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Results for "

anti-leukemic activity

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (5) Akt (2) Anaplastic lymphoma kinase (ALK) (2) Antibiotic (2) Apoptosis (22) Arginase (4) Bacterial (8) Bcl-2 Family (1) Bcr-Abl (1) BCRP (1) Biochemical Assay Reagents (1) BMI1 (1) c-Myc (1) Casein Kinase (2) CDK (3) CMV (1) CRM1 (2) Cytochrome P450 (1) Dihydroorotate Dehydrogenase (1) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (1) DNA/RNA Synthesis (6) Dopamine Receptor (5) Drug Intermediate (1) Endogenous Metabolite (1) Eukaryotic Initiation Factor (eIF) (1) Fat Mass and Obesity-associated Protein (FTO) (1) Ferroptosis (1) Flavivirus (1) FLT3 (6) Fluorescent Dye (1) Fungal (5) HDAC (4) Histone Demethylase (1) Histone Methyltransferase (9) HSV (1) Interleukin Related (1) IRAK (1) Isotope-Labeled Compounds (1) JAK (2) Microtubule/Tubulin (1) MNK (1) mTOR (2) Necroptosis (1) Nucleoside Antimetabolite/Analog (1) Orthopoxvirus (2) Parasite (2) PI3K (3) PROTACs (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) RUNX (1) Ser/Thr Kinase (1) Src (1) STAT (3) Survivin (1) TGF-beta/Smad (2) TGF-β Receptor (2) Topoisomerase (2)
By Research Areas:	Cancer (66) Endocrinology (5) Infection (15) Inflammation/Immunology (5) Metabolic Disease (7) Neurological Disease (5)

By Targets:

Adrenergic Receptor (5)

Akt (2)

Anaplastic lymphoma kinase (ALK) (2)

Antibiotic (2)

Apoptosis (22)

Arginase (4)

Bacterial (8)

Bcl-2 Family (1)

Bcr-Abl (1)

BCRP (1)

Biochemical Assay Reagents (1)

BMI1 (1)

c-Myc (1)

Casein Kinase (2)

CDK (3)

CMV (1)

CRM1 (2)

Cytochrome P450 (1)

Dihydroorotate Dehydrogenase (1)

DNA Alkylator/Crosslinker (1)

DNA Methyltransferase (1)

DNA/RNA Synthesis (6)

Dopamine Receptor (5)

Drug Intermediate (1)

Endogenous Metabolite (1)

Eukaryotic Initiation Factor (eIF) (1)

Fat Mass and Obesity-associated Protein (FTO) (1)

Ferroptosis (1)

Flavivirus (1)

FLT3 (6)

Fluorescent Dye (1)

Fungal (5)

HDAC (4)

Histone Demethylase (1)

Histone Methyltransferase (9)

HSV (1)

Interleukin Related (1)

IRAK (1)

Isotope-Labeled Compounds (1)

JAK (2)

Microtubule/Tubulin (1)

MNK (1)

mTOR (2)

Necroptosis (1)

Nucleoside Antimetabolite/Analog (1)

Orthopoxvirus (2)

Parasite (2)

PI3K (3)

PROTACs (1)

Pyroptosis (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (1)

RUNX (1)

Ser/Thr Kinase (1)

Src (1)

STAT (3)

Survivin (1)

TGF-beta/Smad (2)

TGF-β Receptor (2)

Topoisomerase (2)

By Research Areas:

Cancer (66)

Endocrinology (5)

Infection (15)

Inflammation/Immunology (5)

Metabolic Disease (7)

Neurological Disease (5)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109179A

Itacnosertib hydrochloride TP-0184 hydrochloride	JAK Anaplastic lymphoma kinase (ALK) FLT3 STAT PI3K Akt mTOR TGF-beta/Smad TGF-β Receptor	Cancer
Itacnosertib hydrochloride (TP-0184 hydrochloride) is the inhibitor for FLT3, ACVR1 (ALK2, IC₅₀=8 nM) and JAK2 (IC₅₀=8540 nM). Itacnosertib hydrochloride exhibits anti-leukemic activity .

HY-109179

Itacnosertib TP-0184	JAK Anaplastic lymphoma kinase (ALK) FLT3 STAT PI3K Akt mTOR TGF-beta/Smad TGF-β Receptor	Cancer
Itacnosertib (TP-0184) is the inhibitor for FLT3, ACVR1 (ALK2, IC₅₀=8 nM) and JAK2 (IC₅₀=8540 nM). Itacnosertib exhibits anti-leukemic activity .

HY-112885

nor-NOHA Nω-Hydroxy-nor-L-arginine	Apoptosis Arginase	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA is a selective and reversible arginase inhibitor. nor-NOHA induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA has anti-leukemic activity. nor-NOHA can used in study of endothelial dysfunction, immunosuppression and metabolism .

HY-133900

Deoxyharringtonine	Others	Cancer
Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity .

HY-N14155

Epelmycin A	Bacterial Fungal	Infection Cancer
Epelmycin A has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .

HY-N14156

Epelmycin B	Bacterial Fungal	Infection Cancer
Epelmycin B has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .

HY-N14158

Epelmycin D	Bacterial Fungal	Infection Cancer
Epelmycin D has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .

HY-N14157

Epelmycin C	Bacterial Fungal	Infection Cancer
Epelmycin C has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .

HY-N14159

Epelmycin E	Bacterial Fungal	Infection Cancer
Epelmycin E has anti-Gram positive, negative bacteria and candida albicans activity, and has anti-leukemic L1210 activity, which is stronger than Aclacinomycin .

HY-N8402

Germacrone 4,5-epoxide	Others	Cancer
Germacrone 4,5-epoxide is a sesquiterpene that can be isolated from Curcuma cf. viridiflora. Germacrone 4,5-epoxide has excellent anti-leukemic activities .

HY-119361

(Rac)-Deox B 7,4 (Rac)-Deoxysappanone B 7,4' dimethyl ether	Microtubule/Tubulin	Cancer
(Rac)-Deox B 7,4, a homoisoflavanoid compound, inhibits microtubule polymerization via binding near the colchicine site and promote reversible G2 arrest. (Rac)-Deox B 7,4 possesses nanomolar anti-leukemic activity .

HY-141430

AS-85	Histone Methyltransferase	Cancer
AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC₅₀=0.6 μM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the K_d value of 0.78 μM .

HY-112885A

nor-NOHA acetate 2 Publications Verification Nω-Hydroxy-nor-L-arginine acetate	Arginase Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA acetate (Nω-Hydroxy-nor-L-arginine acetate) is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism .

HY-123954

BTX-A51 Casein Kinase inhibitor A51	Casein Kinase CDK Apoptosis	Cancer
BTX-A51 (Casein Kinase inhibitor A51) is a potent and orally active casein kinase 1α (CK1α) inhibitor. BTX-A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities .

HY-112885C

nor-NOHA dihydrochloride 2 Publications Verification Nω-Hydroxy-nor-L-arginine dihydrochloride	Apoptosis Arginase	Metabolic Disease Inflammation/Immunology Cancer
nor-NOHA dihydrochloride is a selective and reversible arginase inhibitor. nor-NOHA dihydrochloride induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA dihydrochloride has anti-leukemic activity. nor-NOHA dihydrochloride can used in study endothelial dysfunction, immunosuppression and metabolism .

HY-119827

Moflomycin F 860191	Topoisomerase	Cancer
Moflomycin (F 860191) is a compound with strong anti-leukemic activity and low mutagenicity. Moflomycin has an antiproliferative effect on the leukemic cell line HL60 in vitro (IC₅₀=2.9 nM) . Moflomycin enhances topoisomerase II-induced DNA breaks and free radical production .

HY-112885B

nor-NOHA monoacetate 2 Publications Verification Nω-Hydroxy-nor-L-arginine monoacetate	Arginase	Metabolic Disease
nor-NOHA monoacetate is a selective and reversible arginase inhibitor. nor-NOHA monoacetate induces apoptosis in ARG2-expressing cells under hypoxia. nor-NOHA monoacetate has anti-leukemic activity. nor-NOHA monoacetate can used in study of endothelial dysfunction, immunosuppression and metabolism .

HY-107338

Denotivir Vratizolin; Wratizolin	HSV Interleukin Related	Infection Inflammation/Immunology Cancer
Denotivir (Vratizolin) is an orally active antiviral agent for herpes simplex virus (HSV) and varicella-zoster virus (VZV). Denotivir inhibits the proliferation of various cancer cells, and exhibits anti-leukemic activity. Denotivir inhibits the generation of TNF-α, IL-1 and IL-6, exhibits immunosuppressive efficacy .

HY-141429

AS-99 free base	Histone Methyltransferase Apoptosis	Cancer
AS-99 is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 µM, K_d= 0.89 µM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-141429C

AS-99	Histone Methyltransferase Apoptosis	Cancer
AS-99 is a first-in-class, potent, and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 μM, K_d= 0.89 μM) with anti-leukemic activity. AS-99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-141429A

AS-99 TFA 2 Publications Verification	Histone Methyltransferase Apoptosis	Cancer
AS-99 TFA is a first-in-class, potent and selective ASH1L histone methyltransferase inhibitor (IC₅₀= 0.79 μM, K_d= 0.89 μM) with anti-leukemic activity. AS-99 TFA blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo .

HY-B1516

Alovudine 3'-Fluoro-3'-deoxythymidine; 3′-Deoxy-3′-fluorothymidine; FLT	DNA/RNA Synthesis Orthopoxvirus	Infection Cancer
Alovudine (3'-Fluoro-3'-deoxythymidine) is a mtDNA synthesis inhibitor and a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than ¹⁸F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer. Alovudine shows anti-orthopoxvirus and anti-leukemic activity .

HY-163803

CM-444	HDAC DNA Methyltransferase	Cancer
CM-444 is inhibitor for HDAC (IC₅₀ is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC₅₀ is 1.8-2.3 μM). CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models .

HY-B1336

Furazolidone 3 Publications Verification	Bacterial Apoptosis Antibiotic Parasite	Infection Cancer
Furazolidone is a monoamine oxidase (MAO) inhibitor with antiproliferative, apoptosis-inducing and differentiation-promoting activities. Furazolidone may inhibit leukemia fusion protein-mediated bone marrow transformation by upregulating the stability of the tumor suppressor protein p53. Furazolidone exhibits anti-leukemic activity in acute myeloid leukemia (AML) cell lines and can be used for anti-AML research [2].

HY-123955

Casein Kinase inhibitor A86	Casein Kinase CDK Apoptosis	Cancer
Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities .

HY-112041

Unesbulin 3 Publications Verification PTC596	BMI1 Apoptosis	Cancer
Unesbulin (PTC596) is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. Unesbulin downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia (AML) cells. Unesbulin has anti-leukemic activity .

HY-168927

Apoptosis inducer 36	Apoptosis Pyroptosis	Cancer
Apoptosis inducer 36 (Compound 42) exhibits anti-leukemic activity through reduction of leukemia stem cells (LSCs) and induction of differentiation. Apoptosis inducer 36 inhibits the proliferation of AML cells, arrests cell cycle at G1 phase, and induces PANoptosis including apoptosis, pyroptosis and necrosis. Prodrug of apoptosis inducer 36 exhibits orally active antitumor efficacy in mouse model .

HY-100423

Eltanexor 2 Publications Verification KPT-8602	CRM1	Cancer
Eltanexor (KPT-8602) is a second-generation, highly specific and orally active exportin-1 (XPO1) inhibitor with potent anti-leukemic activity. Eltanexor (KPT-8602) inhibits XPO1-dependent nuclear export (EC₅₀=60.9 nM) by directly targeting XPO1. Eltanexor (KPT-8602) induces Caspase-dependent apoptosis in a panel of leukemic cell lines .

HY-402815

(E)-4-(Naphthalen-2-yl)but-3-en-2-one	Drug Intermediate	Cancer
(E)-4-(Naphthalen-2-yl)but-3-en-2-one (Compound 7) is a small active molecule that can be used as building block. (E)-4-(Naphthalen-2-yl)but-3-en-2-one exhibits anti-leukemic activity, that inhibits the proliferation of human chronic myeloid leukemia cell K562 with an IC₅₀ of 7.6 μM .

HY-W740364

3'-Deoxy-3'-fluorothymidine-d3	Isotope-Labeled Compounds DNA/RNA Synthesis Orthopoxvirus	Cancer
3'-Deoxy-3'-fluorothymidine-d₃ is the deuterium labeled Alovudine (HY-B1516). Alovudine (3'-Fluoro-3'-deoxythymidine) is a mtDNA synthesis inhibitor and a marker of DNA synthesis. Alovudine is less susceptible to inflammatory changes than 18F-Fluorodeoxyglucose (FDG) and thus is a better biomarker in pancreatic cancer. Alovudine shows anti-orthopoxvirus and anti-leukemic activity .

HY-108894

Ferumoxytol	Reactive Oxygen Species (ROS) Ferroptosis	Cancer
Ferumoxytol is an iron oxide nanoparticle. Ferumoxytol has anti-leukemic activity, especially against acute myeloid leukemia (AML) cells with low iron transporter protein (FPN) expression. Ferumoxytol increases intracellular iron content, triggers the Fenton reaction, generates reactive oxygen species (ROS), leads to oxidative stress and ferroptosis. Ferumoxytol can selectively kill leukemic cells with low FPN expression while avoiding toxicity to normal cells. Ferumoxytol can be used to study leukemias with targeted iron metabolism abnormalities .

HY-150109A

Purinostat	HDAC	Cancer
Purinostat is a selective inhibitor of HDAC I/IIb with anti-leukemic activity. Purinostat mesylate (HY-150109), the mesylate salt of Purinostat, inhibits the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDAC I/IIb to inhibit several important factors for leukemic stem cell (LSC) survival, including c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR. Purinostat mesylate increases glutamate metabolism in LSC by increasing GLS1 .

HY-157327

AKE-72	Bcr-Abl	Cancer
AKE-72 (compound 5) is a potent inhibitor of Pan-BCR-ABL. AKE-72 inhibits BCR-ABL ^WT, BCR-ABL ^T315, BCR-ABL ^E255K, BCR-ABL ^F3171, BCR-ABL ^H396P and BCR-ABL ^Q252H with IC₅₀s of < 0.5, 9, 8.98, 3.12, < 1.0 and 3.88 nM, respectively. AKE-72 has anti-leukemic activity against K-562 cell line .

HY-112654A

GCN2iB acetate	Endogenous Metabolite	Cancer
GCN2iB acetate is a GCN2 inhibitor that enhances Gcn2 activity and Atf4 expression. GCN2iB can activate Gcn2 mutants lacking functional regulatory regions or certain kinase domain substitution mutants. GCN2iB increases eIF2 phosphorylation by Gcn2 at low concentrations, thereby enhancing the cellular response to nutritional stress. GCN2iB may have potential benefits for the inhibition of cancer cells expressing low basal levels of aspartate synthetase, enhancing their sensitivity to the anti-leukemic compound L-aspartase .

HY-174367

RUNX1/ETO-IN-1	RUNX Apoptosis	Cancer
RUNX1/ETO-IN-1 is a RUNX1-ETO oncogenic fusion protein inhibitor that specifically targets the NHR2 oligomerization domain. RUNX1/ETO-IN-1 directly interacts with the NHR2 (K_D,app = 39 μM). RUNX1/ETO-IN-1 exhibits anti-leukemic activity by inducing apoptosis and promoting differentiation in RUNX1/ETO-translocated AML cells. RUNX1/ETO-IN-1 remains essentially uncharged at physiological pH, demonstrating superior membrane permeability.

HY-N7549

Dehydrobruceantin	Others	Cancer
Dehydrobruceantin has potential antileukemic activity .

HY-126205

Deacetyleupaserrin	Others	Cancer
Deacetyleupaserrin is a sesquiterpenoid with antileukemic activity that can be isolated from Eupatorium semiserratum .

HY-N3171A

(+)-Nortrachelogenin Wikstromol	Apoptosis PI3K	Cancer
(+)-Nortrachelogenin (Wikstromol), a pharmacologically ligand from from wikstroemia indica, possesses antileukemic activity .

HY-117237

Hisphen MD 1	Biochemical Assay Reagents	Cancer
Hisphen is a chemical mutagen that can affect the grain protein content . Hisphen also has antileukemic activities .

HY-N8146

Bruceantinol	STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK	Infection Cancer
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀ = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .

HY-N0838

Cephalotaxine (-)-Cephalotaxine; ZINC19795976	Flavivirus	Infection Cancer
Cephalotaxlen ((-)-Cephalotaxine) is an alkaloid that can be isolated from Cephalotaxus fortunei, with antileukemic and antiviral activities. Cephalotaxlen has anti-ZIKV (Zika virus) activity .

HY-135771

Avarone (+)-Avarone	Others	Cancer
Avarone ((+)-Avarone) is a sesquiterpenoidal quinone that can be isolated from Dysidea avara. Avarone shows cytotoxicity. Avarone shows antileukemic activity .

HY-U00095

Hepsulfam 1 Publications Verification NCI 329680; ZINC01574758	DNA Alkylator/Crosslinker	Cancer
Hepsulfam (NCI 329680; ZINC01574758) is a anticancer agent that shows excellent antileukemic activity with an median IC₅₀ of 0.91 μg/mL in a panel of different tumors.

HY-N14180

6-Deoxyilludin M	Antibiotic	Infection Cancer
6-Deoxyilludin M is an antitumor antibiotic possessing antileukemic activity. 6-Deoxyilludin M can be isolated from the culture broth of the Basidiomycota Pleurotus japonicas .

HY-111008

Trimidox VF-233	DNA/RNA Synthesis	Cancer
Trimidox (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-111008A

Trimidox hydrochloride VF-233 hydrochloride	DNA/RNA Synthesis	Cancer
Trimidox hydrochloride (VF-233) is a ribonucleotide reductase inhibitor with antileukemic activities. Trimidox hydrochloride inhibits the growth of human promyelocytic leukemia HL-60 cells with an IC₅₀ of 35 μM .

HY-118144

PD166326	BCRP Src	Cancer
PD166326 is a pyridopyrimidine-type inhibitor of receptor tyrosine kinases, with IC₅₀s of 6 nM and 8 nM for Src and Abl, respectively. PD166326 exhibits antileukemic activity .

HY-123523

Enocitabine	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis CMV	Infection Cancer
Enocitabine is a nucleoside analog, and is a potent DNA replication inhibitor, and a DNA chain terminator. Enocitabine inhibits the replication of human cytomegalovirus. Enocitabine has antileukemic and antiviral activities .

HY-123718

6-Benzylthioinosine	Parasite	Others
6-Benzylthioinosine is a compound with antileukemic activity that increases cytotoxicity against acute myeloid leukemia cells when combined with metformin, modulating cellular metabolism and signaling pathways through multiple mechanisms.

HY-117996

KPT-251	CRM1 Apoptosis	Cancer
KPT-251 is an orally active chromosome region maintenance 1 protein (CRM1) inhibitor. KPT-251 induces cancer cell apoptosis and shows antileukemic activity .

Cat. No.	Product Name	Category	Target	Chemical Structure