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Results for "

c-Kit Receptor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	c-Kit (10) Apoptosis (6) c-Fms (6) FLT3 (3) PDGFR (4) Src (1) VEGFR (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (2) Inflammation/Immunology (4)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Targets Recommended: c-Kit

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16749A

Pexidartinib hydrochloride Maximum Cited Publications 115 Publications Verification PLX-3397 hydrochloride	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive *colony stimulating factor 1 receptor* (CSF1R or M-CSFR) and c-Kit inhibitor, with IC₅₀*s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit* and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity .

HY-16749

Pexidartinib Maximum Cited Publications 115 Publications Verification PLX-3397	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive *colony stimulating factor 1 receptor* (CSF1R or M-CSFR) and c-Kit inhibitor, with IC₅₀*s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit* and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity .

HY-13894

Tyrphostin AG1296 2 Publications Verification AG1296	PDGFR c-Kit FLT3 Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Tyrphostin AG1296 is a potent and selective inhibitor of *platelet-derived growth factor receptor* (PDGFR), with an IC₅₀ of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors** as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC₅₀ in the micromolar range .

HY-10408

Ki20227 5 Publications Verification	c-Fms VEGFR c-Kit PDGFR	Inflammation/Immunology
Ki20227 is an orally active and highly selective c-Fms tyrosine kinase (CSF1R) inhibitor with IC₅₀s of 2 nM, 12 nM, 451 and 217 nM for CSF1R, VEGFR2 (vascular endothelial growth factor receptor-2), *c-Kit* (stem cell factor receptor) and PDGFRβ (platelet-derived growth factor receptor β). Ki20227 suppresses osteoclast differentiation and osteolytic bone destruction .

HY-P99488

Briquilimab JSP-191; AMG-191	c-Kit	Inflammation/Immunology Cancer
Briquilimab (JSP-191 or AMG-191) is a humanized IgG1 monoclonal antibody that binds human CD117 (c-Kit). Briquilimab blocks the interaction between CD117 receptor and stem cell factor on various CD117 expressing tissues. Briquilimab can lead to inhibition of SCF/c-Kit signaling and MC apoptosis. Briquilimab is a non-toxic approach to target and deplete HSC, enabling blood and immune reconstitution with minimal toxicity with the other agents being used for transient immune suppression to prevent immunologic rejection. Briquilimab can be used in various disease research such as severe combined immunodeficiency (SCID), myelodyplastic syndromes (MDS), acute myeloid leukemia (AML), chronic spontaneous urticarial (CSU), chronic inducible urticarial (CIndU) and asthema .

HY-132166

Velzatinib M4205; IDRX-42	c-Kit PDGFR c-Fms FLT3 Src	Cancer
Velzatinib (M4205) is a multi-target inhibitor for PDGFRB, PDGFRA, CSF1R, c-Kit, FLT3, and LCK, with an IC₅₀s of 2.6, 50, 5.5, 44, 141 and 141 nM, respectively. Velzatinib exhibits antitumor efficacy in xenograft mouse models .

HY-177275

c-Kit Receptor modulator-1	c-Kit	Cancer
c-Kit Receptor modulator-1 (Compound #22) is a **c-Kit Receptor** modulator. c-Kit Receptor modulator-1 can be used for malignant cancers such as canine mastocytoma, human gastrointestinal stromal tumor and small cell lung cancer research .

HY-16749AR

Pexidartinib hydrochloride (Standard)	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib (hydrochloride) (Standard) is the analytical standard of Pexidartinib (hydrochloride). This product is intended for research and analytical applications. Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity .

HY-16749R

Pexidartinib (Standard)	c-Fms c-Kit Apoptosis	Cancer
Pexidartinib (Standard) is the analytical standard of Pexidartinib. This product is intended for research and analytical applications. Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity .

HY-13894R

Tyrphostin AG1296 (Standard)	PDGFR c-Kit FLT3 Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Tyrphostin AG1296 (Standard) is the analytical standard of Tyrphostin AG1296. This product is intended for research and analytical applications. Tyrphostin AG1296 is a potent and selective inhibitor of platelet-derived growth factor receptor (PDGFR), with an IC50 of 0.8 μM. Tyrphostin AG1296 inhibits signaling of human PDGF α- and β-receptors as well as of the related stem cell factor receptor (c-Kit). Tyrphostin AG1296 is also a potent inhibitor of FLT3, with an IC50 in the micromolar range .

Cat. No.	Product Name	Target	Research Area

HY-P99488

Briquilimab JSP-191; AMG-191	c-Kit	Inflammation/Immunology Cancer
Briquilimab (JSP-191 or AMG-191) is a humanized IgG1 monoclonal antibody that binds human CD117 (c-Kit). Briquilimab blocks the interaction between CD117 receptor and stem cell factor on various CD117 expressing tissues. Briquilimab can lead to inhibition of SCF/c-Kit signaling and MC apoptosis. Briquilimab is a non-toxic approach to target and deplete HSC, enabling blood and immune reconstitution with minimal toxicity with the other agents being used for transient immune suppression to prevent immunologic rejection. Briquilimab can be used in various disease research such as severe combined immunodeficiency (SCID), myelodyplastic syndromes (MDS), acute myeloid leukemia (AML), chronic spontaneous urticarial (CSU), chronic inducible urticarial (CIndU) and asthema .

Species:	Human (6) Rhesus Macaque (2) Mouse (2) Rat (2) Cynomolgus (1)
Tag:	His (7) Tag Free (1) Avi (2) Fc (4)
Source:	HEK293 (10) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P72752

	CD117/c-kit Protein, Human (HEK293, His) Mast/stem cell growth factor Receptor Kit; SCFR; PBT; CD117; Kit	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (HEK293, His) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P72879

	CD117/c-Kit Protein, Mouse (HEK293, Fc) Mast/stem cell growth factor Receptor Kit; SCFR; CD117; Kit; Sl	Mouse	HEK293
	CD117/c-Kit protein is a tyrosine protein kinase that acts as a cell surface receptor for KITLG/SCF and regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, function, and melanogenesis . CD117/c-Kit Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD117/c-Kit protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72880

	CD117/c-Kit Protein, Mouse (HEK293, His) Mast/stem cell growth factor Receptor Kit; SCFR; CD117; Kit; Sl	Mouse	HEK293
	CD117/c-Kit protein is a tyrosine protein kinase that acts as a cell surface receptor for KITLG/SCF and regulates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, function, and melanogenesis .CD117/c-Kit Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD117/c-Kit protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P74337

	CD117/c-kit Protein, Rat (HEK293, His) Mast/stem cell growth factor Receptor Kit; SCFR; CD117; Kit; Sl	Rat	HEK293
	CD117, also known as tyrosine-protein kinase KIT or mast/stem cell growth factor receptor (SCFR), is a cytokine receptor that is expressed on the surface of hematopoietic stem cells and other cell types. CD117 signaling pathway plays an important role in cell survival, proliferation and differentiation. CD117 is a proto-oncogene associated with tumor development. CD117/c-kit Protein, Rat (HEK293, His) is the recombinant rat-derived CD117/c-kit protein, expressed by HEK293 , with C-His labeled tag.

HY-P74336

	CD117/c-kit Protein, Rhesus Macaque (HEK293, Fc) Mast/stem cell growth factor Receptor Kit; SCFR; CD117; Kit; Sl	Rhesus Macaque	HEK293
	CD117, also known as tyrosine-protein kinase KIT or mast/stem cell growth factor receptor (SCFR), is a cytokine receptor that is expressed on the surface of hematopoietic stem cells and other cell types. CD117 signaling pathway plays an important role in cell survival, proliferation and differentiation. CD117 is a proto-oncogene associated with tumor development. CD117/c-kit Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P702691

	CD117/c-kit Protein, Human (P10721-1, sf9) Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT, piebald trait; mast/stem cell growth factor Receptor Kit; C Kit; CD117; SCFR; p145 c-Kit; proto-oncogene c-Kit; piebald trait protein; soluble Kit variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein; PBT; C-Kit	Human	Sf9 insect cells
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (P10721-1, sf9) is the recombinant human-derived CD117/c-kit, expressed by Sf9 insect cells, with GST, Flag labeled tag. The total length of CD117/c-kit Protein, Human (P10721-1, sf9) is 433 a.a..

HY-P74338

	CD117/c-kit Protein, Rat (HEK293, Fc) Mast/stem cell growth factor Receptor Kit; SCFR; CD117; Kit; Sl	Rat	HEK293
	CD117, also known as tyrosine-protein kinase KIT or mast/stem cell growth factor receptor (SCFR), is a cytokine receptor that is expressed on the surface of hematopoietic stem cells and other cell types. CD117 signaling pathway plays an important role in cell survival, proliferation and differentiation. CD117 is a proto-oncogene associated with tumor development. CD117/c-kit Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P74341

	CD117/c-kit Protein, Human (141a.a, His) Mast/stem cell growth factor Receptor Kit; SCFR; CD117; Kit; Sl	Human	E. coli
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (141a.a, His) is the recombinant human-derived CD117/c-kit protein, expressed by E. coli , with N-His labeled tag.

HY-P705118

	CD117/c-kit Protein, Human (Biotinylated, HEK293, His-Avi) Mast/stem cell growth factor Receptor Kit; SCFR; CD117; Kit; Sl	Human	HEK293

HY-P73495

	CD117/c-kit Protein, Human (P10721-2, HEK293, His) Mast/stem cell growth factor Receptor Kit; SCFR; CD117; Kit; Sl	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (P10721-2, HEK293, His) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-His labeled tag.

HY-P74339

	CD117/c-kit Protein, Human (P10721-2, HEK293, Fc) Mast/stem cell growth factor Receptor Kit; SCFR; CD117; Kit; Sl	Human	HEK293
	CD117/c-kit is a tyrosine protein kinase receptor for KITLG/SCF that coordinates cell survival, proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration, and melanogenesis. Upon KITLG/SCF binding, CD117 activates the pathway and phosphorylates PIK3R1, PLCG1, SH2B2/APS, and CBL. CD117/c-kit Protein, Human (P10721-2, HEK293, Fc) is the recombinant human-derived CD117/c-kit protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P705187

	CD117/c-kit Protein, Cynomolgus/Rhesus macaque (Biotinylated, HEK293, His-Avi) Mast/stem cell growth factor Receptor Kit; SCFR; CD117; Kit; Sl	Cynomolgus;Rhesus Macaque	HEK293

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HY-P80619

	c-Kit Antibody (YA3501) 2 Publications Verification Kit; SCFR; Mast/stem cell growth factor Receptor Kit; SCFR; Piebald trait protein; PBT; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-Kit; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; CD antigen CD117	WB, IHC-P	Human
	c-Kit Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 110 kDa, targeting to c-Kit. It can be used for WB,IHC-P assays with tag free, in the background of Human.

HY-P85841

	c-Kit Antibody (YA5533) C Kit; c-Kit; c-Kit Ligand; CD117; Kit; Kit Ligand; Kit oncogene; Kit proto oncogene Receptor tyrosine kinase; Kit_HUMAN; Mast cell growth factor Receptor; Mast/stem cell growth factor Receptor Kit; MGF; p145 c-Kit; PBT; Piebald trait protein; Proto oncogene c Kit; Proto oncogene tyrosine protein kinase Kit; Proto-oncogene c-Kit; SCF Receptor; SCFR; soluble Kit variant 1; Steel Factor Receptor; Stem cell factor Receptor; tyrosine protein kinase Kit; Tyrosine-protein kinase Kit; v Kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v Kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog	IHC-P, WB, ICC/IF, ELISA	Human
	c-Kit Antibody (YA5533) is a mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to c-Kit/CD117. It can be applicated for IHC-P, WB, ICC/IF, ELISA assays, in the background of human.

HY-P86655

	c-Kit Antibody (YA6347) C Kit; CD 117; CD117; CD117 antigen; Kit; Kit_HUMAN; Mast/stem cell growth factor Receptor; Mast/stem cell growth factor Receptor Kit; p145 c-Kit; PBT; Piebald trait protein; Proto oncogene c Kit; Proto oncogene tyrosine protein kinase Kit; Proto-oncogene c-Kit; SCF Receptor; SCFR; soluble Kit variant 1; Stem cell factor Receptor; tyrosine protein kinase Kit; Tyrosine-protein kinase Kit; v Kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog; v Kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein; v-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog.	WB, IHC-P, IHC-F, IF-Tissue	Human
	c-Kit Antibody (YA6347) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to c-Kit. It can be applicated for WB, IHC-P, IHC-F, IF-Tissue assays, in the background of human.

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