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Results for "

cGK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ATM/ATR (1) PKG (3) Small Interfering RNA (siRNA) (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (3) Neurological Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CGK733 5+ Cited Publications	ATM/ATR	Cancer
CGK733 is a potent ATM/ATR inhibitor, used for the research of cancer.

CGK012	Wnt β-catenin	Inflammation/Immunology Cancer
CKG012 is an inhibitor for Wnt/βcatenin signaling pathway. CGK012 inhibits release of HMGB1 and transcription of β-catenin, exhibits attenuating activities against cecal ligation and puncture (CLP)-induced sepsis and multiple myeloma cancer .

Rp-8-pCPT-cGMPS sodium	PKG	Neurological Disease
Rp-8-pCPT-cGMPS sodium is the sodium salt form of Rp-8-pCPT-cGMPS. Rp-8-pCPT-cGMPS is an inhibitor for cGMP-dependent protein kinase (cGK). Rp-8-pCPT-cGMPS sodium is an agonist for cyclic nucleotide-gated (CNG) channels in a voltage-dependent manner .

BPDEtide	PKG	Inflammation/Immunology
BPDEtide is a synthetic peptide. BPDEtide has apparent Km values of 68 and 320 μM for *cGK* and cAK, respectively. BPDEtide is the most selective peptide substrate for measuring cGK activity .

Rp-8-Br-PET-cGMPS sodium Rp-8-Bromo-PET-cGMPS	PKG	Inflammation/Immunology
Rp-8-Br-PET-cGMPS sodium (Rp-8-Bromo-PET-cGMPS) is an analog of cyclic GMP (cGMP). It is a cell permeable, competitive, and reversible inhibitor of cGMP-dependent protein kinases (cGKs) that blocks activation of cGKI and cGKII by cGMP (Kis=35 and 30 nM). It less potently inhibits protein kinase A (Ki=11 μM) and cGMP-induced activation of cyclic nucleotide-gated channels (IC₅₀=25 μM). In the absence of cGMP stimulation, Rp-8-bromo-PET-cGMPS can act as a partial agonist of cGKI (Ki=1 μM). Rp-8-bromo-PET-cGMPS is resistant to hydrolysis by phosphodiesterase 11.

PRKG1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PRKG1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRKG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PRKG1 Human Pre-designed siRNA Set A PRKG1 Human Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

BPDEtide	PKG	Inflammation/Immunology
BPDEtide is a synthetic peptide. BPDEtide has apparent Km values of 68 and 320 μM for *cGK* and cAK, respectively. BPDEtide is the most selective peptide substrate for measuring cGK activity .

Cat. No.	Compare	Product Name	Species	Source

	PRKG1 Protein, Human (HEK293, His) cGMP-Dependent Protein Kinase 1; cGK 1; cGK1; cGMP-Dependent Protein Kinase I; cGKI; PRKG1; PRKG1B; PRKGR1A; PRKGR1B	Human	HEK293
	PRKG1 is a serine/threonine protein kinase that mediates the NO/c signaling pathway and phosphorylates various cellular proteins. It affects platelet activation, smooth muscle contraction, cardiac function, central nervous system processes, etc. PRKG1 Protein, Human (HEK293, His) is the recombinant human-derived PRKG1 protein, expressed by HEK293 , with C-6*His labeled tag.

	PRKG2 Protein, Human (sf9, GST) PRKG2; cGMP-dependent protein kinase 2; cGK 2; cGK2; cGMP-dependent protein kinase II; cGKII	Human	Sf9 insect cells
	PRKG2 protein is a key regulator that activates CFTR to promote intestinal secretion and affect bone growth. It phosphorylates CFTR, coordinating cGMP-dependent translocation in the jejunum. PRKG2 Protein, Human (sf9, GST) is the recombinant human-derived PRKG2 protein, expressed by sf9 insect cells , with N-GST labeled tag.

	PRKG1 Protein, Human (sf9, GST) PRKG1; protein kinase cGMP-dependent 1; PKG; cGK; AAT8; PKG1; cGK1; cGKI; cGK 1; PRKG1B; PRKGR1B; cGKI-BETA; cGKI-alpha	Human	Sf9 insect cells
	PRKG1 is a serine/threonine protein kinase that mediates the NO/c signaling pathway and phosphorylates various cellular proteins. It affects platelet activation, smooth muscle contraction, cardiac function, central nervous system processes, etc. PRKG1 Protein, Human (sf9, GST) is the recombinant human-derived PRKG1, expressed by Sf9 insect cells , with GST labeled tag. ,

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PRKG1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PRKG1 Human Pre-designed siRNA Set A contains three designed siRNAs for PRKG1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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