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Results for "

bicyclic

" in MedChemExpress (MCE) Product Catalog:

50

Inhibitors & Agonists

1

Screening Libraries

2

Biochemical Assay Reagents

14

Peptides

17

Natural
Products

3

Isotope-Labeled Compounds

2

Click Chemistry

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W570888
    2'-O,4'-C-Methylenecytidine

    LNA-C(Bz)

    		 Nucleoside Antimetabolite/Analog Cancer
    2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands .
    2'-O,4'-C-Methylenecytidine
  • HY-136561
    GRK5-IN-2
    2 Publications Verification

    		 G Protein-coupled Receptor Kinase (GRK) ERK Metabolic Disease
    GRK5-IN-2 (compound 707), a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor with an IC50 of 49.7 μM. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research .
    GRK5-IN-2
  • HY-108943
    Sabinene
    2 Publications Verification

    		 p38 MAPK Others
    Sabinene is an naturally occurring bicyclic monoterpene which can be used as flavorings, perfume additives, fine chemicals, and advanced biofuels. Sabinene is also an orally active compound to attenuates skeletal muscle atrophy and regulates ROS-mediated MAPK/MuRF-1 pathways .
    Sabinene
  • HY-N10793
    RA-XI

    		Others Cancer
    RA-XI is a bicyclic hexapeptide isolated from Rubia cordifolia with antitumour activity .
    RA-XI
  • HY-W068697
    3-Butenoic acid

    Vinylacetic acid

    		 Biochemical Assay Reagents Others
    3-Butenoic acid (Vinylacetic acid) can be used to synthesize bicyclic 3,6-dihydro-1,2-oxazine. Strained bicyclic 3,6-dihydro-1,2-oxazine is a reactive substrate in domino metathesis with an external alkene .
    3-Butenoic acid
  • HY-P10877
    Bicyclic UK18

    		PAI-1 Cancer
    Bicyclic UK18 is a competitive inhibitor for human urokinase-type plasminogen activator (uPA) with a Ki of 53 nM .
    Bicyclic UK18
  • HY-107025
    Cf1743

    		Nucleoside Antimetabolite/Analog Infection
    Cf1743 is a potent anti-varicella-zoster virus (VZV) bicyclic nucleoside analogue. Cf1743 has antiviral activity, with an IC50 of 3.3 μM for VZV thymidine kinase (TK) .
    Cf1743
  • HY-10116
    PI-540

    		PI3K mTOR Cancer
    PI-540 is a bicyclic thienopyrimidine derivative and an orally active PI3K inhibitor. PI-540 has anti-cancer cell proliferation properties and high tissue distribution. PI-540 can inhibit different isoforms of PI3K, with IC50s of 10 nM (P110α), 3510 nM (P110β), 410 nM (P110δ), and 33110 nM (P110γ). PI-540 also inhibits mTOR (IC50: 61 nM) and DNA-PK (IC50: 525 nM) .
    PI-540
  • HY-P11032
    Mp-4D7-pF2

    		SARS-CoV Virus Protease Infection
    Mp-4D7-pF2, a cell-penetrating bicyclic peptide, is a noncovalent SARS-CoV-2 main protease inhibitor with an IC50 of 4.51 μM. Mp-4D7-pF2 has an antiviral activity against SARS-CoV-2 with no cytotoxicity. Mp-4D7-pF2 can used for COVID-19 infections research .
    Mp-4D7-pF2
  • HY-N7366
    Taxachitriene A

    		Others Others
    Taxachitriene A is a bicyclic taxane diterpenoid that can be found in the needles of Taxus chinensis .
    Taxachitriene A
  • HY-111639
    2’-O,4’-C-Methyleneuridine

    		Nucleoside Antimetabolite/Analog Others
    2’-O,4’-C-Methyleneuridine (Compound 15a) is a bicyclic nucleoside.
    2’-O,4’-C-Methyleneuridine
  • HY-W013021
    Norbornene

    		Others Others
    Norbornene is a bicyclic compound. Norbornene polymers can be used in tissue engineering and drug release system .
    Norbornene
  • HY-N10663A
    (±)-7-epi-Kadsurenone

    		Others Others
    (±)-7-epi-Kadsurenone is a novel lignan with hydrobenzofuran and bicyclic [3.2.1] octane. .
    (±)-7-epi-Kadsurenone
  • HY-P10775
    BT1769

    		Peptide-Drug Conjugates (PDCs) MMP Cancer
    BT1769 is a MT1-MMP-targeted (KD = 3.35 nM) Bicycle toxin conjugate. BT1769 can be used in the study for osteosarcoma. BT1769 consists of a novel bicyclic targeting peptide that selectively binds MT1-MMP; a cytotoxin MMAE; and an enzymatically cleavable dipeptide linker .
    BT1769
  • HY-111638
    1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine

    		Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Infection
    1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine is a bicyclic nucleoside.
    1-(2'-O-4-C-Methylene-beta-D-ribofuranosyl)thymine
  • HY-W068697R
    3-Butenoic acid (Standard)

    Vinylacetic acid (Standard)

    		 Biochemical Assay Reagents Reference Standards Others
    3-Butenoic acid (Standard) is the analytical standard of 3-Butenoic acid. This product is intended for research and analytical applications. 3-Butenoic acid (Vinylacetic acid) can be used to synthesize bicyclic 3,6-dihydro-1,2-oxazine. Strained bicyclic 3,6-dihydro-1,2-oxazine is a reactive substrate in domino metathesis with an external alkene[1][2].
    3-Butenoic acid (Standard)
  • HY-W010922
    Fmoc-Dap(Boc)-OH

    		Amino Acid Derivatives Others
    Fmoc-Dap(Boc)-OH is an amino acid derivative with an Fmoc protecting group, which can be used to synthesize bicyclic peptide tachykinin NK2 antagonists .
    Fmoc-Dap(Boc)-OH
  • HY-126027
    (+)-3-Carene

    		Drug Isomer COX Inflammation/Immunology
    (+)-3-Carene, a bicyclic monoterpene, is one of the major components of the pine tree essential oils. (+)-3-Carene is a (+)-enantiomer of 3-Carene (HY-N6663) .
    (+)-3-Carene
  • HY-P3193A
    Cyclic nona-L-arginine hydrochloride

    		Biochemical Assay Reagents Others
    Cyclic nona-L-arginine hydrochloride, a nonaarginine peptide used for drug delivery, translocates faster than their linear counterparts .
    Cyclic nona-L-arginine hydrochloride
  • HY-177078
    Davotifan

    		HIF/HIF Prolyl-Hydroxylase Cancer
    Davotifan (Compound A17) is a bicyclic compound. Davotifan is an inhibitor of HIF-2α. Davotifan can be studied in research for HIF-2α-related cancer .
    Davotifan
  • HY-139798
    Iboxamycin

    		Bacterial Infection
    Iboxamycin is a potent antibiotic candidate bearing a fused bicyclic amino acid residue. Iboxamycin is orally bioavailable, safe and effective in researching both Gram-positive and Gram-negative bacterial infections in mice .
    Iboxamycin
  • HY-W010835
    Boc-D-Cys(Trt)-OH

    Boc-S-trityl-D-cysteine

    		 Amino Acid Derivatives Others
    Boc-D-Cys(Trt)-OH (Boc-S-trityl-D-cysteine) is an amino acid derivative with a Boc protecting group, which can be used to synthesize the bicyclic depsipeptide histone deacetylase inhibitor spirocysteine .
    Boc-D-Cys(Trt)-OH
  • HY-W408830
    4-Iodobutyl benzoate

    		Biochemical Assay Reagents Others
    4-Iodobutyl benzoate is structurally related to bicyclic heterocycles such as indole and indoline. 4-Iodobutyl benzoate is a metabolite of the drug amide and is used in the treatment of inflammatory bowel disease, degenerative diseases, and bowel disease.
    4-Iodobutyl benzoate
  • HY-N11977
    Stenophyllol B

    		Others Others
    Stenophyllol B (compound 4) is a trimeric stilbene with bicyclic and bridged tricyclic skeletons. Stenophyllol B was first discovered in the dipterocarps plant and has been found in many species of Hopea, Neobalanocarpus, Shorea, Stemonoporus and Vateri .
    Stenophyllol B
  • HY-P10672
    SEI144

    		Biochemical Assay Reagents Others
    SEI144 is a low nanomolar binder of USP15 and does not inhibit USP15 activity .
    SEI144
  • HY-78985
    Benzene-1,3,5-tricarboxylic acid

    Trimesic acid

    		 Biochemical Assay Reagents Others
    Benzene-1,3,5-tricarboxylic acid (Trimesic acid) is a scaffold. Benzene-1,3,5-tricarboxylic acid enhances the binding ability of bicyclic peptides to proteins and improves the mechanical stability of hydrogels .
    Benzene-1,3,5-tricarboxylic acid
  • HY-149872
    DCA-RMR1

    		Biochemical Assay Reagents Others
    DCA-RMR1 is a cross-linker. DCA-RMR1 elicits facile bicyclization of native peptides via N-terminus Cys-Cys cross-linking. DCA-RMR1 derivatizes RMR1 with 1,3-dichloroacetone (DCA) .
    DCA-RMR1
  • HY-N3544
    Caryophyllene oxide

    (-)-Caryophyllene oxide

    		 Apoptosis Bacterial Fungal Parasite Infection Neurological Disease Inflammation/Immunology Cancer
    Caryophyllene oxide ((-)-Caryophyllene oxide) is a bicyclic sesquiterpene with anticancer effects. Caryophyllene oxide induces apoptosis of PC-3 cells. Caryophyllene oxide shows analgesic and anti-inflammatory activities. Caryophyllene oxide has insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic properties .
    Caryophyllene oxide
  • HY-134772
    AS1810722

    		STAT Cytochrome P450 Inflammation/Immunology
    AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research .
    AS1810722
  • HY-176347S
    Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2

    		Isotope-Labeled Compounds Cancer
    Alpha Feto Protein, Arg- 13C36, 15N4, Lys- 13C6, 15N2 is the 13C- and 15N-labeled Alpha Feto Protein.
    Alpha Feto Protein, Arg-13C6,15N4, Lys-13C6,15N2
  • HY-W770090
    CF 1743-d7

    		Isotope-Labeled Compounds Nucleoside Antimetabolite/Analog Infection
    CF 1743-d7 is the deuterium labeled Cf1743 (HY-107025). Cf1743 is a potent anti-varicella-zoster virus (VZV) bicyclic nucleoside analogue. Cf1743 has antiviral activity, with an IC50 of 3.3 μM for VZV thymidine kinase (TK) .
    CF 1743-d7
  • HY-P10033
    SFTI-1

    		Ser/Thr Protease Others
    SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms .
    SFTI-1
  • HY-N6663
    3-Carene

    		COX Inflammation/Immunology
    3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation .
    3-Carene
  • HY-N6951
    Guaiazulene

    		Apoptosis Akt mTOR Reactive Oxygen Species (ROS) Caspase Bacterial Fungal Infection Neurological Disease Inflammation/Immunology Cancer
    Guaiazulene is a bicyclic sesquiterpene that can cross the blood-brain barrier. Guaiazulene exhibits various biological activities such as anti-inflammatory, antioxidant, hepatoprotective, antibacterial, and anti-tumor properties. Guaiazulene is also commonly used as a colorant in cosmetics. Guaiazulene shows in vitro cytotoxicity to rat neuronal cells and N2a neuroblastoma cells at high concentrations .
    Guaiazulene
  • HY-109016
    Valnivudine

    FV-100 free base

    		 Antibiotic Bacterial Infection
    Valnivudine (FV-100 free base), a proagent of CF-1743, is an orally active anti-herpes zoster (HZ) nucleoside analogue. CF-1743, a bicyclic nucleoside analog (BCNA), has highly specific antiviral activity against varicella-zoster virus (VZV). Valnivudine is rapidly and extensively converted to CF-1743 in vivo .
    Valnivudine
  • HY-N3544R
    Caryophyllene oxide (Standard)

    (-)-Caryophyllene oxide (Standard)

    		 Reference Standards Apoptosis Bacterial Fungal Parasite Infection Neurological Disease Inflammation/Immunology Cancer
    Caryophyllene oxide (Standard) ((-)-Caryophyllene oxide (Standard)) is the analytical standard of Caryophyllene oxide (HY-N3544). This product is intended for research and analytical applications. Caryophyllene oxide is a bicyclic sesquiterpene with anticancer effects. Caryophyllene oxide induces apoptosis of PC-3 cells. Caryophyllene oxide shows analgesic and anti-inflammatory activities. Caryophyllene oxide has insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic properties.
    Caryophyllene oxide (Standard)
  • HY-N5132
    (-)-Fenchone

    		Others Others
    (-)-Fenchone, a bicyclic monoterpene, is widely distributed in plants and found in essential oils from Foeniculum vulgare. (-)-Fenchone is oxidized to 6-endo-hydroxyfenchone, 6-exo-hydroxyfenchone and 10-hydroxyfenchone derivatives by CYP2A6 and CYP2B6 in human liver microsomes with CYP2A6 playing a more important role than CYP2B6 .
    (-)-Fenchone
  • HY-78985S
    Benzene-1,3,5-tricarboxylic acid-d3

    Trimesic acid-d3

    		 Isotope-Labeled Compounds Biochemical Assay Reagents Others
    Benzene-1,3,5-tricarboxylic acid-d3 is the deuterium labeled Benzene-1,3,5-tricarboxylic acid (HY-78985). Benzene-1,3,5-tricarboxylic acid (Trimesic acid) is a scaffold. Benzene-1,3,5-tricarboxylic acid enhances the binding ability of bicyclic peptides to proteins and improves the mechanical stability of hydrogels .
    Benzene-1,3,5-tricarboxylic acid-d3
  • HY-121348
    Ficellomycin

    U-47929

    		 Antibiotic Bacterial DNA/RNA Synthesis Infection
    Ficellomycin is a nitrogen-containing bicyclic antibiotic with strong activity against Gram-positive bacteria, including multidrug-resistant strains of Staphylococcus aureus. Ficellomycin works by inducing the formation of defective 34S DNA fragments, which interfere with the semi-conservative DNA replication process. These fragments lack the ability to integrate into larger DNA segments and eventually form a complete bacterial chromosome. Ficellomycin can be used in research for various bacterial diseases .
    Ficellomycin
  • HY-N6663R
    3-Carene (Standard)

    		Reference Standards COX Inflammation/Immunology
    3-Carene (Standard) is the analytical standard of 3-Carene. This product is intended for research and analytical applications. 3-Carene is a bicyclic monoterpene in essential oils extracted from pine trees. 3-Carene inhibits nociceptive stimulus-induced inflammatory infiltrates and COX-2 overexpression, and with antinociceptive effect. 3-Carene stimulates the activity and expression of alkaline phosphatase that is an early phase marker of osteoblastic differentiation .
    3-Carene (Standard)
  • HY-153486
    N3-VC-PAB-PNP

    		Biochemical Assay Reagents Others
    N3-VC-PAB-PNP is the intermediate of bicyclic peptide ligand STING conjugates . N3-VC-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-VC-PAB-PNP
  • HY-N6951R
    Guaiazulene (Standard)

    		Reference Standards Apoptosis Akt mTOR Reactive Oxygen Species (ROS) Caspase Bacterial Fungal Infection Neurological Disease Inflammation/Immunology Cancer
    Guaiazulene (Standard) is the analytical standard of Guaiazulene (HY-N6951). This product is intended for research and analytical applications. Guaiazulene is a bicyclic sesquiterpene that can cross the blood-brain barrier. Guaiazulene exhibits various biological activities such as anti-inflammatory, antioxidant, hepatoprotective, antibacterial, and anti-tumor properties. Guaiazulene is also commonly used as a colorant in cosmetics. Guaiazulene shows in vitro cytotoxicity to rat neuronal cells and N2a neuroblastoma cells at high concentrations .
    Guaiazulene (Standard)
  • HY-N5132R
    (-)-Fenchone (Standard)

    		Reference Standards Others Others
    (-)-Fenchone (Standard) is the analytical standard of (-)-Fenchone. This product is intended for research and analytical applications. (-)-Fenchone, a bicyclic monoterpene, is widely distributed in plants and found in essential oils from Foeniculum vulgare. (-)-Fenchone is oxidized to 6-endo-hydroxyfenchone, 6-exo-hydroxyfenchone and 10-hydroxyfenchone derivatives by CYP2A6 and CYP2B6 in human liver microsomes with CYP2A6 playing a more important role than CYP2B6 .
    (-)-Fenchone (Standard)
  • HY-P10027A
    Clovibactin TFA

    		Antibiotic Bacterial Infection
    Clovibactin TFA is the TFA salt form of Clovibactin (HY-P10027). Clovibactin TFA is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .
    Clovibactin TFA
  • HY-P10027
    Clovibactin

    		Antibiotic Bacterial Infection
    Clovibactin is an antibiotic for drug-resistant bacterial pathogens without detectable resistance. Clovibactin TFA inihibits cell wall synthesis by targeting pyrophosphate of peptidoglycan precursors .
    Clovibactin
  • HY-W010649
    Isoxazole

    		HSP Epigenetic Reader Domain ATP-binding cassette (ABC) transporters Bacterial Fungal Antibiotic Infection Metabolic Disease Inflammation/Immunology Cancer
    Isoxazole is a member of the five-membered heterocycle drug scaffold. Isoxazole has been used as a BET bromodomain inhibitor and can improve β-cell function in a diabetic mouse model. Isoxazole and its derivatives exhibit broad biological activities (such as antimicrobial, antibacterial, antifungal, antiviral, anticancer, anti-inflammatory, immunomodulatory, analgesic, anti-tuberculosis, and anti-diabetic effects). For example, the bicyclic Isoxazole can act as an HSP90 inhibitor, and the tricyclic Isoxazole is promising as a selective multidrug resistance protein (MRP1) inhibitor​ .
    Isoxazole
  • HY-P1206
    CH 275

    		Somatostatin Receptor Neurological Disease
    CH 275 is a peptide analog of somatostatin and binds preferably to somatostatin receptor 1 (sst1) with a Ki of 52 nM . CH 275 acts as a potent and selective sst1 agonist (IC50=30.9 nM) and also displays IC50 values of 345 nM, >1 μM, >10 μM, >10 μM for human sst3, sst4, sst2 and sst5, respectively . CH 275 can be used for the research of alzheimer’s disease .
    CH 275
  • HY-W111141
    BCN-OH

    endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne

    		 Biochemical Assay Reagents Others
    BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps .
    BCN-OH
  • HY-151829
    Fmoc-L-Asn(EDA-N3)-OH

    		ADC Linker Others
    Fmoc-L-Asn(EDA-N3)-OH is a click chemistry reagent containing an azide group. This building block is reported in literature for the modification of Amanitin via Click Chemistry. Alpha-Amanitin is the deadliest member of the amatoxin peptide family produced by the death-cap mushroom A. phalloides. It is an orally available, rigid, bicyclic octapeptide and one of the most lethal known natural products (LD50 = 50-100 μg/kg) acting as highly selective allosteric inhibitor of the RNA polymerase II . It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Fmoc-L-Asn(EDA-N3)-OH
  • HY-N6693
    Valinomycin
    Maximum Cited Publications
    6 Publications Verification

    NSC 122023

    		 Apoptosis Antibiotic Autophagy Fungal Infection Others Cancer
    Valinomycin is a potassium-specific ionophore, the valinomycin-K + complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K + gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic, antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research .
    Valinomycin

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