactosamine(GalN)/LPSSurvival rate of mice treated with doxorubicin prophylaxis (HY-15142A)Induced cardiotoxicity and scopolamine (HY-N0296)-induced neurological injury. AfzelinAlso inhibits asthma and allergies caused by ovalbumin .

HY-128483

Fusaric acid	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-N0103A

Sophocarpine monohydrate Maximum Cited Publications 7 Publications Verification	Autophagy Apoptosis NF-κB PI3K Akt MEK ERK	Cardiovascular Disease Inflammation/Immunology Cancer
Sophocarpine monohydrate is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine monohydrate upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine monohydrate inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine monohydrate can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine monohydrate has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage .

HY-N0103

Sophocarpine Maximum Cited Publications 7 Publications Verification	Autophagy Apoptosis NF-κB PI3K Akt MEK ERK PTEN	Cardiovascular Disease Inflammation/Immunology Cancer
Sophocarpine is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage .

HY-128483R

Fusaric acid (Standard)	TGF-beta/Smad PI3K NF-κB Akt Apoptosis Dopamine β-hydroxylase mTOR Adrenergic Receptor	Cardiovascular Disease Endocrinology Cancer
Fusaric acid (Standard) is the analytical standard of Fusaric acid (HY-128483). This product is intended for research and analytical applications. Fusaric acid is an orally active multi-pathway inhibitor with the activity of inducing oxidative stress and apoptosis. Fusaric acid can chelate divalent metal cations, damage mitochondrial membrane structure, and activate apoptosis-related proteases such as Caspase-3/7, -8, and -9. Fusaric acid also regulates Bax/Bcl-2 protein, inhibits fibrosis-related signaling pathways such as NF-κB, TGF-β₁/SMADs, and PI3K/AKT/mTOR, and reduces collagen deposition. Fusaric acid is also a dopamine β-hydroxylase inhibitor, which reduces endogenous levels of norepinephrine and epinephrine in the brain, heart, spleen, and adrenal glands. Fusaric acid can play a role in myocardial fibrosis and improve cardiac hypertrophy in heart disease, and can also be used in the study of esophageal cancer and liver cancer .

HY-P990294

Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7)	Transmembrane Glycoprotein STAT Collagen Reactive Oxygen Species (ROS) Interleukin Related	Cardiovascular Disease Inflammation/Immunology
Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) is an anti-mouse CD106/VCAM-1 IgG1 monoclonal antibody. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) reduces inflammatory response and oxidative stress by lowering p-STAT3 and reactive oxygen species (ROS) levels. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can alleviate cardiac inflammation and fibrosis by reducing the expression of collagen I and collagen III. Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) can be used for research on cardiovascular conditions such as hypertensive heart condition and subretinal fibrosis .

HY-N0103R

Sophocarpine (Standard)	Reference Standards Autophagy Apoptosis NF-κB PI3K Akt MEK ERK	Cardiovascular Disease Inflammation/Immunology Cancer
Sophocarpine (Standard) is the analytical standard of Sophocarpine (HY-N0103). This product is intended for research and analytical applications. Sophocarpine is a PTEN activator and an inhibitor of PI3K/Akt, MEK/ERK, and NF-κB signaling pathways. Sophocarpine upregulates PTEN expression and inhibits PI3K/Akt phosphorylation, arrests tumor cell cycle and induces apoptosis. Sophocarpine inhibits MEK/ERK phosphorylation and VEGF secretion, reducing tumor cell migration. Sophocarpine can also inhibit NF-κB activation and p38 and JNK phosphorylation, reduce the expression of inflammatory factors such as iNOS and COX-2, and activate the Nrf2/HO-1 pathway to reduce oxidative stress. Sophocarpine has anti-tumor, anti-inflammatory, antioxidant and anti-apoptotic effects, and can be used in the research of cancers such as glioblastoma and colorectal cancer, inflammation-related diseases, and Doxorubicin (HY-15142A)-induced cardiac damage .

HY-B1018A

Phenelzine sulfate 5 Publications Verification	Monoamine Oxidase GABA Receptor Histone Demethylase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Phenelzine sulfate, an antidepressant agent, is an irreversible and orally active monoamine oxidase (MAO-A and MAO-B) inhibitor. Phenelzine sulfate inhibits GABA transaminase and primary amine oxidase (PrAO), and sequester reactive aldehydes. Phenelzine sulfate also inhibits LSD1 (K_i: 5.6 μM) and suppresses oxidative stress and lipogenesis. Phenelzine sulfate elevates neurotransmitters (serotonin, norepinephrine, dopamine). Phenelzine sulfate is studied in neurological, metabolic and cancer diseases for depression and anxiety disorders, stroke, spinal cord injury, traumatic brain injury, multiple sclerosis, Parkinson’s disease, Alzheimer’s disease, inflammatory pain, obesity and prostate cancer .

Cesium chloride	Biochemical Assay Reagents
Cesium chloride is a blocker of potassium channel. Cesium chloride prevents the decrease of Na ⁺ transport produced by Alloxan . Cesium chloride has induced cardiac arrhythmias, including torsade de pointes in animal models .

Cat. No.	Product Name	Target	Research Area