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Results for "

anti-stress

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Antibiotic (2) Apoptosis (6) Bacterial (6) Bcl-2 Family (2) CaMK (1) DNA/RNA Synthesis (1) Endogenous Metabolite (11) Fungal (1) GABA Receptor (1) iGluR (3) Isotope-Labeled Compounds (7) Lactate Dehydrogenase (3) mGluR (1) Parasite (1) Reactive Oxygen Species (ROS) (3) Reference Standards (1) TNF Receptor (1)
By Research Areas:	Cancer (13) Cardiovascular Disease (6) Infection (3) Inflammation/Immunology (8) Metabolic Disease (9) Neurological Disease (14)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-110146

XAP044	mGluR	Neurological Disease
XAP044 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms .

HY-N0368

Linalool 2 Publications Verification	TNF Receptor Apoptosis iGluR Endogenous Metabolite Bacterial	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-111191

ONO-2952	Adrenergic Receptor	Neurological Disease
ONO-2952 is a potent, selective and orally active translocator protein 18 kDa (TSPO) antagonist with K_i of 0.33-9.30 nM for rat and human TSPO. ONO-2952 is more selective for TSPO than other receptors, transporters, ion channels and enzymes. ONO-2952 exerts its anti-stress effects through inhibition of excessive activation of noradrenergic system in the brain without the amnesic effect. ONO-2952 has the potential for irritable bowel syndrome treatment .

HY-N6948

Linalyl acetate 1 Publications Verification	Lactate Dehydrogenase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Linalyl acetate is the principal components of many plant essential oils. Linalyl acetate exhibits anti-anxiety, anti-inflammatory, anti-diabetic, anti-stress, and cardiovascular-regulatory effects. Linalyl acetate is orally active .

HY-W012123

3,4,5-Trimethoxycinnamic acid	GABA Receptor Endogenous Metabolite	Neurological Disease
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals . 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits .

HY-108059

β-Cryptoxanthin (3R)-β-Cryptoxanthin	Endogenous Metabolite	Neurological Disease
β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from tangerines, red peppers, and pumpkin, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin has an anti-stress effect .

HY-N15147

Panax saponin C	DNA/RNA Synthesis	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Panax saponin C is a ginsenoside found in Ginseng with biological activities including regulatory effects on immunomodulation, protection functions in the central nervous and cardiovascular systems, anti-diabetic, anti-aging, anti-carcinogenic, anti-fatigue, anti-pyretic, anti-stress, boosting physical vitality, and promotion of DNA, RNA, and protein synthesis activities .

HY-W010410S

Oct-1-en-3-ol-d3	Isotope-Labeled Compounds	Metabolic Disease
Oct-1-en-3-ol-d₃ is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-N6948R

Linalyl acetate (Standard)	Reference Standards Lactate Dehydrogenase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Linalyl acetate (Standard) is the analytical standard of Linalyl acetate. This product is intended for research and analytical applications. Linalyl acetate is the principal components of many plant essential oils. Linalyl acetate exhibits anti-anxiety, anti-inflammatory, anti-diabetic, anti-stress, and cardiovascular-regulatory effects. Linalyl acetate is orally active .

HY-N6948S

Linalyl acetate-d6	Isotope-Labeled Compounds Lactate Dehydrogenase	Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology
Linalyl acetate-d₆ is deuterated labeled Linalyl acetate (HY-N6948). Linalyl acetate is the principal components of many plant essential oils. Linalyl acetate exhibits anti-anxiety, anti-inflammatory, anti-diabetic, anti-stress, and cardiovascular-regulatory effects. Linalyl acetate is orally active .

HY-N0368S1

Linalool-13C3	Apoptosis Endogenous Metabolite iGluR Bacterial Isotope-Labeled Compounds	Cancer
Linalool- ¹³C₃ is ¹³C labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-152052S

Linalool-d5	Isotope-Labeled Compounds	Others
Linalool-d₅ is the deuterium labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-N0368S2

Linalool-d6	Apoptosis Endogenous Metabolite iGluR Bacterial Isotope-Labeled Compounds	Cancer
Linalool-d₆ is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-15121S

L-Theanine-d5 L-Glutamic Acid γ-ethyl amide-d₅; Nγ-Ethyl-L-glutamine-d₅	Apoptosis Endogenous Metabolite	Neurological Disease
L-Theanine-d₅ is the deuterium labeled L-Theanine. L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake .

HY-Z0478

(-)-Limonene 1 Publications Verification (S)-(-)-Limonene	Bacterial Antibiotic CaMK	Infection Cardiovascular Disease Metabolic Disease
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca ²⁺) and Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture .

HY-W012382

N-Acetyl-L-tyrosine	Endogenous Metabolite	Metabolic Disease Cancer
N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .

HY-W012382S

N-Acetyl-L-tyrosine-d3	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Cancer
N-Acetyl-L-tyrosine-d₃ is the deuterated form of N-Acetyl-L-tyrosine (HY-W012382). N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .

HY-W012382R

N-Acetyl-L-tyrosine (Standard)	Endogenous Metabolite	Metabolic Disease Cancer
N-Acetyl-L-tyrosine (Standard) is the analytical standard of N-Acetyl-L-tyrosine (HY-W012382). This product is intended for research and analytical applications. N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .

HY-N5113

6α-Chloro-5β-hydroxywithaferin A	Bacterial	Others
6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties .

HY-N13197

6-Methyl-5,6-dihydro-2H-pyran-2-one	Antibiotic Bacterial Fungal Parasite	Infection Inflammation/Immunology Cancer
6-Methyl-5,6-dihydro-2H-pyran-2-one is a heterocyclic compound with antitumor, antifungal, antimicrobial, anti-inflammatory, antistress, antibiotic, antituberculosis, antiparasitic, antiviral activities .

HY-15121R

L-Theanine (Standard)	Apoptosis Endogenous Metabolite Reactive Oxygen Species (ROS)	Neurological Disease Cancer
L-Theanine (Standard) is the analytical standard of L-Theanine. This product is intended for research and analytical applications. L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective, anticancer and anti-oxidative activities. L-Theanine can pass through the blood–brain barrier and is orally active .

HY-N12715

Valerena-4,7(11)-diene	Others	Neurological Disease
Valerena-4,7(11)-diene is a tranquilizer. Valerena-4,7(11)-diene suppresses stress-induced excitatory behaviors. Valerena-4,7(11)-diene is expressed via olfactory stimulation and pulmonary absorption .

HY-15121

L-Theanine 2 Publications Verification L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-glutamine	Apoptosis Endogenous Metabolite Reactive Oxygen Species (ROS)	Neurological Disease Cancer
L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective, anticancer and anti-oxidative activities. L-Theanine can pass through the blood–brain barrier and is orally active .

HY-N1440

Koumine	Bcl-2 Family	Inflammation/Immunology Cancer
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-N1440R

Koumine (Standard)	Bcl-2 Family	Inflammation/Immunology Cancer
Koumine (Standard) is the analytical standard of Koumine. This product is intended for research and analytical applications. Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-W010201S

Citronellol-d6 (±)-Citronellol-d₆; (±)-β-Citronellol-d₆	Reactive Oxygen Species (ROS) Isotope-Labeled Compounds	Cancer
Citronellol-d₆ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis ^.

Cat. No.	Product Name	Target	Research Area

HY-105042A

Selank diacetate Selanc diacetate; TP-7 diacetate	Peptides	Neurological Disease
Selank (Selanc) acetate is a synthetic peptide derived from tuftsin. Selank acetate has anxiolytic activity, and is a nootropic, neuropsychotropic, antidepressant, and antistress compound .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0368

Linalool 2 Publications Verification	Cardiovascular Disease Structural Classification Other Monoterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Amberboa moschata (L.) DC. Umbelliferae Plants Endogenous metabolite Disease Research Fields	TNF Receptor Apoptosis iGluR Endogenous Metabolite Bacterial
Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-N6948

Linalyl acetate 1 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Labiatae Source classification Plants Dolichos trilobus Houtt. Inflammation/Immunology Disease Research Fields	Lactate Dehydrogenase
Linalyl acetate is the principal components of many plant essential oils. Linalyl acetate exhibits anti-anxiety, anti-inflammatory, anti-diabetic, anti-stress, and cardiovascular-regulatory effects. Linalyl acetate is orally active .

HY-W012123

3,4,5-Trimethoxycinnamic acid	Structural Classification Simple Phenylpropanols Source classification Polygalaceae Phenylpropanoids Plants Endogenous metabolite Polygala tenuifolia Willd.	GABA Receptor Endogenous Metabolite
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals . 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits .

HY-Z0478

(-)-Limonene 1 Publications Verification (S)-(-)-Limonene	Cardiovascular Disease Structural Classification Other Monoterpenes Microorganisms Classification of Application Fields Terpenoids Source classification Rutaceae Plants Citrus Disease Research Fields	Bacterial Antibiotic CaMK
(-)-Limonene ((S)-(-)-Limonene) is orally active and can cause mild bronchoconstriction. (-)-Limonene alleviates cytosolic and mitochondrial oxidative stress by inhibiting the increase of calcium ions (Ca ²⁺) and Ca ²⁺/calmodulin-dependent protein kinase II (CaMKII). It also exerts anti-stress effects by inhibiting the activity of the hypothalamic-pituitary-adrenal (HPA) axis. Additionally, (-)-Limonene can be used as an antibacterial agent in aquaculture .

HY-W012382

N-Acetyl-L-tyrosine	Structural Classification Classification of Application Fields Source classification Endocrine diseases Metabolic Disease Endogenous metabolite Human Gut Microbiota Metabolites Monophenols Microorganisms Ketones, Aldehydes, Acids Disease markers Phenols Disease Research Fields	Endogenous Metabolite
N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .

HY-W012382R

N-Acetyl-L-tyrosine (Standard)	Structural Classification Human Gut Microbiota Metabolites Monophenols Microorganisms Ketones, Aldehydes, Acids Source classification Disease markers Phenols Endocrine diseases Endogenous metabolite	Endogenous Metabolite
N-Acetyl-L-tyrosine (Standard) is the analytical standard of N-Acetyl-L-tyrosine (HY-W012382). This product is intended for research and analytical applications. N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .

HY-108059

β-Cryptoxanthin (3R)-β-Cryptoxanthin	Other Terpenoids Structural Classification Capsicum annuum L. other families Neurological Disease Classification of Application Fields Terpenoids Source classification Plants Solanaceae Endogenous metabolite Disease Research Fields	Endogenous Metabolite
β-Cryptoxanthin ((3R)-β-Cryptoxanthin), isolated from tangerines, red peppers, and pumpkin, is an oxygenated carotenoid and a potent antioxidant. β-Cryptoxanthin has an anti-stress effect .

HY-N15147

Panax saponin C	Panax ginseng C. A. Meyer Structural Classification Natural Products Source classification Plants Araliaceae	DNA/RNA Synthesis
Panax saponin C is a ginsenoside found in Ginseng with biological activities including regulatory effects on immunomodulation, protection functions in the central nervous and cardiovascular systems, anti-diabetic, anti-aging, anti-carcinogenic, anti-fatigue, anti-pyretic, anti-stress, boosting physical vitality, and promotion of DNA, RNA, and protein synthesis activities .

HY-N6948R

Linalyl acetate (Standard)	Structural Classification Natural Products Microorganisms Labiatae Source classification Plants Dolichos trilobus Houtt.	Reference Standards Lactate Dehydrogenase
Linalyl acetate (Standard) is the analytical standard of Linalyl acetate. This product is intended for research and analytical applications. Linalyl acetate is the principal components of many plant essential oils. Linalyl acetate exhibits anti-anxiety, anti-inflammatory, anti-diabetic, anti-stress, and cardiovascular-regulatory effects. Linalyl acetate is orally active .

HY-N5113

6α-Chloro-5β-hydroxywithaferin A	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Withania somnifera Plants Solanaceae Disease Research Fields	Bacterial
6α-Chloro-5β-hydroxywithaferin A is a withanolide that can be isolated from W. somnifera. W. somnifera has antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic, antibacterial antiparkinsonism and antistress properties .

HY-N13197

6-Methyl-5,6-dihydro-2H-pyran-2-one	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial Fungal Parasite
6-Methyl-5,6-dihydro-2H-pyran-2-one is a heterocyclic compound with antitumor, antifungal, antimicrobial, anti-inflammatory, antistress, antibiotic, antituberculosis, antiparasitic, antiviral activities .

HY-15121R

L-Theanine (Standard)	Structural Classification Microorganisms Source classification Amino acids Camellia sinensis (L.) O. Ktze. Plants Theaceae	Apoptosis Endogenous Metabolite Reactive Oxygen Species (ROS)
L-Theanine (Standard) is the analytical standard of L-Theanine. This product is intended for research and analytical applications. L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective, anticancer and anti-oxidative activities. L-Theanine can pass through the blood–brain barrier and is orally active .

HY-N12715

Valerena-4,7(11)-diene	Structural Classification Terpenoids Sesquiterpenes Source classification Nardostachys jatamansi (D. Don) DC. Plants Valerianaceae	Others
Valerena-4,7(11)-diene is a tranquilizer. Valerena-4,7(11)-diene suppresses stress-induced excitatory behaviors. Valerena-4,7(11)-diene is expressed via olfactory stimulation and pulmonary absorption .

HY-15121

L-Theanine 2 Publications Verification L-Glutamic Acid γ-ethyl amide; Nγ-Ethyl-L-glutamine	Structural Classification Microorganisms Neurological Disease Classification of Application Fields Anti-aging Source classification Amino acids Camellia sinensis (L.) O. Ktze. Plants Disease Research Fields Theaceae	Apoptosis Endogenous Metabolite Reactive Oxygen Species (ROS)
L-Theanine (L-Glutamic Acid γ-ethyl amide) is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective, anticancer and anti-oxidative activities. L-Theanine can pass through the blood–brain barrier and is orally active .

HY-N1440

Koumine	Alkaloids Structural Classification Classification of Application Fields Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Inflammation/Immunology Disease Research Fields Indole Alkaloids	Bcl-2 Family
Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

HY-N1440R

Koumine (Standard)	Alkaloids Structural Classification Source classification Loganiaceae Plants Gelsemium eleganis (Gardn. et Champ.) Benth. Indole Alkaloids	Bcl-2 Family
Koumine (Standard) is the analytical standard of Koumine. This product is intended for research and analytical applications. Koumine is an alkaloid separated from Gelsemium elegans, shows potent anti-tumor activity. Koumine up-regulates the Bax/Bcl-2 ratio and caspase-3 expression in human breast cancer cells . Koumine has anxiolytic, antistress, antipsoriatic, and analgesic activities , protects against the development of arthritis in Rheumatoid arthritis (RA) animal models .

Cat. No.	Product Name	Chemical Structure

HY-152052S

Linalool-d5

Linalool-d₅ is the deuterium labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-15121S

L-Theanine-d5

L-Theanine-d₅ is the deuterium labeled L-Theanine. L-Theanine (L-Glutamic Acid γ-ethyl amide）is a non-protein amino acid contained in green tea leaves, which blocks the binding of L-glutamic acid to glutamate receptors in the brain, and with neuroprotective and anti-oxidative activities. L-Theanine causes anti-stress effects via the inhibition of cortical neuron excitation by oral intake .

HY-W012382S

N-Acetyl-L-tyrosine-d3

N-Acetyl-L-tyrosine-d₃ is the deuterated form of N-Acetyl-L-tyrosine (HY-W012382). N-Acetyl-L-tyrosine is an orally active endogenous mitochondrial stress response regulator that can permeate the cell membrane by passive diffusion. N-Acetyl-L-tyrosine induces low-level reactive oxygen species (ROS) generation by transiently perturbing mitochondrial membrane potential, triggering reverse signaling to activate FoxO and Keap1 pathways. As a result, N-Acetyl-L-tyrosine enhances the expression of antioxidant enzyme genes, exerting anti-stress and cytoprotective effects. N-Acetyl-L-tyrosine can improve heat stress tolerance, inhibit tumor growth, and regulate energy metabolism. N-Acetyl-L-tyrosine can be used in the research of aging, metabolic diseases (such as diabetes), and cancer .

HY-W010410S

Oct-1-en-3-ol-d3

Oct-1-en-3-ol-d₃ is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-N6948S

Linalyl acetate-d6
Linalyl acetate-d₆ is deuterated labeled Linalyl acetate (HY-N6948). Linalyl acetate is the principal components of many plant essential oils. Linalyl acetate exhibits anti-anxiety, anti-inflammatory, anti-diabetic, anti-stress, and cardiovascular-regulatory effects. Linalyl acetate is orally active .

HY-N0368S1

Linalool-13C3

Linalool- ¹³C₃ is ¹³C labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-N0368S2

Linalool-d6

Linalool-d₆ is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-W010201S

Citronellol-d6

Citronellol-d₆ is deuterated labeled Citronellol (HY-W010201). Citronellol ((±)-Citronellol) is an orally active inducer of apoptosis. Citronellol can prevent oxidative stress, mitochondrial dysfunction, and apoptosis in the SH-SY5Y cell Parkinson's disease model induced by 6-OHDA by regulating the ROS-NO, MAPK/ERK, and PI3K/Akt signaling pathways. Citronellol can induce necroptosis in human lung cancer cells through the TNF-α pathway and accumulation of ROS. Citronellol can reduce the levels of LC-3 and p62 to regulate the autophagy pathway, inhibit oxidative stress and neuroinflammation, and thus have neuroprotective effects on Parkinson's rats. Citronellol exhibits anti-fungal activity against Trichophyton rubrum by inhibiting ergosterol synthesis ^.

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